ライフサイエンスコーパス: APC gene

1 contribute to the specific targeting of the APC gene.

2 formation with CpG --> TpG mutations in the Apc gene.

3 gene and the mutation cluster region of the APC gene.

4 s with the D1822V [corrected] variant of the APC gene.

5 gene and the mutation cluster region of the APC gene.

6 tuses bearing a heterozygous mutation in the APC gene.

7 be shown to have truncating mutations of the APC gene.

8 r this disorder by genetically modifying the Apc gene.

9 310 kD and is encoded by exons 1 - 15 of the APC gene.

10 ed due to cancer-associated mutations in the APC gene.

11 pot that is present several times within the APC gene.

12 AP) coli who have germ line mutations in the APC gene.

13 ht to be associated with a disruption in the APC gene.

14 Cre-mediated bi-allelic inactivation of the Apc gene.

15 nd because much is known about the causative APC gene.

16 iduals are heterozygous for mutations in the APC gene.

17 tudied in mice that inherit mutations in the Apc gene.

18 FAP is due to mutations in the APC gene.

19 es and thereby initiated CRC by mutating the APC gene.

20 d are negative for germline mutations in the APC gene.

21 to a thymine-adenine pair (G:C-->T:A) in the APC gene.

22 alterations in key regions of the K-ras and Apc genes.

23 mutations in the adenomatous polyposis coli (APC) gene.

24 mutations in the adenomatous polyposis coli (APC) gene.

25 mutations in the adenomatous polyposis coli (APC) gene.

26 ctivation of the adenomatous polyposis coli (APC) gene.

27 mutations in the Adenomatous polyposis coli (Apc) gene.

28 mutation in the adenomatous polyposis coli (APC) gene.

29 e product of the Adenomatous Polyposis Coli (APC) gene.

30 function of the Adenomatous polyposis coli (APC) gene.

31 mutations in the adenomatous polyposis coli (APC) gene.

32 ressors TP53 and adenomatous polyposis coli (APC) gene.

33 RC occurs in the adenomatous polyposis coli (APC) gene.

34 mutations to the adenomatous polyposis coli (Apc) gene.

35 mutation in the adenomatous polyposis coli (APC) gene.

36 mutations in the adenomatous polyposis coli (APC) gene.

37 mutations of the adenomatous polyposis coli (Apc) gene.

38 The adenomatous polyposis coli (APC) gene, a member of the WNT pathway, has been shown t

39 The adenomatous polyposis coli (Apc) gene also plays an important role in regulating gen

40 he FGPs were shown to carry the same somatic APC gene alteration in 24 (96%) of 25 cases.

41 P patients showed infrequent (one of 13, 8%) APC gene alterations (P: = 0.008).

42 as no difference in the frequency of somatic APC gene alterations between FGPs with foveolar dysplasi

43 Identical APC gene alterations were found in the dysplastic and ad

44 No APC gene alterations were found in the normal epithelium

45 Somatic APC gene alterations were identified frequently (21 of 4

46 Somatic, second-hit APC gene alterations, which precede morphological dyspla

47 own that somatic adenomatous polyposis coli (APC) gene alterations are frequently present in FGPs ass

48 analyzed somatic adenomatous polyposis coli (APC) gene alterations in 41 FAP-associated FGPs (20 with

49 denomas that have homozygous mutation of the APC gene and also select against fetuses bearing a heter

50 from increased nuclear transcription of the APC gene and correlated with a concomitant increase in t

51 Min mice possess a mutation in the APC gene and display a neoplastic phenotype similar to t

52 Other RNAs are expressed from the APC gene and include one form that contains an exon upst

53 nt role for germ-line allele sequence in the APC gene and individual risk of metachronous adenomatous

54 Mutations in the APC gene and other genes in the Wnt signaling pathway co

55 cing and large rearrangement analysis of the APC gene and targeted sequence analysis for the 2 most c

56 hat have a chain-terminating mutation in the Apc gene and that were either wild-type for SCFA metabol

57 single-nucleotide polymorphisms (SNP) in the APC gene and the odds of developing metachronous colorec

58 C57BL/6J-Min/+ (Min/+) mouse bears a mutant Apc gene and therefore is an important in vivo model of

59 ification of the adenomatous polyposis coli (Apc) gene and are excellent models for familial cancer p

60 mutation in the adenomatous polyposis coli (Apc) gene and develop multiple adenomas throughout their

61 terations of the adenomatous polyposis coli (APC) gene and frequently demonstrate epithelial dysplasi

62 iciencies in the adenomatous polyposis coli (APC) gene and in cells stimulated with the Wnt3a ligand.

63 Mutations in the adenomatous polyposis coli (APC) gene and K-ras occur in the majority of human color

64 eficiency in the adenomatous polyposis coli (APC) gene and subsequent activation of beta-catenin lead

65 +/- mice that inherit a mutant allele of the Apc gene, and intermediate effects are seen if a single

66 oth are caused by inherited mutations in the APC gene, and management includes genetic testing, colon

67 vered in colon cancers that retain wild-type APC genes, and also in melanomas, medulloblastomas, pros

68 ancer (CRC) model induced by mutation of the Apc gene (Apc(min)).

69 mutation in the adenomatous polyposis coli (APC) gene (Apc(Min/+) mice).

70 mutations in the adenomatous polyposis coli (APC) gene (APC) that are orthologous to those responsibl

71 mutation in the adenomatous polyposis coli (APC) gene; APC-knockout mice; and p53-knockout mice.

72 Somatic mutations in the APC gene are an early event in colorectal tumorigenesis,

73 Mutations in the APC gene are associated with an inherited susceptibility

74 Mutations in the adenomatous polyposis coli (APC) gene are associated with an early onset of colorect

75 ns of the human adenomatosis polyposis coli (APC) gene are associated with the development of familia

76 mutations in the Adenomatous Polyposis Coli (APC) gene are at increased risk of developing hepatoblas

77 terations of the adenomatous polyposis coli (APC) gene are common events in gastrointestinal tumor de

78 mutations of the adenomatous polyposis coli (APC) gene are initiating events in the majority of spora

79 Mutations in the adenomatous polyposis coli (APC) gene are linked to polyp formation in familial and

80 Mutations in the adenomatous polyposis coli (APC) gene are pivotal in colorectal tumorigenesis.

81 terations of the adenomatous polyposis coli (APC) gene are present in biliary tract cancers and the A

82 mutations in the adenomatous polyposis coli (APC) gene are thought to cause colon adenoma and carcino

83 ons in the human adenomatous polyposis coli (APC) gene are thought to initiate colorectal tumorigenes

84 mutations on the adenomatous polyposis coli (APC) gene as a model of FAP-related malignant cells.

85 Mice with mutations in the Apc gene, as well as in genes that modify or interact wi

86 ations at any of 15 sites on K-ras, p53, and APC genes; Bat-26, a microsatellite instability marker;

87 e germline mutation lay in the region of the APC gene between the first and second beta-catenin degra

88 ce with deletion/duplication analyses of the APC gene but no clinically significant variants were det

89 ers of FAP families in which mutation of the APC gene cannot be found.

90 Germ-line mutations in the APC gene cause adenomatous polyposis coli (APC), a syndr

91 Germline mutations in the APC gene cause FAP and can now be identified by direct m

92 severe polyposis phenotype and mutations at APC gene codons 1309 and 1328.

93 The mutation cluster region in the APC gene defines a region of approximately 660 bp, in wh

94 hemistry to address barriers associated with APC gene delivery, which include cellular uptake and int

95 mutation in the adenomatous polyposis coli (Apc) gene, double heterozygous animals have increased nu

96 N-induced loss of heterozygosity, and indeed Apc gene editing was less efficient in tetraploid than i

97 The APC gene encodes a large protein with multiple cellular

98 The APC gene encodes multiple protein isoforms through a com

99 The APC gene encodes the adenomatous polyposis coli tumour s

100 The adenomatous polyposis coli (APC) gene encodes APC tumour suppressor protein, germlin

101 Similarly, mice that contain a single mutant APC gene encoding a protein truncated at residue 716 (Ap

102 variants identified within the region of the APC gene examined, suggesting that any effect from this

103 n RNA interference showed that the wild-type APC gene expression is required for DNA methylation-indu

104 cells and observing a 5-fold increase in the APC gene expression.

105 We report an aggressive prostate cancer (APC) gene expression signature predictive of increased r

106 Mutations in the APC gene from codons 1310 to 2011 were the most common r

107 n the GI tract of these mice involve loss of Apc gene function in a manner very similar to that seen

108 Mouse models of FAP, in which the APC gene has been genetically inactivated, have been par

109 utely transformed on in vivo deletion of the APC gene; however, the significance of this is unclear.

110 ine sequence alteration at codon 1307 of the APC gene (I1307K) has been reported in 6-7% of the Ashke

111 cently, a germ-line missense mutation in the APC gene, I1307K, was identified that may indirectly cau

112 Sequencing of the Apc gene in a sampling of rat tumors failed to find seco

113 The prominent role of the APC gene in colorectal tumor development is well establi

114 Targeting the Apc gene in lung epithelial progenitors by Nkx2.1-cre st

115 he presence and patterns of mosaicism in the APC gene in patients with colon neoplasms not associated

116 activation of a gatekeeper gene, such as the APC gene in the colon and the CDKN2A gene in the pancrea

117 he mutation cluster region in exon 15 of the APC gene in those SPTs that did not harbor beta-catenin

118 APC genes made up 0.4 to 14.1 percent of all APC genes in the stool.

119 o inactivate the Adenomatous Polyposis Coli (Apc) gene in the murine renal epithelium.

120 beta-catenin or adenomatous polyposis coli (Apc) genes in osteoblasts.

121 denomas for germline variants throughout the APC gene, including promoter mutations.

122 mutation in the adenomatous polyposis coli (Apc) gene increased the tumor number in the GI tract and

123 ether this D1822V [corrected] variant of the APC gene is associated with colon cancer and whether its

124 Inactivation of the APC gene is considered the initiating event in human col

125 The I1307K mutation of the APC gene is found in approximately 6% of the Ashkenazi J

126 APC gene is frequently inactivated by DNA mutations.

127 In previous studies, we have shown that the APC gene is inducible and that the DNA damage-induced le

128 tant regulator in Wnt-signaling pathway, the APC gene is involved in apoptosis and cell cycle arrest.

129 The APC gene is located at chromosome band 5q23, and is dele

130 hat the CaMKII-Cre used to delete the floxed APC gene is present in efferent olivocochlear (OC) neuro

131 nt Apc(Min/+) mice, in which mutation of the Apc gene is responsible for tumor initiation.

132 ctivation of the adenomatous polyposis coli (APC) gene is a critical event in the development of huma

133 Mutation of the adenomatous polyposis coli (APC) gene is an early step in the development of colorec

134 Mutation of the adenomatous polyposis coli (APC) gene is an early step in the initiation of colon ca

135 The adenomatous polyposis coli (APC) gene is important in the etiology of colon cancer.

136 The Adenomatous Polyposis Coli (APC) gene is mutated in the majority of colorectal cance

137 Since the Adenomatous Polyposis Coli (APC) gene is mutated in the majority of human colon canc

138 The adenomatous polyposis coli (APC) gene is mutated within specific sequence contexts i

139 nsplantation, genetic variation in the human APCS gene is associated with susceptibility to invasive

140 P component (SAP, also known as Pentraxin 2; APCS gene) is a component of the humoral arm of innate i

141 mutation of the adenomatous polyposis coli (APC) gene, is characterized by development of colorectal

142 kdown and the pleiotropic effects of EB1 and APC gene knockdown.

143 BER than the cell line expressing the mutant APC gene lacking the proliferating cell nuclear antigen-

144 mutations in the adenomatous polyposis coli (APC) gene lead to colonic epithelial cell resistance to

145 g a fully penetrant dominant mutation in the Apc gene, leading to the development of gastrointestinal

146 ation using polymorphic markers flanking the APC gene locus.

147 We also assessed APC gene loss of heterozygosity.

148 In the patients with positive tests, mutant APC genes made up 0.4 to 14.1 percent of all APC genes i

149 suggest that the codon 1,822 variant of the APC gene may have functional significance.

150 re not functionally equivalent, and that the APC gene may have other tumor suppressor functions besid

151 crossed with mice bearing a mutation in the Apc gene (MIN mice), and the CEA.Tg/MIN progeny develope

152 y efficacious against CRC tumors carrying an APC gene mutation between the first and second 20-amino-

153 APC gene mutation is an early alteration in most colorec

154 When an Apc gene mutation was bred into the Mlh1 mutant mice, th

155 ations (microsatellite instability (MSI) and APC gene mutation).

156 We analyzed somatic beta-catenin and APC gene mutations in 16 sporadic JNAs from nonfamilial

157 curs through induction of the Wnt pathway or APC gene mutations that cause familial adenomatous polyp

158 APC gene mutations were identified by analysis of leukoc

159 Somatic APC gene mutations were identified in 76% (59 of 78) of

160 In those CRC cells, the APC gene mutations were located within a small segment b

161 APC gene mutations were present in six of nine (67%) of

162 atients from 19 FAP kindreds with identified APC gene mutations were reviewed.

163 eas essentially never harbor beta-catenin or APC gene mutations, we have recently identified alterati

164 beta-catenin and adenomatous polyposis coli (APC) gene mutations are well established and are known t

165 Adenomatous polyposis coli (APC) gene mutations have been implicated in familial and

166 ri infection and adenomatous polyposis coli (Apc) gene mutations have been linked to gastric cancer i

167 the role of adenomatous polyposis coli gene (Apc) gene mutations in the GI tumors of Mlh1 mutant mice

168 Mutations in the adenomatous polyposis coli (APC) gene occur in the vast majority of colorectal cance

169 a mutagen-induced nonsense allele of the rat Apc gene on an inbred F344/NTac (F344) genetic backgroun

170 ve mutational analysis in this region of the APC gene on DNA extracted from 240 Italian, Finnish, and

171 tumors that are either solely mutant in the Apc gene or in combination with another colon cancer-ass

172 rigenesis, mice with the min mutation of the APC gene or with the tm1 mutation of the p53 gene were c

173 mutations of the adenomatous polyposis coli (APC) gene or the beta-catenin gene that stabilize beta-c

174 esults indicate that somatic mutation of the APC gene plays an important role in the pathogenesis of

175 The adenomatous polyposis coli (APC) gene plays, among other things, a crucial role in t

176 The protein products of mutant APC genes present in colorectal tumors were found to be

177 So far, a clear biological function for the APC gene product has not been determined.

178 efore, C57Bl/6J(Min/+) mice with a truncated APC gene product were fed diets supplemented with cerami

179 The adenomatous polyposis coli (APC) gene product is mutated in the vast majority of hum

180 The adenomatous polyposis coli (APC) gene product mediates coordinated cell growth in th

181 ctivation of the adenomatous polyposis coli (APC) gene product, we examined protein levels and locali

182 , p120, p27, and adenomatous polyposis coli (APC) gene product.

183 (GSK-3beta), and adenomatous polyposis coli (APC) gene products interact to form a network that influ

184 This investigation shows that APC gene promoter methylation occurs in the majority of

185 However, hypermethylation in APC gene promoter was also observed in different cancers

186 thylation of the adenomatous polyposis coli (APC) gene promoter occurs in primary non-small cell lung

187 ting mutation of adenomatous polyposis coli (APC) gene reduces intestinal adenomatous polyposis via A

188 Variants in the APC gene region also were analyzed.

189 ic losses of 5q (adenomatous polyposis coli [APC] gene region) and 18q (deleted in colorectal cancer

190 A necessary role for p53 in APC gene regulation is supported by the failure of MNNG

191 A direct causal role for p53 in APC gene regulation was further evaluated by transfectin

192 The biological function of CBF in APC gene regulation was further indicated by the decreas

193 omologues or the adenomatous polyposis coli (APC) gene, respectively, are important for the developme

194 Mutations in the APC gene result in an increased propensity to develop in

195 Mutations in the adenomatous polyposis coli (APC) gene result in uncontrolled proliferation of intest

196 mutations in the Adenomatous Polyposis Coli (APC) gene, resulting in the development of numerous colo

197 eliminating the function of both Drosophila APC genes simultaneously.

198 ial flexible sigmoidoscopy and two different APC gene testing approaches.

199 We assessed indications for APC gene testing, whether informed consent was obtained

200 We evaluated the clinical use of commercial APC gene testing.

201 al factors with an inherited mutation of the Apc gene that is associated with colon cancer.

202 mutation of the adenomatous polyposis coli (APC) gene that causes colorectal cancer if prophylactic

203 mutations in the adenomatous polyposis coli (APC) gene that initiate colorectal tumors theoretically

204 ne allele of the adenomatous polyposis coli (Apc) gene that is similar to most mutations observed in

205 mutations of the adenomatous polyposis coli (APC) gene that leads to colon cancer.

206 mutation in the adenomatous polyposis coli (APC) gene that results in the spontaneous development of

207 mutations in the adenomatous polyposis coli (APC) gene that underlies familial adenomatous polyposis.

208 dentified in the adenomatous polyposis coli (APC) gene that was suggested to increase cancer predispo

209 most adenomas have lost their WT copy of the Apc gene through loss of heterozygosity by homologous so

210 his alteration is believed to predispose the APC gene to a secondary mutation at the same locus, resu

211 e pigs with knockout alleles in the DAZL and APC genes to model infertility and colon cancer.

212 ctivation of the adenomatous polyposis coli (Apc) gene to accelerate intestinal tumourigenesis using

213 efective for the adenomatous polyposis coli (APC) gene to reinvestigated the identity and importance

214 nderstanding to date of how mutations in the APC gene translate into changes at the protein level, wh

215 spectrum of DNA polymerase beta in the human APC gene under PCR conditions and compared it with the s

216 Mutations in the Adenomatous Polyposis Coli (APC) gene up-regulate Wnt signaling by stabilizing beta-

217 to detect chain-truncation mutations in the APC gene using DNA or RNA from cancer cell lines as well

218 he two tumors, biallelic inactivation of the APC gene was found.

219 on cancer cell line expressing the wild-type APC gene was more sensitive to a DNA-methylating agent d

220 urements showed that RNA expression from the APC gene was not significantly altered by the presence o

221 The adenomatous polyposis coli (APC) gene was first identified as the gene mutated in an

222 ngle nucleotide polymorphisms in the CRP and APCS genes was examined by application of family-based t

223 ations in the mutation cluster region of the APC gene were detected in the four JNAs without beta-cat

224 /-)Apc1638N mice frameshift mutations in the Apc gene were suppressed by Msh3.

225 Furthermore, colorectal tumors with intact APC genes were found to contain activating mutations of

226 Microsatellites in human TGFBR2, PTEN and APC genes were placed in yeast vectors and analyzed in i

227 mutations in the adenomatous polyposis coli (APC) gene were demonstrated in 50% of dysplastic juvenil

228 heterozygous for a nonsense mutation in the Apc gene, were randomized at weaning to seven groups, in

229 cal onset group versus controls involved the APCS gene, whereas for late-onset cases, one APCS varian

230 Mutational processes act variably across the APC gene, which could contribute to the bias against com

231 mutations in the adenomatous polyposis coli (APC) gene, which encodes a protein necessary for B-caten

232 Mutations in the adenomatous polyposis coli (APC) gene, which initiate almost all human colon cancers

233 mutation of the adenomatous polyposis coli (APC) gene, which leads to activation of the Wnt/beta-cat

234 mutations of the adenomatous polyposis coli (APC) gene, whose product is an important component of th

235 at do not test positive for mutations in the APC gene with routine testing.

236 in allele of the adenomatous polyposis coli (Apc) gene with ethylnitrosourea (ENU) results in approxi

237 deletion of the adenomatous polyposis coli (Apc) gene within the adult bladder led rapidly to coinci