ライフサイエンスコーパス: ATP hydrolysis

1 te) and ECF module (that powers transport by ATP hydrolysis).

2 below thermal equilibrium at the expense of ATP hydrolysis.

3 asures its fast conformational cycling under ATP hydrolysis.

4 hereas pocket 2 engages in ligand-stimulated ATP hydrolysis.

5 +) dissipates the H(+) gradient generated by ATP hydrolysis.

6 is conformational change is not required for ATP hydrolysis.

7 containing mycobacterial GyrB are limited by ATP hydrolysis.

8 as a function of the free energy provided by ATP hydrolysis.

9 ular emphasis on the critical role played by ATP hydrolysis.

10 sence of Pex5 and Pex14, and is sustained by ATP hydrolysis.

11 two intermediate states on DNA, separated by ATP hydrolysis.

12 the catalytic efficiency of actin-activated ATP hydrolysis.

13 lase domain trapped in a transition state of ATP hydrolysis.

14 proton-motive force collapses by inhibiting ATP hydrolysis.

15 are probably the basis of the inhibition of ATP hydrolysis.

16 is not determined by RecA disassembly and/or ATP hydrolysis.

17 d PCNA through one intermediate state before ATP hydrolysis.

18 Thus, substrate is released prior to ATP hydrolysis.

19 substrate binding primes the transporter for ATP hydrolysis.

20 aking them unavailable for actin binding and ATP hydrolysis.

21 lved in copper binding and those involved in ATP hydrolysis.

22 sengagement, of the catalytic site following ATP hydrolysis.

23 his ring are perfectly designed for inducing ATP hydrolysis.

24 ted by Sec17 and Sec18:ATP without requiring ATP hydrolysis.

25 nction is species-specific and requires RecN ATP hydrolysis.

26 e (5NT), rather than AP, was responsible for ATP hydrolysis.

27 ross cell membranes with energy derived from ATP hydrolysis.

28 r, such that the buckled conformation favors ATP hydrolysis.

29 ularly at a checkpoint before RFC commits to ATP hydrolysis.

30 ds on a process driven out of equilibrium by ATP hydrolysis.

31 g is strictly coupled to phosphorylation and ATP hydrolysis.

32 model for the 26S functional cycle driven by ATP hydrolysis.

33 that does not catalyze additional rounds of ATP hydrolysis.

34 ctions within the MBD1-3 group and activates ATP hydrolysis.

35 erse kinetic steps are accelerated by faster ATP hydrolysis.

36 degrade unassembled EMRE using the energy of ATP hydrolysis.

37 ry to unwind DNA, in a process that requires ATP hydrolysis.

38 Reverse operation generates PMF via ATP hydrolysis.

39 A unwinding without negatively affecting the ATP hydrolysis.

40 are likely to be the basis of inhibition of ATP hydrolysis.

41 unt of DNA translocation by Sth1 relative to ATP hydrolysis.

42 nformation on ATPase domain architecture and ATP hydrolysis.

43 during catalysis and how they are coupled to ATP hydrolysis.

44 sites and the cytosolic headpiece mediating ATP hydrolysis.

45 cles of G4 unfolding and refolding fueled by ATP hydrolysis.

46 up, indicating their possible involvement in ATP hydrolysis.

47 ocates DNA into a procapsid shell, fueled by ATP hydrolysis.

48 ate following substrate release but prior to ATP hydrolysis.

49 ting the allosteric transition that triggers ATP hydrolysis.

50 asm to the reticulum lumen at the expense of ATP hydrolysis.

51 axial cores, whose formation requires MukBEF ATP hydrolysis.

52 lagellar beating via adenosine triphosphate (ATP) hydrolysis.

53 ors exhibited 1.8- to 2.5-fold lower rate of ATP hydrolysis, 2.5- to 4.5-fold lower DNA packaging vel

54 sting membrane potential, and the DeltaG' of ATP hydrolysis: a new paradigm.

55 Using the energy of ATP hydrolysis, ABC transporters catalyze the trans-memb

56 The reduced ATP hydrolysis activated AMPK activity in IF1 KO hearts,

57 d rac-cryptopleurine with Hsc70 promotes the ATP hydrolysis activity of Hsc70 in the presence of the

58 er patient, both have gain-of-function Rad50 ATP hydrolysis activity that results not from faster ass

59 al genome replication, RNA-binding affinity, ATP hydrolysis activity, and helicase-mediated unwinding

60 makes them unavailable for actin binding or ATP hydrolysis, although a small fraction of the myosin

61 comprised of a cytoplasmic V(1) complex for ATP hydrolysis and a membrane-embedded V(o) complex for

62 Strictly sequential models of ATP hydrolysis and a power stroke that moves two residue

63 ile the conservative E179D change attenuates ATP hydrolysis and alters single molecule translocation

64 vestigate the role of the N and C termini in ATP hydrolysis and auto-inhibition of the yeast flippase

65 phorylation abolishes the K(+)-dependence of ATP hydrolysis and blocks the catalytic cycle after form

66 ecades of research, the mechanism connecting ATP hydrolysis and chaperone function remains elusive.

67 we propose a model where direct coupling of ATP hydrolysis and conformational flipping rearranges cl

68 his requires fuel consumption in the form of ATP hydrolysis and coordination of the catalytic cycles

69 The open conformation is induced by ATP hydrolysis and corresponds to the post-hydrolysis tr

70 These results challenge sequential models of ATP hydrolysis and coupled mechanical work by ClpAP and

71 vestigations have described the mechanism of ATP hydrolysis and defined the architecture of ABC expor

72 re lethal: non-conservative changes abrogate ATP hydrolysis and DNA translocation, while the conserva

73 main may mediate mechanochemical coupling of ATP hydrolysis and DNA translocation.

74 rified proteins retained drug stimulation of ATP hydrolysis and drug binding affinities.

75 (kcat) is limited by slow, near-irreversible ATP hydrolysis and even slower subsequent phosphate rele

76 hese results help define the linkage between ATP hydrolysis and helicase activities within NS3 and pr

77 ect of retinoschisin on Na/K-ATPase-mediated ATP hydrolysis and ion transport.

78 eir degradation, supporting a model in which ATP hydrolysis and linked mechanical function in the Hsl

79 ity proximal sites bind ATP and enable rapid ATP hydrolysis and phosphate release by the high-affinit

80 After this power stroke, ATP hydrolysis and phosphate release launch the return t

81 the terminal subunit, which likely promotes ATP hydrolysis and rapid phosphate release.

82 ed a wild-type-like enzyme turnover rate for ATP hydrolysis and rate of cellular K(+) uptake.

83 d that the R712G mutation slowed the maximum ATP hydrolysis and recovery-stroke rate constants, where

84 r in combination with direct manipulation of ATP hydrolysis and release.

85 By comparing the rates of ATP hydrolysis and ribozyme refolding, we find that seve

86 tathione transport activity, suggesting that ATP hydrolysis and substrate transport by Atm1 may invol

87 Purified Smc5/6 exhibits DNA-dependent ATP hydrolysis and SUMO E3 ligase activity.

88 l PilB mutant variant, which is deficient in ATP hydrolysis and T4P assembly, supports EPS production

89 They function through ATP hydrolysis and the assembly of multiprotein complexe

90 T cells (from CD39(-/-) mice) did not alter ATP hydrolysis and very likely involves pyrophosphatases

91 by cohesin requires adenosine triphosphate (ATP) hydrolysis and is force sensitive.

92 of P-loop NTPase fold enzymes that catalyze ATP-hydrolysis and utilize its free energy for a stagger

93 tep of tethered-head attachment that follows ATP hydrolysis, and a relatively strong electrostatic in

94 zyme that is triggered by ligand binding and ATP hydrolysis, and have detected specific interactions

95 ns slows supercoiling, impairs DNA-dependent ATP hydrolysis, and limits the extent of DNA supercoilin

96 e propose a model of how substrate cleavage, ATP hydrolysis, and substrate translocation are coordina

97 s dependent on the p97 adaptor NPLOC4-UFD1L, ATP hydrolysis, and substrate ubiquitination, with branc

98 ng motor rotation, negative cooperativity in ATP hydrolysis, and the energetic requirement for at lea

99 ants, we find that Spa47 oligomerization and ATP hydrolysis are needed for complete T3SS apparatus fo

100 l and mechanistic consequences of subsequent ATP hydrolysis are poorly understood.

101 Here we investigate the regulation of ATP hydrolysis as well as the interdependence of the two

102 ts along the chemical reaction coordinate of ATP hydrolysis at an unprecedented level of detail.

103 of DNA at sites of protein adducts requires ATP hydrolysis at both sites, as does the stimulation of

104 uses this multicomponent protein complex and ATP hydrolysis at the inner membrane to promote GPL expo

105 within RecA filaments even in the absence of ATP hydrolysis, at least over short DNA segments.

106 unwinding, demonstrating highly coordinated ATP hydrolysis between six identical subunits.

107 he calcium-replete ER, ADP rebinding to post-ATP hydrolysis BiP-substrate complexes competes with ATP

108 hindrance; Nas6 clashes with the lid in the ATP-hydrolysis-blocked proteasome, but clashes instead w

109 hanism of condensin depends on the energy of ATP hydrolysis but how this activity specifically promot

110 iation and dissociation steps do not require ATP hydrolysis, but subsequent forward and reverse kinet

111 se mutations resulted in a decrease in basal ATP hydrolysis by ABCB5.

112 Our results show that substrate stimulates ATP hydrolysis by accelerating the IF-to-OF transition.

113 Native DNA stimulates ATP hydrolysis by all four sites, causing UvrA2 to trans

114 e, the alpha-helices are proposed to inhibit ATP hydrolysis by assuming an "up" state, where the alph

115 In addition, IF1 inhibits ATP hydrolysis by beta-F1-ATPase in plasma membrane, the

116 Polymerization increases the rate of ATP hydrolysis by changing the positions of the side cha

117 onsequence of the ability of ClpS to repress ATP hydrolysis by ClpA, but several lines of evidence sh

118 Although the free energy liberated on ATP hydrolysis by F(1)-ATPase is rapidly dissipated as h

119 We find that double-stranded DNA stimulates ATP hydrolysis by hMRN over approximately 20-fold in an

120 equired for HSP70's role: we have found that ATP hydrolysis by HSP70, the nucleotide exchange activit

121 d a conserved His-Pro-Asp motif required for ATP hydrolysis by Hsp70s) and also with nucleotide excha

122 These allosteric effects thus reduce ATP hydrolysis by inactive proteasomes and nonspecific p

123 ssium transport through KdpA is coupled with ATP hydrolysis by KdpB remains poorly understood.

124 bulin in the mature microtubule lattice, and ATP hydrolysis by Kif7 enhances this discrimination.

125 ATP hydrolysis by MCM is required for loading and the po

126 try and bound to ATP until ORC-Cdc6 triggers ATP hydrolysis by MCM, promoting both Cdt1 ejection and

127 3' -> 5' exonuclease of MRX, which requires ATP hydrolysis by Rad50.

128 However, the mechanism through which ATP hydrolysis by SecA is coupled to directional movemen

129 and sarcolipin on calcium translocation and ATP hydrolysis by SERCA under conditions that mimic envi

130 ATP hydrolysis by the D1 ring is important for subsequen

131 eraction of the polyubiquitin chain with UN, ATP hydrolysis by the D2 ring moves the polypeptide comp

132 cassettes strongly influence RNA-stimulated ATP hydrolysis by the N-terminal cassette.

133 DNA changes the mechanism again, suppressing ATP hydrolysis by the proximal sites while distal sites

134 This result implies that ATP hydrolysis by the SNF2 domain is coupled to the DNMT

135 haperone Sgt2 and kinetic proofreading after ATP hydrolysis by the targeting factor Get3.

136 ATP hydrolysis by WT proteasomes is activated if they bi

137 tXPB in a closed conformation and stimulates ATP hydrolysis by XPB while AfBax1 maintains AfXPB in th

138 ata, we propose that adenosine triphosphate (ATP) hydrolysis by CglI produces translocation on DNA pr

139 of P-glycoprotein adenosine 5'-triphosphate (ATP) hydrolysis by multiple substrates and illuminate ho

140 esin-5 tails decrease microtubule-stimulated ATP-hydrolysis by specifically engaging motor domains in

141 in the DNA strand geometries resulting from ATP hydrolysis can aid sequence recognition by promoting

142 hat insight into its allosteric mechanism of ATP hydrolysis can be achieved by Arrhenius analysis.

143 tes, providing a paradigm of how energy from ATP hydrolysis can be used for client remodeling.

144 DNA-bound RecA protein increases the rate of ATP hydrolysis catalysed by RecN during the DNA pairing

145 Upon ATP hydrolysis, cohesin's heads associate in a different

146 ATP hydrolysis coincides with release of mature client a

147 some, but clashes instead with the CP in the ATP-hydrolysis-competent proteasome.

148 To achieve this, p97 requires ATP hydrolysis, cooperates with the Ufd1-Npl4 ubiquitin-

149 eveal that substrate-induced acceleration of ATP hydrolysis correlates with stabilization of a high-e

150 nce of Tpm1.12 extends the time required per ATP hydrolysis cycle 3.7-fold, whereas it is shortened b

151 PRNT reveals two mechanical substates of the ATP hydrolysis cycle of the superfamily 2 helicase Hel30

152 of two distinct substates within the Hel308 ATP hydrolysis cycle, one [ATP]-dependent and the other

153 Accordingly, the ATP hydrolysis-defective dna2-K1080E mutant is less able

154 adenosine diphosphate, Gibbs free energy of ATP hydrolysis (DeltaGATP), phosphomonoesters, phosphodi

155 arm priming (recovery stroke) while slowing ATP hydrolysis, demonstrating that it uncouples these tw

156 molecule FRET to derive a model that couples ATP hydrolysis-dependent conformational changes of SecA

157 Here we demonstrate an additional ATP-hydrolysis-dependent association of MukBEF with the

158 ynamics simulations provide insight into how ATP hydrolysis destabilizes strand exchange products.

159 Yet, polyspecific drug binding and ATP hydrolysis-driven drug export in Pgp are poorly unde

160 h I and Switch II motifs of TsaE mediate the ATP hydrolysis-driven reactivation/reset step of the t6A

161 nformations at the seam interface reveal how ATP hydrolysis-driven substrate disengagement and re-bin

162 ly stimulates the adenosine 5'-triphosphate (ATP) hydrolysis-driven motor activity of DNA2 involved i

163 nation and deprotonation of the c-ring, with ATP-hydrolysis-driven rotation causing protonation of a

164 Sec18-mediated ATP hydrolysis drives the mechanical disassembly of SNAR

165 At room temperature, blocking ATP hydrolysis effectively abolished slow endocytosis an

166 r experiments reveal that in the presence of ATP hydrolysis even 75 bp sequence-matched strand exchan

167 new compound series inhibits TarH-catalyzed ATP hydrolysis even though the binding site maps to TarG

168 Repetitive cycles of sequential intra-ring ATP hydrolysis events induce axial excursions of diaphra

169 (~30 aa) steps, each coupled to hundreds of ATP hydrolysis events.

170 However, how ATP hydrolysis facilitates removal of TBP from DNA is no

171 iculum (ER) imports ATP and uses energy from ATP hydrolysis for protein folding and trafficking.

172 membrane-embedded enzymes use the energy of ATP hydrolysis for transmembrane transport of a wide ran

173 and recruits BiP through the stimulation of ATP hydrolysis, forcibly disrupting IRE1 dimers.

174 upported by the observed increase in kcat of ATP hydrolysis, from 7.8 +/- 0.1 min-1 to 457.7 +/- 9.2

175 Biochemical analysis reveals that ATP hydrolysis-fueled translocation of Dna2 on ssDNA fac

176 involved in a functional cycle accompanying ATP hydrolysis has been investigated in unprecedented de

177 ans-arginine finger, R158, indispensable for ATP hydrolysis; (iii) the location of this arginine is c

178 clamp binding and opening, DNA binding, and ATP hydrolysis-implying a remarkably clamp-loader-specif

179 ate contact, but did not address the role of ATP hydrolysis in G4 resolving activity.

180 estigate this type of force originating from ATP hydrolysis in the chaperonin GroEL, by applying forc

181 At its heart are two main ideas: i) ATP hydrolysis in the CI domain provides the thermodynam

182 ng at the distal end of EccC3 and subsequent ATP hydrolysis in the DUF-could be coupled to substrate

183 of the exporter class harness the energy of ATP hydrolysis in the nucleotide-binding domains (NBDs)

184 ATP hydrolysis in the soluble catalytic V1 region drives

185 chronization of ATP binding, ADP release and ATP hydrolysis in three adjacent ATPases drives rigid-bo

186 an average dwell time of 6.5 ms dependent on ATP hydrolysis, indicating rapid binding then translocat

187 separation in their ATP-bound form, whereas ATP hydrolysis induces compartment turnover and release

188 lts enable a quantitative description of how ATP hydrolysis influences Grp94, where sequential ATP hy

189 n ATP-fueled biochemistry, because normally, ATP hydrolysis initiates large-scale conformational chan

190 n how myosins convert the chemical energy of ATP hydrolysis into mechanical movement, followed by a d

191 ht on how superfamily 1 and 2 helicases turn ATP hydrolysis into motion along DNA.

192 al simulations of 1) adenosine triphosphate (ATP) hydrolysis into adenosine monophosphate (AMP) and 2

193 Furthermore, once ATP hydrolysis is abolished, the R117H mutant can be tra

194 , to understand the molecular details of how ATP hydrolysis is coupled to calcium transport, it is ne

195 will be a useful tool for understanding how ATP hydrolysis is coupled to LPS transport.

196 ATP hydrolysis is coupled to polar strand exchange over

197 t Kti12 binds directly to Elongator and that ATP hydrolysis is crucial for Elongator to maintain prop

198 ts nucleolytic processing of DNA ends, while ATP hydrolysis is essential for Mre11 endonuclease activ

199 lied in abiotic systems in the same way that ATP hydrolysis is exploited throughout biochemistry.

200 reveal that the chemical energy produced by ATP hydrolysis is harnessed via the concerted motion of

201 require a single-stranded overhang and that ATP hydrolysis is not directly coupled to G4-unfolding o

202 Additionally, we reveal that actin ATP hydrolysis is not required for VASP-mediated filamen

203 Experiments also indicate that when ATP hydrolysis is present, flanking heterologous dsDNA r

204 ATP hydrolysis is related to detachment of EHD2 from the

205 Interconversion between these two forms by ATP hydrolysis is required for release of Rrp5 from pre-

206 Notably, ATP hydrolysis is required to alter the conformation of

207 However, the rate constant for ATP hydrolysis (k+H + k-H) was reduced by approximately

208 utward-facing, closed NBD conformation), and ATP hydrolysis leads to dissociation of the NBDs with th

209 Subsequent ATP hydrolysis leads to substrate delivery to the cytopl

210 ismatch again instead of bypassing it; thus, ATP hydrolysis licenses the MutS mobile clamp to rebind

211 Kinesin-8/Kip3 uses ATP hydrolysis, like other kinesins, for stepping on the

212 rder of their response times; (3) the matrix ATP hydrolysis mass action ratio [ADP] x [Pi]/[ATP] prov

213 ts of ATP, we conclude that lipid-stimulated ATP hydrolysis may contribute to the reduction in viral

214 After stimulation of ATP hydrolysis, MinE remains bound to the membrane in a

215 mic assembly of filamentous actin, involving ATP hydrolysis, N-WASP and formin, mediates Omega-profil

216 In contrast, under conditions of ATP hydrolysis, Nas6 obstructs base-CP, but not base-lid

217 This does not require ATP hydrolysis nor is it accompanied by entrapment withi

218 p97 N-D1 truncate has been shown to activate ATP hydrolysis of its D1-domain, although the mechanism

219 t bind nucleotide and thereby down-regulates ATP hydrolysis of the complex.

220 acting arginine-finger residue essential for ATP hydrolysis of the D1-domain.

221 strate that polymer activity, in the form of ATP hydrolysis on F-actin coupled to nucleotide-dependen

222 d DNA to examine the putative implication of ATP hydrolysis on the structure, position, and interacti

223 ather than being cooperative or independent, ATP hydrolysis on the two protomers is sequential and de

224 We also demonstrate that mutants perturbing ATP hydrolysis or DNA cleavage in vitro impair P2 OLD-me

225 kbone conformations, so assembly rather than ATP hydrolysis or phosphate dissociation is responsible

226 ons in the DEAD-box ATPase Dhh1 that prevent ATP hydrolysis, or that affect the interaction between D

227 f the nucleotide-binding-domain dimer, while ATP hydrolysis per se does not reset MRP1 to the resting

228 imal cells is vital for actively maintaining ATP hydrolysis-powered Na(+) and K(+) electrochemical gr

229 /closure/release, ptDNA binding/release, and ATP hydrolysis/product release.

230 d activation of NM-2B and the release of the ATP hydrolysis products ADP and phosphate from the activ

231 ADH synthesis and respiration, feedback from ATP hydrolysis products, and stimulation by calcium were

232 y to the stroke or detaches before releasing ATP hydrolysis products.

233 tribution (>/=90%) to the total CFTR-related ATP hydrolysis rate is due to phosphorylation by PKA and

234 k of full-length GiKIN14a nearly reduces its ATP hydrolysis rate to that of GiKIN14a-Deltatail.

235 closed states did not affect stimulation of ATP hydrolysis rates in the absence of membrane binding,

236 KIN14a has significantly higher stepping and ATP hydrolysis rates than does GiKIN14a-Deltatail.

237 embrane-targeting sequence stimulated higher ATP hydrolysis rates than the full-length protein, indic

238 Using energy from ATP hydrolysis, Rca promotes the release of inhibitors a

239 MoFe protein and includes electron transfer, ATP hydrolysis, release of Pi, and dissociation of the o

240 Whether all the pathways are coupled to ATP hydrolysis remains to be determined.

241 respiration from ATP synthesis or increasing ATP hydrolysis restores NAD(+)/NADH homeostasis and prol

242 o allosterically impair J protein-stimulated ATP-hydrolysis, resulting in the inability of modified B

243 In the captured transition state of ATP hydrolysis, SecA's two-helix finger is close to the

244 ion to substrate translocation, during which ATP hydrolysis sequentially navigates through all six AT

245 qual to the independently measured energy of ATP hydrolysis, showing that the distribution of these 9

246 sp90 by small-molecule drugs, acting via its ATP hydrolysis site, has shown promise as a molecularly

247 e DNA-binding channel, forming an additional ATP hydrolysis site.

248 es with stabilization of a high-energy, post-ATP hydrolysis state characterized by structurally asymm

249 Significantly, kinking of TM6 in the post-ATP hydrolysis state stabilized by MgADPVO(4) eliminates

250 es, most notably the slowing of the apparent ATP hydrolysis step (reduced 5-9-fold), leading to a lon

251 ydrolysis influences Grp94, where sequential ATP hydrolysis steps allow Grp94 to transition between c

252 mic localization is driven by MinD-catalyzed ATP hydrolysis, stimulated by interactions with MinE's a

253 p, we found that uptake by the 14A mutant is ATP hydrolysis-, substrate concentration-, and time-depe

254 ion is achieved through expending energy via ATP hydrolysis, suggesting that it is coupled to TFIIH's

255 Tests for ATP hydrolysis / synthesis, oxygen consumption, glycolyt

256 After subtracting nonproductive ATP hydrolysis that occurs in the absence of ribozyme re

257 of A/B heterodimers suggest a mechanism for ATP hydrolysis that triggers a rotation of subunits DF,

258 tial process, which correlates strongly with ATP hydrolysis, the loss of fluorescence, and the buildu

259 nce of verapamil, a substrate that activates ATP hydrolysis, the NBDs of Pgp reconstituted in nanodis

260 eased proteasomal adenosine 5'-triphosphate (ATP) hydrolysis, the step which commits substrates to de

261 unequal distribution requires the energy of ATP hydrolysis through the action of the Na(+)-K(+) ATPa

262 ATP hydrolysis to ADP allows Hsp104 to relax back to its

263 tin remodeling complex, uses the energy from ATP hydrolysis to disrupt nucleosomes at target regions.

264 trostatically couples the energy released by ATP hydrolysis to DNA translocation: The chemical cycle

265 uctural protein recruited by SpoVM that uses ATP hydrolysis to drive its irreversible polymerization

266 x7 has been proposed to utilize the power of ATP hydrolysis to drive the removal of assembly factors

267 This transporter uses energy of ATP hydrolysis to efflux from cells a variety of structu

268 multidrug transporter that uses energy from ATP hydrolysis to export many structurally dissimilar hy

269 n proposed to explain how Cdc48 might couple ATP hydrolysis to forcible unfolding, dissociation, or r

270 rse set of proteins that use the energy from ATP hydrolysis to form dynamic, linear polymers.

271 t mediate p31(comet)-Mad2 binding and couple ATP hydrolysis to local unfolding of Mad2.

272 AdnB motor and the DNA contacts that couple ATP hydrolysis to mechanical work; the position of the A

273 how cohesin regulators harness the energy of ATP hydrolysis to open the cohesin ring and enable dynam

274 arge class of ATPases that use the energy of ATP hydrolysis to perform mechanical work resulting in p

275 tial mechanoenzyme that uses the energy from ATP hydrolysis to physically reshape and remodel, and th

276 mplexes, cohesin, condensin, and Smc5/6, use ATP hydrolysis to power a plethora of functions requirin

277 al DNA configurations and uses the energy of ATP hydrolysis to promote their compaction.

278 ial AAA+ protein, Skd3 (human ClpB), couples ATP hydrolysis to protein disaggregation and reactivatio

279 and ADP-bound states explain the coupling of ATP hydrolysis to RNA translocation, mainly mediated by

280 binding cassette exporters use the energy of ATP hydrolysis to transport substrates across membranes

281 ents, so the protein uses the free energy of ATP hydrolysis to transport them.

282 proteases are degradation machines that use ATP hydrolysis to unfold protein substrates and transloc

283 ntalized proteases that couple the energy of ATP hydrolysis to unfolding and the regulated removal of

284 the family of DExH-box helicases, which use ATP hydrolysis to unwind RNA secondary structures.

285 We propose a mechanism in which CMG couples ATP hydrolysis to unwinding by acting as a lazy Brownian

286 EAH helicases couple adenosine triphosphate (ATP) hydrolysis to conformational changes of their catal

287 ements, Mot1 can use adenosine triphosphate (ATP) hydrolysis to displace TBP from DNA and various mod

288 he equilibrium constant for myosin-catalyzed ATP hydrolysis toward the posthydrolysis biochemical sta

289 tic site of MoFe-protein and how energy from ATP hydrolysis transduces the ET processes.

290 Our results show that ATP hydrolysis triggers sequential conformational waves.

291 the number of myosin motors leaving the off, ATP hydrolysis-unavailable state characteristic of the d

292 serving as an accelerator that enables rapid ATP hydrolysis upon contact with ptDNA and RFC-D Arg-101

293 of nucleotide binding to MukB and subsequent ATP hydrolysis, we demonstrate directly the formation of

294 hods for uncoupling substrate reduction from ATP hydrolysis, which may provide new avenues for studyi

295 that specifically targets and inhibits P-gp ATP hydrolysis while not being transported by the pump.

296 ck dissociation of the protein from RNA upon ATP hydrolysis, while mutations that interfere with bind

297 The finger retracts during ATP hydrolysis, while the clamp domain of SecA tightens

298 ATP hydrolysis will lead to ATPase gate opening to compl

299 the ARL was similar to loops known to couple ATP hydrolysis with DNA binding in a subset of other SF2

300 ts at the intersubunit interfaces coordinate ATP hydrolysis with the subunits' positions in the spira