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1 tein that destabilizes mRNA by binding to an AU-rich element.
2 smic polyadenylation element and an upstream AU-rich element.
3 and binding was dependent on the 11 residue AU-rich element.
4 tent was present immediately upstream of the AU-rich element.
5 or the rapid degradation of mRNAs containing AU-rich elements.
6 lear localization of mRNA species containing AU-rich elements.
7 RNA is unique in having five IREs, linked by AU-rich elements.
8 1-811 of the 3'UTR, which lack any classical AU-rich elements.
9 ors were required for RNA destabilization by AU-rich elements.
10 nes, many of which are controlled through 3' AU-rich elements.
11 three RNP-type concensus motifs and bind to AU-rich elements.
12 nse mRNAs by recruiting the VHS RNase to the AU-rich elements.
13 r P bodies by host proteins that bind to the AU-rich elements.
14 es and cleaves the mRNAs in proximity to the AU-rich elements.
15 characterized this interaction via conserved AU-rich elements.
16 ding of nucleolin to the instability element AU-rich element 1 of bcl-2 mRNA in a cell-free system an
17 Binding of a bcl-2 mRNA instability element (AU-rich element-1) to nucleolin in S100 extracts from AT
18 cript with a large 3' UTR containing several AU rich elements and poly(U) regions that may regulate m
21 at tristetraprolin recruits VHS RNase to the AU-rich elements and enables the degradation of the stre
23 in cDNA reporter construct revealed that the AU-rich elements and, in particular the nonameric UUAUUU
26 ver, during stress induced by ATP depletion, AU-rich elements are necessary to maintain stability of
30 ied two components of this complex to be the AU-rich element (ARE) binding proteins AUF1 and HuR.
31 matory gene expression can be mediated by an AU-rich element (ARE) cluster present in the 3' untransl
33 ein complex, required for the degradation of AU-rich element (ARE) containing messenger RNAs (mRNAs).
35 at the level of mRNA decay is mediated by an AU-rich element (ARE) found in the 3'-untranslated regio
37 egradation of cytokine mRNAs, mediated by an AU-rich element (ARE) in the 3' noncoding region and by
38 ression in monocytes and macrophages, and an AU-rich element (ARE) in the 3' untranslated region (UTR
39 nd TIAR are related proteins that bind to an AU-rich element (ARE) in the 3' untranslated region of t
40 alysis revealed the existence of a conserved AU-rich element (ARE) in the 3'-untranslated region (UTR
41 ciency of TNF transcript are regulated by an AU-rich element (ARE) in the 3'-UTR of messenger RNA.
44 Among previously identified patterns, the AU-Rich Element (ARE) is found here to occur within the
46 example, previous evidence suggests that the AU-rich element (ARE) present in the 3'-UTR of murine tu
50 nscriptional regulation mediated through the AU-rich element (ARE) within the COX-2 mRNA 3'-untransla
52 proteins such as TIA-1, TIAR and HuR bind to AU-rich element (ARE)-containing mRNAs and control their
55 CX(3)H tandem zinc finger protein that binds AU-rich element (ARE)-containing transcripts to enhance
56 We found that this polymorphism influenced AU-rich element (ARE)-mediated decay (AMD) of IFNL3 mRNA
57 ate functions of human mRNA decay enzymes in AU-rich element (ARE)-mediated mRNA decay (AMD) and find
61 that CSF-1 3' untranslated region containing AU-rich elements (ARE) could regulate CSF-1 posttranscri
62 tion of TNF-alpha mRNA expression identified AU-rich elements (ARE) in the 3' untranslated region as
63 f the mRNAs detected in human saliva contain AU-rich elements (ARE) in their 3' untranslated regions
64 timulating factor mRNAs after binding to the AU-rich elements (ARE) in their 3'-untranslated regions.
65 nger RNA (mRNA) stability and translation by AU-rich elements (ARE) located in its 3' untranslated re
67 o the Sox2 mRNA 3'UTR, which is dependent on AU-rich elements (ARE) present in the Sox2 mRNA 3'UTR.
70 contrast, miR-430 target sequences, UAUUUAUU AU-rich elements (ARE), CCUC, and CUGC elements emerged
71 eins that can bind to transcripts containing AU-rich elements (ARE), resulting in deadenylation and d
75 uences the stability of key mRNAs containing AU rich elements (AREs) known to be associated with glau
76 variant resembled the mRNA-destabilizing AT(AU)-rich elements (AREs) and resulted in a 10-fold diffe
79 is-acting regulatory elements, which include AU-rich elements (AREs) and microRNA (miRNA) targeting s
81 d selective deadenylation of RNAs containing AU-rich elements (AREs) and Pumilio-response elements (P
85 -untranslated region (UTR) that contains six AU-rich elements (AREs) as well as several uridine-rich
86 trigger the degradation of mRNAs containing AU-rich elements (AREs) at the 3' untranslated regions.
87 8 complex, disassembles mRNPs containing the AU-rich elements (AREs) bound by HuR proteins in a nonde
91 a AU-binding proteins (AUBPs) that recognize AU-rich elements (AREs) found within many transcripts.
95 m CCCH zinc finger proteins that can bind to AU-rich elements (AREs) in cellular mRNAs and destabiliz
99 dem zinc finger proteins can bind to certain AU-rich elements (AREs) in mRNAs, leading to their deade
100 d that RNPC1 and HuR, both of which can bind AU-rich elements (AREs) in p21 3'-UTR, preferentially bi
104 ol of cytoplasmic mRNA stability mediated by AU-rich elements (AREs) in the 3' untranslated region of
108 rase reporter assay, we demonstrate that the AU-rich elements (AREs) in the 3'-untranslated region of
109 ment RNA-binding protein 1 (AUF1) binding to AU-rich elements (AREs) in the 3'-untranslated regions o
111 s are normally unstable because they contain AU-rich elements (AREs) in their 3' noncoding regions th
112 level of mRNA turnover contain destabilizing AU-rich elements (AREs) in their 3' untranslated regions
114 of a subset of short-lived mRNAs containing AU-rich elements (AREs) in their 3' untranslated regions
115 destabilize target mRNAs by first binding to AU-rich elements (AREs) in their 3'-untranslated regions
116 Second, Olfr mRNAs have a higher density of AU-rich elements (AREs) in their 3'UTR and upstream open
117 In mammals, rapid mRNA turnover directed by AU-rich elements (AREs) is mediated by selective associa
119 en reported to be altered by the presence of AU-rich elements (AREs) located in the 3'-untranslated r
120 s are targeted for rapid degradation through AU-rich elements (AREs) located in their 3' untranslated
121 tem that recapitulates the in vivo effect of AU-rich elements (AREs) on mRNA deadenylation has been d
123 slated region of the TNF transcript contains AU-rich elements (AREs) that are targeted by the RNA-bin
124 onferred by 3' untranslated region-localized AU-rich elements (AREs) that associate with RNA-binding
126 , Hsp70 also binds U-rich RNA including some AU-rich elements (AREs) that regulate the decay kinetics
127 taining the AUUUA pentamer characteristic of AU-rich elements (AREs) that regulate the stability of m
128 selective, and we identified RNAs containing AU-rich elements (AREs) that were upregulated after infe
129 thway in gene regulation subjects mRNAs with AU-rich elements (AREs) to rapid decay by a poorly under
130 n the Spisula 3' UTRs we identified multiple AU-rich elements (AREs) which may control translation ac
131 karyotic mRNA stability can be influenced by AU-rich elements (AREs) within mRNA primary sequences.
132 H2 genes, which encode proteins that bind to AU-rich elements (AREs) within the 3' untranslated regio
133 A levels are regulated by proteins that bind AU-rich elements (AREs) within the 3' UTR region of Pth
135 ates mRNA turnover after binding to class II AU-rich elements (AREs) within the 3'-untranslated regio
136 Inherently unstable mammalian mRNAs contain AU-rich elements (AREs) within their 3' untranslated reg
137 sized in bacterial systems to many different AU-rich elements (AREs), in vivo studies have pointed to
139 P D discriminates among the three classes of AU-rich elements (AREs), most effectively blocking rapid
141 tabilization of short-lived mRNAs containing AU-rich elements (AREs), serves as an adapter for c-fos
142 s partner, p54(nrb), binds RNAs that contain AU-rich elements (AREs), such as those for proinflammato
145 on (UTR) of NSPB1 mRNA also contains several AU-rich elements (AREs), which are associated with rapid
155 d that nucleolin specifically recognized the AU-rich elements (AUUUA) in the 3'-UTR of the Bcl-X(L) m
157 ing protein interacting protein; hnRNP D, an AU-rich element binding protein; and NSAP1, an hnRNP R-l
158 nts, described here, revealed that the known AU-rich element binding proteins, ElrA and ElrB, and TIA
160 n PD-L1 mRNA stability via modulation of the AU-rich element-binding protein tristetraprolin (TTP).
161 ically, Pin1 mediated the association of the AU-rich element-binding protein, AUF1, with GM-CSF mRNA,
162 rs could bind to certain isoforms of another AU-rich element-binding protein, HNRNPD/AUF1, as well as
168 l line-specific instability does not involve AU-rich elements, but is mediated by several novel eleme
169 quent cleavage near the adenylate-uridylate (AU)-rich elements; (c) it does not effectively degrade v
170 AUF1 is an RNA-binding protein that targets AU-rich elements, cis-acting regulatory sequences common
172 EX1 augments the stability and expression of AU-rich element containing mRNAs typically found within
173 ng proteins and miRNAs and how they regulate AU-rich elements containing cytokine mRNA stability/degr
174 mulation, and protein secretion, but not non-AU-rich elements containing cytokine mRNAs, including TG
175 colon cancer, we examined the ability of the AU-rich element-containing (ARE-containing) 3' untransla
178 HuA may transiently stabilize a subset of AU-rich element-containing transcripts following T lymph
179 aprolin (TTP), can decrease the stability of AU-rich element-containing transcripts in cell transfect
180 known as KHSRP) interacts with single-strand AU-rich-element-containing mRNAs and is a key mediator o
181 ing factor shown to be capable of regulating AU-rich element-dependent mRNA turnover at the level of
182 ing factor shown to be capable of regulating AU-rich element-dependent mRNA turnover at the level of
183 HuR specifically bound to RNAs containing an AU-rich element derived from the TNF-alpha mRNA in the i
185 containing a strongly destabilizing class II AU-rich element from the GM-CSF mRNA 3'-untranslated reg
192 lity shift assays identified a single 125-bp AU-rich element in the 3' untranslated region that forme
193 sults suggest that TTP binds to a functional AU-rich element in the 3'-untranslated region of IFN-gam
197 nding and stabilization of BCL2 mRNA through AU-rich elements in 3'-untranslated region and consequen
201 of CCCH tandem zinc finger proteins bind to AU-rich elements in certain cellular mRNAs, leading to t
202 Tristetraprolin (TTP) acts by binding to AU-rich elements in certain mRNAs, such as tumor necrosi
203 is an RNA-binding protein that recognizes U/AU-rich elements in diverse RNAs through two RNA-recogni
204 s a mRNA-destabilizing protein that binds to AU-rich elements in labile transcripts, such as the mRNA
206 em zinc finger proteins can bind directly to AU-rich elements in mRNAs and promote transcript deadeny
207 m them showed that TTP could bind to certain AU-rich elements in mRNAs, leading to increases in the r
210 e expression of cytokines through binding to AU-rich elements in the 3' untranslated region and promo
211 tigen R (HuR) and tristetraprolin (TTP) bind AU-rich elements in the 3' untranslated region of many c
212 A-binding proteins (RBPs) that interact with AU-rich elements in the 3' untranslated region of mRNA,
213 conserved in plants and mammals, to specific AU-rich elements in the 3' untranslated region of mRNAs
214 BPs interacted with evolutionarily conserved AU-rich elements in the 3' untranslated region of Notch1
218 y of tandem CCCH finger proteins can bind to AU-rich elements in the 3'-untranslated region of mRNAs,
219 P) plays a central role in PTR by binding to AU-rich elements in the 3'-untranslated region of proinf
224 tion mechanism relies on KSRP recognition of AU-rich elements in the mRNA 3'UTR, that is mediated by
227 ponse mRNAs characterized by the presence of AU-rich elements in their 3' untranslated regions (UTRs)
228 n that can stabilize labile mRNAs containing AU-rich elements in their 3' untranslated regions and ha
229 scripts of mRNA expressed early had abundant AU-rich elements in their 3' untranslated regions, where
232 ger proteins, which bind to mRNAs containing AU-rich elements in their 3'-untranslated region and tar
234 el system for studies of zinc finger protein/AU-rich element interactions that result in mRNA decay.
235 TR): introduction of copies of destabilizing AU-rich elements into the 3'-UTR or swapping in naturall
236 Regulation of messenger RNA stability by AU-rich elements is an important means of regulating gen
237 that the Hro-notch 3' UTR, containing seven AU-rich elements, is key to regulating transcript stabil
238 As are deadenylated and cleaved close to the AU-rich elements, leading to long-term persistence of no
239 invasion, and metastasis by stabilizing the AU-rich element located at the 3'-untranslated region (U
240 e cleavage sites are centered at or near the AU-rich elements located at the 3' untranslated region o
241 stitutions have been introduced into the two AU-rich elements located between 50 and 66 nucleotides u
242 and AUF1 associate with labile mRNAs bearing AU-rich elements located in the 3' untranslated regions
243 acts with high specificity with at least two AU-rich elements located within the 3'-untranslated regi
245 cripts that relieves intrinsic microRNA- and AU-rich-element-mediated repression has been observed to
247 revealed a highly significant enrichment of AU-rich element motifs, with AUUUA pentamers present in
250 When this 217-nucleotide nutrient sensor AU-rich element (NS-ARE) is present in a chimeric mRNA i
252 the 3' stem-loop structure and a downstream AU-rich element of petD pre-mRNA and that its binding af
253 reporter gene activity was dependent on the AU-rich element of the COX-2 3'-untranslated region.
255 he stability of target mRNAs via binding the AU-rich elements of the 3' untranslated region (3'UTR) o
256 r 1 (AUF1), a cellular protein that binds to AU-rich elements, or AREs, in the 3' noncoding regions (
257 Nup475 protein bound a tumor necrosis factor AU-rich element over a broad range of pH and salt concen
260 ability of many target mRNAs via binding the AU-rich elements present in the 3' untranslated region o
261 inger protein tristetraprolin (TTP) binds to AU-rich elements present in the 3' untranslated regions
262 destabilization likely occurs via conserved AU-rich elements present in the 3'-untranslated regions
265 ptosis, and inflammation by associating with AU-rich elements residing in their 3'-untranslated regio
266 lu-Ala-His) box RNA helicase associated with AU-rich element (RHAU) (also named DHX36 or G4R1) specif
269 s including RNA helicase AU (associated with AU rich elements) (RHAU) (G4 resolvase 1), Bloom helicas
270 ammalian cell extracts bound less well to an AU-rich element RNA probe than did the same amount of TT
273 eous nuclear ribonucleoprotein (hnRNP) I and AU-rich element RNA-binding protein 1 (AUF1), respective
274 ed proteins including a novel isoform of the AU-rich element RNA-binding protein and KH-type splicing
277 th longer 3'UTR and with higher density of U/AU-rich elements, suggesting that DHTS inhibits the asso
278 sequence downstream of the single nonameric AU-rich element that is present in its 3'-untranslated r
279 3'-UTR of COX-2 contains a highly conserved AU-rich element that was able to confer lipopolysacchari
280 uR protein has been shown to avidly bind the AU-rich elements that confer instability upon their mRNA
281 kin-2 mRNA is a labile transcript containing AU-rich elements that is transiently stabilized by CD28
282 We previously characterized a 250-nucleotide AU-rich element, the Vg1 translation element (VTE), in t
283 translation through coupling with cis-acting AU-rich elements to nucleate the formation of a MIWI/piR
285 hat tristetraprolin directs VHS RNase to the AU-rich elements, we mapped the domains of VHS and trist
286 region of TR3, there are three copies of an AU-rich element which has previously been shown to be in
288 ate that RNPC1 can bind to MIC-1 mRNA via an AU-rich element within MIC-1 3'-UTR and then enhances MI
289 t-1 mRNA stability requires an 11 nucleotide AU-rich element within the distal 217 bases of the 3'-un
290 r, and ZFP36/Tristetraprolin, which binds to AU-rich elements within 3'-untranslated regions to desta
291 P) is a zinc finger protein that can bind to AU-rich elements within certain mRNAs, resulting in dead
293 s are selected by their position relative to AU-rich elements within plant introns and by their degre
295 he binding of the glycolysis enzyme GAPDH to AU-rich elements within the 3' UTR of IFN-gamma mRNA.
297 nd recruitment of RNA decay machinery to the AU-rich elements within the 3'-UTR of the target transcr
299 binds with high specificity to at least two AU-rich elements within the MYCN 3'-untranslated region.
300 proinflammatory cytokine mRNAs by binding to AU-rich elements within their 3' untranslated regions, t