ライフサイエンスコーパス: AP2

1 irst postcontrast and the unenhanced series (AP2).

2 uit the clathrin adaptor, Adaptor protein 2 (AP2).

3 2 of the mammalian ADAPTOR PROTEIN COMPLEX2 (AP2).

4 miR156, miR172f, miR172g, miR408a, SPL6 and AP2.

5 rabidopsis MINI3, IKU2, SHB1, AGL62, FIE and AP2.

6 functional interactions between clathrin and AP2.

7 binding gene), RAV (related to ABI3/VP) and AP2.

8 cargo-selecting, clathrin adaptors, CALM and AP2.

9 lant AP4 but not that of plant and mammalian AP2.

10 FCHo and SGIP proteins, that directly binds AP2.

11 exposing membrane and cargo binding sites on AP2.

12 m prevents clathrin recruitment by cytosolic AP2.

13 mediates its binding to the clathrin adaptor AP2.

14 onfirm these domains cooperate to inactivate AP2.

15 h domains of NECAP engaging closed, inactive AP2.

16 , via a site distinct from where NECAP binds AP2.

17 gnano adhesion protein 1 (Mlig-ap1) and Mlig-ap2.

18 unit of the main endocytic clathrin adaptor, AP2.

19 structures of NECAP bound to phosphorylated AP2.

20 or mutants were found to harbor mutations in AP2.

21 114 common bean genes that coexpressed with AP2-1 and proposed these as being targets for transcript

22 have to be silenced, through miR172c-induced AP2-1 cleavage, in active mature nodules.

23 ic roots overexpressing miR172c or a mutated AP2-1 insensitive to miR172c cleavage demonstrated the p

24 A drastic decrease in miR172c and high AP2-1 mRNA levels were observed in ineffective nodules.

25 The expression of AP2-1 target showed a negative correlation with miR172c

26 ng targets for transcriptional activation by AP2-1.

27 endocytosis mediated by the clathrin adaptor AP2; 2) Tf, which was suggested to facilitate TfR1 inter

28 L1 also interacted with Adaptor protein2-2A (AP2-2A), which is part of a complex that recruits cargo

29 Inactivation of AP1 or AP2 (A-function genes) in hua-pep mutants reduced homeot

30 Adaptor protein-2 (AP2), a central component of clathrin-coated vesicles (C

31 AP2, a heterotetramer of alpha, beta, mu and sigma subun

32 ay a critical role in the earliest stages of AP2 activation and CCP nucleation.

33 erformed a transcriptomic analysis, inducing AP2 activity in meristems close to arrest.

34 inding alpha-adaptin appendage domain of the AP2 adaptor as switches in a regulated, multistep matura

35 ly thought that trafficking adaptors such as AP2 adaptor assemble spontaneously.

36 In this work, however, we discovered that AP2 adaptor assembly is an ordered process controlled by

37 d, and the recruitment of the beta2-adaptin, AP2 adaptor complex to clathrin as well as transferrin i

38 AP2 adaptor, in particular, plays a central role in clat

39 g adaptors operate in an analogous manner to AP2 adaptor, their assembly likely involves a similar re

40 xpression of PPARgamma target genes, such as aP2 and adipsin.

41 lar endocytic pathway that is independent of AP2 and clathrin, activated upon ligand binding to cargo

42 nteractions with the core endocytic proteins AP2 and dynamin.

43 demonstrated that ARF3 is a direct target of AP2 and partially mediates AP2's function in FM determin

44 and live imaging analysis demonstrated that AP2 and PICALM cross-link LC3 with APP-CTF.

45 box motif binding surface, binds to SNX9 and AP2 and potently and acutely inhibits CME.

46 on favors a new, cargo-bound conformation of AP2 and simultaneously creates a binding platform for th

47 ics by perturbing clathrin interactions with AP2 and SNX9.

48 y reduces the binding efficiency of GluR2 to AP2 and subsequently decreases AMPA receptor endocytosis

49 Cre lines driven by the adipocyte protein 2 (aP2) and adiponectin (Adipoq) gene promoters, as well as

50 t of the clathrin-associated adaptor protein AP2) and clathrin, was disproportionately affected by th

51 clathrin adaptor protein (AP) complexes AP1, AP2, and AP3.

52 achinery, including beta-arrestin, clathrin, AP2, and dynamin, significantly reduced JCPyV infection.

53 on FAC treatment, TfR1 was endocytosed in an AP2- and Tf-independent pathway and trafficked to the ly

54 ired internalization of MACs in a clathrin-, AP2-, and dynamin-dependent manner into Rab5(+)endosomes

55 pment that encode proteins with apicomplexan AP2 (ApiAP2) DNA binding domains.

56 articularly enriched within the Apicomplexan AP2 (ApiAP2) DNA-binding protein family.

57 Orthologous Apicomplexan AP2 (ApiAP2) expression has been rearranged relative to

58 P2-G, a conserved member of the apicomplexan AP2 (ApiAP2) family of DNA-binding proteins, is essentia

59 actor PfAP2-I, belonging to the Apicomplexan AP2 (ApiAP2) family, that is responsible for regulating

60 ulators of the host adaptor proteins AP1 and AP2, are essential for hepatitis C virus (HCV) infection

61 dormant meristem, and they strongly support AP2 as a master regulator of this process.

62 tionally, we identified the clathrin adaptor AP2 as an interacting partner of a previously uncharacte

63 cultures induced ADAM10 endocytosis through AP2 association and decreased surface ADAM10 levels and

64 We found that the ADAM10/AP2 association was increased in the hippocampi of AD pa

65 tive form of the clathrin adaptor protein 2 (AP2) at clathrin-coated pits.

66 opose an attachment-release model where Mlig-ap2 attaches to the substrate and Mlig-ap1 exhibits a co

67 motifs in C. parvum upstream regions are not AP2 binding motifs.

68 Expression of native FABP4/aP2 (but not the non-fatty acid binding mutant R126Q) in

69 tly proposed that NECAP negatively regulates AP2 by binding open and phosphorylated complexes (Beacha

70 y directly repressing genes of the APETALA2 (AP2) clade.

71 three families of transcription factors: ERF/AP2 class I, homeobox-leucine zipper and R2R3 MYB.

72 WRINKLED1 (WRI1), a member of the APETALA2 (AP2) class of transcription factors, positively regulate

73 The AP2 clathrin adaptor complex links protein cargo to the

74 and membrane-facing in the open form of the AP2 clathrin adaptor complex.

75 ransmembrane proteins is orchestrated by the AP2 clathrin adaptor complex.

76 This study reveals a novel role for the AP2 clathrin adaptor in promoting the abundance of GluRs

77 OR endocytosis through an adaptor protein 2 (AP2)/clathrin-dependent mechanism, attenuated morphine-i

78 Clathrin/AP2-coated vesicles are the principal endocytic carriers

79 In mammals, the AP2 complex acts as the central hub of CME by docking to

80 ted to CCPs through interactions between the AP2 complex and its N-terminal domain, which in turn rec

81 The AP2 complex of the CME pathway is conserved in yeast, an

82 tic analysis between TWD40-2 and AP2M of the AP2 complex revealed that the roles of TWD40-2 in CME ar

83 nt of Cx43, which does not interact with the AP2 complex, and by expressing mutants that cannot be ph

84 both distinct from and cooperative with the AP2 complex.

85 lasmic domain of CD4 bound to the tetrameric AP2 complex.

86 subunits of the clathrin adaptor protein 2 (AP2) complex in Caenorhabditis elegans to characterize t

87 o proteins of the classic adaptor protein 2 (AP2) complex of the clathrin-mediated endocytosis (CME)

88 subunit of the endocytosis adaptor protein, AP2, complexed with Kir6.2 predicted that mu2 docks by i

89 It is well known that adaptor protein 2 (AP2) complexes trigger clathrin assembly on the plasma m

90 Heterotetrameric adaptor protein 2 (AP2) complexes, which initiate clathrin-coated pit (CCP)

91 Our results suggest that AP2 controls meristem arrest by repressing genes related

92 Here, we have discovered that AP1 and AP2 cotraffic with HCV particles in live cells.

93 c subunits of AMPK (AMPK-ASKO mice) by using aP2-Cre and adiponectin-Cre.

94 we show that biallelic Dicer1 deletion with aP2-Cre drives aggressive and metastatic angiosarcoma in

95 In addition, the aP2-Cre line can lead to germline recombination of floxe

96 in any other tissues examined, whereas both aP2-Cre lines resulted in recombination in endothelial c

97 ene (Fsp27(DeltaAd)) were generated using an aP2-Cre transgene with the Cre/LoxP system.

98 -fat diet (HFD)-induced obesity using female aP2-Cre(-/+)/ERalpha(fl/fl) mice (atERalphaKO).

99 on of Ptpn11/Shp2 in adipocytes, mediated by aP2-Cre, led to premature death, lack of white fat, low

100 aP2-cre-mediated GRP78 deletion leads to lipoatrophy wit

101 Angiosarcomas in aP2-Cre;Dicer1(Flox/-) mice histologically and genetical

102 s, four established cell lines from PEL (CRO-AP2, CRO-AP3, CRO-AP5, and CRO-AP6) were characterized b

103 FABP4/aP2-deficient macrophages are resistant to LPS-induced m

104 Silencing of UCP2 mRNA in FABP4/aP2-deficient macrophages negated the protective effect

105 ing clathrin- and adaptor protein complex 2 (AP2)-dependent endocytosis.

106 lathrin-binding beta2 hinge and developed an AP2-dependent budding assay.

107 volved in the stabilization of Clathrin- and AP2-dependent endocytic pits.

108 via both adapter protein complex (AP)1- and AP2-dependent trafficking pathways.

109 ernalized vesicles, costained with Rab5, had AP2 depleted from the cell surface and exhibited increas

110 and a doubling of CCP/CCV diameter, whereas AP2 depletion has opposite effects.

111 These data demonstrate that FABP4/aP2 directly regulates intracellular FFA levels and indi

112 recognition sequence, one in each of its two AP2 DNA binding domains.

113 e containing a non-sense mutation within the AP2 DNA-binding domain.

114 of apicomplexa-specific proteins containing AP2 DNA-binding domains (ApiAP2s) was identified in mala

115 Although PfAP2-I contains three AP2 DNA-binding domains, only one is required for bindin

116 AP2 does not repress the transcription of AG in the inne

117 tein binding microarrays, we established the AP2 domain of AP2IX-9 binds a CAGTGT DNA sequence motif

118 s9 and a gRNA targeting the exon of the rice AP2 domain-containing protein gene Os01g04020.

119 AP2 domain-containing proteins have evolved to be the ma

120 We show that apicomplexan and perkinsid AP2 domains cluster distinctly from other chromalveolate

121 tein-binding specificity assays of C. parvum AP2 domains combined with motif conservation upstream of

122 C. parvum AP2 domains display reduced binding diversity relative t

123 nding motif was identified in one of the two AP2 domains of AtWRI1, which was also found to be critic

124 apicomplexan transcriptional regulation, pre-AP2 domination.

125 AP2 dwells in a closed, inactive state in the cytosol, b

126 AP2 tagged with enhanced green fluorescence (AP2-EGFP) and on lateral protrusions from immobile SUM15

127 east carcinoma cells, gene-edited to express AP2-EGFP.

128 oping coarse-grained models for clathrin and AP2, employing a Monte Carlo click interaction, to simul

129 was a major force in expanding B. distachyon AP2/EREBP (BdAP2/EREBP) family.

130 Especially AP2/EREBP and WRKY TFs may be important regulators of su

131 Except a few members, the AP2/EREBP family has not been characterized in Brachypod

132 further function analysis of stress tolerant AP2/EREBP genes in B. distachyon.

133 A total of 149 AP2/EREBP genes were identified and divided into four su

134 ethylene-responsive element binding protein (AP2/EREBP) transcription factors constitute one of the l

135 y network was deduced where targets, such as AP2/ERF and bHLH transcription factors and chromatin rem

136 e to low temperature, encode closely related AP2/ERF DNA-binding proteins that recognize the C-repeat

137 alyzed the binding residues of the conserved AP2/ERF domain in the DNA recognition sequence.

138 s study showed only the NMR structure of the AP2/ERF domain of AtERF100 in complex with a GCC box DNA

139 In addition to the AP2/ERF domain, an N-terminal alpha-helix of AtERF96 par

140 mechanisms of the N-terminal alpha-helix and AP2/ERF domain.

141 signals that may impact ethylene's effect on AP2/ERF family members.

142 Fs), OsEREBP1 and OsEREBP2, belonging to the AP2/ERF family were identified.

143 a unique conserved motif in the group IX of AP2/ERF family, might involve in the transactivation of

144 ion factors (TFs) in Group IX of the tobacco AP2/ERF family.

145 We isolated PsAP2 a novel AP2/ERF from Papaver somniferum which was highly upregul

146 The fast responses of four AP2/ERF genes, ERF6, RRTF1, ERF104, and ERF105, were ent

147 AP2/ERF proteins play crucial roles in plant growth and

148 The jasmonic acid (JA)-responsive AP2/ERF transcription factor (TF), ORCA3, and its regula

149 EXCESSIVE NUMBER OF FLORAL ORGANS (ENO), an AP2/ERF transcription factor which regulates floral meri

150 oned the responsible gene, ERN1, encoding an AP2/ERF transcription factor.

151 sponse factors (CRFs) are a group of related AP2/ERF transcription factors that are transcriptionally

152 LE/BRANCHED FLORETLESS 1 (FZP/BFL1) encoding AP2/ERF transcription factors.

153 e, PsnSHN2, a counterpart of the Arabidopsis AP2/ERF type transcription factor, SHINE2.

154 pathway, APETALA2/ETHYLENE RESPONSE FACTOR (AP2/ERF) family genes, and jasmonic acid (JA) pathway ge

155 er of the APETALA2/ethylene response factor (AP2/ERF) superfamily, is a transcription factor that reg

156 of the APETALA2/ethylene-responsive factor (AP2/ERF) transcription factor family in rose (Rosa hybri

157 ly of the APETALA2/ETHYLENE RESPONSE FACTOR (AP2/ERF) transcription factor ORA59, which controls the

158 er of the APETALA2/ETHYLENE RESPONSE FACTOR (AP2/ERF) transcription factor superfamily; the gene is s

159 x binding APETALA2/ETHYLENE RESPONSE FACTOR (AP2/ERF) transcription factors ERF1 or ORA59, we found t

160 encoding Apetala2/Ethylene-Response Factor (AP2/ERF)-domain transcription factors (TFs) in Group IX

161 ther transcription factor families like MYC, AP2/ERF, bZIP, etc. are enriched in OsMADS1-bound DNAs.

162 d on the expression of the six TFs families (AP2/ERF, NAC, MYB, MYB-related, bZIP and WRKY) and the m

163 Here, we report that CBF1, an AP2/ERF-family transcription factor essential for plant

164 se Factor 6 (CRF6) is a cytokinin-responsive AP2/ERF-family transcription factor that, through the cy

165 ent MPK6 activation leading to initiation of AP2/ERF-TF gene expression and other downstream gene tar

166 YLENE RESPONSE FACTOR transcription factors (AP2/ERF-TFs) were found to respond within 10 min after t

167 WRKY33, OCTADECANOID-RESPONSIVE ARABIDOPSIS AP2/ERF59 (ORA59), and PDF1.2 is inhibited, whereas tran

168 The AP2/ERFs are one of the most important family of transcr

169 a physical cluster with two uncharacterized AP2/ERFs, ORCA4 and 5.

170 in mice, we have identified a population of aP2-expressing progenitors in the stromal vascular fract

171 When isolated and grown in culture, the aP2-expressing SVF cells proliferate and differentiate i

172 n transcriptional processes that involve ERF/AP2 family members.

173 iva) that BABY BOOM1 (BBM1), a member of the AP2 family(2) of transcription factors that is expressed

174 tion by down-regulation of the mRNA level of aP2, FAS, LPL, HSL and PLIN1.

175 n adipose Grp78-knockout mouse utilizing the aP2 (fatty acid binding protein 4) promoter-driven Cre-r

176 gulation (CRY2, PHYA), and flowering (AGL20, AP2, FLC).

177 t requires the transcriptional activation of ap2-g (PF3D7_1222600), the master regulator of sexual de

178 AP2-G expression during this 'commitment cycle' prepares

179 in a persistent infection, the expression of ap2-g is limited to a sub-population of parasites (1-30%

180 e parasite transcriptomes from a conditional AP2-G knockdown line and NF54 wild-type parasites at mul

181 rmine the transcriptional changes induced by AP2-G within this sub-population.

182 evelopment, we show that sexually committed, AP2-G(+) mature schizonts specifically upregulate additi

183 r expression levels of GDV1-dependent genes, ap2-g, msrp1 and gexp5, as well as a gdv1 allele encodin

184 8 genes is regulated by transcription factor AP2-G, which is required for gametocytogenesis.

185 P2-SP proteins in blood stages, and identify AP2-G2 as a repressor active in both asexual and sexual

186 molecules and transcription factors such as AP2, Gbx2, Pax3 and Zic1.

187 he microRNA BLINDBEN belongs to the TOE-type AP2 gene family, members of which control flowering time

188 l as a tamoxifen-inducible Cre driven by the aP2 gene promoter (iaP2), were bred to the Rosa26R (R26R

189 The AP2 genes maintain shoot apical meristem (SAM) activity

190 Thus, we speculate that AP2 has evolved as a key regulatory node to coordinate C

191 The probe AP2 has excellent ability to detect ~10(3) copies of tar

192 BP4), commonly known as adipocyte protein 2 (aP2), has been extensively used as a marker for differen

193 redox intercalating probes (AP probes: AP1, AP2) have been designed, synthesized, characterized and

194 Thus, our results identify a new role for AP2 in extracellular calcium homeostasis.

195 elegans to characterize the in vivo role of AP2 in GluR trafficking.

196 we show that inhibition or deletion of FABP4/aP2 in macrophages results in increased intracellular fr

197 Fatty acid-binding protein 4 (FABP4 or aP2 in mice) has been identified as a key regulator of c

198 Here, we describe a role of AP2 in promoting the maintenance of floral stem cell fat

199 The presence of clathrin and AP2 in the LRP6 signalosomes depended on PtdIns(4,5)P(2)

200 ntify null mutations in the alpha subunit of AP2 in the nematode Caenorhabditis elegans.

201 of GluRs at synapses in vivo, and implicates AP2 in the regulation of GluR trafficking at an early st

202 Disrupted miR172 targeting of AP2 in the Zeo1.b barley mutant caused lower mitotic act

203 P4/aP2(-/-) macrophages, as well as in FABP4/aP2 inhibitor-treated cells, but partially rescued in FA

204 PICK1-AP2 interactions are required for clustering AMPARs at e

205 by a hippocampal-specific increase in PICK1-AP2 interactions, followed by PICK1-dependent lysosomal

206 e-associated proteins FCHo and SGIP1 convert AP2 into an open, active conformation.

207 he endocytic machinery but it is unclear how AP2 is activated on the plasma membrane.

208 that PICK1 binding to the endocytic adaptor AP2 is enhanced by OGD in hippocampal, but not cortical

209 However, whether aP2 is expressed in adipogenic progenitors is controvers

210 Therefore, the expression of aP2 is not limited to mature adipocytes, but also marks

211 Coincident with the loss of FABP4/aP2 is the upregulation of the antioxidants superoxide d

212 The clathrin adaptor complex AP2 is thought to be an obligate heterotetramer.

213 acid binding protein 4 (FABP4, also known as aP2) is a cytoplasmic fatty acid chaperone expressed pri

214 Fatty acid binding protein 4 (FABP4 or aP2) is an intracellular lipid chaperone that is induced

215 APETALA2 (AP2) is best known for its function in the outer two flo

216 e that microRNA (miRNA) control of APETALA2 (AP2) is required for rapid, complete elongation of stem

217 Assembly polypeptide 2 (AP2) is the most abundant adaptor and is pivotal to CME.

218 ing binding site in the mRNA of an APELATA2 (AP2)-like transcription factor, HvAP2.

219 the balance in the expression of miR172 and AP2-like genes is crucial for the correct development of

220 The wheat AP2-like transcription factor gene Q has played a major

221 Previous studies showed that Q encodes an AP2-like transcription factor, but the causal polymorphi

222 Conversely, ablation of the aP2 lineage greatly reduces the adipogenic potential of

223 When grafted into wild-type mice, the aP2-lineage progenitors give rise to adipose depots in r

224 The aP2-lineage progenitors reside in the adipose stem cell

225 uch as adipocyte fatty acid-binding protein (aP2), lipoprotein lipase (LPL), fatty acid synthase (FAS

226 ced mitochondrial protein oxidation in FABP4/aP2(-/-) macrophages attenuates the mitochondrial unfold

227 Consistent with a diminished mtUPR, FABP4/aP2(-/-) macrophages exhibit reduced expression of cleav

228 inflammasome activation, is ablated in FABP4/aP2(-/-) macrophages, as well as in FABP4/aP2 inhibitor-

229 These data suggest that AP2 may function as two partially independent hemicomple

230 propose that miR172-mediated restriction of AP2 may modulate the jasmonate pathway to facilitate gib

231 of double flowers, and we found that miR172-AP2, miR156-SPLs were critical regulatory nodes contribu

232 mpared with wild-type mice, transgenic mice (aP2-MRAP) overexpressing MRAP fat specifically exhibited

233 We showed that silencing of Act, Ap2, NDK, and Rom1 reduced invasion, proliferation, and

234 -fatty acid binding mutant R126Q) into FABP4/aP2 null cells reduced UCP2 expression, suggesting that

235 reated cells, but partially rescued in FABP4/aP2-null macrophages when UCP2 is silenced.

236 We describe non-essential functions for AP2-O and AP2-SP proteins in blood stages, and identify

237 Furthermore, depletion of AP2 or clathrin by siRNA treatment significantly inhibit

238 The site of AP2 phosphorylation is directly coordinated by residues

239 This molecular mechanism linking AP2/PICALM and AD is consistent with genetic evidence in

240 Moreover, aP2-PPARgamma response element (PPRE) interacts with bot

241 ely abolish the association of PPARgamma and aP2-PPRE.

242 EL (WUS) to terminate floral stem cell fate, AP2 promotes the expression of WUS.

243 ytosis by increasing receptor binding to the AP2 protein of the endocytotic machinery.

244 asome, as demonstrated for the wrinkled1 ERF/AP2 protein.

245 With the AP2 protocol, the sensitivity was 0.85 (95% CI: 0.78, 0.

246 Knockdown of AP2 reduced autophagy-mediated APP-CTF degradation.

247 Further analysis showed that AP2 regulated the cellular levels of APP-CTF.

248 ese data offer a novel pathway whereby FABP4/aP2 regulates macrophage redox signaling and inflammasom

249 Here, we demonstrate that ablation of FABP4/aP2 regulates systemic redox capacity and reduces cellul

250 lusters allowed the construction of putative AP2 regulons across the in vitro life cycle.

251 copy the loss of AP2 subunits and found that AP2 remains inactive in fcho-1 mutants.

252 tin (Act), Apicomplexan DNA-binding protein (Ap2), Rhomboid protein 1 (Rom 1), and nucleoside diphosp

253 proteins but without significantly altering AP2's cargo affinity in vitro.

254 direct target of AP2 and partially mediates AP2's function in FM determinacy.

255 his molecular switching mechanism can couple AP2's membrane recruitment to its key functions of cargo

256 Here we show that missense mutations of AP2 sigma subunit (AP2S1) affecting Arg15, which forms k

257 We identify five (clathrin, dynamin1, AP2, sorting nexins [SNX] SNX27, and SNX1) that increase

258 scribe non-essential functions for AP2-O and AP2-SP proteins in blood stages, and identify AP2-G2 as

259 ous as the majority of them, except those of AP2 subfamily, had no intron.

260 s elegans mutants that phenocopy the loss of AP2 subunits and found that AP2 remains inactive in fcho

261 AAGAB guides the sequential association of AP2 subunits and stabilizes assembly intermediates.

262 cord (VNC) of animals with mutations in the AP2 subunits APM-2/mu2, APA-2/alpha, or APS-2/sigma2.

263 Without the assistance of AAGAB, AP2 subunits fail to form the adaptor complex, leading t

264 tified 71 compensatory mutations in all four AP2 subunits.

265 nse to environmental signals also respond to AP2, suggesting that it could modulate the end of flower

266 ng U373 glioblastoma cells stably expressing AP2 tagged with enhanced green fluorescence (AP2-EGFP) a

267 We show that transcription factor AP2 (Tfap2), a regulator of mammalian germ lines, acts t

268 and miR172, which target the NF-YA/HAP2 and AP2 TFs, respectively.

269 Here, we determined a structure of AP2 that includes the clathrin-binding beta2 hinge and d

270 ly regulated conformational changes activate AP2 to drive both nucleation and subsequent stabilizatio

271 ssory proteins collaborate with clathrin and AP2 to drive CCV formation.

272 onformational changes occurs in both Nef and AP2 to enable CD4 binding and downregulation.

273 ependent recruitment of the clathrin adaptor AP2 to IR.

274 ough recruiting the clathrin adaptor complex AP2 to IR.

275 Binding of the transcription factor AP2 to the BST2 promoter was attenuated by inhibition of

276 uits beta-arrestins and the clathrin adaptor AP2 to trigger PC1 internalization.

277 and SnRK2.6 interact physically with an ERF/AP2 transcription factor RAP2.6, which can directly bind

278 d species Arabidopsis thaliana, the AP2-type AP2 transcription factor represents a major A-function p

279 Arabidopsis AINTEGUMENTA (ANT), an AP2 transcription factor, is known to control plant grow

280 a particularly strong selective sweep at an AP2 transcription factor.

281 e3 at the binding site for the PF3D7_1466400 AP2 transcription factor.

282 f a single particular var gene that involves AP2 transcription factors and lncRNAs.

283 ion upon DTT treatment revealed a network of AP2 transcription factors and their targets being activa

284 transcriptional regulation and suggest that AP2 transcription factors may play a limited regulatory

285 cells negatively regulates the expression of Ap2 transcription factors, and enhances the Wnt agonist

286 gulators of gene expression, including other AP2 transcription factors, histone-modifying enzymes, an

287 (miR172) and its conserved target APETALA2 (AP2) transcription factor in the common bean (Phaseolus

288 of ethylene response factor (ERF)/APETALA2 (AP2) transcription factors, mediated by Math-BTB/POZ (fo

289 and insulin resistance (AKT2 KO, Adiponectin aP2-transgenic), suggested that scWAT TAG Elovl6 ratio w

290 aled that several NAC-, WRKY-, and APETALA2 (AP2)-type transcription factors were upregulated just be

291 the rosid species Arabidopsis thaliana, the AP2-type AP2 transcription factor represents a major A-f

292 In turn, we demonstrate that the petunia AP2-type REPRESSOR OF B-FUNCTION (ROB) genes repress the

293 the murine fatty acid binding protein (FABP4/aP2) uncouples obesity from inflammation although the me

294 adipocyte fatty acid-binding protein (FABP4/aP2) uncouples obesity from inflammation via upregulatio

295 e mimetics to generate conformationally open AP2, we find that a second domain of NECAP binds these c

296 ed on PtdIns(4,5)P(2), and both clathrin and AP2 were required for the formation of LRP6 signalosomes

297 we show that clathrin and adaptor protein 2 (AP2) were part of the LRP6 signalosomes.

298 cal for FM maintenance, and AG and APETALA2 (AP2), which regulate FM determinacy by repression and pr

299 of increased WISP2 in vivo, we generated an aP2-WISP2 transgenic (Tg) mouse.

300 Pharmacologic inhibition of FABP4/aP2 with the FABP inhibitor HTS01037 also upregulated UC