ライフサイエンスコーパス: ARC

1 ARC after 6 months was 95% in the control group and 91%

2 ARC glial activation non-specifically depolarizes both A

3 ARC interacts with DAXX in a CARD-dependent manner to bl

4 ARC TH cells project to the hypothalamic paraventricular

5 re-independent arachidonate-regulated Ca(2+)(ARC) channels are regulated by STIM1.

6 In total, 290 adult ARC patients (148 females; 142 males) with established H

7 uide strands was observed within 5 min after ARC-520 injection, and was detected for at least 4 weeks

8 CR simulation in the case of partial agonist ARC binding to the M2 receptor.

9 These findings uncover ACBP as an ARC gliopeptide playing a key role in energy balance con

10 X binding to block ASK1-JNK activation as an ARC-specific endogenous mechanism that interferes with n

11 expression in MSC and PGE2 production in an ARC/IL1beta-dependent manner.

12 he kisspeptin enriched hypothalamic AVPV and ARC respectively, which are essential for progesterone r

13 ional states are identified for the IXO- and ARC-bound M2 receptor.

14 JNK, suggesting interaction between JNK and ARC decreases amyloid-induced JNK phosphorylation and do

15 flux ratio of 12 from the mantle at MOR and ARC is comparable to the C/S ratio in the surface invent

16 deficiency in Vps33b(fl/fl)-ER(T2) mouse and ARC patients.

17 mouse hypothalamic cell line mHypoE-N41 and ARC neuron primary cultures, 2) likewise blocked by a pe

18 POA and ARC Kp neurons and DMH RFRP-3 neurons display sexual dim

19 re found in the POA, SCN, PVN, DMH, VMH, and ARC.

20 t a new mechanism of action of antiapoptotic ARC by which ARC regulates PGE2 production in the tumor

21 We apply ARC-seq to directly assess transcriptome-wide epimutatio

22 i-related protein (AgRP) neurons in the ARC (ARC(AgRP) neurons) are stimulated by fasting and, once a

23 a (POA), suprachiasmatic (SCN), and arcuate (ARC) nuclei, and that RFRP-3 neurons are present in the

24 oventral periventricular (AVPV) and arcuate (ARC) nuclei, while the region-specific role of progester

25 xtracted from laser micro-dissected arcuate (ARC) and paraventricular (PVN) hypothalamic nuclei.

26 to investigate whether hypothalamic arcuate (ARC) dopamine/tyrosine hydroxylase (TH) neurons interact

27 peroxo (IXO), the partial agonist arecoline (ARC), and the inverse agonist 3-quinuclidinyl-benzilate

28 Interestingly, blood ARC transcripts decreased in VNS rats performing NPTP, b

29 Activity Recording Capillary Feeder or CAFE (ARC), a machine-vision (automated image tracking)-based

30 uction of the apoptosis repressor with CARD (ARC) in in vitro and in vivo models of cerebral ischemia

31 describe that apoptosis repressor with CARD (ARC) interacts and inhibits DAXX and proximal signals of

32 Apoptosis Repressor with CARD (ARC) is a cell death inhibitor that antagonizes multiple

33 therapy (BBT) and assisted referral to care (ARC) studied 185 youths (aged 8.0-16.9 years) from 9 ped

34 e been associated with age-related cataract (ARC).

35 ions proceed through aminium radical cation (ARC) intermediates and occur at room temperature under v

36 ently not previously appreciated, the caudal ARC showed a far greater density of vGluT2 cells than th

37 ore common (by a factor of 10) in the caudal ARC, an area which has received relatively little attent

38 linchpins for type II anion relay chemistry (ARC) has been achieved.

39 multicomponent Type I Anion Relay Chemistry (ARC) tactic, and a dithiane-epoxide union in conjunction

40 tions include Type II Anion Relay Chemistry (ARC) to construct the polyol chain, a Ti-catalyzed asymm

41 Anion relay chemistry (ARC), an effective, multicomponent union tactic, was suc

42 itial nucleophile for anion relay chemistry (ARC).

43 ryposis, renal dysfunction, and cholestasis (ARC) syndrome is caused by deficiencies in the trafficki

44 KS, TNKS2) uses its ankyrin repeat clusters (ARCs) to bind a wide range of proteins and thereby contr

45 to generate antibody-siRNA (1:2) conjugates (ARCs) that are structurally defined and easy to assemble

46 nerates monomeric antibody-siRNA conjugates (ARCs) that retain antibody and siRNA activities.

47 The Academic Research Consortium (ARC) recently proposed a list of clinical criteria to de

48 n-immunoreactive boutons appeared to contact ARC TH neurons.

49 tecture of the left auditory-related cortex (ARC), this specific trait possibly enabling an optimized

50 Percentages of average recession coverage (ARC) and complete recession coverage (CRC) were evaluate

51 The primary end point was the average daily ARC total combined score (TCS) during the birch pollen s

52 cells; inhibition of beta-catenin decreased ARC and sensitized AML cells to chemotherapy.

53 ny cell type-specific markers for developing ARC neurons.

54 ll transcriptome analyses for the developing ARC uncovered a panel of transcription factors that are

55 s repressor with caspase recruitment domain (ARC) binds and inactivates components of the intrinsic a

56 s repressor with caspase recruitment domain (ARC) protein is a strong independent adverse prognostic

57 requirement for normal function of dopamine ARC neurons and prolactin homeostasis.

58 membrane potential oscillations of dopamine ARC neurons.

59 eurons that synthesize TH in the dorsomedial ARC also contain immunoreactive dopamine, and show eithe

60 roperties were identified in the dorsomedial ARC where 94% of TH neurons contained immunoreactive dop

61 A-mEC pathway mediates effects on downstream ARC-based synaptic plasticity related to these competing

62 For proof-of-concept, we generated DVD-ARCs targeting various cell surface antigens on multiple

63 A set of BCMA-targeting DVD-ARCs at concentrations as low as 10 nM revealed signific

64 gle cell RNA-seq analyses of mouse embryonic ARC revealed many cell type-specific markers for develop

65 areas: the arcuate nucleus-median eminence (ARC-ME) and the paraventricular nucleus (PVN).

66 ein we assessed the importance of endogenous ARC in maintaining islet structure and function in vivo.

67 t focal cerebral ischemia reduced endogenous ARC protein in neurons in the ischemic striatum at early

68 This excitatory ARC-->PVH satiety circuit, and its modulation by alpha-M

69 he developmental pathways and regulators for ARC neurons remain understudied.

70 Two different binding poses are revealed for ARC in the orthosteric pocket.

71 The C-G-T haplotype increased the risk for ARC overall (P = 0.005, OR = 1.8), and both alleles and

72 ining and, 45 min later, were sacrificed for ARC analysis in synaptoneurosomes from the DH and DLS.

73 ondary amines are established substrates for ARC-based olefin amination under similar conditions.

74 candidates for cocaine use/addiction (FOSB, ARC, KCNJ9/GIRK3, NR4A2, JUNB, and MECP2).

75 indeed displayed an overexpression of FosB, ARC, Zif268 and FRA2 only in dyskinetic rats.

76 ich displayed an overexpression of the FosB, ARC, and Zif268 immediate-early genes only in rats exper

77 We found ARC knockdown enhances JNK pathway activation, whereas A

78 t time substantial synaptic projections from ARC TH cells to other ARC neurons.

79 ections synaptically converge with GABAergic ARC(AgRP) projections on melanocortin-4 receptor (MC4R)-

80 These glutamatergic ARC projections synaptically converge with GABAergic ARC

81 vels of IL1beta/PGE2, and lower tissue human ARC and beta-catenin levels, prolonged survival, and inc

82 in the arcuate nucleus of the hypothalamus (ARC) also regulate overall glucose homeostasis via insul

83 of the arcuate nucleus of the hypothalamus (ARC) are oppositely regulated by caloric depletion and c

84 of the arcuate nucleus of the hypothalamus (ARC) promote homeostatic feeding at times of caloric ins

85 in the arcuate nucleus of the hypothalamus (ARC)-are both necessary and sufficient for driving feedi

86 in the arcuate nucleus of the hypothalamus (ARC).

87 via a highly efficient four-component type I ARC union.

88 We identify ARCs that induce targeted silencing in vitro and extend

89 n the cortex, the immediate early gene (IEG) ARC was increased in VNS rats and correlated with transc

90 hemisphere was constructed via a new type II ARC/CuCN cross-coupling tactic, while the southern hemis

91 lergen peptide 8x6Q2W significantly improved ARC symptoms after rye grass allergen challenge in an EE

92 effect prevented by viral rescue of ACBP in ARC astrocytes.

93 ombinase-dependent ChIEF-AAV-DJ expressed in ARC TH neurons evoked postsynaptic GABA currents in the

94 ased c-fos expression and spike frequency in ARC TH neurons.

95 ment with the platelet phenotype observed in ARC patients.

96 Similarly, ACBP overexpression in ARC astrocytes reduced feeding and weight gain.

97 le disruption of Ca(2+) signaling pathway in ARC glia reduces food intake.

98 When AgRP/NPY neurons are inactivated, ARC glial activation fails to evoke any significant chan

99 found that spatial training alone increased ARC levels in the DH above those observed in control rat

100 ngly, insulin-induced hypoglycemia increases ARC POMC neuron activity.

101 dent CRAC channels and the store-independent ARC channels are regulated by the protein STIM1, CRAC ch

102 nges in islet amyloid deposition, indicating ARC acts downstream of amyloid formation.

103 rgoid SCIT dose finding study in HDM-induced ARC, concentrations of >/=20 000 AUeq/ml showed both imm

104 escents and adults with birch pollen-induced ARC (EudraCT 2015-004821-15).

105 igated for treatment of grass pollen-induced ARC.

106 mptoms in patients with grass pollen-induced ARC.

107 R) neurons, receive input from interoceptive ARC(AgRP) neurons, respond to caloric state, and are suf

108 The greatest input arose from non-KNDy ARC neurons, including proopiomelanocortin-expressing ce

109 ial functional connectivity between the left ARC and DLPFC in a sample of musicians with and without

110 HBR if they met at least 1 major or 2 minor ARC-HBR criteria.

111 These modified "ARC" reactors operate with a transition-metal catalyst t

112 availability of food to dynamically modulate ARC(AgRP) neuron activity and feeding behavior.

113 er, the circuitry by which the BLA modulates ARC in multiple competing memory systems remains unclear

114 Optogenetic stimulation of mouse ARC TH neurons increased food intake; attenuating transm

115 Coexistence of multiple ARC-HBR criteria showed additive prognostic value.

116 -1, plant resistance proteins, and CED-4 (NB-ARC) domain, a tetratricopeptide repeat (TPR) domain, an

117 y of the NB-ARC-LRR in vitro, while Sw-5b NB-ARC-LRR is activated only when NSm and NSm(21) levels ar

118 ed from the fusion of an RPW8 domain to a NB-ARC domain of CNL.

119 s and animal NLRs (and, by extension, all NB-ARC and NACHT domains) possessed a domain structure that

120 in wheat at the Ta7ANPR1 locus through an NB-ARC-NPR1 fusion protein negatively regulating the defenc

121 In addition, we show that the CC-NB-ARC can operate independently of the recognition specifi

122 The genetic fusion of the CC-NB-ARC of Gpa2 with the LRR of Rx1 (Gpa2CN/Rx1L) results in

123 r prediction software, the highly complex NB-ARC domain is described in detail using several individu

124 ense (including genes putatively encoding NB-ARC and leucine-rich repeat sequences, protein kinases a

125 e-resistance genes such as those encoding NB-ARC domain-containing proteins during Echinochloa polypl

126 usly reported major locus, underlying MYB/NB-ARC/tyrosine kinase candidate genes conferring resistanc

127 Rs, and their homologs that represent the NB-ARC (nucleotide-binding adaptor shared by APAF-1, certai

128 Here we show that the NB-ARC (nucleotide-binding, Apaf-1, R-proteins, and CED-4)

129 ress and purify Rv0890c and find that the NB-ARC domain binds ATP and ADP, but does not hydrolyze the

130 In addition, the output of the NB-ARC domain sequence can directly be used for phylogeneti

131 b SD functions as an extra sensor and the NB-ARC-LRR as an activator, and that Sw-5b NLR adopts a two

132 ts the nucleotide binding activity of the NB-ARC-LRR in vitro, while Sw-5b NB-ARC-LRR is activated on

133 itory effect of coiled-coil domain on the NB-ARC-LRR region.

134 significantly enhance the ability of the NB-ARC-LRR to detect low levels of NSm effector and facilit

135 tion failed to enhance the ability of the NB-ARC-LRR to sense low levels of NSm and NSm(21).

136 denylyl cyclases, and Rv0890c harbors the NB-ARC-TPR-HTH domains.

137 However, unlike ARC(AgRP) neurons, ARC(POMC) neurons are extremely slow in affecting hunger

138 In a manner reciprocal to ARC(AgRP) neurons, ARC-projecting leptin receptor-expressing GABAergic vDMH

139 We characterize PNOC(ARC) neurons as a novel ARC neuron population activated upon palatable food cons

140 For rats engaged in NPTP, ARC correlated with performance.

141 alamus, ACBP is enriched in arcuate nucleus (ARC) astrocytes, ependymocytes and tanycytes.

142 ithin the hypothalamus, the arcuate nucleus (ARC) functions as a gateway for hormonal signals of ener

143 pathway in the hypothalamic arcuate nucleus (ARC) mediates MCH-induced feeding, adiposity, and glucos

144 Arcuate nucleus (ARC) neurons sense the fed or fasted state and regulate

145 ority of mouse hypothalamic arcuate nucleus (ARC) neurons that synthesize TH in the dorsomedial ARC a

146 gen species (ROS) levels in arcuate nucleus (ARC) neurons.

147 number of microglia in the arcuate nucleus (ARC) of the hypothalamus.

148 vation of glia in the mouse arcuate nucleus (ARC) reversibly induces increased food intake while disr

149 Neurons in the hypothalamic arcuate nucleus (ARC) that co-express kisspeptin, neurokinin B and dynorp

150 neurons in the hypothalamic arcuate nucleus (ARC) that utilizes glutamate as a fast neurotransmitter

151 neurons of the hypothalamic arcuate nucleus (ARC) tonically inhibit the release of the protein hormon

152 t only the SCN but also the arcuate nucleus (ARC), are involved in the Tb setting through afferents t

153 In the hypothalamic arcuate nucleus (ARC), proopiomelanocortin (POMC) neurons and the POMC-de

154 neurons in the hypothalamic arcuate nucleus (ARC), such as growth, reproduction and energy homeostasi

155 roxylase (TH) neuron of the arcuate nucleus (ARC), that we show makes an orexigenic contribution.

156 in the rostral hypothalamic arcuate nucleus (ARC), the subregion that has received the most attention

157 found that the hypothalamic arcuate nucleus (ARC), ventromedial nucleus (VMN), and lateral hypothalam

158 through its actions in the arcuate nucleus (ARC).

159 eptors, in the hypothalamic arcuate nucleus (ARC).

160 neurons in the hypothalamic arcuate nucleus (ARC).

161 Deletion of CHOP in ob/ob; ARC -/- mice led to reversal of beta-cell death and abno

162 Mechanistically, the absence of ARC increased levels of C/EBP homologous protein (CHOP)

163 The specific activation of ARC glia enhances the activity of agouti-related protein

164 f the BLA-mEC pathway altered the balance of ARC expression in the DH vs. DLS, specifically shifting

165 to revealing new insight into the biology of ARC channels in neuroblastoma cells, these findings prov

166 te fate specification and differentiation of ARC neurons.

167 Microdrop excitation of ARC glutamate cells in brain slices rapidly increased ex

168 tify these cells as a functional exponent of ARC(AgRP) neuron-driven hunger.

169 Finally, firing of ARC neurons was also rapidly modulated within seconds of

170 Immunoprecipitation of ARC from mouse islet lysates showed ARC binds JNK, sugge

171 pathogenesis and confirm the involvement of ARC and NMDAR postsynaptic complexes.

172 ther establishing that, even at the level of ARC(AgRP) neurons, choices are remarkably flexible compu

173 suppression of CHOP by endogenous levels of ARC is critical for beta-cell viability and maintenance

174 While generalized loss of ARC did not result in detectable abnormalities, its abse

175 Included among these genes were members of ARC and NMDAR postsynaptic protein complexes, as well as

176 tribute to the preconsummatory modulation of ARC(AgRP) neurons.

177 Furthermore, real-time monitoring of ARC(AgRP) activity revealed time-locked responses to con

178 viously unrecognized GABAergic population of ARC neurons distinct from well-defined feeding regulator

179 emory system, although the precise region of ARC changes differed by sex.

180 y, these results reveal an important role of ARC glia in the regulation of energy homeostasis through

181 tricular nucleus; optogenetic stimulation of ARC TH axons inhibited paraventricular nucleus neurons b

182 Optogenetic stimulation of ARC TH cells inhibited pro-opiomelanocortin (POMC) neuro

183 The stringency of ARC-seq can be scaled to accommodate the quality of inpu

184 Here, we report that a subset of ARC POMC neurons innervate the liver via preganglionic p

185 ts could therefore contribute to symptoms of ARC syndrome, a disease linked to loss of Vps33B.

186 nditions and only observed using a subset of ARCs.

187 s suggest that BLA-mEC pathway influences on ARC in downstream regions are a mechanism by which the B

188 Pro-opiomelanocortin (ARC(POMC)) neurons are viewed as the counterpoint to ARC

189 t local axonal connections that excite other ARC neurons including proopiomelanocortin neurons that c

190 ndicating local synaptic excitation of other ARC neurons.

191 aptic projections from ARC TH cells to other ARC neurons.

192 hydroxylase (TH) neurons interact with other ARC neurons, how they respond to hypothalamic neuropepti

193 PNOC(ARC) neurons arborize densely in the ARC and provide inh

194 PNOC(ARC) neurons represent a previously unrecognized GABAerg

195 We characterize PNOC(ARC) neurons as a novel ARC neuron population activated

196 Optogenetic activation of PNOC(ARC) neurons in the ARC and their projections to the bed

197 binoid degradation in mHypoE-N41 and primary ARC neuronal cultures from MAGL(-/-) mice, respectively,

198 AML.Significance: The antiapoptotic protein ARC promotes AML aggressiveness by enabling detrimental

199 y-regulated cytoskeleton-associated protein (ARC) and N-methyl-D-aspartate receptor (NMDAR) complexes

200 y-regulated cytoskeletal-associated protein (ARC) in downstream brain regions.

201 ionally lensed post-reionization galaxy PSZ1-ARC G311.6602-18.4624 (nicknamed the "Sunburst Arc"), re

202 Thus, a temporally analogous, rapid ARC satiety pathway does not exist or is presently unide

203 nstrates that the SQ tree SLIT-tablet reduce ARC symptoms triggered by birch or oak pollen.

204 store-independent arachidonic acid-regulated ARC channels.

205 expression of beta-catenin, which regulated ARC and augmented chemoresistance in AML cells; inhibiti

206 inor pool of plasma membrane STIM1 regulates ARC channel activity.

207 Here we show that glutamate-releasing ARC neurons expressing oxytocin receptor, unlike ARC(POM

208 interact with plasma membrane (PM)-resident ARC forming subunits in the neuroblastoma cell line SH-S

209 proportion of allergic rhinoconjunctivitis (ARC) patients experience recurrent symptoms after succes

210 as the average allergic rhinoconjunctivitis (ARC) total symptom score (TSS) after 24 weeks of treatme

211 (HDM)-induced allergic rhinoconjunctivitis (ARC) using a titrated nasal provocation test (TNPT).

212 pollen-induced allergic rhinoconjunctivitis (ARC).

213 erapy to treat allergic rhinoconjunctivitis (ARC).

214 ter density of vGluT2 cells than the rostral ARC, as seen in transgenic vGluT2-GFP mice and mRNA anal

215 with tunnel technique leads to satisfactory ARC and increase in KTW similar to CTG, but yields lower

216 Accurate RNA consensus sequencing (ARC-seq) uniquely combines RNA barcoding and generation

217 bjects (12-65 years) with moderate-to-severe ARC despite use of symptom-relieving medication.

218 ic mouse model of islet amyloidosis, we show ARC knockdown increases amyloid-induced beta-cell apopto

219 Importantly, the synthesis of 1 showcases ARC as a rapid, scalable coupling strategy for the union

220 ation of ARC from mouse islet lysates showed ARC binds JNK, suggesting interaction between JNK and AR

221 te commitment or differentiation of specific ARC neuronal types.

222 P = .0403) in patients with more symptomatic ARC.

223 -based screening programme against tankyrase ARC domains, using a combination of biophysical assays,

224 TAT.ARC protein delivery led to a dose-dependent better surv

225 TAT.ARC-treated mice showed better performance in the pole t

226 territory of the middle cerebral artery, TAT.ARC salvages brain tissue when given during occlusion or

227 Functionally, TAT.ARC treatment inhibited DAXX-ASK1-JNK signaling in the i

228 ; p = 0.005; T2-weighted MRI) smaller in TAT.ARC-treated mice (1 mug intraventricularly during MCAo)

229 Delayed delivery of TAT.ARC may present a promising target for stroke therapy.

230 tially stronger response to BBT (76.5%) than ARC (7.1%) (chi21 = 14.90; P < .001; number needed to tr

231 tions in the protein-coupling interface than ARC, especially in the receptor transmembrane helix 5 (T

232 These data indicate that ARC overexpression diminishes amyloid-induced JNK pathwa

233 odistribution studies in mice indicated that ARC-520 guide strands predominantly accumulated in liver

234 We previously reported that ARC is abundant in pancreatic beta-cells and modulates s

235 We previously reported that ARC regulates leukemia-microenvironment interactions thr

236 Together these data support the view that ARC TH cells play an unrecognized and influential positi

237 The ARC families received personalized referrals to mental h

238 The ARC is efficiently assembled with minimal training, and

239 The ARC-HBR definition identified patients at increased risk

240 Transmission across the ARC(Glutamatergic)-->PVH(MC4R) synapse is potentiated by

241 eprivation increased Deptor mRNA in both the ARC and VMH of obese rats.

242 c)-->PVH(MC4R) synapse is potentiated by the ARC(POMC) neuron-derived MC4R agonist, alpha-melanocyte

243 F1 (0.3 ug/side) bilaterally into either the ARC-ME area or PVN of Zucker Diabetic Fatty rats, a mode

244 er an action of FGF1 localized to either the ARC-ME or the PVN is capable of mimicking the sustained

245 ed by the number of times they fulfilled the ARC-HBR definition.

246 Agouti-related protein (AgRP) neurons in the ARC (ARC(AgRP) neurons) are stimulated by fasting and, o

247 he evidence that rare exonic variants in the ARC (p = 4.0 x 10(-4)) and NMDAR (p = 1.7 x 10(-5)) syna

248 preserves the carbonyl functionality in the ARC adducts, thus permitting access to functionally comp

249 PNOC(ARC) neurons arborize densely in the ARC and provide inhibitory synaptic input to nearby anor

250 netic activation of PNOC(ARC) neurons in the ARC and their projections to the bed nucleus of the stri

251 pulsatile secretion via its receptor in the ARC and/or AVPV nuclei.

252 n of gamma-aminobutyric acid receptor in the ARC did not prevent the orexigenic action of MCH, and th

253 T group (n = 95), compared with those in the ARC group (n = 90), had significantly higher rates of cl

254 ipitation revealed reduced gammaH2A.X in the ARC promoter.

255 at vGluT2 cells may be more prevalent in the ARC than previously appreciated, and play predominantly

256 owering glucose sensing, specifically in the ARC, resulted in glucose intolerance due to deficient in

257 ease in number of activated microglia in the ARC, the expression of the proinflammatory cytokine tumo

258 calized with leptin receptors (LEPRs) in the ARC.

259 tors of leptin-mediated ROS formation in the ARC.

260 rone blockade LH surge, while RU486 into the ARC shortened LH pulse interval in the progesterone trea

261 ng bilateral microinjection of FGF1 into the ARC-ME.

262 We now demonstrate that activation of the ARC channels, but not CRAC channels, is uniquely depende

263 is necessary for effective activation of the ARC channels, whilst phosphorylation of the same residue

264 Performance of two versions of the ARC reactors with different combustion volumes was chara

265 in detail the structure and function of the ARC-PVH circuit in mediating leptin signaling and in reg

266 ctions at leptin-sensitive AgRP cells of the ARC.

267 We have demonstrated that the ARC ACBD7 isoform was produced and processed into a bioa

268 e consistent with models suggesting that the ARC glutamatergic neurons may play both a rapid and a sl

269 It is also well established that the ARC is a primary residence for hypothalamic melanocortin

270 ia or other parameters, we conclude that the ARC-ME area (but not the PVN) is a target for sustained

271 isk corresponding to the number of times the ARC-HBR definition was fulfilled.

272 of AT1A and LEPR was almost exclusive to the ARC and occurred primarily within neurons expressing ago

273 ng was found in the fibers projecting to the ARC of obese mice (ob/ob and high-fat diet fed) concurre

274 This study sought to validate the ARC definition for HBR patients in a contemporary real-w

275 This study validates the ARC-HBR definition in a contemporary group of patients w

276 ulates store-independent Ca(2+)entry via the ARC channels.

277 appeared to release synaptic GABA within the ARC onto dopamine neurons and unidentified neurons, sugg

278 municate extensively with neurons within the ARC.

279 The ARCs recognise a conserved tankyrase-binding peptide mot

280 he RNA interference (RNAi)-based therapeutic ARC-520 for chronic hepatitis B virus (HBV) infection co

281 This ARC platform is based on engineered dual variable domain

282 Our work identifies for the first time ARC-DAXX binding to block ASK1-JNK activation as an ARC-

283 )) neurons are viewed as the counterpoint to ARC(AgRP) neurons.

284 Trafficking studies point to ARC entrapment in endocytic compartments as a limiting f

285 In a manner reciprocal to ARC(AgRP) neurons, ARC-projecting leptin receptor-expres

286 However, unlike ARC(AgRP) neurons, ARC(POMC) neurons are extremely slow

287 neurons expressing oxytocin receptor, unlike ARC(POMC) neurons, rapidly cause satiety when chemo- or

288 Utilizing ARC(AgRP) neurons as an entry point, we analyzed the hie

289 Most ventrolateral ARC TH cells did not contain dopamine and did not show b

290 sulphur flux of 720 Gmol/y at arc volcanoes (ARC) with a contribution from the mantle of 2.9%, which

291 own enhances JNK pathway activation, whereas ARC overexpression reduces JNK, c-Jun phosphorylation, a

292 pathway activation, we investigated whether ARC affects JNK signaling in amyloid-forming islets.

293 nism of action of antiapoptotic ARC by which ARC regulates PGE2 production in the tumor microenvironm

294 -induced beta-cell apoptosis and loss, while ARC overexpression decreases amyloid-induced apoptosis,

295 y STIM1 in the endoplasmic reticulum, whilst ARC channels are regulated by the STIM1 constitutively r

296 468 in the CRYAA promoter is associated with ARC through increasing binding of KLF-10 and thus decrea

297 Three SNPs nominally associated with ARC were identified in the promoter region of CRYAA: rs3

298 e CRYAA promoter region for association with ARC and elucidates the mechanisms of this association.

299 region due to stronger binding compared with ARC.

300 IL2RgammaNull-3/GM/SF mice transplanted with ARC-knockdown AML cells had significantly lower leukemia