ライフサイエンスコーパス: AMP

1 AMP-activated protein kinase (AMPK) activation vasodilat

2 AMP-activated protein kinase (AMPK) is a fundamental com

3 AMP-activated protein kinase (AMPK) is a key energy sens

4 AMP-activated protein kinase (AMPK) is a key regulator o

5 AMP-activated protein kinase (AMPK) senses energy status

6 AMP-activated protein kinase (AMPK), a key energy stress

7 AMPs exhibit pharmacodynamic properties that reduce the

8 AMPs have been classically assumed to have broad-spectru

9 is into adenosine monophosphate (AMP) and 2) AMP into adenosine (Ado) via two representative nucleoti

10 sional DJ-OIHP (AMP)(MA)Pb(2)I(7) (DJP(n=2), AMP = 4-(aminomethyl)piperidinium; MA = methylammonium),

11 at 3.8 angstrom, both in complex with Mg(2+)-AMP-PNP.

12 membrane-permeable form of 2',3'-cAMP and 3'-AMP mimicked the potentiating effects of IAA/DNP on exos

13 that metabolizes 2',3'-cAMP into 2'- and 3'-AMP), effects of IAA/DNP on exosome secretion were enhan

14 In RGCs expressing mutated Opa1, active 5' AMP-activated protein kinase (AMPK) and its autophagy ef

15 nd glucagon, the cellular master switches 5' AMP-activated protein kinase and mTOR, and also numerous

16 involving stress-responsive activation of 5'-AMP-activated protein kinase (AMPK) and neuroprotective

17 through a stress-responsive induction of 5'-AMP-activated protein kinase and autophagy.

18 this effect is primarily mediated through a AMP-activated protein kinase (AMPK) pathway and a novel

19 sified for all individuals based on the ACMG-AMP 2015 guidelines.

20 y two additional laboratories using the ACMG-AMP guidelines.

21 TDRD7 inhibited the virus-activated AMP-activated protein kinase (AMPK), which was essential

22 nosine], which mimics the tightly bound acyl-AMP reaction intermediate, was able to effectively inhib

23 We find that OAS1 adds AMP residues in 2',5' linkage to PAR, inhibiting its syn

24 igoadenylate synthetase 1 (OAS1), which adds AMP residues in 2',5' linkage to a variety of substrates

25 Furthermore, 35 lowered the ratio of ADO/AMP significantly and reversed immunosuppression in mous

26 er which binds indiscriminately to ATP, ADP, AMP, and adenosine.

27 fer at 37 degrees C; 45-fold faster than Ala-AMP and 120-fold faster than Phe-AMP.

28 infection might initiate a cross talk among AMP-activated protein kinase-Hippo-TBK1 pathways, which

29 TP/ADP hydrolysing ectoenzyme CD39 into AMP; AMP is then converted into adenosine by CD73, which is e

30 loped for selective detection of ampicillin (AMP) at picomolar level based on 3,4,9,10-perylenetetrac

31 ination of daptomycin (DAP) plus ampicillin (AMP), ertapenem (ERT), or ceftaroline has been demonstra

32 acrophages in vitro, heme activates an AMPK (AMP-activated protein kinase)/ATF1 (activating transcrip

33 tivation of the cellular energy sensor AMPK (AMP-activated protein kinase), and decreases EC prolifer

34 Here, we show that AMPK (AMP-activated protein kinase), activated in mouse metast

35 h glucose by stimulation of glycolysis by an AMP-activated protein kinase-independent mechanism throu

36 with structural modelling that identifies an AMP-binding interface between CFAP45 and AK8.

37 sed glucose uptake in skeletal muscles in an AMP-activated protein kinase (AMPK)-dependent manner, an

38 Host hedgehog signaling was modulated in an AMP-activated protein kinase (AMPK)-mammalian target of

39 F(KD) in complex with MEK and the ATP analog AMP-PCP, revealing interactions between BRAF and ATP tha

40 resence of the non-hydrolysable ATP analogue AMP-PNP at an overall resolution of 3.1 angstrom.

41 lmodulin-dependent kinase kinase (CaMKK) and AMP-activated protein kinase (AMPK) regulate metabolic a

42 A1 showed enhanced collagen content and AMP-activated protein kinase activation in the scar, inc

43 te-spreading behavior, nodule formation, and AMP expression.

44 ted in the presence of hydrogen peroxide and AMP-PNP, an ATP analog and competitive inhibitor of ATPa

45 ficant impairment in expression of IL-22 and AMPs, increased intestinal damage, and failed to contain

46 resistance to the lipopeptide daptomycin and AMPs by diverting the antibiotic away from critical sept

47 lution of resistance in target microbes, and AMPs may synergize with one another and with conventiona

48 the balance of additional co-factors such as AMP and ADP.

49 e extract enhances glycolysis and attenuates AMP-activated protein kinase (AMPK)-dependent inhibition

50 liver antimicrobial peptide and cathepsin B (AMP-CatB) mRNA.

51 stal structures of Gly-AMP, Pro-AMP, betaPro-AMP and Phe-AMP bound to RNase A as crystallization chap

52 CFAP45 binds AMP in vitro, consistent with structural modelling that

53 ation and identification of the biomolecules AMP, ATP, and CoA, which are fundamental for numerous bi

54 that uses ATP to convert biotin into biotin-AMP, a reactive intermediate that covalently labels prox

55 induced starvation-like behavior mediated by AMP-activated protein kinase (AMPK).

56 dKO mice, but energy charge was preserved by AMP deamination.

57 actinomyosin contractility are regulated by AMP/ATP levels independently of AMPK, and point to hypox

58 o-nucleotidases, CD39 (ATP -> AMP) and CD73 (AMP -> ADO).

59 fically required for homeostatic goblet cell AMP production.

60 ells and catalyzes the formation of 2'3'cGMP-AMP (cGAMP), which in turn triggers interferon (IFN) pro

61 2',5'/3',5'-cGMP-AMP (cGAMP) is a second messenger produced in response t

62 olves the activation of cyclic GMP-AMP (cGMP-AMP) synthase (cGAS) and generation of the cyclic dinucl

63 Cyclic cGMP-AMP synthase (cGAS) is a pattern recognition cytosolic D

64 In these pathways, cGMP-AMP synthase (cGAS) and the pyrin and HIN domain family

65 Here, we report that cGMP-AMP synthase (cGAS), a DNA sensor, is a critical regulat

66 Transcription activation by cyclic AMP (cAMP) receptor protein (CAP) is the classic paradig

67 sis that are responsive to changes in cyclic AMP (cAMP)-dependent signaling, consistent with metaboli

68 that the ubiquitous second messenger cyclic AMP (cAMP) is an activator of the Hypr GGDEF enzyme GacB

69 ity of beta-cells to the elevation of cyclic AMP (cAMP) levels and reduced proliferation of beta-cell

70 toxin (PTX) insensitive inhibition of cyclic AMP (cAMP) levels in mammalian cells, suggesting couplin

71 S]GTPgammaS binding and inhibition of cyclic AMP production, allow for general opioid characterizatio

72 NA modifications in the regulation of cyclic AMP signaling involved in stemness and tumor initiation.

73 The cyclic AMP (adenosine monophosphate; cAMP)-hydrolyzing protein

74 nversion of N6-methyl-(d)ATP to N6-methyl-(d)AMP, followed by ADAL1-catalyzed deamination producing (

75 free surfactants seem optimal for delivering AMPs to the lung.

76 The primary importance of c-di AMP stems from its essentiality for many bacteria under

77 ve intracellular pathogen that secretes c-di-AMP and activates STING, yet the in vivo role of the STI

78 We also compare the mechanisms of c-di-AMP and c-di-GMP binding by the respective receptors tha

79 current knowledge on the homeostasis of c-di-AMP and its function(s) in the control of cellular proce

80 f non-covalent-pai interactions between c-di-AMP and its receptor proteins, including pai-pai, C-H-pa

81 c-di-AMP becomes dispensable if the bacteria are cultivated o

82 is and signaling, and the mechanisms of c-di-AMP binding, including the principal conformations of c-

83 Recent research has demonstrated that c-di-AMP binds to a large number of proteins and riboswitches

84 ylococcus aureus strain deleted for the c-di-AMP cyclase gene dacA is unable to survive in rich mediu

85 Thus, the essentiality of c-di-AMP does not result from an interaction with a single es

86 nd both KimA and KtrCD are inhibited by c-di-AMP in vivo For KimA, c-di-AMP-dependent regulation requ

87 Hydrolysis of c-di-AMP is critical for normal growth and differentiation in

88 e specific high-affinity binding of the c-di-AMP ligand.

89 We discuss how these c-di-AMP molecules are bound to the protein and riboswitch re

90 lular glutamine concentration inhibited c-di-AMP production, while glutamate uptake had no effect.

91 c-di-AMP promotes interaction between CpeA and the predicted

92 h a L. monocytogenes mutant impaired in c-di-AMP secretion failed to elicit a protective response, wh

93 sponse, whereas a mutant with increased c-di-AMP secretion triggered enhanced protection.

94 -AMP, but the mechanism for terminating c-di-AMP signaling and the proteins that bind the molecule to

95 sent the discovery of two components of c-di-AMP signaling in bacteria and show that precise control

96 cation/proton antiporter, CpeB, linking c-di-AMP signaling to ion homeostasis in Actinobacteria.

97 As an effector of c-di-AMP signaling, we characterize the RCK_C domain protein

98 nection between nitrogen metabolism and c-di-AMP signalling in S. aureus.

99 Overproduction of the STING agonist c-di-AMP significantly enhanced the protective efficacy of BC

100 structures of the domains that regulate c-di-AMP synthesis and signaling, and the mechanisms of c-di-

101 binds Mn(2+) to specifically hydrolyze c-di-AMP to AMP via the intermediate 5'-pApA.

102 Cyclic diadenylate (c-di-AMP) is a widespread second messenger in bacteria and ar

103 econd messenger molecule cyclic di-AMP (c-di-AMP) is formed by many bacteria and archaea.

104 cyclic dimeric adenosine monophosphate (c-di-AMP).

105 thesize the nucleotide second messenger c-di-AMP, but the mechanism for terminating c-di-AMP signalin

106 ncluding the principal conformations of c-di-AMP, observed in various crystal structures.

107 In many species that produce c-di-AMP, this second messenger is essential for viability on

108 otein of unknown function, as bona fide c-di-AMP-binding proteins.

109 Thus, the physiological impact of the c-di-AMP-dependent control of potassium uptake seems to be le

110 inhibited by c-di-AMP in vivo For KimA, c-di-AMP-dependent regulation requires the C-terminal domain.

111 Here, we identify the AtaC protein as a c-di-AMP-specific phosphodiesterase that is also conserved in

112 The second messenger molecule cyclic di-AMP (c-di-AMP) is formed by many bacteria and archaea.

113 oural release of the STING agonist cyclic di-AMP transforms the tumour microenvironment from immunosu

114 a combination adjuvant composed of cyclic-di-AMP (cdAMP) and the plant-derived nanoparticle adjuvant

115 oval of a huge amount of Mo in the dissolved AMP.

116 mice is rescued with the addition of either AMP or ADP with ATP, compared to ATP alone.

117 H2A enhances AMP-induced pores, depolarizes the bacterial membrane po

118 Yet, despite thousands of known examples, AMPs have only infrequently proceeded as far as clinical

119 s a non-cannonical antimicrobial pathway for AMP induction.

120 ng sirtuin 1 (SIRT1), forkhead box O (FoxO), AMP-activated protein kinase (AMPK), peroxisome prolifer

121 sociated with the generation of a functional AMP population.

122 Cyclic-G/AMP (cGAMP) synthase (cGAS) triggers host innate immune

123 harmacological AMPK activators that generate AMP, unlike allosteric activators, downregulated pMLC bu

124 Crystal structures of Gly-AMP, Pro-AMP, betaPro-AMP and Phe-AMP bound to RNase A a

125 ated to catalyse the synthesis of cyclic GMP-AMP (cGAMP) from GTP and ATP(3).

126 3',3'-cyclic GMP-AMP (cGAMP) is the third cyclic dinucleotide (CDN) to be

127 ic DNA-sensing pathway comprising cyclic GMP-AMP (cGAMP) synthase (cGAS) and stimulator of IFN gene (

128 Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a major responder to the

129 oduction of the second messenger, cyclic GMP-AMP (cGAMP), which binds and activates stimulator of int

130 cGAS synthesizes cyclic GMP-AMP (cGAMP), which binds to the adaptor STIMULATOR OF IN

131 : this involves the activation of cyclic GMP-AMP (cGMP-AMP) synthase (cGAS) and generation of the cyc

132 erial infection and in endogenous cyclic GMP-AMP signalling during viral infection and anti-tumour im

133 ost cell cytosol is sensed by the cyclic GMP-AMP synthase (cGAS) and stimulator of IFN genes (STING)

134 Cyclic GMP-AMP synthase (cGAS) is a critical cytosolic DNA sensor t

135 Cyclic GMP-AMP synthase (cGAS) is a double-stranded DNA sensor that

136 Detection of viral DNA by cyclic GMP-AMP synthase (cGAS) is a first line of defence leading t

137 CYCLIC GMP-AMP SYNTHASE (cGAS) is the sensor protein that directly

138 ot by telomere shortening, but by cyclic GMP-AMP synthase (cGAS) recognizing cytosolic chromatin frag

139 The enzyme cyclic GMP-AMP synthase (cGAS) senses cytosolic DNA in infected and

140 The cytosolic dsDNA sensor, cyclic GMP-AMP synthase (cGAS), and the stimulator of IFN genes (ST

141 nt of cGAS, and activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STIN

142 virus 1 (HSV-1) triggers both the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STIN

143 eic acid sensor pathways, such as cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STIN

144 creased expression of DNA sensors cyclic GMP-AMP synthase and stimulator of interferon genes in wild-

145 tivation of the stimulator of the cyclic GMP-AMP synthase interferon genes (cGAS-STING) innate immune

146 Specifically, the CGAS (cyclic GMP-AMP synthase)-STING (stimulator of interferon genes) pat

147 dinucleotide cyclases, including cyclic GMP-AMP synthase, and their involvement in STING-mediated im

148 ss-presentation and activation of cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING)

149 ng the DNA damage response (DDR), cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING)

150 the present study, we studied the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING)

151 hput screen for inhibitors of the cyclic GMP-AMP synthase/stimulator of interferon genes pathway, whi

152 thesis of the cyclic dinucleotide cyclic GMP-AMP, which mediates the induction of type I interferons

153 Extracellular 2'3'-cyclic-GMP-AMP (cGAMP) is an immunotransmitter exported by diseased

154 ATP by two ecto-nucleotidases, CD39 (ATP -> AMP) and CD73 (AMP -> ADO).

155 scle cells have lower levels of ATP and have AMP-activated protein kinase dysfunction.

156 ted with a significant activation of hepatic AMP-activated protein kinase (AMPK), peroxisome prolifer

157 m6 (EiCsm6) degrades its cognate cyclic hexa-AMP (cA6) activator, and report the crystal structure of

158 is lower than that for the n = 1 homologue (AMP)PbI(4) (DJP(n=1),0.4 kV/cm).

159 We demonstrate that the human AMP LL-37 lowers the susceptibility to vancomycin in the

160 urther exploration is needed to determine if AMP upregulation provides protection against CS-associat

161 However, if AMPs are to be used clinically, it is crucial to underst

162 ioning (PreCon) is decreased due to impaired AMP-activated protein kinase (AMPK) signaling.

163 y in the synthesis of biologically important AMP-activated protein kinase deprived of any metal Pd co

164 ergy stress sensor, responds to increases in AMP/ATP ratio by activating multiple signaling cascades

165 for adaptive maintenance of polymorphism in AMP genes than has previously been appreciated, as well

166 Several emerging examples include AMP-activated protein kinase AMPK, nutrient/energy senso

167 e-1 and fructose bisphosphatase-1, including AMP, P(i), and glycerol 3-phosphate.

168 course experiments revealed that PF induces AMP-activated protein kinase (AMPK) activation before in

169 cerol component of surfactant was inhibiting AMP function and that an exogenous surfactant, with a re

170 eolar RNA (snoRNA)-activated PARP-1 inhibits AMP kinase-mediated phosphorylation of adjacent H2B-Ser3

171 We demonstrated in vitro that AC6 inhibits AMP-activated kinase (AMPK), an important modulator of c

172 ial ATP/ADP hydrolysing ectoenzyme CD39 into AMP; AMP is then converted into adenosine by CD73, which

173 , we found that ABHD5 elevates intracellular AMP content, which activates AMPK, leading to inhibition

174 astically deplete and that the intracellular AMP-to-ATP ratio strongly increases within 20 to 30 s.

175 ti-inflammatory signaling pathways involving AMP-activated protein kinase (AMPK), Akt and eNOS, and i

176 nt and anti-inflammatory signaling involving AMP-activated protein kinase (AMPK), Akt, endothelial ni

177 ic peptide concentrations, presence of known AMPs and effectiveness of Bd growth inhibition in vitro.

178 e evolved and optimized one family of linear AMPs into a new generation with high solubility, low cyt

179 rk highlights the ability of acute localized AMP-activated protein kinase signaling to affect mitocho

180 assic ligases, NgrRnl forms a covalent lysyl-AMP intermediate.

181 Both of these properties make AMPs attractive for translational applications.

182 vels independently of energy stress-mediated AMP-activated protein kinase activation and possibly thr

183 Unfortunately, mixing AMPs with commercially available exogenous surfactants h

184 hereas ADP-DnaA was predominantly monomeric, AMP-PNP-DnaA (a non-hydrolysable ATP-analog bound-DnaA)

185 tural substrate, adenosine 5'-monophosphate (AMP).

186 monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase (cGAS), which produces the second

187 TP) hydrolysis into adenosine monophosphate (AMP) and 2) AMP into adenosine (Ado) via two representat

188 odulatory effect of adenosine monophosphate (AMP) and adenosine diphosphate (ADP) on flagellar beatin

189 hydrogen bonds with adenosine monophosphate (AMP) during incorporation, this base pair hydrogen bondi

190 osine monophosphate-adenosine monophosphate (AMP) synthase (cGAS) drives IRF3 activation in both alco

191 monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS) recognizes cytosolic foreign or dam

192 f the energy sensor adenosine monophosphate (AMP)-activated protein kinase (AMPK) is repressed in NAS

193 sine (P = 0.03) and adenosine monophosphate (AMP; P < 0.0001) concentrations during nicotine withdraw

194 open a venue to the understanding of a novel AMP killing mechanism and allows the rational design of

195 ge of fatty acids (FAs), purine nucleotides (AMP and GMP), a vitamin (pyridoxal-5P), and a cofactor (

196 D(+) to form a covalent ligase-(lysyl-Nzeta)-AMP intermediate and release pyrophosphate (PP(i)) or ni

197 particles allow the specific accumulation of AMP-CatB in macrophage lysosomes, which is the key locat

198 s depend on metformin-mediated activation of AMP kinase (AMPK).

199 Activation of AMP-activated protein kinase (AMPK) results in vasodilat

200 Both direct and indirect activation of AMP-activated protein kinase isolated to the distal axon

201 oxidative fibres and decreased activation of AMP-activated protein kinase signalling in transgenics c

202 pound berberine (BBR), a potent activator of AMP-activated protein kinase (AMPK), can reduce beta-cat

203 orrelated significantly with the activity of AMP-activated protein kinase (AMPK).

204 Following the addition of AMP, Aptamer/CS-modified AuNPs releases CS and so, the f

205 RNA-seq analysis of AMP cells showed that genes associated with proliferatio

206 and an optimized assay for the detection of AMP by luciferase.

207 ed satisfactory results for the detection of AMP in the spiked human serum samples.

208 An example of AMP is Epsilon-Poly-L-lysine (EPL), a polypeptide formed

209 addition, the active phosphorylated form of AMP kinase was significantly increased in Atp7b (-/-) mi

210 lecular evolution and population genetics of AMP genes reveals more evidence for adaptive maintenance

211 ucleotidase CD73 catalyzes the hydrolysis of AMP at the cell surface to form adenosine, a potent supp

212 ve adenosine (ADO) through the hydrolysis of AMP.

213 Inactivation of AMP-activated protein kinase (AMPK), a sensor of cellula

214 een appreciated, as well as adaptive loss of AMP activity.

215 PR-1, in turn, stimulates phosphorylation of AMP-activated protein kinase, which leads to phosphoryla

216 ve to an open (bulk) system, 2) the rates of AMP and ADO formation are accelerated by restricting the

217 elial cell line, we investigated the role of AMP-activated protein kinase (AMPK), a master regulator

218 ession and role in the skin, a major site of AMP production, have never been investigated.

219 reduced ERK1/2 activation and stimulation of AMP kinase in skeletal muscle from smPit1(-/-); smPit2(-

220 erestingly, metformin-induced stimulation of AMP-activated protein kinase (a nutrient deprivation sen

221 metformin is mediated by the stimulation of AMP-activated protein kinase (AMPK).

222 tion of CncC stimulated the proliferation of AMPs, which demonstrates that pro-proliferative signals

223 f the ferroelectric two-dimensional DJ-OIHP (AMP)(MA)Pb(2)I(7) (DJP(n=2), AMP = 4-(aminomethyl)piperi

224 SAXS performed on AMP-PNP-DnaA (H136Q) indicates that the protein has lost

225 nmental solid samples and preconcentrated on AMP-PAN column.

226 apo state and bound to phospholipid, ADP or AMP-PNP to a resolution of 3.3-4.1 angstrom and establis

227 es not influence cellular immune function or AMP production.

228 Sestrins affect multiple signaling pathways: AMP-activated protein kinase, mammalian target of rapamy

229 iAMP21, IKZF1 deletions, ERG deletions, PAX5(AMP), which have clinical significance or are associated

230 Rose Bengal (RB) to the amphipathic peptide (AMP) C(KLAKLAK)(2) and determined the effectiveness of t

231 for the induction of antimicrobial peptide (AMP) genes but dispensable for antiviral RNAi.

232 sed the expression of antimicrobial peptide (AMP) genes.

233 nt interaction of the antimicrobial peptide (AMP) LL-37 with the meningococcal surface and meningococ

234 IL-22, which promote antimicrobial peptide (AMP) production and bacterial clearance.

235 ntified as a cationic antimicrobial peptide (AMP), but its putative expression and role in the skin,

236 -1 (PG-1) is a potent antimicrobial peptide (AMP).

237 Antimicrobial peptides (AMP) are molecules consisting of 12-100 amino acids synt

238 Antimicrobial peptides (AMP) were upregulated in vaginal delivery compared to CS

239 Antimicrobial peptides (AMPs) are central components of the innate immune system

240 Antimicrobial peptides (AMPs) are components of immune defense in many organisms

241 Antimicrobial peptides (AMPs) are essential components of immune defenses of mul

242 brane permeabilizing antimicrobial peptides (AMPs) have long been considered a potentially promising,

243 ion of histones with antimicrobial peptides (AMPs) in immune cells suggests that histones may be part

244 perties, for example Antimicrobial peptides (AMPs), can disrupt this protective barrier by formation

245 rfactants to deliver antimicrobial peptides (AMPs), like CATH-2, to infected regions of the lung.

246 ed to release stored antimicrobial peptides (AMPs).

247 the Pediatric HIV/AIDS Cohort Study (PHACS) AMP Up cohort approaching or having completed transition

248 res of Gly-AMP, Pro-AMP, betaPro-AMP and Phe-AMP bound to RNase A as crystallization chaperone showed

249 er than Ala-AMP and 120-fold faster than Phe-AMP.

250 DAP plus AMP was the only efficacious regimen against DAP-R R497

251 Only DAP (10 mg/kg) plus AMP or amoxicillin was efficacious against a DAP-R E. fa

252 reduced ATP levels, but not its precursors (AMP).

253 The ongoing Antibody Mediated Prevention (AMP) trials will uncover whether passive infusion of the

254 Crystal structures of Gly-AMP, Pro-AMP, betaPro-AMP and Phe-AMP bound to RNase A as crystal

255 h a half-life time as short as 2.4 h for Pro-AMP in ethylimidazole-containing buffer at 37 degrees C;

256 portantly, the abnormal myeloid progenitors (AMPs), a leukemia-initiating cell population induced by

257 role in governing the antimicrobial protein (AMP) response.

258 orin signals via the energy sensing protein, AMP-activated protein kinase (AMPK), in the autophagic d

259 duction of mucus and antimicrobial proteins (AMPs), and complement production.

260 phagic flux - mammalian target of rapamycin, AMP-activated protein kinase and sirtuins are key regula

261 Signaling by the master metabolic regulator AMP-activated protein kinase (AMPK) was a critical node

262 Here, we show that the energy sensor AMP kinase (AMPK) governs gastric epithelial progenitor

263 The cellular energy sensor AMP-activated protein kinase (AMPK) is a metabolic regul

264 gy sensors, which include sirtuin-1 (SIRT1), AMP-activated protein kinase (AMPK), and hypoxia inducib

265 nt and oxygen deprivation-sirtuin-1 (SIRT1), AMP-activated protein kinase (AMPK), and hypoxia-inducib

266 Given that a decrease in stored AMP concentrations as temperatures warm in spring likely

267 , the concentration and expression of stored AMPs cycled synchronously with Bd dynamics.

268 ction in the Pediatric HIV/AIDS Cohort Study-AMP Up protocol, a prospective study of young adults liv

269 In addition, this result suggests AMP-activated protein kinase signaling pathway's role in

270 hesises an l-threonylcarbamoyl adenylate (TC-AMP) intermediate, and OSGEPL1 transfers the TC-moiety t

271 In particular, we observed that AMP-activated protein kinase-mediated phosphorylation at

272 llisional activation experiments reveal that AMPs can exhibit a range of behaviors from nonspecific i

273 The AMP-activated kinase AMPK was investigated as a potentia

274 The AMP-activated protein kinase (AMPK) inhibitor dorsomorph

275 The AMP-activated protein kinase (AMPK) is a molecular senso

276 Among the AMP molecules, bacteriocins are produced by both gram-po

277 with NH(4)Cl solution without dissolving the AMP.

278 revealed that the PYGM mutation impairs the AMP-independent myophosphorylase activity, whereas the A

279 Finally, we show that the deletion of the AMP-activated protein kinase ortholog-encoding gene SNF1

280 y gene Fos and Stk11, a master kinase of the AMP-related kinase pathway with important roles in growt

281 hematical modeling framework to simulate the AMP trials and infer the breakthrough mechanisms using m

282 and C(KLAKLAK)(2) has been attributed to the AMP sensitizing cells to reactive oxygen species (ROS),

283 NUAK1/2 belong to the AMP-activated protein kinase (AMPK) family, whose member

284 ndent myophosphorylase activity, whereas the AMP-dependent activity was preserved.

285 aureus through membrane pores formed by the AMPs LL-37 and magainin-2.

286 toxin), and HepT/MntA (antitoxin adds three AMPs to Tyr104 of the toxin).

287 led that MntA mediates the transfer of three AMPs to a tyrosine residue next to the RNase domain of H

288 vitro enzymatic assays showed that the three AMPs are transferred to HepT by MntA consecutively with

289 Mn(2+) to specifically hydrolyze c-di-AMP to AMP via the intermediate 5'-pApA.

290 y that relies on the degradation of cGAMP to AMP by ectonucleotide pyrophosphatase phosphodiesterase

291 e signals are transduced from enterocytes to AMPs.

292 d transgenic mice carrying a bovine tracheal AMP gene promoter-controlled PG-1 transgene.

293 Many bacteria use AMP-forming acid:CoA ligases to convert organic acids in

294 nfection risk during the colder periods when AMP synthesis and bacterial growth is slow and pathogen

295 by chromatographic separation of cesium with AMP-PAN and AG50W-X8 columns and sensitive measurement o

296 DAP at 8, 6, and 4 mg/kg in combination with AMP was efficacious but showed delayed killing compared

297 ated the efficacy of DAP in combination with AMP, ERT, ceftaroline, ceftriaxone, or amoxicillin again

298 CAR substrate-binding domain in complex with AMP and succinate and engineered three mutant CARs with

299 -designed ATP-TTR-3 aptamer with and without AMP.

300 Yeast AMP-activated protein kinase (AMPK) directly phosphoryla