ライフサイエンスコーパス: Ad

1 Ad hoc analyses evaluated day 0-69 findings using a Pois

2 (Ad Hoc Percutaneous Coronary Intervention Study in Acute

3 Ad libitum access to a Western-style diet was provided a

4 Ad libitum eating from a buffet lunch was quantified imm

5 Ad libitum energy intake was assessed at lunch and dinne

6 Ad libitum food intake was assessed through the use of a

7 Ad-3Delta-A20T-treated animals showed higher viral genom

8 Ad-E1A12 increased phosphorylation of AKT1 and ribosomal

9 Ad-E1A12 infection of epithelial cancer cells displayed

10 Ad-E1A12-induced AKT1 phosphorylation was PI3K-dependent

11 Ad-GcR(-/-) mice had a lower concentration of fasting pl

12 Ad-GsKO mice had impaired BAT function, absent browning

13 Ad-GsKO mice had improved insulin sensitivity and glucos

14 Ad-MD-2s given before HDM sensitization significantly in

15 Ad-PLIN5 in islets enhanced the augmentation of glucose-

16 Ad-S16E-PLB-transduced hES2-vCMs displayed an intermedia

17 Ad.5/3-CTV infection of neuroblastoma cells increased AT

18 Ad.5/3-CTV promotes these effects through a unique pathw

19 Ad.EPCR treatment elicited recruitment of macrophages an

20 Ad.EPCR treatment resulted in a marked increase in tumor

21 Ad.scIL-23-treated mice developed erythema, scales, and

22 Ad/VNA-Stx treatment had no impact on diarrhea.

23 l as the double salt cocrystal, [P(4444)](2)[Ad][Thy].3H(2)O.2HThy.

24 iral vector encoding single-chain (sc)IL-23 (Ad.scIL-23) was able to induce systemic antitumor immuni

25 Adenovirus-delivered MDA-7/IL-24 (Ad.mda-7) reduced the viability of NSCLC cells of varyin

26 n adenovirus construct that expressed MD-2s (Ad-MD-2s).

27 lphosphine-nickel complex [Ad(3)PNiBr(3)](-)[Ad(3)PH](+) upon activation with an alkylaluminoxane cat

28 ted salts of deprotonated adenine, [N(4444)][Ad].2H(2)O, and thymine, [P(4444)][Thy].2H(2)O, as well

29 ncorporates the synthetic auxin derivative 5-Ad-IAA and its high-affinity-binding partner OsTIR1F74A.

30 ne diammonium ion complexes (e.g., CB[7].2,6-Ad(NH3)2 and CB[7].2,6-Ad(NMe3)2) are less effective at

31 exes (e.g., CB[7].2,6-Ad(NH3)2 and CB[7].2,6-Ad(NMe3)2) are less effective at realizing the potential

32 An adenovirus expressing VEGF-A (Ad-VEGF-A(164)) replicates the tumor vasculature in mice

33 Despite the presence of these abnormalities, Ad-GsKO mice maintained normal energy balance on both st

34 -vCMs with the recombinant adenoviruses (Ad) Ad-PLB or Ad-S16E-PLB to overexpress wild-type PLB or th

35 replication incompetent GFP-expressing ad, (Ad/GFP)-ABP-PEG-HCBP1, showed a hepatoma cancer specific

36 ing disulfide-bridged biguanidyl adamantine (Ad-SS-GD) with beta-cyclodextrin-conjugated low-molecula

37 In addition, Ad-GsKO mice maintained at thermoneutrality on a standar

38 a replication incompetent type 5 adenovirus (Ad.mda-7) or with His-MDA-7/IL-24 protein, down-regulate

39 utant (mut) were delivered by an adenovirus (Ad) vector.

40 e describe a method for cloaking adenovirus (Ad) in silica (SiAd) as a nanoparticle formulation that

41 Despite adenovirus (Ad) vector's numerous advantages for cancer gene therapy

42 then administered Cre-expressing adenovirus (Ad-Cre) to inactivate Tgfbr2 in transplanted TICs.

43 en treated with a Cre-expressing adenovirus (Ad-Cre), there was a localized knockdown of Nf1 in the h

44 The human adenovirus (Ad) early protein E4-ORF3 forms a unique scaffold throug

45 The human adenovirus (Ad) serotype 5 has been tested in malaria vaccine clinic

46 DA-5 via replication-incompetent adenovirus (Ad.Mda-5) initiates multiple signaling cascades, culmina

47 r lavage (BAL) following mucosal adenovirus (Ad)-SIV recombinant priming, intramuscular SIV envelope

48 lation of the model nanomedicine adenovirus (Ad) can be substantially enhanced.

49 .) injection of a nonreplicating adenovirus (Ad) vector carrying a secretory transgene of VNA-Stx (Ad

50 Our understanding of adenovirus (Ad) biology is largely extrapolated from human species C

51 help is required at the time of adenovirus (Ad) vector immunization for the development of functiona

52 ls (DCs) combined with oncolytic adenovirus (Ad) expressing antitumor cytokines induces a potent anti

53 esigned tumor-targeted oncolytic adenovirus (Ad-TD) to deliver non-secreting (ns) IL-12 to tumor cell

54 mucosal priming with replicating adenovirus (Ad)-SIV recombinants, systemic boosting with SIV envelop

55 Here, we show that adenovirus (Ad) vector-based ZIKV vaccines induce potent neutralizin

56 The adenovirus (Ad) E4orf4 protein contributes to virus-induced inhibiti

57 e have previously shown that the adenovirus (Ad) E4orf4 protein inhibits DDR signaling, but the mecha

58 t a novel mechanism by which the adenovirus (Ad) E4orf4 protein inhibits the DDR.

59 The adenovirus (Ad) E4orf4 protein was reported to contribute to inhibit

60 The adenovirus (Ad) early region 4 (E4)-ORF3 protein regulates diverse c

61 entional influenza vaccines with adenovirus (Ad) gene-based vaccines demonstrated that these viral ve

62 MIN6 cells expressing PLIN5 (adenovirus [Ad]-PLIN5) and those expressing perilipin 2 (PLIN2) (Ad-

63 e that a novel chimeric serotype adenovirus, Ad.5/3-mda-7, displays greater efficacy in delivering md

64 Human adenoviruses (Ad) are double-stranded DNA (dsDNA) viruses associated w

65 hES2-vCMs with the recombinant adenoviruses (Ad) Ad-PLB or Ad-S16E-PLB to overexpress wild-type PLB o

66 deficiency in mature BAT and WAT adipocytes (Ad-GsKO).

67 of Rb1, Pten, and Trp53 floxed alleles after Ad-CMVcre infection in a wide variety of lung epithelial

68 enic vessel type to form in tumors and after Ad-VEGF-A(164).

69 increased by 12% relative to baseline after Ad.SCF therapy, whereas it decreased by 4.2% (P=0.004) i

70 e of a "translational block" occurring after Ad.5-mda-7 gene delivery.

71 s a reduced degree of apoptosis 1 week after Ad.SCF injection.

72 not induce an innate immune response against Ad.

73 innate and adaptive immune response against Ad. shMet-expressing oncolytic Ad (oAd; RdB/shMet) compl

74 innate and adaptive immune responses against Ad, and blood retention time was markedly prolonged by P

75 erences expands the knowledge of alternative Ad species and may inform the selection of related Ads f

76 tinued characterization of these alternative Ad serotypes.

77 Notably, although Ad-gold-PEG was of similar size and surface charge to Ad

78 cquisition of infection by both Ad Alone and Ad/Env vaccines.

79 ts were also seen with Ad-PLB-transduced and Ad-S16E-transduced hvCMTs.

80 production were seen between vaccinated and Ad-empty/alum controls, suggesting responses were due to

81 3b the Gapdh panels for Ad-Fhit-wt and Ad-Fhit-Y114F are incorrect and have been replaced with

82 The cocrystal includes the anionic [Ad(-)(HThy)] base pair which is a stable formation in th

83 class I Ag presentation and impair host anti-Ad cellular activities.

84 vened an Expert Panel of members of the ASCO Ad Hoc Palliative Care Expert Panel to develop an update

85 on sarco/endoplasmic reticulum Ca2+-ATPase, Ad-PLB transduction significantly attenuated electricall

86 ion against acquisition of infection by both Ad Alone and Ad/Env vaccines.

87 Tgfbr2 inactivation by Ad-Cre led to a 5-fold increase of H19 expression in TIC

88 Anti-HER2 IgG was induced by Ad/E2TM or naked pE2TM, both encoding HER2 extracellular

89 These data demonstrate robust protection by Ad/Env vaccines against acquisition of neutralization-re

90 -driven angiogenesis, a response reversed by Ad-HO-1.

91 DICER is unchanged by Ad.mda-7/IL-24 in normal immortal prostate cells, wherea

92 In most cases, Ad vaccines are engineered to be replication-defective (

93 demonstrate that pH-sensitive polymer-coated Ad complex significantly increases net positive charge u

94 In contrast, replication-competent Ad (RC-Ad) vaccines are markedly more potent but risk ca

95 n mediated by the iron dipyrrinato complex ((Ad) L)FeCl(OEt2 ) provided a model for diastereoinductio

96 the tri-1-adamantylphosphine-nickel complex [Ad(3)PNiBr(3)](-)[Ad(3)PH](+) upon activation with an al

97 In conclusion, Ad/VNA-Stx treatment is effective in protecting piglets

98 ction of an adenovirus PAI-1 cDNA construct (Ad-PAI-1) suppressed expression of uPA and collagen-I an

99 found that hyaluronic acid (HA)-decorated CP/Ad-SS-GD/RNP nanocomplexes targeting mutant KRAS effecti

100 hydrogen bonding and salt bridge effects, CP/Ad-SS-GD well interact with Cas9 RNP to form stable nano

101 rough supramolecular assembly to generate CP/Ad-SS-GD.

102 with Cas9 RNP to form stable nanocomplex CP/Ad-SS-GD/RNP, which can be readily released in the reduc

103 adenovirus (Onc.Ad) with a helper-dependent Ad (HDAd) that expresses a PD-L1 blocking mini-antibody

104 During Ad infection, PARP is activated, but its activity is not

105 nd ATR-regulated DNA damage signaling during Ad infection and following treatment with DNA-damaging d

106 recombinant adenovirus expressing Ad12 E1A (Ad-E1A12) that can strongly induce apoptosis.

107 xpress a fusion protein of HPV-16 E6 and E7 (Ad.E6E7) alone or fused with p16 (Ad.E6E7p16) and also e

108 ll as by colocalization of DNA-PK with early Ad replication centers and distancing of DNA-PK from lat

109 al IgG and IgG2(a/b/c) Ab response to either Ad/E2TM or pE2TM.

110 At pH6.4, GFP-expressing Ad/PEGbPHF induced significantly higher GFP expression t

111 High-fat diet (HFD)-fed Ad-GcR(-/-) mice were protected against the development

112 ulin response was ~10-fold higher in HFD-fed Ad-GcR(-/-) mice.

113 AL MAIT cells only increased after the first Ad immunization.

114 3b the Gapdh panels for Ad-Fhit-wt and Ad-Fhit-Y114F are incorrect and have been

115 ibiting AIF rescued neuroblastoma cells from Ad.5/3-CTV-induced cell death, whereas pan-caspase inhib

116 Bronchoalveolar lavage fluid from Ad-MD-2s mice transferred into lungs of naive mice befor

117 encoding for SCF (Ad.SCF, n=9) or beta-gal (Ad.beta-gal, n=6) into the infarct border area.

118 Consequently, GRbeta-Ad mice had increased glycogen synthase kinase 3beta (GS

119 Furthermore, GRbeta-Ad mice had increased hepatic lipid accumulation and ser

120 ery of hepatic GRbeta overexpression (GRbeta-Ad) resulted in suppression of gluconeogenic genes and h

121 Furthermore, we implemented heterologous Ad/protein immunization regimens that include a single i

122 However, Ad-PLB altered neither the global transcriptome nor ICa,

123 However, Ad-PLIN5 cells had higher lipolysis than Ad-PLIN2 cells,

124 4.03 xenografts with trace amounts of (125)I-Ad-3Delta-A20T up to 48 h after tail vein delivery.

125 rexpression of DICER in cancer cells impedes Ad.mda-7 or His-MDA-7/IL-24 inhibition of cell growth, c

126 Inhibition of these pathways improved Ad replication, and when expressed alone, E4orf4 sensiti

127 Moreover, inhibition of DNA-PK improves Ad replication more effectively when a DNA-PK inhibitor

128 of adipose lipolysis was improved by 40% in Ad-GcR(-/-) mice.

129 Replenishing adiponectin in Ad-KO mice increased LC3-II and Beclin1 and decreased p6

130 Intriguingly, reduced adiposity in Ad-FLD mice was associated with increased oxygen consump

131 H2AX, which in turn inhibited AIF changes in Ad.5/3-CTV-infected neuroblastoma cells.

132 tumor cells, and prevents LPS development in Ad/N1ICD mice.

133 od intake decreased by 3 kcal/kg per hour in Ad-GcR(-/-) mice.

134 perilipin dephosphorylation was increased in Ad-GcR(-/-) mice.

135 nt role for the E4orf4-DNA-PK interaction in Ad replication and in facilitation of E4orf4-induced can

136 nt role for the E4orf4-DNA-PK interaction in Ad replication and in facilitation of E4orf4-induced can

137 however, these changes were not observed in Ad-KO mice.

138 the loss of cell viability were "rescued" in Ad.mda-7-treated cells incubated with Bcl-x(s) siRNA.

139 like receptor 4, which has a central role in Ad pathogenesis and is known to be tightly regulated by

140 -PARP-1 interaction has an important role in Ad replication and in promotion of E4orf4-induced cancer

141 reduced significantly compared with that in Ad AdrA mut-injected mice.

142 C and N), and lignin composition (inherited (Ad/Al)s and C/V) were not completely consistent in refle

143 or a tandem Michael addition-intramolecular Ad(N)E process to furnish a range of pharmacophoric, div

144 To overcome these issues, Ad has been engineered physically or chemically with num

145 e in wild-type (WT) or adiponectin knockout (Ad-KO) mice with and without adiponectin replenishment.

146 e-specific glucocorticoid receptor-knockout (Ad-GcR(-/-)) mice to explore potential mechanisms.

147 Ad-poly[N-(2-hydroxypropyl)methacrylamide] (Ad-PHPMA).

148 pty vector lacking a transgene control mice, Ad-MD-2s delivery resulted in significantly less LPS-ind

149 fic targeting of the tumor microenvironment, Ad was coated with the pH-sensitive block copolymer, met

150 d-PEG construct was compared to non-modified Ad or conventionally stealthed Ad-poly[N-(2-hydroxypropy

151 Moreover, Ad-FLD mice exhibited increased glucose tolerance.

152 ke and transduction compared to either naked Ad/GFP or Ad/GFP-ABP.

153 apy, the intravenous administration of naked Ad still encounters unfavorable host responses, non-spec

154 gnificantly higher GFP expression than naked Ad in both coxsackie and adenovirus receptor (CAR)-posit

155 cal properties of the generated nanocomplex, Ad/PEGbPHF, were assessed.

156 Acid uptake into CCD-112-CoN and NHDF-Ad cells was slower and comparable to levels in CRC cell

157 derived CCD-112-CoN), skin fibroblasts (NHDF-Ad), and colorectal cancer (CRC) cells (HCT116, HT29) gr

158 n acid uptake, cell-to-cell coupling in NHDF-Ad and CCD-112-CoN cells was strengthened with TGFbeta1.

159 insertion to iron(II) amides (Me2IPr)RFe{NR(Ad)} (R = (neo)Pe (4a), 1-nor (4b)) without evidence of

160 PEG-HCBP1 can protect biological activity of Ad against serum, and considerably reduced both innate a

161 nt is a consequence rather than the cause of Ad-E1A12-induced apoptosis.

162 These results reveal that silica cloaking of Ad can enhance viral gene delivery while reducing immuno

163 Strikingly, intraperitoneal delivery of Ad-TD-nsIL-12 significantly enhanced survival of animals

164 Strikingly, intratumoral delivery of Ad.Mda-5 led to regression of preestablished prostate ca

165 Intravenous delivery of Ad.scIL-23 did not accelerate the onset of hyperglycemia

166 mimicking phantom, the level and distance of Ad-gold-PEG transport was shown to be substantially grea

167 One i.m. dose of Ad/VNA-Stx prevented fatal central nervous system (CNS)

168 he host environment for the establishment of Ad replication.

169 .66, p-value </=0.05) at 72 h and/or 96 h of Ad-eIF5A-shRNA transduction.

170 ion of Nur77 by intramyocardial injection of Ad-Nur77 substantially inhibited cardiac hypertrophy and

171 Intrapleural injection of Ad.EPCR into mice with an established MPM originating fr

172 eletion normalizes the glucose metabolism of Ad/N1ICD mice, it dramatically accelerates the LPS progn

173 ced insulin resistance in skeletal muscle of Ad-KO mice.

174 age tracing confirms the adipocyte origin of Ad/N1ICD LPS.

175 ssion caused a loss-of-function phenotype of Ad-infected cell corpses that, in contrast to cells infe

176 supplementation induces redifferentiation of Ad/N1ICD adipocytes and tumor cells, and prevents LPS de

177 hese data suggest that careful sequencing of Ad.E6E7.p16 with Ad.alphaPD1 could improve antitumor imm

178 Viremia in serum of Ad AdrA wt-treated mice was reduced significantly compar

179 Atomic structures of Ad provide the basis for the development of antivirals a

180 was chemically crosslinked to the surface of Ad, generating a systemically injectable hybrid system,

181 n occur at a time displaced from the time of Ad vector immunization by depletion of CD4(+)T cells.

182 irus 14p1 (Ad14p1) is an emergent variant of Ad serotype 14 (Ad14) that has caused increased severity

183 form aberrant acini, which was dependent on Ad-cyclin E or Ad-LMW-E expression.

184 y properties of an oncolytic adenovirus (Onc.Ad) with a helper-dependent Ad (HDAd) that expresses a P

185 HER2.CAR T cells and coadministration of Onc.Ad in an HER2(+) prostate cancer xenograft model.

186 R T cells alone or HER2.CAR T cells plus Onc.Ad.

187 ced tumors only to volumes comparable to Onc.Ad treatment.

188 he Ad/PEGbPHF complex platform, an oncolytic Ad expressing VEGF promoter-targeting transcriptional re

189 latin-based hydrogel to co-deliver oncolytic Ad co-expressing interleukin (IL)-12 and granulocyte-mac

190 e polymer could be used to deliver oncolytic Ad safely and efficiently to treat hepatoma.

191 hMSCs, a relaxin (RLX)-expressing oncolytic Ad (oAd/RLX), which degrades dense tumor extracellular m

192 ponse against Ad. shMet-expressing oncolytic Ad (oAd; RdB/shMet) complexed with ABP-PEG-HCBP1 deliver

193 haracteristics of polymer modified oncolytic Ad following each strategy for cancer treatment.

194 s have been done with either naked oncolytic Ad or combination with chemotherapies.

195 imitations in systemic delivery of oncolytic Ad (oAd) and to specifically target pancreatic cancer, n

196 elatin gel-mediated co-delivery of oncolytic Ad and DCs might be a promising strategy to efficiently

197 However, the systemic injection of oncolytic Ad in clinical applications is restricted due to signifi

198 for the design and engineering of optimised Ad-based therapeutics.

199 acini, which was dependent on Ad-cyclin E or Ad-LMW-E expression.

200 dritic cells (DC) transduced with Ad.E6E7 or Ad.E6E7p16 with or without Ad.alphaPD1 were used to acti

201 nsduction compared to either naked Ad/GFP or Ad/GFP-ABP.

202 the recombinant adenoviruses (Ad) Ad-PLB or Ad-S16E-PLB to overexpress wild-type PLB or the pseudoph

203 through adenovirus-mediated overexpression (Ad-FLD) not only induces WAT lipolysis in vivo but also

204 E6 and E7 (Ad.E6E7) alone or fused with p16 (Ad.E6E7p16) and also encoding an anti-programmed death (

205 5) and those expressing perilipin 2 (PLIN2) (Ad-PLIN2) had higher [(3)H]FA incorporation into triglyc

206 ty, and Inclusion in Trauma Surgery Practice Ad Hoc Task Force of the Eastern Association for the Sur

207 In contrast, replication-competent Ad (RC-Ad) vaccines are markedly more potent but risk causing a

208 Replication-competent adenoviral (RC-Ad) vectors generate exceptionally strong gene-based vac

209 zation of Syrian hamsters, both SC-Ad and RC-Ad expressed transgenes at levels hundreds of times high

210 Surprisingly, SC-Ad, but not RC-Ad, generated higher levels of transgene-specific antibo

211 to generate the same immune responses as RD-Ad vectors.

212 otent vaccine platforms than conventional RD-Ad vectors and may have utility as "needle-free" mucosal

213 potent vectors and vaccines than current RD-Ad vectors.

214 e engineered to be replication-defective (RD-Ad) vectors.

215 els hundreds of times higher than that of RD-Ad.

216 gglutination inhibition (HAI) titers than RD-Ad in Syrian hamsters.

217 and more persistent immune responses than RD-Ad vectors in Syrian hamsters and rhesus macaques.

218 evels of transgene-specific antibody than RD-Ad, which notably climbed in serum and vaginal wash samp

219 had markedly lower influenza titers than RD-Ad-vaccinated animals after challenge with influenza A/P

220 When RD-Ad and SC-Ad were tested by single sublingual immunizati

221 and (B6xNOD)F1 HER2 transgenic mice received Ad/E2TM after NK cell depletion, and they produced less

222 clude a single immunization with recombinant Ad vectors.

223 PARP-1 inhibition assists E4orf4 in reducing Ad-induced DDR signaling and improves the efficiency of

224 The resulting Ad-gold-PEG construct was compared to non-modified Ad or

225 SC-Ad vaccines generated significant circulating antibody t

226 SC-Ad-vaccinated cotton rats had markedly lower influenza t

227 with replicating single-cycle adenovirus (SC-Ad) vaccines expressing clade B HIV-1 gp160 by the intra

228 we engineered "single-cycle" adenovirus (SC-Ad) vectors by deleting the gene for IIIa capsid cement

229 es testing newer single-cycle adenovirus (SC-Ad) vectors that replicate transgenes to amplify protein

230 , we developed "single-cycle" adenovirus (SC-Ad) vectors.

231 When RD-Ad and SC-Ad were tested by single sublingual immunization in rhes

232 sal immunization of Syrian hamsters, both SC-Ad and RC-Ad expressed transgenes at levels hundreds of

233 blingual immunization in rhesus macaques, SC-Ad generated higher gamma interferon (IFN-gamma) respons

234 However, mucosally SC-Ad-immunized animals had lower viral loads in their gast

235 oute of second immunization with the same SC-Ad serotype allowed a significant boost in these antibod

236 Surprisingly, SC-Ad, but not RC-Ad, generated higher levels of transgene-

237 These data suggest that SC-Ad vectors may have utility as mucosal vaccines.

238 duce equal amounts of HA antigen in vitro SC-Ad produced markedly higher HA binding and hemagglutinat

239 r a recombinant adenovirus encoding for SCF (Ad.SCF, n=9) or beta-gal (Ad.beta-gal, n=6) into the inf

240 ly generated the novel replication-selective Ad-3Delta-A20T to improve tumour targeting by increasing

241 cyte-specific activation of Notch signaling (Ad/N1ICD) develop LPS with complete penetrance.

242 protection was also observed with a similar Ad/Env vaccine against repeated, heterologous, intrarect

243 ance of differential expression of the small Ad E1B gene product.

244 non-modified Ad or conventionally stealthed Ad-poly[N-(2-hydroxypropyl)methacrylamide] (Ad-PHPMA).

245 r carrying a secretory transgene of VNA-Stx (Ad/VNA-Stx) protected mice challenged with Stx2 and prot

246 pe 5 to deliver a LANA-specific Cas9 system (Ad-CC9-LANA) into various KSHV latent target cells.

247 d rearrangement of Mes*P=C=C(H)R' (R' = tBu, Ad) afforded by C-H activation, isobutene elimination, a

248 er, Ad-PLIN5 cells had higher lipolysis than Ad-PLIN2 cells, which increased further by 8-Br-cAMP, in

249 3)H]FA incorporation into triglycerides than Ad-GFP control, which support their roles as LD proteins

250 Competition assays demonstrated that Ad/GFP-ABP-PEG-HCBP1-mediated transduction was specifica

251 train.IMPORTANCE We previously reported that Ad-infected human cells exhibit E1B 19K-dependent repres

252 Here we show that Ad prime, Env protein boost vaccines protect against neu

253 t expression of mda-7/IL-24 We now show that Ad.5/3-CTV induces profound neuroblastoma antiproliferat

254 These data suggest that Ad-based ZIKV vaccines may be able to provide protection

255 The Ad/N1ICD LPS resembles human dedifferentiated LPS in his

256 conform to our general understanding of the Ad transcriptional program.

257 We report the x-ray crystal structure of the Ad type 4 (Ad4) E3-19K of species E bound to HLA-A2 at 2

258 study also demonstrates that the dose of the Ad vectors has an impact on the memory profile and prote

259 for the usual repression and control of the Ad-triggered host innate immune response.

260 To assess the therapeutic efficacy of the Ad/PEGbPHF complex platform, an oncolytic Ad expressing

261 single, high-dose challenge study, only the Ad/Env vaccine affords significant protection against ac

262 lly with numerous polymers for shielding the Ad surface, accomplishing extended blood circulation tim

263 Specifically, the Ad-encoded E3-19K immunomodulatory protein targets MHC c

264 iruses from this study demonstrates that the Ad/Env vaccine blocks both neutralization-sensitive and

265 ntrols, suggesting responses were due to the Ad-vector and alum vaccine components.

266 Thus, these Ad.scIL-23-treated mice represent a physiologically rele

267 EG was of similar size and surface charge to Ad-PHPMA the increase in density, resulting from the inc

268 yed DNA-PK inhibition greatly contributes to Ad replication efficiency.

269 PARP-1 inhibition is important to Ad infection since treatment with a PARP inhibitor enhan

270 polyethyleneglycol (PEG) and then linked to Ad via a single reduction-cleavable 5kDa PEG.

271 DICER renders cancer cells more resistant to Ad.mda-7 inhibition of primary and secondary tumor growt

272 lial cells did not further sensitize them to Ad-E1A12-induced apoptosis, suggesting that cell detachm

273 imited mTOR signaling and sensitized them to Ad-E1A12-induced cell killing.

274 Before transformation, Ad/N1ICD adipocytes undergo dedifferentiation that leads

275 ficantly higher in pigs after SCF treatment (Ad.SCF, 55.5+/-11.6 mm Hg versus Ad.beta-gal, 31.6+/-12.

276 As in tumors, Ad-VEGF-A(164) strikingly increased endothelial nitric o

277 In in vivo studies 0.1% of an unmodified Ad dose was shown to accumulate in tumours, whereas over

278 Epithelial cancer cells upon Ad-E1A12-induced detachment could not sustain AKT activa

279 Meanwhile, inactivation of these genes using Ad-K5cre in basal cells leads to the development of SCLC

280 treatment (Ad.SCF, 55.5+/-11.6 mm Hg versus Ad.beta-gal, 31.6+/-12.6 mm Hg, P=0.005), indicating enh

281 a tropism-modified cancer terminator virus (Ad.5/3-CTV), which selectively replicates in cancer cell

282 al tissues; however, this did not occur when Ad-FLD mice were fed a high-fat diet.

283 4 in normal immortal prostate cells, whereas Ad.mda-7 down-regulates DICER in multiple cancer cells i

284 CAL1 association with the RPA complex, while Ad-induced SMARCAL1 phosphorylation also contributed to

285 be substantially greater than achieved with Ad-PHPMA.

286 cacy in delivering mda-7/IL-24 compared with Ad.5-mda-7, although overall translation of the protein

287 p16-transduced DC (DC.E6E7p16) compared with Ad.E6E7 (DC.E6E7), a result that may be due to an effect

288 of CTL were increased after incubation with Ad.E6E7p16-transduced DC (DC.E6E7p16) compared with Ad.E

289 ytes from Sox9(flox/flox) mice infected with Ad-CMV-Cre.

290 that careful sequencing of Ad.E6E7.p16 with Ad.alphaPD1 could improve antitumor immunity against HPV

291 ionally, similar results were also seen with Ad-PLB-transduced and Ad-S16E-transduced hvCMTs.

292 helial and endothelial cells transduced with Ad-CC9-LANA underwent significant reductions in the KSHV

293 derived dendritic cells (DC) transduced with Ad.E6E7 or Ad.E6E7p16 with or without Ad.alphaPD1 were u

294 ts, which were reversed by transduction with Ad-PAI-1.

295 overed from the tumours of mice treated with Ad-gold-PEG and ultrasound.

296 lary density compared with pigs treated with Ad.beta-gal was found at 3 months and suggests an angiog

297 eased by 4.2% (P=0.004) in pigs treated with Ad.beta-gal.

298 e effects, in contrast to the treatment with Ad-TD expressing unmodified IL-12.

299 ined from wt mice and infected in vitro with Ad vector containing AdrA wt, but not mut, had increased

300 d with Ad.E6E7 or Ad.E6E7p16 with or without Ad.alphaPD1 were used to activate autologous CD8 CTL in