ライフサイエンスコーパス: ATP synthase

1 its of oxidative phosphorylation, complex V (ATP synthase).

2 x II/III of the electron transport chain and ATP synthase.

3 substep in the synthetic cycle of mammalian ATP synthase.

4 e encodes the alpha subunit of mitochondrial ATP synthase.

5 ggested a different binding site for SQAs on ATP synthase.

6 the encoded Atp6p and Atp8p subunits of the ATP synthase.

7 bly of the Atp6p and Atp8p products into the ATP synthase.

8 elease requires H135 in the ATP5O subunit of ATP synthase.

9 g protein subunits of the mitochondrial F1FO ATP synthase.

10 s dissociation from the beta subunit of F1Fo-ATP synthase.

11 tp5g1 encodes a subunit of the mitochondrial ATP synthase.

12 ryo-EM) analysis of the bovine mitochondrial ATP synthase.

13 d of PS II, the cytochrome b6/f complex, and ATP synthase.

14 Ca(2+) stimulates the citric acid cycle and ATP synthase.

15 tion pore (mPTP) within the c-subunit of the ATP synthase.

16 f the ion-driven membrane rotor of an F-type ATP synthase.

17 version in the coupled rotary motors of FoF1-ATP synthase.

18 modes of bending and twisting in the intact ATP synthase.

19 omplex, it might not function as a bona fide ATP synthase.

20 aryotic cells primarily by the mitochondrial ATP synthase.

21 itor of the Mycobacterium tuberculosis (Mtb) ATP synthase.

22 n that suppresses the hydrolysis activity of ATP synthase.

23 n of the full-conductance megachannel from F-ATP synthase.

24 rticipation of actin, myosin, ferritin2, and ATP synthase.

25 ne, and it inhibits the activity of F(0)F(1) ATP synthase.

26 ills mycobacteria by inhibiting the F(1)F(0) ATP synthase.

27 respiration such as the beta-subunit of the ATP synthase.

28 diolipin is an essential component of active ATP synthases.

29 for proton-translocation-driven rotation in ATP synthases.

30 al and universal life process carried out by ATP synthases.

31 -chain complexes and adenosine triphosphate (ATP) synthase.

32 drogenase 1, 3, and 6 (ND-1, ND-3, ND-6) and ATP synthase 6 (ATP-6) genes was significantly down-regu

33 nt pathway that involved reduced activity of ATP synthase (80% inhibition in pancreatic mitochondria

34 ies indicate that the leash is important for ATP synthase activity and support a mechanism in which r

35 cal and NMR studies show that GaMF1 inhibits ATP synthase activity by binding to the loop.

36 The subsequent inhibition of ATP synthase activity causes complex I oxidative damage,

37 1 inhibits ATP synthase activity from isolated mitochondria and tri

38 ts indicate that Abeta-mediated reduction of ATP synthase activity in AD pathology results from direc

39 The low light-specific decrease in ATP synthase activity in ntrc resulted in a buildup of t

40 ATP synthase activity increased in only the longest esta

41 trol mechanism of the nanomotor to favor the ATP synthase activity over the ATPase turnover in the al

42 which was likely caused by the 33-51% lower ATP synthase activity present in both vehicle- and rapam

43 clein concentrations is able to increase the ATP synthase activity that rescues the mitochondrial phe

44 that ATP5G1 is a rate-limiting component for ATP synthase activity, knockdown of ZC3H14 decreases cel

45 rate, mitochondrial membrane potential, F1F0-ATP synthase activity, or gross mitochondrial morphology

46 phosphate was reduced to levels that limited ATP synthase activity.

47 phate dissolution on the maintenance of F0F1-ATP synthase activity.

48 cifically inhibited mitochondrial complex V (ATP synthase) activity.

49 show that, after exposure to MgATP, E. coli ATP synthase adopts a different conformation with a cata

50 We used a mutant gamma ATP synthase allele (MGA) to circumvent the normal essen

51 the F1-gamma-subunit of the two-sector F1Fo-ATP synthase allow for Fo-independent generation of a mi

52 Last, inhibition of ATP synthase alone was sufficient to impair IFN-gamma pr

53 obacterial C-terminal domain to a standard F-ATP synthase alpha subunit suppresses ATPase activity.

54 ed system containing purified yeast F(1)F(0) ATP synthase, although, thermodynamically, a sufficientl

55 rgetics through its ability to interact with ATP synthase and increase its efficiency.

56 esults from direct binding between Abeta and ATP synthase and inhibition of O-GlcNAcylation of Thr432

57 eaum equitans, lacks several subunits of the ATP synthase and is suspected to be energetically depend

58 oncentration of drugs targeting the F(1)F(0) ATP synthase and the cytochrome bc (1):aa (3), as well a

59 that the pore is associated with the dimeric ATP synthase and the oligomycin sensitivity conferral pr

60 onferring protein (OSCP) subunit of the F1FO-ATP synthase and the physical interaction of OSCP with a

61 Dimerization of the F1FO-ATP synthase and the presence of the MICOS complex are n

62 through stretch-sensitive regulation of the ATP synthase and VDAC1, the channel that releases ATP in

63 erium Pseudobutyrivibrio ruminis possesses 2 ATP synthases and 2 distinct respiratory enzymes, the fe

64 yo-EM structures complete our picture of the ATP synthases and reveal the unique mechanism by which t

65 rast, transcripts of adenosine triphosphate (ATP) synthase and ribosomal protein genes were depleted

66 ) synthesis, combining Escherichia coli F1Fo ATP-synthase and the primary proton pump bo3-oxidase, in

67 rotations of the Fo and F1 rotary motors in ATP synthase, and explain the need for the finer steppin

68 s lacking membrane subunits ATP6 and ATP8 of ATP synthase, and in other cells lacking the enzyme's c(

69 force: the bacterial flagellar motor, the Fo ATP synthase, and the gliding motor.

70 electron transport chain membrane complexes, ATP synthase, and the mitochondrial contact site and cri

71 We found that UCP4, F0F1-ATP synthase, and the mitochondrial marker voltage-depen

72 A3B3DF, from the Methanosarcina mazei Go1 A-ATP synthase, and the thermophilic motor alpha3beta3gamm

73 ng the unique features of the P. tetraurelia ATP synthase are directly responsible for generating the

74 is that uncoupling protein 4 (UCP4) and F0F1-ATP synthase are spatially separated to eliminate compet

75 P synthases are well characterized, archaeal ATP synthases are relatively poorly understood.

76 F-type ATP synthases are rotary nanomotor enzymes involved in c

77 F1Fo-ATP synthases are universal energy-converting membrane p

78 Whereas eukaryotic and prokaryotic ATP synthases are well characterized, archaeal ATP synth

79 rmophilus (formerly known as Bacillus PS3) F-ATP synthase, are resolved at 5 mus resolution for the f

80 of resistant mutants implicates the vacuolar ATP synthase as a genetic determinant of resistance to T

81 ments can be corrected using theory, with F1-ATP synthase as an example.

82 ant mutants of SQAs unambiguously identified ATP synthase as its molecular target.

83 ulosis has validated adenosine triphosphate (ATP) synthase as an attractive target to kill Mycobacter

84 ron transfer system (ETS) complexes I-IV and ATP-synthase as well as by neonatal upregulation of unco

85 opsis (Arabidopsis thaliana) chloroplast (cp)ATP synthase assembly mutant cgl160, with decreased cpAT

86 t with the beta subunit of the mitochondrial ATP-synthase (ATP5B), which may therefore represent a co

87 F1F0 ATP synthase (ATPase) either facilitates the synthesis o

88 ATP synthases (ATPases) are enzymes that produce ATP and

89 MT) targeting the c-subunit of mitochondrial ATP synthase (ATPSc), and was therefore renamed ATPSc-KM

90 We knocked out the mitochondrial ATP synthase beta subunit gene in the rodent malaria par

91 We crossed the self-infertile ATP synthase beta subunit knockout parasites with a male

92 , but not FX synapses, by stimulus-dependent ATP synthase beta subunit translation; this increases th

93 ce knockout of hpRNA1 derepresses its target ATP synthase-beta in testes and compromises spermatogene

94 he C2H2-inhibition, while genes encoding for ATP synthase, biosynthesis, and Hym hydrogenase were dow

95 healthy mitochondria, a pool of SIRT3 binds ATP synthase, but upon matrix pH reduction with concomit

96 cells abrogated trimethylation of Lys-43 in ATP synthase c-subunit (ATPSc), a modification previousl

97 Therefore, ATP synthase c-subunit leak closure encourages developme

98 d proton density to the crista tip where the ATP synthase can readily utilize the localized proton de

99 The recent demonstration that the F-ATP synthase can reversibly undergo a Ca(2+)-dependent t

100 changes as rotation progresses underpin the ATP synthase catalytic mechanism.

101 Mitochondrial ATP synthase catalyzes the coupling of oxidative phospho

102 cation and extent of PTMs in the chloroplast ATP synthase (cATPase) purified from spinach leaves.

103 e role of rotational molecular motors of the ATP synthase class is integral to the metabolism of cell

104 Fo-dependent rotation of the c10 ring in the ATP synthase (clockwise) direction against the countercl

105 the beta-subunit of the human mitochondrial ATP synthase co-immunoprecipitates with hsp60 indicating

106 Perturbation of ATP synthase completely blocks transmission to the mosqu

107 sed aberrant incorporation of ATPSc into the ATP synthase complex and resulted in decreased ATP-gener

108 suggest that the pore is associated with the ATP synthase complex and specifically with the ring of c

109 by the addition of subunit j, leading to an ATP synthase complex that is coupled to the proton motiv

110 protein C7orf55 (FMC1) and the mitochondrial ATP synthase complex that we have experimentally validat

111 o be associated with the dimeric form of the ATP synthase complex, therefore we propose that the inte

112 roposed that the pore is associated with the ATP synthase complex.

113 ing, but instead in the stabilization of the ATP synthase complex.

114 Furthermore, the F1Fo ATP synthase (complex V) is unique, with the highly cons

115 din A, selective inhibitors of the mammalian ATP synthase (complex V).

116 ochondrial vesicles (SMVs) enriched for F1FO ATP synthase (complex V).

117 ransport chain (complexes I-IV) and the FoF1-ATP synthase (complex V).

118 Thus, although N. equitans possesses an ATP synthase core A3B3 hexameric complex, it might not f

119 Notably, blockade of the F1F0 ATP synthase-CypD interaction by CypD ablation protected

120 evation of CypD triggers enhancement of F1F0 ATP synthase-CypD interaction, which in turn leads to mP

121 ss in diseases, at least, in those with F1Fo ATP synthase defects.

122 Leigh syndrome (MILS) patient iPS cells with ATP synthase deficiency.

123 in intact membrane-embedded mycobacterial F-ATP synthases deletion of the C-terminal domain enabled

124 t dimers results in the formation of helical ATP synthase dimer arrays, which differ from the loose d

125 ned the structure of an intact mitochondrial ATP synthase dimer by electron cryo-microscopy at near-a

126 report the cryo-EM structure of a divergent ATP synthase dimer from mitochondria of Euglena gracilis

127 ucture and organization of the mitochondrial ATP synthase dimer of the ciliate Paramecium tetraurelia

128 iates and other eukaryotes, the formation of ATP synthase dimer rows is a universal feature of mitoch

129 It is most unlikely that the ATP synthase, dimer or monomer, or any component, provid

130 Hypoxic HepG2 cell adaptation decreases ATP synthase dimers and ATP production in inflated crist

131 Long rows of ATP synthase dimers are a conserved feature of mitochond

132 No specific lipids or proteins other than ATP synthase dimers are required for row formation and m

133 ATP synthase dimers determine sharp cristae edges, where

134 Tomographic volumes revealed that ATP synthase dimers from both species self-assemble into

135 constituted detergent-purified mitochondrial ATP synthase dimers from the green algae Polytomella sp.

136 mine the in situ structures of mitochondrial ATP synthase dimers from two organisms belonging to the

137 Structures of mitochondrial ATP synthase dimers indicate how they shape the inner me

138 despite major structural differences between ATP synthase dimers of ciliates and other eukaryotes, th

139 ATP synthase dimers vs monomers and state-3/state-4 resp

140 rmancy in glycolytic cells via disruption of ATP synthase dimers.

141 gGlu-83 with Lys rescued digitonin-stable F-ATP synthase dimers.

142 , the molecular mechanisms that connect F1FO-ATP synthase dysfunction and AD remain unclear.

143 Therefore, mitochondrial F1FO-ATP synthase dysfunction associated with AD progression

144 ore, synuclein deficiency results in reduced ATP synthase efficiency and lower ATP levels.

145 lein in its unfolded monomeric form improves ATP synthase efficiency and mitochondrial function.

146 lity of monomeric alpha-synuclein to enhance ATP synthase efficiency under physiological conditions m

147 nit translation; this increases the ratio of ATP synthase enzyme to its c-subunit, enhancing ATP prod

148 get mRNAs, we selected the gene encoding the ATP synthase F0 subunit C (ATP5G1) transcript.

149 stress responses, whereas the mitochondrial ATP synthase F0 subunit component is a vasoactive peptid

150 g fatty acid oxidation and inhibiting ATP5A (ATP synthase F1 subunit alpha)-an electron transport cha

151 nges in the relative abundance of cytb(6) f, ATP synthase, FNR2, TIC62 and PGR6 positively correlate

152 The proton-driven ATP synthase (FOF1) is comprised of two rotary, stepping

153 tem II (PSII), cytochrome b6f (cyt b6f), and ATP synthase (FOF1).

154 The H(+) gradient was then used by the ATP synthase for energy conservation.

155 Mitochondrial ATP synthases form dimers, which assemble into long ribb

156 The ATP synthase forms U-shaped dimers with parallel monomer

157 In mitochondria of yeast and mammals, the ATP synthase forms V-shaped dimers, which assemble into

158 tial role in determining the transition of F-ATP synthase from and energy-conserving into an energy-d

159 The structure of the dimeric ATP synthase from bovine mitochondria determined in thre

160 eotide-bound A3B3 structure of the related A-ATP synthase from Enterococcus hirae, the arrangements o

161 The ATP synthase from Gram-positive and -negative model bact

162 We reconstitute purified monomeric ATP synthase from porcine heart mitochondria into small

163 We applied this strategy to the F-type ATP synthase from spinach chloroplasts (cATPase) providi

164 The structure of the intact ATP synthase from the alpha-proteobacterium Paracoccus d

165 The structure of the intact monomeric ATP synthase from the fungus, Pichia angusta, has been s

166 ed the structure of a complete, dimeric F1Fo-ATP synthase from yeast Yarrowia lipolytica mitochondria

167 The mitochondrial ATP synthase fuels eukaryotic cells with chemical energy

168 olecular mechanism whereby vacuolar (V-type) ATP synthase fulfills its biological function remains la

169 Here, we inhibited F1Fo ATP synthase function in primary cultured hippocampal ne

170 th ATP synthase subunit alpha, and modulates ATP synthase function.

171 connecting link between diabetic insult and ATP synthase function.

172 F(1)F(o) ATP synthase functions as a biological rotary generator

173 rasites lacking the beta subunit gene of the ATP synthase generated viable gametes that fuse and form

174 1, murine ribosomal protein S27, and murine ATP synthase H(+) transporting, mitochondrial Fo complex

175 hrome C oxidase copper chaperone (COX17) and ATP Synthase, H(+) transporting, Mitochondrial Fo Comple

176 kinetes lacking the beta subunit gene of the ATP synthase had normal motility but were not viable in

177 tional information obtained on the E. coli F-ATP synthase has been generated using cryo-electron micr

178 Purified mitochondrial ATP synthase has been shown to form Ca(2+)-activated, la

179 alytic domain of the adenosine triphosphate (ATP) synthase has been determined from Mycobacterium sme

180 ence of Mg(2+), the three catalytic sites of ATP synthase have vastly different affinities for nucleo

181 F-type ATP synthases have been investigated for more than 50 ye

182 Under pathological conditions, ATP synthase hydrolyzes ATP to replenish protons from th

183 ported cryo-EM maps of autoinhibited E. coli ATP synthase imaged without addition of nucleotide (Sobt

184 that probably do not involve the chloroplast ATP synthase, implicating this system in multiple photos

185 ment, we have functionally reconstituted the ATP synthase in giant unilamellar vesicles and tracked t

186 dehydrogenase (MDH), and the beta-subunit of ATP synthase in in-vitro protein-folding assays.

187 The endogenous inhibitor of ATP synthase in mitochondria, called IF(1), conserves ce

188 ndamental role for sequestration of SIRT3 by ATP synthase in mitochondrial homeostasis.

189 demonstrates that the structures of dimeric ATP synthases in a tetrameric porcine enzyme have been s

190 emergence of collective effects of rotating ATP synthases in lipid membranes.

191 The adenosine triphosphate (ATP) synthase in human mitochondria is a membrane bound

192 lags significantly behind its inhibition of ATP synthase, indicating a mode of action more complex t

193 functionally tagged PSI, PSII, Cyt b6f, and ATP synthase individually with fluorescent proteins, and

194 ATP synthase inhibition in myotubes triggers the ISR via

195 n reduced by mitochondrial depolarization or ATP synthase inhibition, eliminated local IP(3)-mediated

196 regulation as a new area for mycobacterial F-ATP synthase inhibitor development.

197 screening identified a novel mycobacterial F-ATP synthase inhibitor disrupting epsilon's coupling act

198 reating MDM with oligomycin (a mitochondrial ATP synthase inhibitor), both 2-DG and glucose starvatio

199 and carboxyatractyloside (CAT), and the F1FO-ATP synthase inhibitor, oligomycin (OLIG), inhibited ure

200 very of a novel class of anti-tuberculosis F-ATP synthase inhibitors.

201 ATP synthase inhibitory factor 1 (IF1), a novel myokine,

202 ibitory factor 1 (IF1) is a nuclear-encoded, ATP synthase-interacting protein that selectively inhibi

203 ATPase inhibitory factor 1 (IF1) is an ATP synthase-interacting protein that suppresses the hyd

204 Thus, blockade of ATP synthase interaction with CypD provides a promising

205 Ca(2+) can transform the energy-conserving F-ATP synthase into an energy-dissipating device.

206 ixfold ring arrangement typical of all other ATP synthases investigated so far.

207 In silico analyses revealed that 1 ATP synthase is [Formula: see text]-dependent and the ot

208 The mitochondrial F-ATP synthase is a complex molecular motor arranged in V-

209 F1Fo ATP synthase is a pivotal mitochondrial enzyme and the d

210 ATP synthase is a rotating membrane protein that synthes

211 F1FO-ATP synthase is critical for mitochondrial functions.

212 Mitochondrial ATP synthase is driven by chemiosmotic oxidation of pyru

213 The proton-driven ATP synthase is embedded in a proton tight-coupling memb

214 oites, which demonstrates that mitochondrial ATP synthase is essential for ongoing viability through

215 The chloroplast ATP synthase is known to be regulated by redox modulatio

216 at the inner boundary membrane, whereas F0F1-ATP synthase is more centrally located at the cristae me

217 h begs the question of whether mitochondrial ATP synthase is necessary during the blood stage of the

218 ATP synthase is organized into supramolecular units call

219 The F(1) F(O) -ATP synthase is required for growth and viability of Myc

220 e efficiency of ATP production, while within ATP synthase is the cyclophilin D (CypD) regulated mitoc

221 ATP synthase is the most prominent bioenergetic macromol

222 Mitochondrial adenosine 5'-triphosphate (ATP) synthase is a multiprotein complex that synthesizes

223 The F1F0 -ATP (F-ATP) synthase is essential for growth of Mycobacterium t

224 However, expression of complex V (ATP synthase) is relatively low in alphaICs, even when s

225 ), a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobact

226 ss and its interplay with Abeta disrupt F1FO-ATP synthase, leading to reduced ATP production, elevate

227 d in Fmr1(-/y) mouse neurons, closure of the ATP synthase leak channel by mild depletion of its c-sub

228 ns down a large electrochemical gradient via ATP synthase located on the folded inner membrane, known

229 ns down a large electrochemical gradient via ATP synthase located on the folded inner membrane, known

230 Inhibition of mitochondrial ATP synthase markedly reduces macrophage cholesterol eff

231 gy-converting hydrogenase in concert with an ATP synthase may be the simplest form of respiration; it

232 g enhanced interaction of cyclophilin D with ATP synthase mediates L-arginine-induced pancreatitis, a

233 This suggests that this ATP synthase might be a rudimentary machine.

234 We then generated a heterologous F-ATP synthase model system, which demonstrated that trans

235 of PD-1 decreased the efficacy of later F1F0-ATP synthase modulation.

236 Based on our findings we conclude that the ATP synthase monomer is sufficient, and dimer formation

237 density map reveals the presence of a single ATP synthase monomer with no density seen for a second m

238 w that this preparation of SUV-reconstituted ATP synthase monomers, when fused into giant unilamellar

239 The ATP synthases of these organisms present a unique model

240 s critical for the biogenesis of chloroplast ATP synthase oligomycin-sensitive chloroplast coupling f

241 Disruption of the beta subunit gene of the ATP synthase only marginally reduced asexual blood-stage

242 ATP synthases operate by a rotary catalytic mechanism wh

243 rane (largely reflecting the activity of the ATP synthase), or the steady-state rates of the photosyn

244 to changes in the supramolecular assembly of ATP synthases, particularly pronounced at membrane segme

245 n addition to their synthase function most F-ATP synthases possess an ATP-hydrolase activity, which i

246 ATP synthases produce ATP by rotary catalysis, powered b

247 F(1)F(o) ATP synthases produce most of the ATP in the cell.

248 ATP synthase produces the majority of cellular energy in

249 Monomers of mitochondrial ATP synthase reconstituted into liposomes do not bend me

250 ese results, we reassess previous models for ATP synthase regulation and propose that NTRC is most li

251 r Lys destabilized the digitonin-extracted F-ATP synthase, resulting in decreased dimer formation as

252 tly related a subunit from the bovine F-type ATP synthase revealed a conserved pattern of residues, s

253 increased levels of ATPIF1, an inhibitor of ATP synthase reversal-dependent mitochondrial repolariza

254 We find that ATP synthase rotates at a frequency of about 20 Hz, prom

255 finity changes of the catalytic sites during ATP synthase rotation.

256 P production by increasing the expression of ATP synthase's catalytic domain, cytochrome c oxidase an

257 ehyde-3-phosphate dehydrogenase, calmodulin, ATP synthase, sperm equatorial segment protein 1, peroxi

258 dulated sequentially using respiratory chain-ATP synthase substrates (ethanol and ADP) and inhibitor

259 s, in particular the transcript encoding the ATP synthase subunit 6 (A6).

260 rome oxidase subunit 1, Apocytochrome b, and ATP synthase subunit 6 in the cytoplasm of HeLa cells co

261 d a triplet ATT codon (Ile) insertion within ATP synthase subunit 8, were unique within our assemblie

262 Here, we found that ATP synthase subunit alpha (ATP5A) was O-GlcNAcylated at

263 nd localizes to mitochondria, interacts with ATP synthase subunit alpha, and modulates ATP synthase f

264 oteins such as CALR, GRP78, NPM, Hsp27, PDI, ATP synthase subunit alpha, PRDX1, and GAPDH are associa

265 els of carbamyl-palmitoyl transferase 1a and ATP synthase subunit ATP5G1 were reduced in livers of AL

266 chondrial DNA-encoded circRNAs interact with ATP synthase subunit beta (ATP5B) to inhibit the output

267 atient isolates had nonsynonymous changes in ATP synthase subunit c (atpE), the primary target of BDQ

268 The lysosomes contain mitochondrial F0-ATP synthase subunit c along with undigested membranes,

269 N- and C-terminal domains of mycobacterial F-ATP synthase subunit epsilon is proposed to contribute t

270 r assays, and western blot also verified the ATP synthase subunit genes ATP5G1 and ATPIF1 as bone fid

271 we showed that human mitochondrial membrane ATP synthase subunit O is an intramitochondrial target.

272 orophyll-binding proteins in chloroplasts to ATP synthase subunits in bacteria.

273 In the yeast F-ATP synthase, subunits e and g of the F(O) sector consti

274 leotide-binding subunit alpha (Mtalpha) of F-ATP synthase suppresses its ATPase activity and determin

275 on of proteolytic fragments of chloroplastic ATP synthase, termed inceptins.

276 epine 423, a ligand of the OSCP subunit of F-ATP synthase that activates the MMC/PTP, and were inhibi

277 refore, none of the membrane subunits of the ATP synthase that are involved directly in transmembrane

278 ation in the PTP; thus, the only subunits of ATP synthase that could participate in pore formation ar

279 and a reassessment of the modifications of F-ATP synthase that take place in the heart under patholog

280 The functional Na(+) specificity of this ATP synthase thus results from two opposing factors, nam

281 e present nine cryo-EM structures of E. coli ATP synthase to 3.1-3.4 angstrom resolution, in four dis

282 cteriorhodopsin (BR) proteins cooperate with ATP synthase to convert captured solar energy into a bio

283 Living organisms rely on the FoF1 ATP synthase to maintain the non-equilibrium chemical gr

284 electrochemical gradient that is used by the ATP synthase to make ATP.

285 emical ion gradient is harnessed by a rotary ATP synthase to phosphorylate adenosine diphosphate to A

286 tons that can enter the molecular machine of ATP synthase to resynthesize ATP.

287 report that BDQ-mediated inhibition of Mtb's ATP synthase triggers a complex metabolic response indic

288 cells were oligomycin resistant, suggesting ATP synthase uncoupling and bypass of the normal Fo-A6-s

289 into the mitochondrial matrix independent of ATP synthase, uncoupling nutrient metabolism from ATP ge

290 , is formed within the c-subunit ring of the ATP synthase, upon its dissociation from the catalytic d

291 ATP synthase uses a rotary mechanism to couple transmemb

292 In contrast, when ATP synthase was coreconstituted with an active proton-t

293 The enzymatic activities of Complex II and ATP synthase were also significantly reduced.

294 conformational states that occur in E. coli ATP synthase when ATP binding prevents the epsilon C-ter

295 ectively inhibits the hydrolysis activity of ATP synthase, which may render the protective role of IF

296 ystem in question continuously supports H(+)-ATP synthase with ADP until glucose or creatine is avail

297 ining highly purified, fully active bovine F-ATP synthase with preformed liposomes we show that Ca(2+

298 ndria in HAP1-A12 cells assemble a vestigial ATP synthase, with intact F1-catalytic and peripheral st

299 hondrial impairments are located upstream of ATP synthase within the electron transport system.

300 opposed rotary molecular motors of the F0F1-ATP synthase work together to provide the majority of AT