ライフサイエンスコーパス: AP endonuclease

1 nzymatic activity in repair of abasic sites (AP endonuclease).

2 nts following incision of the abasic site by AP endonuclease.

3 ic/apyrimidinic (AP) site intermediate by an AP endonuclease.

4 turn corresponds to a decreased abundance of AP endonuclease.

5 the 5' side of the deoxyribose phosphate by AP endonuclease.

6 in from yeast and show that it is a class II AP endonuclease.

7 emove the 5' sugar-phosphate residue left by AP endonuclease.

8 notion that yeast contains only one major 5'-AP endonuclease.

9 itors of a critical DNA repair enzyme, human AP endonuclease.

10 ecognition of bistranded AP lesions by human AP endonuclease.

11 RP residues that remain after cleavage by 5'-AP endonuclease.

12 n of bistranded abasic site lesions by human AP endonuclease.

13 significantly stimulated by the presence of AP-endonuclease.

14 that are toxic if they are not processed by AP endonucleases.

15 homologous to the exonuclease III family of AP endonucleases.

16 critical elements in targeted recognition by AP endonucleases.

17 n/Escherichia coli exonuclease III family of AP endonucleases.

18 N-terminus show only low homology with other AP endonucleases.

19 new molecular insights into the evolution of AP endonucleases.

20 stored by addition of apurinic/apyrimidinic (AP) endonuclease.

21 d by reactive oxygen species are repaired by AP-endonucleases.

22 DG) and mitochondrial apurinic/apyrimidinic (AP) endonucleases.

23 ons is carried out by apurinic/apyrimidinic (AP) endonucleases.

24 ons and resembles the apurinic/apyrimidinic (AP) endonucleases.

25 uman tyrosyl-DNA phosphodiesterase 1 (TDP1), AP endonuclease 1 (APE1) and three-prime repair exonucle

26 their levels are regulated by repair enzymes AP endonuclease 1 (APE1) and tyrosyl-DNA phosphodiestera

27 erential oxidative deamination in vitro, and AP endonuclease 1 (APE1) can cleave the resulting ICL DN

28 AP endonuclease 1 (APE1) is the predominant enzyme for p

29 AP endonuclease 1 (APE1) is the predominant mammalian en

30 dent and that this activity co-purifies with AP endonuclease 1 (APE1) over phosphocellulose and gel f

31 We find that human AP endonuclease 1 (APE1) physically interacts with flap

32 , we further provide the first evidence that AP endonuclease 1 (APE1) prevented TNR expansions via it

33 ystallographic studies reveal loops in human AP endonuclease 1 (APE1) that interact with the major an

34 e is less efficiently incised by recombinant AP endonuclease 1 (APE1) when the DNA backbone is facing

35 The follow-on base excision repair enzyme, AP endonuclease 1 (APE1), stimulates the turnover of TDG

36 hOGG1, the damaged DNA substrate, and human AP endonuclease 1 (APE1).

37 Human AP endonuclease 1 (APE1, REF1) functions within the base

38 at the appropriate time in development when AP endonuclease 1 (Apex), the upstream protein in BER, i

39 We found that AP endonuclease 1 incised an abasic site on the nontempl

40 We conclude that AP endonuclease 1 is involved in both repairing DNA and

41 5'-flanking T:G mispair; this reduces OGG1, AP endonuclease 1, and DNA polymerase beta activities.

42 the substrate specificity of the major human AP endonuclease 1, APE1, toward U in duplex DNA.

43 sic site that was subsequently 5'-incised by AP endonuclease 1, introducing a single-strand breakage

44 P site with either endonuclease III or human AP endonuclease 1, strongly inhibit excision of 8-oxoG b

45 s to AP sites inhibits the activity of human AP endonuclease 1, which is as a valid anticancer drug t

46 AP endonuclease 1, which possesses 3'-->5' exonuclease a

47 Human apurinic/apyrimidinic (AP) endonuclease 1 (APE1) is a central participant in th

48 erexpression of human apurinic/apyrimidinic (AP) endonuclease 1 (APE1/Ref-1), a key enzyme in the DNA

49 glycosylase 1 (OGG1), apurinic/apyrimidinic (AP) endonuclease 1, DNA polymerase beta, and DNA ligases

50 ubstrate specificity, lack of stimulation by AP-endonuclease 1 (APE1) and anomalous DNA binding confo

51 syl DNA phosphodiesterase 1 (TDP1) and human AP-endonuclease 1 (APE1) could not hydrolyze T5PNP.

52 Within BER, AP-endonuclease 1 (APE1) is a multifunctional enzyme tha

53 The major human AP-endonuclease 1 (APE1) is a multifunctional protein th

54 However, we find that purified human AP-endonuclease 1 (APE1) is able to remove 3'-8-oxoG les

55 Finally, our results reveal that AP-Endonuclease 1 (APE1) proofreads nick repair intermed

56 the base excision repair (BER) endonuclease AP-endonuclease 1 (APE1) recognizes and cleaves DNA dama

57 Finally, AP-Endonuclease 1 (APE1) shows distinct substrate specif

58 tect both uracil DNA N-glycosylase (UNG) and AP-endonuclease 1 (APE1) within few nanograms of nuclear

59 Finally, we demonstrate that AP-endonuclease 1 (APE1), as a compensatory proofreading

60 rinic/apyrimidinic (AP) site cleavage by the AP-endonuclease 1 (APE1).

61 re particles using the known repair enzymes, AP-endonuclease 1, DNA polymerase beta and DNA ligase II

62 Addition of human APE1 (AP endonuclease-1) increased dissociation of hNTH1 from

63 se excision repair (homologs of XPF, XPC and AP-endonuclease-1), and repair of double-stranded DNA br

64 Finally, deletion of AP endonuclease 2 (APE2) has no effect on CSR in either

65 ision repair protein, Apurinic/apyrimidinic (AP) endonuclease 2 (APE2, APN2, or APEX2), is required f

66 CRT0044876 inhibits the AP endonuclease, 3'-phosphodiesterase and 3'-phosphatase

67 air enzyme whose nuclease activities include AP-endonuclease, 3'-exonuclease, 3'-phosphodiesterase an

68 omology to the gene encoding the major human AP endonuclease, a component of the highly conserved DNA

69 R.PabI-mediated restriction was promoted by AP endonuclease action in vivo or in vitro.

70 esions or single-strand nicks resulting from AP-endonuclease action.

71 cells to ROS rapidly stimulated increases in AP endonuclease activities and APE1 protein levels.

72 tivity of an E.coli mutant deficient for the AP endonuclease activities associated with exonuclease I

73 eneral 3' phosphodiesterase, exonuclease, or AP endonuclease activities.

74 g on a double-flap substrate, which prevents AP endonuclease activity and endonuclease-induced double

75 Apn2 also has an AP endonuclease activity and functions in the removal of

76 etabolism, decreases the efficiency of human AP endonuclease activity and that this effect is mostly

77 ver, glutathione-agarose was able to deplete AP endonuclease activity from GST-PO fusion protein prep

78 Overexpression of APE1 and enhanced AP endonuclease activity have been linked to increased r

79 The increased mitochondrial AP endonuclease activity in combination with decreased p

80 uced with Ape1/ref-1 exhibited 2-fold higher AP endonuclease activity in the oligonucleotide cleavage

81 hin NExo that is responsible for its lack of AP endonuclease activity is also important for its 3'-ph

82 n interactions of Ape1, we conclude that the AP endonuclease activity is essential for cellular viabi

83 Thus, in apn1 cells where the major AP endonuclease activity is missing, ETH1 offers an alte

84 ormational change; this in turn enhances the AP endonuclease activity of APE1.

85 tion of Asp-210 by Asn or Ala eliminates the AP endonuclease activity of HAP1, while substitution by

86 The lack of AP endonuclease activity of NExo is shown to be attribut

87 titution of alanine for Asn212 abolished the AP endonuclease activity of purified recombinant HAP1 pr

88 of the carboxyl terminus does not affect the AP endonuclease activity of the protein, but this protei

89 The AP endonuclease activity of this enzyme and two active s

90 nylated APE1 displayed significantly reduced AP endonuclease activity on abasic-site-containing oligo

91 the base excision repair pathway, exhibiting AP endonuclease activity that incises the DNA backbone 5

92 This AP site is further processed by an AP endonuclease activity that incises the phosphodiester

93 As a means of confirming that the source of AP endonuclease activity was in fact due to PO, glutathi

94 were generally not altered in rho(0) cells, AP endonuclease activity was substantially reduced in nu

95 Likewise, AP endonuclease activity was unaffected by the absence o

96 P1 and Ref-1) accounts for >95% of the total AP endonuclease activity, and is essential for the prote

97 ly been shown to be independent of Apn1-like AP endonuclease activity, and the main reason for the MM

98 Of these, only NApe possesses AP endonuclease activity, while the primary function of

99 e enzyme, their kcat values were similar for AP endonuclease activity.

100 product functionally complements the missing AP endonuclease activity.

101 cid-inducible protein repertoire includes an AP endonuclease activity.

102 f its homologues, however, L1 EN exhibits no AP endonuclease activity.

103 A methyltransferase activity but loss of all AP endonuclease activity.

104 ns were subsequently found to have authentic AP endonuclease activity.

105 he S-glutathionylation that leads to reduced AP endonuclease activity.

106 ire of model substrates on which Ape1 exerts AP endonuclease activity.

107 -independent class II apurinic/apyrimidinic (AP) endonuclease activity and represents greater than 90

108 r >/=95% of the total apurinic/apyrimidinic (AP) endonuclease activity in human cells.

109 Ape1 is the major apurinic/apyrimidinic (AP) endonuclease activity in mammalian cells, and a key

110 urified and exhibited apurinic/apyrimidinic (AP) endonuclease activity.

111 chanism that differs from its more canonical AP-endonuclease activity.

112 tercalating loop (Y269) that is critical for AP-endonuclease activity.

113 me initiating repair of AP sites is the Ape1 AP endonuclease (also called Apex or Hap1), which also f

114 ave weak dRP lyase activity and to stimulate AP endonuclease and FEN1 activities on BER substrates.

115 a molecular weight of 28 kDa and is free of AP endonuclease and phosphatase activities.

116 al lysates with pure uracil DNA glycosylase, AP endonuclease and/or the catalytic subunit of polymera

117 oli strain defective for the major 5'-acting AP endonucleases and the fusions purified using glutathi

118 NA glycosylase (UDG), apurinic/apyrimidinic (AP) endonuclease and DNA ligase I, pol iota can use its

119 e1 is the major human apurinic/apyrimidinic (AP) endonuclease and initiates repair of abasic sites by

120 Apurinic/apyrimidinic (AP) endonuclease and polymerase gamma activities were mo

121 sms are equipped with apurinic/apyrimidinic (AP) endonucleases and 3'-nucleases that initiate repair.

122 apyrimidinic endonuclease (APE1) having both AP-endonuclease and 3' to 5' exonuclease (exo) DNA cleav

123 onuclease III and endonuclease IV (prototype AP endonucleases) and S.POMBE: Uve1p.

124 revealed that the expression of RecA, SmnA (AP endonuclease), and Nth (endonuclease) were down-regul

125 he HSV-1 uracil DNA glycosylase (UL2), human AP endonuclease, and the HSV-1 DNA polymerase.

126 in-protein contact between Polbeta and human AP endonuclease (Ape protein).

127 s ability to interact directly both with the AP endonuclease (APE) and with DNA polymerase beta (pol

128 sed on studies in Escherichia coli, in which AP endonuclease (APE) removes all 3' blocking groups (in

129 sites in DNA is through the participation of AP endonuclease (APE), which initiates the removal of ba

130 , human 8-oxoguanine glycosylase (hOGG1) and AP endonuclease (APE).

131 ected to function in this system, a putative AP endonuclease (APE).

132 Apurinic/apyrimidinic (AP) endonuclease (APE) is a multifunctional protein poss

133 Apurinic/apyrimidinic (AP) endonuclease (APE; EC 4.2.99.18) plays a central rol

134 Abasic (AP)-endonuclease (APE) is responsible for repair of AP s

135 We examined substrate binding by the human AP endonuclease, Ape protein (also called Hap1, Apex or

136 ein-DNA complex formation by the major human AP endonuclease, Ape.

137 The human AP endonuclease Ape1 acts on abasic or 3'-blocking DNA l

138 single-strand DNA (ssDNA), whereas the major AP endonuclease APE1 does not.

139 Apurinic/apyrimidinic (AP) endonuclease Ape1 is a key enzyme in the mammalian b

140 The human AP endonuclease (Ape1 or ref-1) DNA base excision repair

141 ining AP sites were resistant to cleavage by AP endonuclease (APE1) and mitochondrial extracts.

142 4 as an N-terminally truncated form of human AP endonuclease (Ape1) lacking residues 1-35 (delta35-Ap

143 In addition, inhibition of AP endonuclease (APE1) led to an elevated level of GS-dd

144 vior of PARP1 in the absence and presence of AP endonuclease (APE1) on AP DNA damage arrays.

145 the presence of a comparable amount of human AP endonuclease (APE1) the specific activity of OGG1 was

146 ntaining duplex is a substrate for the human AP endonuclease (APE1), an enzyme that cleaves an apurin

147 t repairs AP sites in mammalian cells is the AP endonuclease (APE1), which functions through the base

148 using murine homolog of MutY (Myh) and human AP endonuclease (Ape1), which shares 94% amino acid iden

149 ines, alkyladenine DNA glycosylase (AAG) and AP endonuclease (APE1).

150 The mammalian apurinic/apyrimidinic (AP) endonuclease (APE1) is a multifunctional protein tha

151 The mammalian AP-endonuclease (APE1) overexpression is often observed

152 The mammalian AP-endonuclease (APE1) repairs apurinic/apyrimidinic (AP

153 hosphodeoxyribose (dRP) moiety, generated by AP-endonuclease (APE1), is removed by the lyase activity

154 The human AP-endonuclease (APE1), which cleaves the phosphodiester

155 iciently processed by the downstream enzyme, AP-endonuclease (APE1).

156 Human AP-endonuclease (APE1/Ref-1), a central enzyme involved

157 The human AP-endonuclease (APE1/Ref-1), a multifunctional protein

158 The human AP-endonuclease (APE1/Ref-1), an essential multifunction

159 epair and between the apurinic/apyrimidinic (AP) endonuclease, Ape1, and the 8-oxoguanine DNA glycosy

160 B and the major human apurinic/apyrimidinic (AP) endonuclease, APE1, physically and functionally inte

161 It has been demonstrated that the minor AP endonuclease APE2 contains only one Zf-GRF motif medi

162 d bases by DNA glycosylases, are repaired by AP-endonucleases (APEs).

163 myces cerevisiae, the apurinic/apyrimidinic (AP) endonucleases Apn1 and Apn2 act as alternative pathw

164 g, Nth, and NTH1) and apurinic/apyrimidinic (AP) endonucleases (Apn1, APE1, and Nfo), the analysis of

165 oth cases, expression of the unrelated yeast AP endonuclease, Apn1, largely restored resistance.

166 s are removed via the action of two class II AP endonucleases, Apn1 and Apn2.

167 d here suggest that the APE1 exonuclease and AP endonuclease are two distinct activities.

168 Apurinic/apyrimidinic (AP) endonucleases are key enzymes responsible for the re

169 R pathway, such as an apurinic-apyrimidinic (AP) endonuclease, as turnover-enhancing cofactors.

170 ation of oxidized bases must be processed by AP endonucleases before they compromise cell integrity.

171 ing" of the AP site-containing DNA strand by AP endonuclease, beta-pol performs DNA synthesis prior t

172 using the following purified human proteins: AP endonuclease, beta-pol, and DNA ligase I.

173 study, there is no structure of a bacterial AP endonuclease bound to substrate DNA.

174 the first to demonstrate the inducibility of AP-endonuclease by a human class I carcinogen associated

175 OGG1's activity in vitro in the presence of AP-endonuclease by reducing its affinity for the abasic

176 The major human apurinic/apyrimidinic (AP) endonuclease (class II) is known to cleave DNA 5' ad

177 -stimulated PDE and Mg2+-stimulated class II AP endonuclease copurify during this procedure.

178 ses caused a 7- to 18-fold mutator effect in AP endonuclease-deficient (deltaapn1) yeast, which depen

179 Here, we show that AP endonuclease-deficient cells can be protected from NO

180 nts that complemented the MMS sensitivity of AP endonuclease-deficient E. coli.

181 The chimeric protein protected AP endonuclease-deficient Escherichia coli cells against

182 However, apyrimidinic/apurinic (AP) endonuclease-deficient cells (xth nfo strain) were v

183 Apurinic/apyrimidinic (AP) endonuclease-deficient cells are sensitive to NO* to

184 Class II AP endonuclease, deoxyribonucleotide phosphate (dRP) lya

185 Pretreatment of the linear DNA with AP endonuclease did not improve repair, indicating that

186 Herein we report that the human AP endonuclease directly catalyzes incision in a defined

187 hese data suggest that following incision by AP endonuclease, DNA Pol beta recognizes and binds to th

188 Human AP endonuclease, DNA polymerase beta and a DNA ligase (e

189 sion repair pathway (uracil DNA glycosylase, AP endonuclease, DNA polymerase beta, and an NAD+-depend

190 When human uracil DNA glycosylase, AP endonuclease, DNA polymerase beta, and DNA ligase 1 r

191 the lysate contained uracil DNA glycosylase, AP endonuclease, DNA polymerase, flap endonuclease, and

192 ER proteins required for PCNA-dependent BER (AP endonuclease, DNA polymerases delta, beta and DNA lig

193 that is slower than the respective rates of AP endonuclease, DNA synthesis, and ligation, suggesting

194 III, lambda exonuclease, RNase H, RNase HII, AP endonuclease, duplex-specific nuclease, DNase I, or T

195 AP sites are repaired by AP endonucleases during the process of base excision rep

196 in and a strain deficient in the known yeast AP endonuclease encoded by APN1.

197 In Saccharomyces cerevisiae, the AP endonucleases encoded by the APN1 and APN2 genes prov

198 mutans expresses an inducible, class II-like AP endonuclease, encoded by the smx gene, that exhibits

199 The effect of the AP endonucleases endonuclease IV (Endo IV), exonuclease

200 The action of many AP endonuclease enzymes at abasic sites in DNA leaves a

201 re we report that the apurinic/apyrimidinic (AP) endonucleases--Escherichia coli Xth and human APE1--

202 t xth mutant strains (deficient in the major AP endonuclease, exonuclease III) are sensitive.

203 studies are described using Escherichia coli AP endonucleases, exonuclease III and endonuclease IV.

204 bacterial Nfo represent the two conserved 5' AP endonuclease families in the biosphere; they both rec

205 ain homologous to the apurinic/apyrimidinic (AP) endonuclease family and shows nicking in vitro with

206 etype for a conserved apurinic/apyrimidinic (AP) endonuclease family that primes DNA repair synthesis

207 iled structural and biochemical study of the AP endonuclease from Neisseria meningitidis that has all

208 We find that after dissociation of AP endonuclease from the incised abasic site, both DNA p

209 an E.coli mutant lacking the major 5'-acting AP endonucleases from sensitivity to an alkylating agent

210 ies, RPA blocks/inhibits the ss, but not ds, AP endonuclease function of Ape1.

211 an ExoIII-like pocket into Ape2 enhances its AP endonuclease function.

212 We have cloned an AP endonuclease gene (APEA) from Dictyostelium discoideu

213 cells is a novel function of the major human AP endonuclease (HAP1).

214 In addition, the major human AP endonuclease, HAP1 (also known as APE1, APEX, Ref-1),

215 Human apurinic/apyrimidinic (AP) endonuclease (hAPE) initiates the repair of an abasi

216 These data indicate that diminution of AP endonuclease has a significant effect on spontaneous

217 ant frequencies in spermatogenic cell types, AP endonuclease heterozygous (Apex(+/-)) knockout mice w

218 at human uracil-DNA glycosylase 1 (UNG1) and AP endonuclease I (APE1) have optimal activities at spec

219 The major AP endonuclease in human cells (APE1, also termed HAP1 a

220 DNA ligase in young animals, and limited by AP endonuclease in old animals.

221 and studies using siRNA implicate the major AP endonuclease in the initial cleavage.

222 st that Topo-V most likely acts as a Class I AP endonuclease in vivo.

223 thought to be processed by Apn1p, the major AP endonuclease in yeast.

224 For repair, AP sites must be processed by 5' AP endonucleases in initial stages of base repair.

225 E/Ref-1, is the major apurinic/apyrimidinic (AP) endonuclease in human cells.

226 Apn1 is the major apurinic/apyrimidinic (AP) endonuclease in yeast.

227 ues are eliminated by apurinic/apyrimidinic (AP) endonucleases in the nucleotide incision repair path

228 permutating B cells, whereas APE1, the major AP-endonuclease in faithful base excision repair, does n

229 he DNA repair enzyme, apurinic/apyrimidinic (AP)-endonuclease, in isolated mesothelial cells, the pro

230 lso can excise deoxyribose 5-phosphate after AP endonuclease incision.

231 Smx is likely the primary, if not the sole, AP endonuclease induced during growth at low pH values.

232 3' side following incision at its 5' side by AP endonuclease is a prerequisite to completion of these

233 ial phosphorylation sites, recombinant human AP endonuclease is weakly phosphorylated in vitro (4% at

234 is property of the exonuclease III family of AP endonucleases is remarkably conserved from Archaea to

235 APE1, the major human AP endonuclease, is a druggable target in cancer and its

236 intercalated TXNA-DNA adducts are incised by AP endonuclease less efficiently than those formed by 7m

237 Furthermore, inhibition of AP endonuclease may be effective in decreasing the dose

238 5 and 2.5 microg/cm2 significantly increased AP-endonuclease mRNA and protein levels as well as enzym

239 g BER in single and multiple glycosylase and AP-endonuclease mutants confirmed that Mag1 is the major

240 The major human AP-endonuclease (named APE-1) has two unrelated activiti

241 s in DNA repair: one is a typical Neisserial AP endonuclease (NApe), whereas the other is a specialis

242 of Nth can substitute for the meningococcal AP endonuclease, NApe.

243 processing of these noncoding lesions by the AP endonucleases Nfo, ExoA, and Nth contribute to the pr

244 iency similar to Apn1p, the major hydrolytic AP endonuclease of yeast.

245 APN1 encodes the major AP-endonuclease of Saccharomyces cerevisiae.

246 nic endodeoxyribonuclease 1 (APE1), the main AP-endonuclease of the DNA base excision repair pathway,

247 We demonstrate here that these two AP endonuclease paralogues have distinct activities in D

248 and characterised two apurinic/apyrimidinic (AP) endonuclease paralogues in the human pathogen Neisse

249 ocess of damaged bases, apurinic-apyrimidic (AP) endonucleases play an essential role in enabling the

250 se activity on an intact AP site than for an AP endonuclease-preincised site.

251 reviously, we showed that when the zebrafish AP endonuclease protein (ZAP1) level is knocked down, em

252 ble-nucleotide flipping and sharp bending by AP endonucleases provide exquisite damage specificity wh

253 e of action used by both human and bacterial AP endonucleases raises important questions regarding th

254 The magnesium dependence of steady-state AP endonuclease reactions was sigmoidal for both wild-ty

255 redox sensitive signaling molecules, such as AP endonuclease/redox effector factor-1.

256 AP sites are corrected via incision by AP endonucleases, removal of deoxyribose 5-phosphate, re

257 ing agents cause imbalances of base excision/AP endonuclease repair in vivo and in vitro.

258 f AP sites with six purified human proteins: AP endonuclease, replication factor C, PCNA, flap endonu

259 he AP site has been previously 5'-incised by AP endonuclease, resulting in a 5' 2-deoxyribose 5-phosp

260 irectly test whether a genetic diminution of AP endonuclease results in increased spontaneous mutant

261 omer of the carbocyclic abasic site by human AP endonuclease showed that the enzyme recognizes both c

262 sion of the S. mutans apurinic/apyrimidinic (AP) endonuclease, Smx, in Escherichia coli; initial char

263 inic/apyrimidinic (AP) sites is initiated by AP endonucleases, such as the human Ape1 protein (also c

264 lycosylase that generates these sites and an AP endonuclease that processes them.

265 Following 5' incision by AP endonuclease, the pathways diverge as two different e

266 the incision of DNA at an abasic site by an AP endonuclease, they all lack the ability for the subse

267 epair AP site damage including the essential AP endonuclease TK endonuclease IV.

268 itochondrial class II apurinic/apyrimidinic (AP) endonuclease to cleave the DNA backbone on the 5' si

269 ycosylase activity by apurinic/apyrimidinic (AP) endonuclease using murine homolog of MutY (Myh) and

270 nfocal scanning laser microscopy showed that AP-endonuclease was primarily localized in the nucleus b

271 ifunctional glycosylase/AP lyases as well as AP endonuclease, were significantly higher in cerebellar

272 Human HAP1 (REF1) encodes the major AP endonuclease which, in addition to its role in DNA re

273 : oxidative Polbeta-DPC depended on the Ape1 AP endonuclease, which generates the Polbeta lyase subst

274 by repair initiated by 'class II' apurinic (AP) endonucleases, which cleave immediately 5'to abasic

275 Furthermore, AP-endonuclease, which catalyzes the first damage-genera