ライフサイエンスコーパス: ARIC

1 ARIC participants were enrolled from four communities ac

2 ARIC participants with elevated hs-CRP and low LDL-C had

3 ARIC study (Atherosclerosis Risk in Communities) partici

4 ARIC-based limits for diastolic function improved risk d

5 ARIC-based reference limits for TDI e' (4.6 and 5.2 cm/s

6 Among 15,140 ARIC participants followed from 1987-1989 (baseline) to

7 Among 12,149 ARIC (Atherosclerosis Risk In Communities) participants

8 KD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham Heart Study participants

9 We followed up 12 230 ARIC participants free of prior HF at baseline (visit 2,

10 or missing data and prevalent cancer, 13 253 ARIC participants were included for analysis.

11 r disease: DHS (Dallas Heart Study; n=2535), ARIC (Atherosclerosis Risk in Communities; n=1595), MESA

12 The 2616 ARIC study participants who wore a leadless, ambulatory

13 his study used a cohort study design of 3229 ARIC participants enrolled at the Minnesota field center

14 120 of 804 CHS participants and 181 of 3517 ARIC participants developed incident AF.

15 a median follow-up of 7.3 and 13.1 years, 44 ARIC study participants and 275 CHS participants had SCD

16 A total of 14,446 ARIC study participants (baseline mean +/- SD age: 54 +/

17 From 14,709 ARIC (Atherosclerosis Risk in Communities) study partici

18 d by genotyping an independent sample of 718 ARIC African Americans (minor allele frequency=1%; P=1.2

19 of black participants within CHS (n = 811), ARIC (n = 3112), and Health ABC (n = 1015).

20 More than 1700 additional ARIC CAD events have since accrued.

21 By reanalyzing data from an ARIC study of coronary heart disease and simulations bas

22 pants in CHS (11.4%; 95% CI, 2.9%-29.9%) and ARIC (31.7%; 95% CI, 16.0%-53.0%).

23 ted Framingham, recalibrated Health ABC, and ARIC risk scores by 18%, 12%, and 13%, respectively.

24 correlates of circulating LCMUFAs in CHS and ARIC and US dietary sources of LCMUFAs in the 2003-2010

25 re related to circulating LCMUFAs in CHS and ARIC, consistent with food sources of LCMUFAs in NHANES,

26 ent congestive heart failure in both CHS and ARIC; hazard ratios were 1.34 (95% confidence interval,

27 correlation was 0.80 when comparing EHR and ARIC type 2 diabetes mellitus phenotypes.

28 r allele frequency 4.45 and 3.96% in FHS and ARIC, respectively) was associated with higher CKD preva

29 activity, lipid levels, blood pressure, and ARIC Study center, compared with adults who never smoked

30 ecalibrated, Health ABC HF recalibrated, and ARIC risk scores were 0.610, 0.762, 0.783, and 0.797, re

31 tudied 9240 individuals without HF or CVD at ARIC visit 4 and followed them for a mean of 10.5 years.

32 ses were ascertained by electrocardiogram at ARIC follow-up visits, hospital discharge diagnosis, or

33 Vascular risk factors at ARIC baseline (age 45-64 years; risk factors included bo

34 Cp was measured at ARIC visit 4 (1996-1998).

35 nical stroke who underwent a cerebral MRI at ARIC visit 3 (n = 1622) and a second cerebral MRI approx

36 cestry individuals from the population-based ARIC (Atherosclerosis Risk In Communities) Study cohort

37 had DBP between 80 to 89 mm Hg at baseline (ARIC visit 2), the adjusted odds ratio of having hs-cTnT

38 al CHD incidence was assessed from baseline (ARIC=1987-1989, CHS=1989-1990, REGARDS=2003-2007) throug

39 l change in hs-cTnT over the 6 years between ARIC visits 2 and 4.

40 rson-years in African-American and Caucasian ARIC participants, respectively.

41 y increase the C statistic in either cohort (ARIC, change in C statistic, -0.001; 95% CI, -0.009 to 0

42 osclerosis Risk in Communities study cohort (ARIC) and the Framingham Heart Study cohort (FHS)].

43 osclerosis Risk in Communities study cohort (ARIC).

44 rticipants of four population-based cohorts (ARIC, CHS, FHS, RS; n = 19,877; 2,388 CKD cases), and te

45 k) from Atherosclerotic Risk in Communities (ARIC) (enrolled 1987-1989), observed through 1996-1998.

46 3), the Atherosclerosis Risk in Communities (ARIC) (n = 12341) study, and the Health, Aging, and Body

47 in the Atherosclerosis Risk in Communities (ARIC) and Multi-Ethnic Study of Atherosclerosis cohorts.

48 in the Atherosclerosis Risk in Communities (ARIC) cohort (3679 African-Americans and 10 427 Whites)

49 rom the Atherosclerosis Risk in Communities (ARIC) cohort (n = 14,222, 27% African Americans).

50 was the Atherosclerosis Risk in Communities (ARIC) cohort of 7197 European-ancestry participants (159

51 rom the Atherosclerosis Risk in Communities (ARIC) cohort study who underwent 3-dimensional intracran

52 in the Atherosclerosis Risk in Communities (ARIC) cohort study.

53 rom the Atherosclerosis Risk in Communities (ARIC) cohort, we tested the hypotheses that the incidenc

54 rom the Atherosclerosis Risk in Communities (ARIC) cohort, which sampled middle-aged adults and their

55 n-based Atherosclerosis Risk in Communities (ARIC) cohort.

56 examine Atherosclerosis Risk in Communities (ARIC) participants in midlife and to explore association

57 in the Atherosclerosis Risk in Communities (ARIC) participants.

58 in the Atherosclerosis Risk in Communities (ARIC) Study (1987-1998).

59 of the Atherosclerosis Risk in Communities (ARIC) study (76+/-5 years and 60% women) who underwent t

60 of the Atherosclerosis Risk in Communities (ARIC) Study (baseline 1990-1992, with follow-up through

61 in the Atherosclerosis Risk in Communities (ARIC) Study (mean age-62 years, moderate CP-43% and seve

62 in the Atherosclerosis Risk in Communities (ARIC) Study (n = 42).

63 in the Atherosclerosis Risk in Communities (ARIC) study (N = 5,392).

64 in the Atherosclerosis Risk in Communities (ARIC) Study (n=3517).

65 in the Atherosclerosis Risk in Communities (ARIC) study and 2390 participating in the Multi-Ethnic S

66 of the Atherosclerosis Risk in Communities (ARIC) study and 4559 participants of the Cardiovascular

67 in the Atherosclerosis Risk in Communities (ARIC) Study and compared it with these other schemes.

68 in the Atherosclerosis Risk in Communities (ARIC) study and focusing on loss-of-function (LoF) varia

69 rom the Atherosclerosis Risk in Communities (ARIC) study and included 7,260 nondiabetic Caucasian ind

70 of the Atherosclerosis Risk in Communities (ARIC) Study and interrogated the regions of the nine pub

71 rom the Atherosclerosis Risk in Communities (ARIC) Study and quantified the independent association b

72 revious Atherosclerosis Risk in Communities (ARIC) Study article that evaluated the Mg-CAD associatio

73 in the Atherosclerosis Risk in Communities (ARIC) study at year 9 of follow-up.

74 le-aged Atherosclerosis Risk in Communities (ARIC) Study cohort members.

75 iethnic Atherosclerosis Risk in Communities (ARIC) Study cohort.

76 in the Atherosclerosis Risk in Communities (ARIC) study for the association between baseline urine a

77 rom the Atherosclerosis Risk in Communities (ARIC) Study in 1987-1989.

78 y-based Atherosclerosis Risk in Communities (ARIC) Study in 1990 to 1992 (baseline).

79 of the Atherosclerosis Risk in Communities (ARIC) study in 1990-92 (baseline).

80 rom the Atherosclerosis Risk in Communities (ARIC) Study in 1996 to 1998.

81 The Atherosclerosis Risk in Communities (ARIC) study investigators, for example, typically report

82 The Atherosclerosis Risk in Communities (ARIC) study is a large, predominantly biracial, National

83 The Atherosclerosis Risk in Communities (ARIC) Study is a prospective, observational cohort.

84 rom the Atherosclerosis Risk in Communities (ARIC) study matched for age, gender, and, for the majori

85 in the Atherosclerosis Risk In Communities (ARIC) study over 17 to 19 years of follow-up.

86 Atherosclerosis Risk in Communities (ARIC) study participants (n = 1980) underwent brain MR i

87 14 569 Atherosclerosis Risk in Communities (ARIC) study participants aged 45 to 64 years with mean f

88 in the Atherosclerosis Risk in Communities (ARIC) study participants at 5 examination visits between

89 ed 6516 Atherosclerosis Risk in Communities (ARIC) Study participants who were free of prevalent hype

90 14,590 Atherosclerosis Risk In Communities (ARIC) study participants with lipid measurements in 1987

91 ased on Atherosclerosis Risk in Communities (ARIC) Study surveillance adjudicating 12,450 eligible ho

92 in the Atherosclerosis Risk in Communities (ARIC) Study visit 4 (1996-1998).

93 of the Atherosclerosis Risk in Communities (ARIC) Study was conducted from 1987-1989 through 2011-20

94 rom the Atherosclerosis Risk in Communities (ARIC) study were enrolled in the ARIC Carotid MRI Study.

95 rom the Atherosclerosis Risk in Communities (ARIC) study were followed from 1987 to 1998.

96 in the Atherosclerosis Risk in Communities (ARIC) Study who attended visit 4 (1996-1998) were analyz

97 in the Atherosclerosis Risk in Communities (ARIC) study who completed in-home polysomnography assess

98 in the Atherosclerosis Risk in Communities (ARIC) Study who were aged 47-68 years, had normal kidney

99 rom the Atherosclerosis Risk in Communities (ARIC) study who were free of cardiovascular disease at b

100 rom the Atherosclerosis Risk in Communities (ARIC) study who were free of coronary heart disease at b

101 in the Atherosclerosis Risk in Communities (ARIC) study who were in sinus rhythm, free of valvular d

102 in the Atherosclerosis Risk in Communities (ARIC) Study with acute incident MI, there was a decline

103 in the Atherosclerosis Risk in Communities (ARIC) study without cardiovascular disease at baseline (

104 of the Atherosclerosis Risk in Communities (ARIC) Study without heart failure or diabetes at baselin

105 in the Atherosclerosis Risk in Communities (ARIC) study, 21,222 in the Women's Genome Health Study (

106 in the Atherosclerosis Risk in Communities (ARIC) Study, a community-based prospective cohort of whi

107 rom the Atherosclerosis Risk in Communities (ARIC) Study, a large multicenter cohort study that enrol

108 S), the Atherosclerosis Risk in Communities (ARIC) Study, and the Cardiovascular Health Study (CHS).

109 rom the Atherosclerosis Risk in Communities (ARIC) study, and the GWAS for PT was conducted in 2,583

110 dy, the Atherosclerosis Risk in Communities (ARIC) Study, and the San Antonio Heart Study.

111 rom the Atherosclerosis Risk in Communities (ARIC) study, Cardiovascular Health Study (CHS), and Fram

112 n-based Atherosclerosis Risk in Communities (ARIC) study, including associations with eGFR decline, v

113 ongoing Atherosclerosis Risk in Communities (ARIC) Study, the authors assessed the relation of tradit

114 of the Atherosclerosis Risk in Communities (ARIC) study, the Illumina Infinium HumanMethylation450 (

115 rom the Atherosclerosis Risk in Communities (ARIC) study, we demonstrate that ACAT-V complements the

116 dy, the Atherosclerosis Risk in Communities (ARIC) Study, we measured change in performance on 3 cogn

117 S-based Atherosclerosis Risk in Communities (ARIC) Study.

118 in the Atherosclerosis Risk in Communities (ARIC) Study.

119 rom the Atherosclerosis Risk in Communities (ARIC) study.

120 in the Atherosclerosis Risk in Communities (ARIC) study.

121 in the Atherosclerosis Risk in Communities (ARIC) study.

122 of the Atherosclerosis Risk in Communities (ARIC) Study.

123 rom the Atherosclerosis Risk in Communities (ARIC) study.

124 pective Atherosclerosis Risk in Communities (ARIC) study.

125 in the Atherosclerosis Risk in Communities (ARIC) study.

126 of the Atherosclerosis Risk in Communities (ARIC) study.

127 in the Atherosclerosis Risk in Communities (ARIC) study.

128 in the Atherosclerosis Risk in Communities (ARIC) study.

129 in the Atherosclerosis Risk in Communities (ARIC) study.

130 in the Atherosclerosis Risk in Communities (ARIC) Study.

131 HS) and Atherosclerosis Risk in Communities (ARIC) Study.

132 in the Atherosclerosis Risk in Communities (ARIC) study.

133 y-based Atherosclerosis Risk in Communities (ARIC) Study.

134 in the Atherosclerosis Risk in Communities (ARIC) Study.

135 rom the Atherosclerosis Risk in Communities (ARIC) Study.

136 in the Atherosclerosis Risk in Communities (ARIC) Study.

137 of the Atherosclerosis Risk in Communities (ARIC) study.

138 in the Atherosclerosis Risk in Communities (ARIC) Study.

139 in the Atherosclerosis Risk in Communities (ARIC) Study.

140 of the Atherosclerosis Risk in Communities (ARIC) Study.

141 iethnic Atherosclerosis Risk in Communities (ARIC) Study.

142 and the Atherosclerosis Risk in Communities (ARIC) Study.

143 rom the Atherosclerosis Risk in Communities (ARIC) study.

144 rom the Atherosclerosis Risk in Communities (ARIC) Study.

145 in the Atherosclerosis Risk in Communities (ARIC) Study.

146 y-based Atherosclerosis Risk in Communities (ARIC) study.

147 The Atherosclerosis Risk in Communities (ARIC) Surveillance study conducts hospital surveillance

148 The Atherosclerosis Risk in Communities (ARIC)-PET Amyloid Imaging Study, a prospective cohort st

149 S), and Atherosclerosis Risk in Communities (ARIC).

150 tates (Atherosclerosis Risks in Communities [ARIC] and Cardiovascular Health Study [CHS]) to assess t

151 es in the Atherosclerosis Risk in Community (ARIC) HF prediction model.

152 d the Atherosclerosis Risk In the Community (ARIC) visit 5 examination (2011-2013) and underwent tran

153 ta-analysis incorporating these contemporary ARIC findings.

154 plored as a secondary analysis of the Dental ARIC (Atherosclerosis Risk in Communities) study using s

155 an American adult participants of the Dental ARIC study.

156 centile values for the hs-cTnT assay in DHS, ARIC, and CHS were 18, 22, and 36 ng/l (subcohort 1) and

157 nt improvement in reclassification in either ARIC (NRI, 0.018, 95% CI, -0.012 to 0.036) or MESA (NRI,

158 We included 1,887 eligible ARIC African Americans, and 671 deaths occurred during a

159 tudy (HAPI; n = 861) were genotyped at five (ARIC) and two (FHS) common TCF7L2 variants.

160 core variables had a C statistic of 0.61 for ARIC study and 0.67 for CHS; the full multivariable mode

161 phic variables had a C statistic of 0.76 for ARIC study and 0.74 for CHS.

162 Results for ARIC demonstrated similar lifetime risks for HF in black

163 t brain MR imaging from 2011 to 2013 at four ARIC sites.

164 The Framingham, ARIC, and San Antonio models maintained high discriminat

165 ere 0.78, 0.84, and 0.83 for the Framingham, ARIC, and San Antonio risk prediction models, respective

166 The EHR IHD risk profile differed from ARIC and indicates that treatment and prevention efforts

167 Evidence from ARIC community surveillance suggests that the severity o

168 The study included 11153 participants from ARIC, 4830 from CHS, and 5887 from MESA.

169 -cause deaths were ascertained starting from ARIC visit 4 until 2010.

170 n kidney disease in mice as well as in human ARIC study participants.

171 Similarly, among humans (ARIC study participants), high consumption of cruciferou

172 In ARIC and MESA, the categorical net reclassification impr

173 In ARIC, of 680 pneumonia cases, 112 had CVD over 10 years

174 In ARIC, polygenic scores for MDD and loneliness were assoc

175 1.89 (95% confidence interval, 1.42-2.51) in ARIC, 1.25 (95% confidence interval, 0.81-1.92) in REGAR

176 from 0.60 (0.51-0.69) to 0.67 (0.60-0.75) in ARIC and 0.68 (0.52-0.84) to 0.75 (0.60-0.91) in MESA (v

177 Cohort risk equations (c-statistic 0.808 in ARIC and 0.743 in CHS).

178 imination for SCD risk (c-statistic 0.820 in ARIC and 0.745 in CHS).

179 Participants 45 to 64 years of age in ARIC (men=6479, women=8488) and REGARDS (men=5296, women

180 ck versus white men 45 to 64 years of age in ARIC and REGARDS were 2.09 (95% confidence interval, 1.4

181 Among women 45 to 64 years of age in ARIC and REGARDS, age-adjusted hazard ratios comparing b

182 s from a genome-wide Affymetrix 6.0 array in ARIC African Americans yielded similar results.

183 ociated with higher hazard ratios for CHD in ARIC.

184 igher low-density lipoprotein cholesterol in ARIC but not in REGARDS or KPSC.

185 s is the first study to characterize CNPs in ARIC and the first genome-wide analysis of CNPs and uric

186 variance in serum magnesium concentration in ARIC African-American participants.

187 variance in serum magnesium concentration in ARIC African-American participants.

188 nd TRPM6 on serum magnesium concentration in ARIC European-American participants.

189 CP, no other loci were associated with CP in ARIC or aggressive periodontitis in the German sample.

190 de significant interactions were detected in ARIC for systolic blood pressure between PLEKHA7 (a know

191 ARDS, 6547 events in KPSC, and 583 events in ARIC.

192 aluate their association with incident HF in ARIC participants.

193 hazards ratio estimates for incident IHD in ARIC (Pearson correlation [r]=0.62), indicating that the

194 ated with increased risk of CVD incidence in ARIC cigarette nonsmokers.

195 tly associated with 10-year CHD incidence in ARIC with hazard ratios per SD increment of 1.24 (95% CI

196 the test of gene-environment interaction in ARIC EA participants, the index variant at MUC1 had 2.5

197 enome-wide significant local interactions in ARIC in the 4p16.1 region located mostly in an intergeni

198 ps), finding association with LDL-C level in ARIC Caucasians (P = 0.0064).

199 festyle to 5.1% for a favorable lifestyle in ARIC, from 4.6% to 2.0% in WGHS, and from 8.2% to 5.3% i

200 nal effects and three epistatic SNP pairs in ARIC-three marginal SNPs were located within SLC2A9 and

201 An analysis of metabolic phenotypes in ARIC also showed that the P wave was genetically correla

202 r multivariable adjustment, hazard ratios in ARIC and REGARDS were 0.67 (95% confidence interval, 0.3

203 ardiovascular risk factors, hazard ratios in ARIC and REGARDS were 1.19 (95% confidence interval, 0.7

204 dently associated with long-term CAD risk in ARIC and in a meta-analysis with other prospective studi

205 milar findings were observed for CHD risk in ARIC, in analyses stratified by premature FHx, and in an

206 bes passed the threshold for significance in ARIC (P < 1 x 10(-7); Bonferroni), including probes in t

207 nteraction P = 2.9 x 10(-9)) with smoking in ARIC was not replicated in Health ABC, although estimate

208 ing glucose genome-wide association study in ARIC.

209 Validation in ARIC was robust (AUC = 0.85).

210 ents occurred during 39 238 person-years; in ARIC, 330 events congestive heart failure events occurre

211 Association Detection Project in Industry), ARIC (Atherosclerosis Risk in Communities), and CHS (Car

212 validate these findings for CP in the larger ARIC cohort (n = 821 participants with severe CP, 2031-m

213 Fifty-nine percent of cases met ARIC criteria for ADHF and 13.9% and 27.1% were classifi

214 In NHANES (ARIC/CHS), the cut-point of 5 or more points selected 35

215 Compared with normotensive ARIC participants, IDH by the 2017 ACC/AHA definition wa

216 95% confidence interval, 1.20-2.73) but not ARIC (hazard ratio, 1.21; 95% confidence interval, 0.96-

217 he community-based multicenter observational ARIC study (Atherosclerosis Risk in Communities) using v

218 Harrell's C-statistic of ARIC-HF was 0.845 (95% CI, 0.831-0.859).

219 ith inflection points for risk supportive of ARIC-based limits.

220 In the prospective ARIC Study, the outcome of AF on the rates of stroke, he

221 e Atherosclerosis Risk in Communities Study (ARIC) population.

222 , Atherosclerosis Risk in Communities Study (ARIC), and Multiethnic Study of Atherosclerosis (MESA).

223 e Atherosclerosis Risk in Communities Study (ARIC), the Cardiovascular Health Study (CHS), and the Re

224 e Atherosclerosis Risk in Communities study (ARIC), the Cardiovascular Health Study (CHS), and the Re

225 e Atherosclerosis Risk in Communities Study (ARIC).

226 e Atherosclerosis Risk in Communities study (ARIC, n = 15,792; enrollment age, 45-64 years; enrollmen

227 e Atherosclerosis Risk in Communities Study (ARIC; n = 11,061 self-identified white and n = 4014 blac

228 2013, through the ARIC Neurocognitive Study (ARIC-NCS), participants underwent a detailed neurocognit

229 a large population-based prospective study, ARIC (Atherosclerosis Risk in Communities), and in the p

230 k in Communities Study, Minnesota subcohort (ARIC; 1987-2008).

231 The ARIC HF risk score is more parsimonious yet performs sli

232 From 1987 through 1989, the ARIC Study enrolled 15792 men and women and conducted 4

233 isk SNPs among participants from CHS and the ARIC study.

234 nterview, for participants not attending the ARIC-NCS visit, or by an International Classification of

235 irwise genetic correlations (rG) between the ARIC and EHR phenotypes using linear mixed models.

236 he genetic correlation estimates between the ARIC risk factors and the EHR IHD were modestly linearly

237 48 (68%; n=9276 weighted) such events by the ARIC reviewer panel.

238 The authors studied 11,565 adults from the ARIC (Atherosclerosis Risk In Communities) cohort, analy

239 METHODS AND We analyzed data from the ARIC (Atherosclerosis Risk in Communities) Study Heart F

240 African Americans (27%) and whites from the ARIC cohort [aged 45-64 y at baseline (1987-1989)] were

241 We included 2229 participants from the ARIC study (Atherosclerosis Risk in Communities) and 700

242 +/-5.7 years; 26% black; 55% women) from the ARIC study (Atherosclerosis Risk in Communities).

243 ed on 2383 participants (1993-1995) from the ARIC study (Atherosclerosis Risk in Communities; 100% bl

244 ETHODS AND We used ECG measurements from the ARIC study (Atherosclerosis Risk in Communities; n=6731

245 udy population included 4847 adults from the ARIC study (mean [SD] age, 62.9 [5.6] years; 56.4% women

246 5016 women [52.3%]) and 8703 adults from the ARIC Study (mean [SD] baseline age, 56.0 [5.6] years; 49

247 an independent subsample (N = 1088) from the ARIC study, suggests that the ABO blood group may influe

248 nts (AA) free of diagnosed diabetes from the ARIC Study.

249 otal of 16,169 European individuals from the ARIC, GHS, MARTHA and PROCARDIS studies, were meta-analy

250 dy included 11,715 middle-aged adults in the ARIC (Atherosclerosis Risk In Communities) cohort with h

251 In the ARIC (Atherosclerosis Risk In Communities) cohort, VTE r

252 mean baseline age 59 years, 43% male) in the ARIC (Atherosclerosis Risk In Communities) study and the

253 up.Among 14,082 participants enrolled in the ARIC (Atherosclerosis Risk in Communities) Study initial

254 d with acute or chronic heart failure in the ARIC (Atherosclerosis Risk In Communities) study surveil

255 f European descent (aged 45-64 years) in the ARIC (Atherosclerosis Risk in Communities) study were fo

256 ,355 participants aged 45 to 64 years in the ARIC (Atherosclerosis Risk In Communities) study without

257 In the ARIC (Atherosclerosis Risk In Communities) study, we use

258 cipants free of CHD and heart failure in the ARIC (Atherosclerosis Risk in Communities) study.

259 ipoprotein cholesterol (LDL-C) strata in the ARIC (Atherosclerosis Risk in Communities) study.

260 T to TRF improves CHD risk prediction in the ARIC (Atherosclerosis Risk In Communities) study.

261 models discriminated reasonably well in the ARIC and Multi-Ethnic Study of Atherosclerosis data (C s

262 ommunities (ARIC) study were enrolled in the ARIC Carotid MRI Study.

263 ntified in MESA, were also replicated in the ARIC cohort (Atherosclerosis Risk in Communities).

264 factors for SCD were first identified in the ARIC cohort to derive a 10-year risk model of SCD.

265 No identified variant in the ARIC or FHS cohorts was associated with albuminuria.

266 with incident HF, mortality, and CVD in the ARIC population.

267 ardiographic measures in participants in the ARIC study (Atherosclerosis Risk in Communities) (n=13 6

268 cular disease events or heart failure in the ARIC Study (Atherosclerosis Risk in Communities) underwe

269 VRF and incidence of AF over 25 years in the ARIC study (Atherosclerosis Risk in Communities).

270 Among 5801 elderly participants in the ARIC study (Atherosclerosis Risk in Communities; age ran

271 We used 37 phenotypes measured in the ARIC study (Atherosclerosis Risk in Communities; n=7716,

272 , and the 12 independent risk factors in the ARIC study included age, male sex, black race, current s

273 spective cohort study of participants in the ARIC study who did not have diagnosed diabetes and who a

274 his lack of association was confirmed in the ARIC study, even after the analysis was restricted to le

275 HF), and chronic kidney disease (CKD) in the ARIC Study.

276 s) (n = 2029, p value = 6.7 x 10(-3)) of the ARIC and was confirmed by replication in both EAs and AA

277 trics for echocardiography in visit 5 of the ARIC cohort.

278 food groups used in previous studies of the ARIC cohort.

279 e optimism-corrected area under curve of the ARIC HF risk score increased from 0.773 (95% CI, 0.753-0

280 ighest category (>/=0.014 mug/L; 7.4% of the ARIC population) had significantly increased risk for CH

281 valvular disease from the fifth visit of the ARIC study (Atherosclerosis Risk in Communities) who und

282 We studied 4343 participants of the ARIC study (Atherosclerosis Risk in Communities) who wer

283 the community surveillance component of the ARIC study (Atherosclerosis Risk in Communities).

284 art failure, who attended the visit 5 of the ARIC study (Atherosclerosis Risk in Communities).

285 The community surveillance component of the ARIC Study consisted of tracking residents 35 to 74 year

286 Pooling the ARIC and replication data yielded two additional loci in

287 from 3 population-based cohort studies, the ARIC Study (Atherosclerosis Risk in Communities), the DH

288 Most recently, in 2011-2013, through the ARIC Neurocognitive Study (ARIC-NCS), participants under

289 Addition of PASP to the ARIC model resulted in a significant improvement in mode

290 s to derive a SCD prediction model using the ARIC cohort and validate it in CHS.

291 were also genetically correlated with these ARIC risk factors.

292 estimated from 4,089 women is comparable to ARIC in direction and magnitude (1.414.707.88, p=5.46x10

293 documented MI (CMI) after the baseline until ARIC visit 4 (1996-1998).

294 During follow-up, ARIC identified incident HF and subcategorized HF with p

295 as ADHF, chronic stable HF, or no HF, using ARIC classification guidelines.

296 The setting was ARIC field centers (Washington County, Maryland; Forsyth

297 ncreased risk of dementia in black and white ARIC Study participants.

298 specificity of the automated algorithm with ARIC reviewer panel as the referent standard were 0.68 (

299 phenotype was most strongly correlated with ARIC metabolic phenotypes, including total:high-density

300 0 participants, the mean age was 62.4 years (ARIC, 57.9 years; MESA, 62.4 years; and CHS, 72.5 years)