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1  gene we have identified by this means, RSI1/APC2.
2 strate recognition--and the cullin domain of Apc2.
3 ibution of Apc1 is much greater than that of Apc2.
4    We isolated six new alleles of Drosophila APC2.
5  with the anaphase promoting complex protein Apc2.
6                         However, the minimal APC2/11 ubiquitin ligase module does not possess substra
7 e treatment also perturbed the enrichment of Apc2, a component of the centrosome-anchoring machinery,
8 lins while APC11 specifically interacts with APC2, a cullin-related APC subunit.
9  reduced only anterograde movements, whereas APC2 (aa 1034-2130) or APC3 (aa 2130-2844) reduced both
10 e in situ hybridization analysis revealed an APC2 allelic imbalance in 19 of 20 ovarian cancers scree
11 eveal that the combined activity of Apc1 and Apc2 allows a tight regulation of transcriptional activa
12             In addition they accumulate with APC2 and APC1 in nerves formed by axons of the progeny o
13                                              APC2 and APC1 localize to very different places when exp
14 ction was dependent on APC1, suggesting that APC2 and APC1 may act cooperatively in the destruction c
15  generated ovaries and embryos null for both APC2 and APC1, and assessed the consequences of total lo
16 h Ubc4 or UbcH10, a heterodimeric complex of APC2 and APC11 is sufficient to catalyze the ubiquitinat
17 g the cullin domain and RING finger subunits Apc2 and Apc11, respectively, and a tetratricopeptide re
18  the requirement for nuclear localization of APC2 and Axin in the Wg signal transduction pathway duri
19                                              APC2 and cullins may be distantly related members of a u
20 furrow extension, our analysis suggests that APC2 and DIA function in a novel complex that affects ac
21 rtebrate APC and DIA1, may not function with APC2 and DIA in furrow extension.
22                            Colocalization of APC2 and DIA peaks during furrow extension, and localiza
23 c hypomorphs, suggesting an additive role of APC2 and F-actin in maintaining the adherens junctions t
24 alytic core contains the cullin-like subunit APC2 and its RING partner APC11, which collaborates with
25 hese domains are regulated, using Drosophila APC2 and its two SAMP repeats as our model.
26 ctly mediates self-association of Drosophila APC2 and plays an essential role in the assembly and sta
27 normal lungs, including the tumor suppressor APC2 and the oncogene Ros 1.
28 polarity factor aPKC, the junctional protein APC2, and basal integrins in epithelial spindle orientat
29 gulates a complex containing Zw3, Armadillo, APC2, and EB1 and that this complex has a role in stabil
30 inds a C-terminal RPQPSG motif in Drosophila APC2, and that this motif is conserved in human APC2, bu
31 s of APC in a model epithelium, we generated APC2 APC1 double null clones in the Drosophila wing imag
32 o regulate Wnt signaling in APC2 null and in APC2 APC1 double-null embryos.
33  catalytic and substrate recognition module (Apc2, Apc11 and Apc10 (also known as Doc1)), and TPR-pho
34  Seven core subunit homologs of APC/C (APC1, APC2, APC11, CDC16, CDC23, CDC27, and DOC1) were identif
35 onformational change of the catalytic module APC2:APC11 to allow E2 binding, in S. cerevisiae apo-APC
36       The remaining four human APC subunits, APC2, APC4, APC5, and APC7, as well as human CDC23, were
37  adenomatous polyposis coli (APC)-like gene, APC2/APCL, was recently described and localized to chrom
38 The two Drosophila homologs of APC (Apc1 and Apc2) appear to have predominantly different tissue dist
39          I find that nuclear localization of APC2 appears to be required, but Axin can block signalin
40                                          The Apc2-Armadillo complex appears to link cap expansion to
41                        Our findings identify APC2 as a radiographically distinguishable recessive for
42                                 Furthermore, APC2 binds DIA directly through a region of APC2 not pre
43 2, and that this motif is conserved in human APC2, but not human APC1.
44  directly PARylates both Drosophila Axin and APC2, but that PARylation does not globally regulate APC
45                    In addition, we find that APC2 can recruit TNKS into the beta-catenin destruction
46              We show that loss of Drosophila Apc2 causes protein isoform changes reflecting misregula
47 , and test models suggesting Dishevelled and APC2 compete for association with Axin.
48 no similarity to proteins of known function, APC2 contains a region that is similar to a sequence in
49 d genomic stability, e.g., hBUB3, hZW10, and APC2, contribute to the molecular pathogenesis and tumor
50  ovarian cancers screened and indicates that APC2 could be a potential tumor suppressor gene in ovari
51 wo separable subcomplexes, one that contains Apc2 (Cullin), Apc11 (RING), and Doc1/Apc10, and another
52 n in total Apc activity, achieved by loss of Apc2, decreases the effective threshold at which Wg elic
53                                     Thus, an APC2-DIA complex appears crucial for actin furrow extens
54 ho family GTPases, our data suggest that the APC2-DIA complex might be independent of RHOGEF2 and RHO
55 t that Drosophila syncytial embryos null for Apc2 display defects in the formation and extension of p
56                      These data suggest that APC2 does not have to shuttle into the nucleus or locali
57 matosis polyposis coli (APC)-related protein APC2/E-APC and the MT + Tip protein EB1.
58 ed families and have bi-allelic mutations in APC2, encoding adenomatous polyposis coli protein 2.
59 an cancer cells, which express low levels of APC2, exogenous APC2 localized to the Golgi apparatus, a
60  used mouse transgenics to delete Apc and/or Apc2 from mouse mammary epithelium to elucidate the sign
61  mechanism of action of APC2, revealing that APC2 functions at the embryonic cortex with several prot
62 n pattern was observed for TrkC-miR2 and the APC2 gene in colorectal cancer specimens.
63                                          The APC2 gene is essential in Saccharomyces cerevisiae, and
64 PCR and luciferase assays indicated that the APC2 gene is targeted by TrkC-miR2, and Wnt signaling is
65 ein-protein interactions and localization of Apc2-GFP and Apc-RFP to branch points suggests that thes
66  are not known for folate biology, including APC2, GRM8, SLC16A12, OPCML, PRPH, LHX1, KLK4 and PRSS21
67                           We show that axin, APC2, GSK-3beta and N-terminally phosphorylated forms of
68                                              APC2 has a highly dynamic, asymmetric localization throu
69 t, simultaneously inactivating both APC1 and APC2 in clones of cells in the Drosophila larval optic l
70                      The established role of APC2 in integrating the actin and microtubule cytoskelet
71 d levels of Akt result in mislocalization of APC2 in postcellularized embryonic mitoses and misorient
72 roteins adenomatous polyposis coli (APC) and APC2 in the pathogenesis of human breast cancer are ill-
73 t the formin Diaphanous (DIA) functions with APC2 in this process.
74 -conserved D-box residues abrogates inversin-Apc2 interaction.
75 aken together, our results suggest that RSI1/APC2 is a subunit of APC.
76  terminus of human APC2 show that endogenous APC2 is diffusely distributed in the cytoplasm and coloc
77                   These results suggest that APC2 is involved in actin-associated events and could in
78  which express low levels of APC2, exogenous APC2 localized to the Golgi apparatus, actin-containing
79 t places when expressed in the larval brain: APC2 localizes to the cell cortex and APC1 to centrosome
80                    Our findings suggest that APC2 loss leads to increased rates of chromosome segrega
81 radation, and cell signaling are affected by Apc2 loss.
82 , reduction of dia enhances actin defects in Apc2 mutant embryos.
83 s essential in Saccharomyces cerevisiae, and apc2 mutants arrest at metaphase and are defective in th
84                   Temperature-sensitive rsi1/apc2 mutants arrest in metaphase and are unable to degra
85                   In addition, like our rsi1/apc2 mutations, cdc23-1, encoding a known APC subunit, i
86                   We find that both Apc1 and Apc2 negatively regulate Arm activity in photoreceptors,
87  APC2 binds DIA directly through a region of APC2 not previously shown to interact with DIA-related f
88 f these mutants to regulate Wnt signaling in APC2 null and in APC2 APC1 double-null embryos.
89 ll lines stably transfected with LEF1(DN) or APC2, or transiently transfected with short-interfering
90                        We find that APC1 and APC2 play overlapping roles in regulating Wingless signa
91 eracts with junctional components, including APC2, Polychaetoid and Sidekick, and actomyosin regulato
92            Our in vivo data demonstrate that APC2 protects genome stability by modulating mitotic fid
93 t that PARylation does not globally regulate APC2 protein levels as it does for Axin.
94 mplex activity at the level of both Axin and APC2, providing further mechanistic insight into TNKS in
95                                              APC2 remained associated with actin filaments after trea
96 rexpression of Adenomatous Polyposis Coli 2 (APC2) rescued GSC loss in chic hypomorphs, suggesting an
97 risingly, although complete loss of APC1 and APC2 resulted in strong activation of Wingless signaling
98 theses related to the mechanism of action of APC2, revealing that APC2 functions at the embryonic cor
99 rylation and extended region interactions in APC2's destruction complex function, but suggest that th
100 Antibodies against the NH2 terminus of human APC2 show that endogenous APC2 is diffusely distributed
101                       We show mr encodes the APC2 subunit of the anaphase promoting complex/cyclosome
102  activity through binding the surface on the APC2 subunit that recruits the E2 enzyme UBE2C, and ulti
103  as a putative binding partner of Drosophila APC2, suggesting that TNKS may play multiple roles in de
104 nzyme UBE2C, and ultimately reveal that this APC2 surface is also a Ub-binding exosite with preferenc
105                            As expected of an Apc2 target, inversin possesses D-boxes and site-directe
106           Indeed, the anaphase block in rsi1/apc2 temperature-sensitive mutants is overcome by remova
107    We also identify a zinc-binding module in APC2 that confers structural stability to the complex, a
108 argeted mutations in Drosophila melanogaster APC2 that disrupt phosphorylation and extended region in
109 eta-catenin destruction complex, placing the APC2/TNKS interaction at the correct intracellular locat
110                          We have fine mapped APC2 to a small region of chromosome 19p13.3 containing
111 during furrow extension, and localization of APC2 to furrows is DIA-dependent.
112 th localizes the microtubule binding protein Apc2 to orient one GSC centrosome at the niche-GSC inter
113                Inhibition of an APC subunit (APC2) using short interfering RNA knockdown impaired s80
114 estruction complex by generating a series of APC2 variants to which we added tags relocalizing otherw
115  to the C-terminal cullin homology domain of APC2, whereas Ubc4 interacts with APC11 directly.
116  UBCH10 is corecruited via interactions with APC2, which we visualized in a trapped complex represent
117 he Axin/Adenomatous polyposis coli (Apc1 and Apc2)/Zeste-white 3 destruction complex, and Wg-dependen

 
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