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1 ART in HIV controllers reduces T-cell activation and imp
2 ART significantly reduced HIV-specific T-cell responses
3 ART use was effective in further increasing the proporti
4 ART use was summarized within Global Burden of Disease (
6 were (1) ART initiation in <=7 days and (2) ART initiation in <=28 days and retention in care at 8 m
7 reps on longitudinal plasma samples from 50 ART-suppressed individuals in the Reservoir Assay Valida
8 from 47.4% (41.3-53.4) to 76.2% (71.8-80.6), ART use among diagnosed people living with HIV increased
13 ound, and we compare rebound viral RNA after ART discontinuation with near full-length viral DNA from
19 rformed nationwide plasma CrAg testing among ART-experienced Ugandan adults with virologic failure (>
20 were randomly assigned to receive either an ART-only (n=30) or an ART + V + V (n=30) regimen; all 60
21 d to receive either an ART-only (n=30) or an ART + V + V (n=30) regimen; all 60 participants complete
25 ic factors, HIV disease characteristics, and ART components and weight change following ART initiatio
26 ccordance with the CAP, Evans', JPS, MDA and ART grading systems, and interobserver concordance was c
27 ART initiation with quarterly monitoring and ART refills through mobile vans; ART initiation at the c
29 with viral suppression using antiretroviral [ART] therapy; n = 2 with rebound viremia after stopping
30 participants with HIV (CD4 < 50 cells/uL) at ART initiation to receive either empiric TB treatment or
33 viral suppression compared with clinic-based ART, particularly among men, eliminating disparities in
34 ntage points, enrolment into community-based ART delivery by 25 percentage points, and switching to s
38 ith mobile phone software to community-based ART initiation with quarterly monitoring and ART refills
39 When given to all men and women, DTG-based ART could reduce the level of NNRTI PDR from 52.4% (with
40 n resistance levels, whereas using DTG-based ART in all men, or in men and women beyond childbearing
42 everse transcriptase inhibitor (NNRTI)-based ART between January 2007 and June 2016 were included.
43 compared to the continuation of NNRTI-based ART, introducing DTG would lead to a reduction in NNRTI
47 by clonal expansion of cells infected before ART initiation.IMPORTANCE There are limited data about t
48 Pol is protecting against toxicity caused by ART and individuals with inactivating mutations may be p
49 at were clustered closely, indicating that c-ART partially reversed the gut dysbiosis associated with
50 ggest that complete viral suppression with c-ART could potentially revert microbial dysbiosis observe
51 ted to transition from the standard of care (ART eligibility at CD4 counts of <350 cells/mm3 until Se
55 onsidered the situation in 2018 and compared ART initiation policies of an efavirenz-based regimen in
56 started ART 8 weeks postinfection, continued ART for >7 months, and controlled plasma viremia at <10(
58 cohort (range of 1 to 19 years of continuous ART suppression) showed a median viral load of 0.54 cp/m
59 he absence of drug resistance to the current ART regimen.METHODSSamples were collected from at least
61 offered universal HIV-treatment and same-day ART with a dolutegravir-based regimen at first clinic vi
62 mphasize adherence counseling while delaying ART switch may promote drug resistance and should be rec
66 se of bNAbs at 30 h, or a 21-day triple-drug ART regimen at 48 h, are aviremic with almost no virus i
68 hese animals prior to ART initiation, during ART suppression, and following viral rebound, and we com
70 se data demonstrate that bNAb therapy during ART interruption is associated with enhanced HIV-1-speci
72 shedding in HIV/HSV-coinfected women during ART may sustain HIV tissue reservoirs via Ag exposure or
75 hort Collaboration who initiated their first ART regimen, containing either InSTI (i.e., raltegravir,
81 ed with deficits in SIP and motor functions; ART and higher CD4 are associated with better cognitive
82 unction are common on ART, relate to greater ART-mediated CD4 T-cell restoration, and are associated
84 a reduction in NNRTI PDR in all scenarios if ART initiators are started on a DTG-based regimen, and t
85 ts to important health benefits of immediate ART initiation; however, the policy's impact on the econ
87 ative risk of SIV-induced TB reactivation in ART-treated macaques in the early phase of treatment.
90 lence of undiagnosed HIV infection, increase ART use among all people living with HIV, and make subst
93 ses can be detected in children who initiate ART after 2.3 months of age and are probably, as in adul
94 ortion of those diagnosed who ever initiated ART; and proportion of those ever treated who achieved v
96 .1%, 95% CI 53.7-60.6) individuals initiated ART within 1 day of linkage, 589 (73.7%, 70.6-76.7) of 7
97 ences were from three children who initiated ART after 2.3 months of age, one of whom had two identic
99 n among adults living with HIV who initiated ART and had serum 25-hydroxyvitamin D concentrations of
100 ith HIV aged 15 years or older who initiated ART at a programme site were eligible for analysis.
102 tive cohort study included adults initiating ART at facilities providing universal ART since January
103 LWH with severe immunosuppression initiating ART, baseline low BMI and hemoglobin and high CRP and D-
104 itive adults >=18 years old newly initiating ART in 4 Zambian provinces (Eastern, Lusaka, Southern, a
105 e previous concerns, participants initiating ART with CD4 counts >=500 cells/uL had very good virolog
109 ated to initiating (including re-initiating) ART in the hospital and its association with linkage to
111 te to viral rebound in some PWH interrupting ART.IMPORTANCE To cure HIV, we likely need to target the
114 d HIV-seropositive, qualified for first-line ART, planned to reside in the area for more than 1 year,
115 centage points, and switching to second-line ART by 1 percentage point compared with standard of care
116 ved among candidates screened for third-line ART in LMIC, ranging from no resistance to resistance to
117 Food insecurity was associated with lower ART concentrations in hair, suggesting that food insecur
118 months controlling for enrollment measures, ART group, age, and RTI using generalized estimating equ
119 re, 35 (3.0%) were CrAg positive with median ART duration of 41 months (interquartile range, 10-84 mo
120 2 HIV-infected participants receiving modern ART to determine the kinetics of plasma viral rebound fo
122 ission (0.3-86.1/100PY, by HIV RNA), monthly ART costs ($2,290-$3,780), and HIV per-screen costs ($38
124 equation and generalized linear models (non-ART group pVL and hemoglobin) in as-treated analyses.
125 or those who were CrAg positive, we obtained ART history, meningitis occurrence, and 6-month survival
126 group had virological failure at month 12 of ART (95% CI 6.0-11.7) compared with 39 (9.7%) of 402 (7.
128 ible studies investigated the association of ART, CD4+ count, or HIV PVL on histology-confirmed CIN2+
130 rica and Uganda, community-based delivery of ART significantly increased viral suppression compared w
132 randomised trial to determine the effect of ART-only versus ART plus kick and kill on markers of the
137 /mm3 thereafter) to the 'Early Initiation of ART for All' (EAAA) intervention at one of seven timepoi
138 r well-established nonhuman primate model of ART-suppressed HIV-1 infection, we tested strategies to
139 nts (cholecalciferol) for the first month of ART followed by daily 2000 IU vitamin D(3) supplements o
142 f Tregs, the side effects in the presence of ART prevent their clinical use and call for different Tr
144 Although an interruption in the supply of ART drugs would have the largest impact of any potential
146 V RNA expression in the blood and tissues of ART-suppressed bone-marrow-liver-thymus (BLT) humanized
147 ght gain is ubiquitous in clinical trials of ART initiation and is multifactorial in nature, with dem
149 fic and sex-specific gaps in the scale-up of ART, to estimate the historical and future effect of att
153 al blood samples from 400 HIV-1(+) adults on ART from several diverse cohorts, representing a robust
154 n of people living with HIV diagnosed and on ART; proportion of people living with HIV on ART with vi
156 and decreases in lung function are common on ART, relate to greater ART-mediated CD4 T-cell restorati
157 control of HIV-1 infection (controllers) on ART, included because controllers have strong HIV-1-spec
158 ART; proportion of people living with HIV on ART with viral suppression; and proportion of HIV-negati
159 living with HIV (HIV+) who were initiated on ART before 3 years of age in a prior clinical trial comp
160 lity, 1315 people living with HIV and not on ART with detectable viral load at baseline were randomly
163 6.0), and viral load suppression of those on ART increased from 88.7% (83.6-93.8) to 91.3% (88.6-94.1
167 people living with HIV (91% of 1353) were on ART; 1166 people living with HIV (88% of 1321 with avail
168 HIV infection, we hypothesized that women on ART would have a lower frequency of latent HIV compared
169 d for eligibility (HIV+, age >= 14 years, on ART >6 months, not acutely ill, CD4 count not <200 cells
171 PFS 50%, 32 to 67; n=59) and etoposide plus ART (20%, 6 to 33; n=59), and -20% (-33% to -7%) for the
172 wing superiority to both oral etoposide plus ART and bleomycin and vincristine plus ART, supporting i
174 o -7%) for the comparison of paclitaxel plus ART (64%, 55 to 73; n=138) and bleomycin and vincristine
175 to -8) for the comparison of paclitaxel plus ART (week 48 PFS 50%, 32 to 67; n=59) and etoposide plus
176 rvention was not shown, with paclitaxel plus ART showing superiority to both oral etoposide plus ART
178 plus ART and bleomycin and vincristine plus ART, supporting its use in treating advanced AIDS-associ
179 ntly later (median of 66 versus 42 days post-ART interruption, P < 0.01) and reached lower levels (me
181 preserved Th17 homeostasis, including at pre-ART, are the main features associated with sustained vir
183 s; however the relative contributions of pre-ART drug resistance mutations (DRMs) vs nonadherence in
184 uals with undetectable residual viremia (pre-ART vs after 24-48 weeks of ART: 19% vs 94%, P < .001).
185 tions to expand donor options and to prevent ART interruptions for patients with HIV in need of alloB
187 disease with LPs and blood cultures, prompt ART initiation, and more intensive antifungals may reduc
190 adults linked to study clinics before rapid ART introduction and 800 after rapid ART introduction.
191 gibility policies (Treat All) improved rapid ART initiation after care enrollment among 10-14-year-ol
193 idence rates in HIV-positive women receiving ART were higher than those in untreated HIV-positive wom
198 macaques (RMs), defined as PTCs, who started ART 8 weeks postinfection, continued ART for >7 months,
202 y; n = 2 with rebound viremia after stopping ART), who provided serial blood samples before death and
205 of the HIV DNA reservoir during suppressive ART, even when ART is initiated during the earliest phas
206 ain HIV tissue reservoirs during suppressive ART, suggesting future cure strategies should study inte
207 useful for screening children on suppressive ART for enrolment into therapeutic vaccine trials and ot
209 The ability of malaria parasites to survive ART monotherapy may relate to an innate growth bistabili
210 ecies with alternative reproductive tactics (ARTs) exhibit robust, consistent differences in behavior
212 who were HIV-positive and not already taking ART were offered universal HIV-treatment and same-day AR
213 Persons who are HIV positive and taking ART and persons taking PrEP to prevent HIV infection are
214 rts of tenofovir toxicity in patients taking ART for HIV cannot be explained solely on the basis of o
215 Men living with HIV with urethritis taking ART >=12 weeks were enrolled at a sexually transmitted i
216 eful for assisted reproductive technologies (ARTs), as it can allow specific selection of sperm cells
219 ent analysis, among patients enrolled in the ART (n=3102), we excluded those who did not undergo surg
220 ity of gut microbiome composition, while the ART group appeared to recover towards the diversity leve
221 perfect adherence to antiretroviral therapy (ART) (OR, 2.8; P < .001), and depression (OR, 1.9; P < .
222 (HIV) infection and antiretroviral therapy (ART) are associated with bone loss leading to increased
224 mmune restoration on antiretroviral therapy (ART) can drive inflammation in people living with human
225 of data on access to antiretroviral therapy (ART) care and social or clinical context at the destinat
226 In adults starting antiretroviral therapy (ART) during acute infection, 2% of proviruses that persi
227 fering same-day (SD) antiretroviral therapy (ART) during home-based human immunodeficiency virus test
228 A key component of antiretroviral therapy (ART) for HIV patients is the nucleoside reverse transcri
231 d after cessation of antiretroviral therapy (ART) in 18 acutely treated and durably suppressed indivi
232 Despite the use of antiretroviral therapy (ART) in HIV-1 infected mothers approximately 5% of new H
233 te initiation of HIV antiretroviral therapy (ART) in pregnancy is associated with not achieving viral
235 Early initiation of antiretroviral therapy (ART) in vertically HIV-infected children limits the size
236 0%), linkage-to-care/antiretroviral therapy (ART) initiation (76%), HIV transmission (0.3-86.1/100PY,
237 oad (VL) early after antiretroviral therapy (ART) initiation appears frequently in pregnant and postp
238 V) seroconversion to antiretroviral therapy (ART) initiation during an era of expanding HIV testing a
239 effect of very early antiretroviral therapy (ART) initiation on the rate of recrudescence and the vir
242 itive individuals on antiretroviral therapy (ART) is an important milestone for efforts to cure HIV-1
244 sessed the effect of antiretroviral therapy (ART) on HIV suppression, immune activation, and quality
246 nitiated suppressive antiretroviral therapy (ART) regimens in infancy, HIV-1-specific antibody concen
247 ants receiving older antiretroviral therapy (ART) regimens with infrequent virologic monitoring.
252 ents (94.3%) were on antiretroviral therapy (ART), 88.7% had HIV virologic suppression, and 80.8% had
253 HIV testing, earlier antiretroviral therapy (ART), and strengthened male circumcision services, and 1
254 e global scale-up of antiretroviral therapy (ART), incarcerated people have not benefited equally fro
258 of plasma viremia in antiretroviral therapy (ART)-treated simian immunodeficiency virus-infected rhes
274 40 copies/mL) despite reported adherence to ART and the absence of drug resistance to the current AR
276 06-2017 who switched to or added an INSTI to ART (SWAD group) were compared to women on non-INSTI ART
277 RNA and viral DNA in these animals prior to ART initiation, during ART suppression, and following vi
278 ates over time since linkage with respect to ART initiation, retention in care, transfers, and mortal
279 lementation of the new model reduced time to ART initiation from 264 to 23 days and increased communi
280 line demographic characteristics and time to ART initiation using Cox proportional hazard models, and
281 ic and clinical variables, including time to ART initiation, and the proportion of participants with
282 whether universal antiretroviral treatment (ART) eligibility policies (Treat All) improved rapid ART
283 HIV infection and antiretroviral treatment (ART) have been associated with increased rates of preter
284 d persons starting antiretroviral treatment (ART) in a high tuberculosis endemic area is described.
285 (CLHIV) receiving antiretroviral treatment (ART) in resource limited settings are susceptible to hig
289 itoring and ART refills through mobile vans; ART initiation at the clinic followed by mobile van moni
290 l to determine the effect of ART-only versus ART plus kick and kill on markers of the HIV reservoir.
294 reservoir during suppressive ART, even when ART is initiated during the earliest phases of HIV infec
297 roach that could be used in combination with ART to suppress residual HIV replication and/or latent H
299 five SHIV(SF162P3)-infected RMs treated with ART for 12 months and with plasma viremia consistently b
300 mmune recovery during HIV-HBV treatment with ART may drive higher rates of functional cure than durin