ライフサイエンスコーパス: Abelson

1 Abelson (Abl) family tyrosine kinases have been implicat

2 Abelson (Abl) tyrosine kinase is an important cellular e

3 Abelson family kinases (Abls) are key regulators of cell

4 Abelson family kinases (AFKs; Abl1, Abl2) are non-recept

5 Abelson kinase (c-Abl) is a ubiquitously expressed, nonr

6 Abelson murine leukemia virus (A-MuLV) is an acute trans

7 Abelson murine leukemia virus (Ab-MLV) arose from a reco

8 Abelson murine leukemia virus (Ab-MLV) encodes the v-Abl

9 Abelson murine leukemia virus (Ab-MLV) mutants expressin

10 Abelson murine leukemia virus (Ab-MLV) transforms NIH 3T

11 Abelson murine leukemia virus encodes the related oncoge

12 Abelson murine leukemia virus transforms pre-B cells in

13 Abelson murine leukemia virus, which encodes v-Abl/p160,

14 Abelson murine leukemia virus-transformed cell lines hav

15 Abelson non-receptor tyrosine kinases are also found in

16 Abelson tyrosine kinase (Abl) is regulated by the arrang

17 Abelson tyrosine kinase may also help regulate myosin II

18 Abelson virus-transformed Rag2(-/-) pro-B cells engineer

19 Abelson-transformed pre-B cell lines derived from these

20 Abi1 (Abelson interactor 1) is an adapter protein that has bee

21 The adapter protein Abi1 (Abelson interactor 1) participates in the control of smo

22 c-Abl (v-Abl Abelson murine leukemia viral oncogene homolog 1) tyrosi

23 tion of the actin-regulatory proteins c-Abl (Abelson tyrosine kinase) and N-WASP (neuronal Wiskott-Al

24 ally, forces applied to E-cadherin activated Abelson (Abl) tyrosine kinase to phosphorylate vinculin;

25 The foundation for this system is an Abelson virus-transformed cell line derived from RAG-1(-

26 cooperativity for Aurora A kinase (AurA) and Abelson kinase (Abl) with different combinations of orth

27 cipitation analyses of bone marrow cells and Abelson murine leukemia virus-transformed pre-B cell lin

28 activation of the tyrosine kinases EGFR and Abelson kinase (Abl), which promote nuclear entry of bet

29 ELISA) using less than 5 muL of sample, and Abelson tyrosine kinase activity was detectable in sampl

30 e analyzed the solution conformations of apo Abelson tyrosine kinase (c-Abl) and c-Abl complexes with

31 deregulated breakpoint cluster region (Bcr)-Abelson tyrosine kinase (Abl) fusion protein.

32 c arena (eg, breakpoint cluster region [BCR]/Abelson [ABL] kinase inhibitors in chronic myeloblastic

33 Transformation of pre-B cells by Abelson murine leukemia virus (Ab-MLV) involves a balanc

34 The v-Abl protein tyrosine kinase encoded by Abelson murine leukemia virus (Ab-MLV) induces pre-B-cel

35 The v-Abl protein encoded by Abelson murine leukemia virus (Ab-MLV) induces transform

36 The v-Abl protein tyrosine kinase encoded by Abelson murine leukemia virus (Ab-MLV) induces transform

37 v-Abl protein tyrosine kinase encoded by Abelson murine leukemia virus (Ab-MLV) transforms pre-B

38 re-B cell transformation process mediated by Abelson murine leukemia virus (Ab-MLV), we examined the

39 be negatively regulated during oogenesis by Abelson kinase.

40 Transformation by Abelson murine leukemia virus (Ab-MLV) is a multistep pr

41 step process of pre-B-cell transformation by Abelson murine leukemia virus.

42 Pre-B-cell transformation by Abelson virus (Ab-MLV) is a multistep process in which p

43 gene involved in malignant transformation by Abelson virus.

44 we show that parkin in inactivated through c-Abelson kinase phosphorylation of parkin in three alpha-

45 of the nonreceptor tyrosine kinase cellular Abelson (c-Abl), and c-Abl inhibitors, including imatini

46 y, we investigated the roles of the cellular Abelson tyrosine kinase (c-Abl) and the related protein

47 p1 acts as an essential, convergent node for Abelson kinase and cAMP signaling to mediate BMP-induced

48 9ARF was previously shown to be required for Abelson murine leukemia virus transformation of primary

49 reported at several loci including the gene Abelson's Helper Integration 1 (AHI1).

50 e most common breakpoint cluster region gene-Abelson murine leukemia viral oncogene homolog 1 (BCR-AB

51 in, the Src homology 3 (SH3) domain of human Abelson tyrosine kinase (Abl), was fused to green fluore

52 Recent studies suggest that the human Abelson helper integration site-1 (AHI1) gene on chromos

53 em was shown to be compatible with the human Abelson tyrosine kinase.

54 ronavirus replication in which we identified Abelson (Abl) kinase inhibitors, including the anticance

55 In Abelson murine leukemia virus (A-MuLV)-transformed cells

56 Ectopic expression of Blimp-1 in Abelson-transformed precursor B cells repressed endogeno

57 hat we show is crucial for Rag expression in Abelson pre-B cell lines.

58 found Ikaros localized to heterochromatin in Abelson-transformed pre-B lymphocytes by using immunogol

59 e Tp53 tumor suppressor gene plays a role in Abelson virus transformation, conformation-specific mono

60 d by the Ink4a/Arf locus also play a role in Abelson virus transformation.

61 ient to induce germline Igk transcription in Abelson-transformed pro-B cell lines.

62 n using isoform MIG-10A as bait and isolated Abelson-interactor protein-1 (ABI-1).

63 The proto-oncogenic kinase Abelson (Abl) regulates actin in response to cell signal

64 2 targets a transcript coding for the kinase Abelson Tyrosine-Protein Kinase 2 (ABL2), which we found

65 at the conserved nonreceptor tyrosine kinase Abelson (Abl) contributes to rapid embryonic wound closu

66 ctivation of the nonreceptor tyrosine kinase Abelson (Abl) contributes to the development of leukemia

67 report that the cytoplasmic tyrosine kinase Abelson (Abl) facilitates Notch internalization into lat

68 In Drosophila, the tyrosine kinase Abelson (Abl) interfaces with multiple signaling pathway

69 t to a possible role for the tyrosine kinase Abelson in cell-cell adhesive junctions in both the CNS

70 edicted that the nonreceptor tyrosine kinase Abelson murine leukemia viral oncogene (c-Abl) is a puta

71 gene encoding the Drosophila tyrosine kinase Abelson substantially enhanced the severity of the CNS p

72 he small GTPase RAB5 and the tyrosine kinase Abelson tyrosine-protein kinase (ABL), to modulate endoc

73 two other SH3 domains (lymphoid cell kinase, Abelson kinase).

74 h B-agonists and inhibitors of the mammalian Abelson tyrosine kinase (Abl1 or c-Abl).

75 kinase, and the cellular signaling mediator Abelson murine leukemia viral oncogene homolog 1 (ABL1)

76 ole of the core guidance signaling molecule, Abelson (Abl) tyrosine kinase, is to modulate the organi

77 Frazzled (Fra), and the signaling molecules Abelson tyrosine kinase (Abl), the guanine nucleotide-ex

78 naling couples the BMP-induced activation of Abelson kinase to this Vav-mediated macropinocytosis.

79 imal models of PD suggest that activation of Abelson tyrosine kinase (c-Abl) plays an essential role

80 A necessary downstream element of Abelson murine leukemia virus (Ab-MLV)-mediated transfor

81 The temperature-sensitive form of Abelson murine leukemia virus offers a reversible model

82 mation of SCID temperature-sensitive form of Abelson murine leukemia virus pre-B cells.

83 Here, we report the identification of Abelson kinase (Abl) as a novel ventral furrow regulator

84 by genetic and pharmacological inhibition of Abelson kinase (Abl) both in Dscam-overexpressing neuron

85 The absence of p53 shortens the latency of Abelson disease induction but does not affect the freque

86 nsformed by temperature-sensitive mutants of Abelson murine leukemia virus and PCR was used to identi

87 nsformed by temperature-sensitive mutants of Abelson virus that undergo kappa and lambda gene rearran

88 ansforming activity of the v-Abl oncogene of Abelson murine leukemia virus (A-MuLV) in immortal cell

89 ine kinase, encoded by the v-Abl oncogene of Abelson murine leukemia virus induces transformation of

90 In addition, the v-abl oncogene of Abelson murine leukemia virus, whose protein product lac

91 used to examine p53 expression in a panel of Abelson virus-transformed pre-B cells.

92 ay central roles in the multistep process of Abelson murine leukemia virus (Ab-MLV) transformation.

93 s to the oncogenic Gag-Abl fusion protein of Abelson Murine Leukaemia Virus and found that in contras

94 ligated subdomains of the SH(32) segment of Abelson kinase in solution, using the orientational depe

95 mology type 3 and 2 domains (SH3 and SH2) of Abelson protein tyrosine kinase, which constitute the re

96 inhibition by imatinib and gene silencing of Abelson (Abl) tyrosine kinase reduced the lysosomal pH i

97 oncogenic signaling in pathways like that of Abelson kinase.

98 We report here that treatment of Abelson virus-transformed pre-B cell lines with the smal

99 e identified a cellular trafficking protein, Abelson helper integration site-1 (Ahi1), which could in

100 ole for the ciliary transition zone protein, Abelson-helper integration site 1 (AHI1), in mediating c

101 led a novel function of Shank3 in recruiting Abelson interactor 1 (ABI1) and the WAVE complex to the

102 he majority of the breakpoint cluster region Abelson proto-oncogene 1 (BCR-ABL1) kinase inhibitors us

103 d unique role in Breakpoint Cluster Region - Abelson 1 (BCR-ABL1)-driven neoplasias.

104 kinase oncofusions breakpoint cluster region-Abelson (BCR-ABL) and DNAJ-PKAc where dynamic cellular p

105 (CML) patients, a breakpoint cluster region-Abelson (BCR-ABL1) value >10% at 3 months of therapy is

106 Breakpoint Cluster Region-Abelson kinase (BCR-Abl) is a driver oncogene that cause

107 o therapy with the breakpoint cluster region-Abelson murine leukemia (BCR/ABL) kinase inhibitor imati

108 to engraftment of breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (BCR-AB

109 Breakpoint cluster region/Abelson (BCR/ABL) tyrosine kinase enhances the ability o

110 Here, we grew breakpoint cluster region/Abelson murine leukemia (Bcr/Abl) P190 lymphoblasts on s

111 rom the oncogenic break point cluster region/Abelson murine leukemia viral oncogene homolog 1 translo

112 opment of BCR-ABL (breakpoint cluster region/Abelson oncogene) tyrosine kinase domain mutations that

113 c manipulation of the cytoskeletal regulator Abelson (Abl) with 3D imaging to explore how the distinc

114 uence length polymorphism analysis to screen Abelson virus-transformed pre-B cells for evidence of LO

115 cell precursors with a temperature-sensitive Abelson murine leukemia virus mutant (ts-Ab-MLV).

116 ll precursors with the temperature-sensitive Abelson murine leukemia virus.

117 entify a novel type of temperature-sensitive Abelson virus.

118 s transformed with the temperature-sensitive Abelson-murine leukemia virus, we show that large quanti

119 ritical mediator of axon guidance signaling, Abelson (Abl) tyrosine kinase, shows that while Abl weak

120 ALL) is associated with activated JAK/STAT, Abelson kinase (ABL), and/or phosphatidylinositol 3-kina

121 ene)) is closely related to the well-studied Abelson kinase cABL.

122 specifically identified the imatinib target, Abelson tyrosine-protein kinase 2 (Abl2), as required fo

123 Here, we provide evidence that Abelson interactor (Abi), a substrate for Abl kinase and

124 We also find that Abelson tyrosine kinase affects RP2 migration in a simil

125 Using live imaging, we found that Abelson (Abl) tyrosine kinase depletion causes apically

126 We also show that Abelson tyrosine kinase, a major regulator of Enabled in

127 We show that Abelson tyrosine-protein kinase 2 (Abl2) has a key role

128 Instead, our data suggest that Abelson kinase acts in parallel to UNC-34/Ena, antagoniz

129 The Abelson (Abl) family of non-receptor tyrosine kinases ha

130 The Abelson (ABL) tyrosine kinases were identified as driver

131 The Abelson murine leukemia virus (A-MuLV) expresses an alte

132 The Abelson Murine Leukemia Virus (A-MuLV) is the acute tran

133 The Abelson murine leukemia virus (Ab-MLV), like other retro

134 The Abelson tyrosine kinase (Abl) is integrated into signal

135 The Abelson tyrosine kinase (Abl) plays a crucial role in mu

136 The Abelson-helper integration site 1 (AHI1) gene encodes fo

137 The Abelson-interacting protein-1 (Abi-1) forms the core of

138 cooperative interactions between Eya and the Abelson (Abl) tyrosine kinase during development of the

139 d exhibited reduced binding to zyxin and the Abelson Src homology 3 domain.

140 ein CT10 regulator of kinase (CrkII) and the Abelson-interacting protein Abi1, a component of the WAV

141 ene occurs during the generation of both the Abelson murine leukemia virus and the bcrabl fusion gene

142 The v-Abl tyrosine kinase encoded by the Abelson murine leukemia virus (A-MuLV) can either stimul

143 ncoprotein, a tyrosine kinase encoded by the Abelson murine leukemia virus, is a multi-step process r

144 ortant in the cellular events induced by the Abelson murine leukemia virus, the effects of IL-4 and I

145 ect on transformation of NIH3T3 cells by the Abelson murine leukemia virus.

146 minal center in response to infection by the Abelson murine leukemia virus.

147 tein that binds and is phosphorylated by the Abelson protein tyrosine kinase.

148 FOX2 mediated splicing of ABI1, encoding the Abelson-interactor 1 adapter protein, controls the abund

149 show a previously unappreciated role for the Abelson (Abl) family kinases (Abl and Arg) in endothelia

150 horylated human SH3 domains derived from the Abelson-family kinases ABL1 and ABL2 at 1.6 and 1.4 angs

151 Mutations in the Abelson helper integration site 1 gene, which encodes th

152 nant genetic suppressors of mutations in the Abelson tyrosine kinase (Abl), suggesting that Ena and A

153 as a genetic suppressor of mutations in the Abelson tyrosine kinase and subsequently was shown to be

154 inant genetic suppressor of mutations in the Abelson tyrosine kinase and, more recently, as a member

155 Mutations in the Abelson-helper integration site-1 gene (AHI1) cause JBTS

156 all molecule drug that in vitro inhibits the Abelson (Abl), Arg (abl-related gene), stem cell factor

157 ial for transformation by derivatives of the Abelson (abl) gene.

158 duced fibrosis mediated by activation of the Abelson (Abl) tyrosine kinase.

159 iated protein Orbit/MAST as a partner of the Abelson (Abl) tyrosine kinase.

160 which represent the mammalian members of the Abelson family of nonreceptor protein tyrosine kinases (

161 c-Abl represent the mammalian member of the Abelson family of nonreceptor protein tyrosine kinases.

162 c-Abl represent the mammalian members of the Abelson family of nonreceptor protein-tyrosine kinases.

163 rg is a ubiquitously expressed member of the Abelson family of nonreceptor protein-tyrosine kinases.

164 c-Abl represent the mammalian members of the Abelson family of protein-tyrosine kinases.

165 he effects of the combined inhibition of the Abelson kinase (c-Abl) and platelet-derived growth facto

166 id cells, introduction and expression of the Abelson leukemia virus causes growth factor independence

167 The v-abl oncogene of the Abelson murine leukemia virus (A-MuLV) encodes a cytopla

168 of apoptosis is an important feature of the Abelson murine leukemia virus (Ab-MLV) transformation pr

169 used to prepare NMR sample quantities of the Abelson protein tyrosine kinase-SH(32) domain pair, in w

170 The inadvertent activation of the Abelson tyrosine kinase (Abl) causes chronic myelogenous

171 Two novel dosage-sensitive modifiers of the Abelson tyrosine kinase (Abl) mutant phenotype have been

172 (AKAPs), which bind to the SH3 domain of the Abelson tyrosine kinase (Abl).

173 that the N-terminal cap (NCap) region of the Abelson tyrosine kinase (c-Abl) is important for maintai

174 es of model protein-peptide complexes of the Abelson tyrosine kinase SH3 domain (abl-SH3) and the S-P

175 binding to the src homology 3 domain of the Abelson tyrosine kinase.

176 Using this method, we targeted the Abelson proto-oncogene (Abl).

177 We report that the Abelson (Abl) and Abl-related gene (Arg) nonreceptor tyr

178 s study, we show for the first time that the Abelson (Abl) kinases regulate proximal signaling downst

179 nt genetic and biochemical evidence that the Abelson (Abl) tyrosine kinase and its substrate Enabled

180 Here we show that the Abelson helper integration site 1 (Ahi1) gene, whose hum

181 Here we show that the Abelson tyrosine kinase c-Abl/ABL1 causes formation of R

182 2(dok) bind through their PTB domains to the Abelson tyrosine kinase in a kinase-dependent manner in

183 The molecular mechanisms by which the Abelson (Abl) or Abl-related gene (Arg) kinases interfac

184 covered as the proto-oncogene from which the Abelson leukemia virus derived its Gag-v-Abl oncogene, r

185 vely activated in cells transformed with the Abelson murine leukemia virus.

186 -transfer of BRD4 binder to tags appended to Abelson kinase (ABL) induced proximity between ABL and B

187 Differences to Abelson kinase (ABL) are observed in the DDR1 P-loop, wh

188 Using Abelson murine leukemia virus-transformed B cells to mod

189 Using Abelson transformed pre-B cell lines, we find that H2AX

190 transcription during clonal expansion using Abelson murine leukemia virus-transformed B cells.

191 blished lambda5(-/-)/VpreB1(-/-)/VpreB2(-/-) Abelson virus-transformed cell lines and reconstituted t

192 rovide insights into the mechanisms by which Abelson non-receptor tyrosine kinases relay information

193 in bone marrow B cells after infection with Abelson murine leukemia retrovirus (Ab-MLV), and in huma