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1 ectly suppress both mouse and human OGG1 via AMP-activated protein kinase.
2 displayed increased activation of SIRT3 and AMP-activated protein kinase.
3 tion, have recently emerged as activators of AMP-activated protein kinase.
4 bust activation of skeletal muscle SIRT3 and AMP-activated protein kinase.
5 tivation of the kinase upstream of ULK1, the AMP-activated protein kinase.
6 but nitrite increased the phosphorylation of AMP-activated protein kinase.
7 erestingly, metformin-induced stimulation of AMP-activated protein kinase (a nutrient deprivation sen
8 of LKB1 in suppressing ROS is independent of AMP-activated protein kinase, a canonical substrate of L
11 vels independently of energy stress-mediated AMP-activated protein kinase activation and possibly thr
13 phosphorylation complexes, restored cardiac AMP-activated protein kinase activation, and improved my
17 ylation (acetyl-Lys)-dependent activation of AMP-activated protein kinase, AKT, and PKA kinases durin
18 rinsic interaction between the expression of AMP-activated protein kinase alpha (AMPKalpha) and the i
19 rates that polymet-CDDP NPs can activate the AMP-activated protein kinase alpha (AMPKalpha) pathway a
20 reperfusion recovered poorly with no phospho-AMP-activated protein kinase alpha activation, decreased
21 evates SIRT1 levels and activity in an AMPK (AMP-activated protein kinase alpha)-dependent manner.
24 nt of cigarette smoke, selectively activates AMP-activated protein kinase alpha2 (AMPKalpha2) in adip
27 ere preceded by increased phosphorylation of AMP activated protein kinase (Ampk) at tyrosine 172 and
29 the energy-sensing adenosine monophosphate (AMP)-activated protein kinase (AMPK) is genetically requ
30 f the energy sensor adenosine monophosphate (AMP)-activated protein kinase (AMPK) is repressed in NAS
31 course experiments revealed that PF induces AMP-activated protein kinase (AMPK) activation before in
32 content (-45% vs. M-ERRalphaWT) and enhanced AMP-activated protein kinase (AMPK) activation in M-ERRa
39 to modulate both ATP-citrate lyase (ACL) and AMP-activated protein kinase (AMPK) activity in rodents.
41 nduced activation of autophagy, or use of 5'-AMP-activated protein kinase (AMPK) agonists, promoted t
42 te for the first time that the activation of AMP-activated protein kinase (AMPK) alpha in sensory hai
43 idney, metformin increased the activation of AMP-activated protein kinase (AMPK) and decreased inflam
44 eraction with the master metabolic sensor 5' AMP-activated protein kinase (AMPK) and Folliculin, a pr
45 In RGCs expressing mutated Opa1, active 5' AMP-activated protein kinase (AMPK) and its autophagy ef
47 strate that the metabolic checkpoint kinases AMP-activated protein kinase (AMPK) and LKB1 are not req
48 involving stress-responsive activation of 5'-AMP-activated protein kinase (AMPK) and neuroprotective
50 and AdipoR2, increases the activities of 5' AMP-activated protein kinase (AMPK) and peroxisome proli
51 e in muscle coordinated by signaling through AMP-activated protein kinase (AMPK) and peroxisome proli
52 n of TWEAK inhibited ( approximately 31%) 5' AMP-activated protein kinase (AMPK) and reduced ( approx
53 lation by PKG2 is triggered by activation of AMP-activated protein kinase (AMPK) and requires endothe
54 the signaling pathways of the CR mediators, AMP-activated protein kinase (AMPK) and sirtuin-1 are ac
55 nstrate that NT attenuates the activation of AMP-activated protein kinase (AMPK) and stimulates fatty
56 spontaneously activate the metabolic sensor AMP-activated protein kinase (AMPK) and that activation
59 t of rapamycin (mTOR) pathway, downstream of AMP-activated protein kinase (AMPK) and upstream of ribo
60 Target of rapamycin complex 1 (TORC1) and AMP-activated protein kinase (AMPK) antagonistically mod
61 this study, we identify the metabolic sensor AMP-activated protein kinase (AMPK) as a beta1-integrin
63 ) analysis to identify the gamma1 subunit of AMP-activated protein kinase (AMPK) as an essential cont
67 target of rapamycin (mTOR) or activation of AMP-activated protein kinase (AMPK) during the contracti
73 nistically, SIRT2 maintained the activity of AMP-activated protein kinase (AMPK) in aged and Ang II-i
74 that activation of the low-energy sensor 5'-AMP-activated protein kinase (AMPK) in hepatocytes and s
75 ibrotic effects and specifically the role of AMP-activated protein kinase (AMPK) in kidney tubular ep
76 gly, stretch induced the acute activation of AMP-activated protein kinase (AMPK) in normal cardiomyoc
79 phosphorylation of the downstream substrate AMP-activated protein kinase (AMPK) in response to ionom
81 resveratrol required activation of Sirt1 and AMP-activated protein kinase (Ampk) in this tissue to in
82 ed aerobic glycolysis, a process mediated by AMP-activated protein kinase (AMPK) independently of HIF
104 As a central regulator of metabolism, the AMP-activated protein kinase (AMPK) is an established th
106 potential controls calcium homeostasis, and AMP-activated protein kinase (AMPK) is regulated, in par
111 at inhibition of the metabolic stress sensor AMP-activated protein kinase (AMPK) led to deranged gluc
112 f beta-oxidation genes, greater reduction in AMP-activated protein kinase (AMPK) levels, and diminish
113 tiates the stimulating effect of LKB1 on the AMP-activated protein kinase (AMPK) metabolic sensor thr
115 urthermore, the mechanism by which activated AMP-activated protein kinase (AMPK) negatively regulates
116 this effect is primarily mediated through a AMP-activated protein kinase (AMPK) pathway and a novel
117 lso exhibit constitutive activation of liver AMP-activated protein kinase (AMPK) pathway and nuclear
119 osed to trehalose resisted trehalose-induced AMP-activated protein kinase (AMPK) phosphorylation and
120 SG improved NAFLD significantly by enhancing AMP-activated protein kinase (AMPK) phosphorylation and
121 over, Sirt3-/- osteoclast precursors reduced AMP-activated protein kinase (AMPK) phosphorylation thro
122 kinase B1 (LKB1) and its downstream effector AMP-activated protein kinase (AMPK) play critical roles
124 egans larvae, the master metabolic regulator AMP-activated protein kinase (AMPK) plays a critical rol
127 lmodulin-dependent kinase kinase (CaMKK) and AMP-activated protein kinase (AMPK) regulate metabolic a
133 he PKM1/2 knockdown in H1299 cells activated AMP-activated protein kinase (AMPK) signaling and stimul
135 been recently proposed as activators of the AMP-activated protein kinase (AMPK) signaling pathway an
136 e in the AMP/ATP ratio and activation of the AMP-activated protein kinase (AMPK) signaling pathway in
137 background, cAMP/protein kinase A (PKA) and AMP-activated protein kinase (AMPK) signaling pathways a
139 c checkpoint controlled by the energy sensor AMP-activated protein kinase (AMPK) that regulated mRNA
140 or glucose restriction (GR) regulate PKA and AMP-activated protein kinase (AMPK) to protect against D
141 In response to low energy, the cellular AMP-activated protein kinase (AMPK) triggers a physiolog
142 yclic AMP (cAMP) signalling independently of AMP-activated protein kinase (AMPK) via direct inhibitio
143 Signaling by the master metabolic regulator AMP-activated protein kinase (AMPK) was a critical node
144 Recently, it has been demonstrated that AMP-activated protein kinase (AMPK) was deregulated in t
148 with increased pseudopodial activity of the AMP-activated protein kinase (AMPK), a critically import
149 show that apoptotic cells potently activate AMP-activated protein kinase (AMPK), a highly sensitive
152 demonstrate that VPA is a novel activator of AMP-activated protein kinase (AMPK), a key regulator of
153 s a direct target for phosphorylation by the AMP-activated protein kinase (AMPK), a key sensor and re
154 ncer cell growth via the metabolic sensor 5'-AMP-activated protein kinase (AMPK), a kinase that class
156 elial cell line, we investigated the role of AMP-activated protein kinase (AMPK), a master regulator
160 stressed microenvironments that activate 5'-AMP-activated protein kinase (AMPK), a ubiquitous regula
161 ti-inflammatory signaling pathways involving AMP-activated protein kinase (AMPK), Akt and eNOS, and i
162 nt and anti-inflammatory signaling involving AMP-activated protein kinase (AMPK), Akt, endothelial ni
164 lin, mechanistic target of rapamycin (mTOR), AMP-activated protein kinase (AMPK), and autophagy pathw
165 coneogenesis, protein phosphatase 2A (PP2A), AMP-activated protein kinase (AMPK), and FoxO1 proteins.
166 gy sensors, which include sirtuin-1 (SIRT1), AMP-activated protein kinase (AMPK), and hypoxia inducib
167 nt and oxygen deprivation-sirtuin-1 (SIRT1), AMP-activated protein kinase (AMPK), and hypoxia-inducib
168 (ADP-ribose) polymerases (PARPs), sirtuins, AMP-activated protein kinase (AMPK), and mechanistic tar
169 lated the essential metabolic stress sensor, AMP-activated protein kinase (AMPK), and targeting AMPK
171 oy receptor 8 (IL-1R8) and the activation of AMP-activated protein kinase (AMPK), because both inhibi
173 quired miR-33 targeting of the energy sensor AMP-activated protein kinase (AMPK), but not cholesterol
174 sensor of energy status in mammalian cells, AMP-activated protein kinase (AMPK), can also be activat
175 pound berberine (BBR), a potent activator of AMP-activated protein kinase (AMPK), can reduce beta-cat
176 how that HSF1, a physiological substrate for AMP-activated protein kinase (AMPK), constitutively supp
177 regulate both O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK), cooperatively conne
178 d its downstream effector, the energy sensor AMP-activated protein kinase (AMPK), in repressing Yki a
179 orin signals via the energy sensing protein, AMP-activated protein kinase (AMPK), in the autophagic d
180 ynthesis and a well-established activator of AMP-activated protein kinase (AMPK), induces widespread
181 A key sensor of cellular energy status, AMP-activated protein kinase (AMPK), interacts allosteri
182 ng sirtuin 1 (SIRT1), forkhead box O (FoxO), AMP-activated protein kinase (AMPK), peroxisome prolifer
183 ted with a significant activation of hepatic AMP-activated protein kinase (AMPK), peroxisome prolifer
185 lity or starvation-regulated mechanisms like AMP-activated protein kinase (AMPK), reactive oxygen spe
186 Fluctuations in these pools can activate AMP-activated protein kinase (AMPK), the central regulat
189 Particularly relevant to this process is 5'-AMP-activated protein kinase (AMPK), which functions as
190 to determine the role in this process of the AMP-activated protein kinase (AMPK), which is intimately
191 Nisch binds to and inhibits the activity of AMP-activated protein kinase (AMPK), which regulates ene
193 ed activation of the metabolic stress enzyme AMP-activated protein kinase (AMPK), which was mediated
195 e extract enhances glycolysis and attenuates AMP-activated protein kinase (AMPK)-dependent inhibition
196 sed glucose uptake in skeletal muscles in an AMP-activated protein kinase (AMPK)-dependent manner, an
197 plex 1 and laminin gamma1 accumulation in an AMP-activated protein kinase (AMPK)-dependent manner.
198 urrent study, we find that metformin, via an AMP-activated protein kinase (AMPK)-dependent mechanism,
199 originally postulated to be due to a hepatic AMP-activated protein kinase (AMPK)-dependent mechanism.
200 we show that nutrient starvation results in AMP-activated protein kinase (AMPK)-dependent phosphoryl
201 e beta-cell electrical activity by promoting AMP-activated protein kinase (AMPK)-dependent traffickin
202 glycolytic enzyme, is a critical mediator of AMP-activated protein kinase (AMPK)-driven Sirt1 activat
203 tion and/or activation of the adiponectin-5'-AMP-activated protein kinase (AMPK)-forkhead box O (FOXO
205 Host hedgehog signaling was modulated in an AMP-activated protein kinase (AMPK)-mammalian target of
206 ate here that glucose deprivation results in AMP-activated protein kinase (AMPK)-mediated acetyl-CoA
207 turn governs autophagic response through an AMP-activated protein kinase (AMPK)-mediated feedforward
208 ession of GOF mutant p53 G245D decreases the AMP-activated protein kinase (AMPK)-mediated phosphoryla
227 biopsy tissue revealed misregulation of the AMP-activated protein kinase (AMPK)/4E-binding protein 1
228 yceride lipase, acetyl-CoA carboxylase 2 and AMP-activated protein kinase (AMPK)gamma3 were higher in
232 unx2 knockdown cells displayed activation of AMP-activated protein kinase (AMPKalpha), the sensor of
233 tochondria for oxidation, which responded to AMP-activated protein kinase and acetyl-CoA carboxylase
235 -derived oxidative stress and stimulation of AMP-activated protein kinase and downstream signaling pa
236 e edema formation, including aquaporin-4 and AMP-activated protein kinase and its downstream effector
237 renal levels of the phosphorylated forms of AMP-activated protein kinase and its target acetyl-CoA c
238 nd glucagon, the cellular master switches 5' AMP-activated protein kinase and mTOR, and also numerous
240 resulting in activation of the energy sensor AMP-activated protein kinase and phosphorylation of euka
241 phagic flux - mammalian target of rapamycin, AMP-activated protein kinase and sirtuins are key regula
242 f downstream protein kinases - such as AMPK (AMP-activated protein kinase) and CAMK types I and IV.
243 the cell metabolism (IR-alpha, IR-beta, and AMP-activated protein kinase), and a stabilizing effect
244 tivation of the cellular energy sensor AMPK (AMP-activated protein kinase), and decreases EC prolifer
245 including endothelial nitric oxide synthase, AMP-activated protein kinase, and the actin-binding MARC
246 ylation of CAR by metformin was primarily an AMP-activated protein kinase- and extracellular signal-r
249 erted its anti-inflammatory function through AMP-activated protein kinase as AMP kinase knockout or i
250 ion of liver kinase B1 and the energy sensor AMP-activated protein kinase, as well as enhanced fatty
252 acrophages in vitro, heme activates an AMPK (AMP-activated protein kinase)/ATF1 (activating transcrip
253 LKB1 in Tregs is largely independent of the AMP-activated protein kinase, but is mediated by the MAP
254 icroglia/macrophage WAP domain protein in an AMP-activated protein kinase-dependent manner and favora
255 y in the synthesis of biologically important AMP-activated protein kinase deprived of any metal Pd co
257 ased ATP levels and increased phosphorylated AMP-activated protein kinase, exposing an energy deficie
260 ociated with the negative regulator of mTOR, AMP-activated protein kinase, have higher translational
261 infection might initiate a cross talk among AMP-activated protein kinase-Hippo-TBK1 pathways, which
262 th sets is regulated positively by the yeast AMP-activated protein kinase homolog, Snf1, in response
263 etabolism may have in chemotransduction; the AMP-activated protein kinase hypothesis and its current
266 ular ATP levels and concomitantly stimulated AMP-activated protein kinase in vitro and in vivo As an
268 h glucose by stimulation of glycolysis by an AMP-activated protein kinase-independent mechanism throu
272 ed treatment with DHA and Physcion activates AMP-activated protein kinase, leading to synergistic inh
273 Sestrins affect multiple signaling pathways: AMP-activated protein kinase, mammalian target of rapamy
274 FF depletes intracellular ATP, activates the AMP-activated protein kinase-mammalian target of rapamyc
276 Finally, we show that the deletion of the AMP-activated protein kinase ortholog-encoding gene SNF1
277 get of rapamycin pathways and stimulated the AMP-activated protein kinase pathway in both muscles.
280 nal validation did not identify NF-kappaB or AMP-activated protein kinase phosphorylation, but uric a
281 ed kinases, increased the phosphorylation of AMP-activated protein kinase, reduced intracellular pota
282 creased and the expression and activation of AMP-activated protein kinase signaling and cyclooxygenas
285 rk highlights the ability of acute localized AMP-activated protein kinase signaling to affect mitocho
287 oxidative fibres and decreased activation of AMP-activated protein kinase signalling in transgenics c
288 stimulation of a signaling cascade involving AMP-activated protein kinase, sirtuin 1, PGC-1alpha, sir
289 uttle systems, NAD(+) concentrations and the AMP-activated protein kinase/sirtuin 1/peroxisome prolif
290 ack loop on protein kinase A mediated by the AMP-activated protein kinase Snf1 is coupled with a nega
292 signature includes 3 prominent features: (i) AMP-activated protein kinase subunit alpha (AMPKalpha) d
293 ed level of ATP results in activation of the AMP-activated protein kinase that leads to reduced lipog
296 romyces cerevisiae ortholog of the mammalian AMP-activated protein kinase was required for the full b
297 PR-1, in turn, stimulates phosphorylation of AMP-activated protein kinase, which leads to phosphoryla
299 SLC13A5 depletion promotes activation of the AMP-activated protein kinase, which was accompanied by d