ライフサイエンスコーパス: African

1 s were women and all participants were black African.

2 ine CVD 103-HgR among H. pylori seropositive African adults provides further evidence of the immunomo

3 he first risk tool applicable to sub-Saharan African AGYW, and compare performance of Balkus and Ayto

4 ents with HFpEF were more often women (59%), African American (68%), obese (median body mass index 41

5 less effective in improving knowledge among African American (AA) kidney transplant candidates compa

6 Older age, male sex, and being black or African American (compared to being white) remained sign

7 nal connectivity (rs-fc) were collected from African American (n = 131) and white (n = 685) cognitive

8 C], 0.931), Asian (n=557; AUC, 0.961), black/African American (n=651; AUC, 0.937), Hispanic/Latino (n

9 s, 31% were female (natal sex), 43% black or African American and 15% Asian, the median body mass ind

10 nd "Hispanic" members, and less progress for African American and other ethnic populations.

11 Overall, only <= 9.5% of African American cases and controls from the SCCS drank

12 e samples from 148 predominantly low-income, African American children (aged 5-17 years) with establi

13 irty-three nonsevere and 22 severe asthmatic African American children were included in an epigenome-

14 ositive) Th cells from 59 obese Hispanic and African American children with asthma and 61 normal-weig

15 ith asthma and 61 normal-weight Hispanic and African American children with asthma underwent quantifi

16 ed IBD status in European, AJ, Hispanic, and African American cohorts in BioMe.

17 ral trends was particularly noticeable among African American individuals, where each additional cale

18 We compared data from African American members screened when they were 45-50 y

19 her active surveillance is a safe option for African American men.

20 Compared to white participants, African American participants had greater neurodegenerat

21 The African American patient group showed increases in extra

22 nt signaling activation has been observed in African American patients.

23 ey disease progression in human cohorts: the African American Study of Kidney Disease and Hypertensio

24 African American subjects have thinner corneas than whit

25 cally detected AF was substantially lower in African American than in white participants, without or

26 more diverse training datasets that include African American Vernacular English-to reduce these perf

27 The 4323 included patients (29% women, 60% African American) contributed 30 007 person-years.

28 mean +/- SD age: 54 +/- 6 y, 57% women, 27% African American) were followed for incident CAD through

29 ng 2385 participants (65% PWH, 95% male, 68% African American), higher CD45RO+ memory CD4+ T cells an

30 41.2 +/- 13.1 years, 59.5% were women, 25.5% African American, and 64.0% Hispanic.

31 in 2018 with data from previously unscreened African American, white, Hispanic, and Asian/Pacific Isl

32 ations were more likely to be younger, male, African American, with a higher American Society of Anes

33 423 participants, 1806 were men and 617 were African American.

34 rquartile range [IQR], 54, 66), and 23% were African American.

35 African American/Black and Hispanic populations experien

36 lished between April 2006 and May 2019 in 20 African, American, Asian, and Middle Eastern countries w

37 ios for success were significantly lower for African-American (0.67; 95% confidence interval [CI] = 0

38 associated with DR is two-fold higher in the African-American (AA) compared to non-Hispanic white.

39 SD, 14.4), 25.9% were female, and 75.4% were African-American or Hispanic.

40 Incidence is higher in African-American women and in women with older maternal

41 of vitamin D on breast cancer subtypes among African-American/black women, who tend to develop more a

42 The ADHD cases included 116 African Americans (AA) and 89 of European Ancestry (EA)

43 ic on clinical presentations and outcomes in African Americans (AAs) compared to white patients.

44 ass was inversely associated with SIClamp in African Americans (beta = -0.05, SE = 0.03, P = 0.04) bu

45 AAT) was associated with a higher SIClamp in African Americans (beta = 0.11, SE = 0.05, P = 0.02) but

46 ll allotypes that are common in European and African Americans (n = 97), which revealed a broad conti

47 t in BVA was significantly faster in men and African Americans (P < .05).

48 ations with height in European Americans and African Americans ancestries.

49 the DNA repairome in prostate cancer between African Americans and Caucasians.

50 tumors and matched normal tissue samples in African Americans and Caucasians.

51 African Americans and Latinos are overrepresented among

52 isk for Caucasians and attenuated risk among African Americans and people with type II diabetes.

53 African Americans are consistently found to have a lower

54 Black/African Americans are contracting and dying from COVID-1

55 A common belief is that African Americans are hyposensitive to pain compared to

56 ore, disease transition is higher among ANA+ African Americans compared with ANA+ European Americans.

57 likelihood of having an approved donor among African Americans compared with Caucasians.

58 ibrate interaction on MACE was replicated in African Americans from ACCORD (N = 585, P = 0.02) and in

59 ng 1801 cancer cases and 3337 controls among African Americans from the Southern Community Cohort Stu

60 African Americans had significantly higher prevalence an

61 Among 10,232 African Americans in the early screening group who were

62 xplain the higher cardiometabolic risk among African Americans is unknown.

63 yposensitive to pain compared to Whites, but African Americans show increased pain sensitivity in cli

64 tate cancer, such as the higher mortality in African Americans than Caucasians.

65 droxyvitamin D [25(OH)D] tend to be lower in African Americans than in non-Hispanic whites, but wheth

66 ulin sensitivity may have a genetic basis in African Americans that is reflected in the pattern of bo

67 Americans, or both; for consistency, we use African Americans throughout.).

68 associated with increased susceptibility of African Americans to SARS-CoV-2.

69 ts (death: 6.6%, hospitalization: 30.1%) and African Americans with COVID-19 and SUD had worse outcom

70 African Americans with elevated saturated transferrin an

71 ginal increase in mutation rate in tumors in African Americans with increasing age.

72 In African Americans, a 5' untranslated region insertion (r

73 om 1,693 non-Hispanic white individuals, 385 African Americans, and 90 Hispanics with >=20 pack-years

74 us never in European Americans, one locus in African Americans, and one in Hispanic Americans.

75 her expression of ACE2 and TMPRSS2 in males, African Americans, and patients with diabetes mellitus p

76 ith SUD, especially individuals with OUD and African Americans, as having increased risk for COVID-19

77 ncer (CRC) screening before age 50 years for African Americans, but there are few data on screening u

78 Hispanics/Latinos, isolation-by-distance in African Americans, elevated levels of relatedness and ho

79 errepresented groups (URGs), including Black/African Americans, Hispanic/Latinx, Pacific Islanders, a

80 dietary factors in relation to NAFLD risk in African Americans, Japanese Americans, Latinos, native H

81 a cited for this article varied from blacks, African Americans, or both; for consistency, we use Afri

82 nucleotide excision repair pathway genes in African Americans, whereas >40% of tumors had mutations

83 f cancer has not been thoroughly examined in African Americans.

84 variant signals from stratified analysis of African Americans.

85 ma deficiency was examined in four unrelated African Americans.

86 parities in the outcome of the disease among African Americans.

87 ominant cause of C8alpha-gamma deficiency in African Americans.

88 in 1295 sub-Saharan Africans (SSAs) with 559 African-Americans (AAms) and 2464 European-Americans (EA

89 are ALCAM, PF-4, properdin, and VCAM-1 among African-Americans, sE-selectin, VCAM-1, BFL-1 and Hemope

90 ted with the genetic predisposition to CD in African-Americans.

91 ean ancestry (EA) cohorts, their validity in African ancestry (AA) and Hispanic ethnicity (HE) indivi

92 non-coding and more common in individuals of African ancestry (~10% and ~1% minor allele frequency, r

93 of collapsing glomerulopathy in patients of African ancestry and high-risk APOL1 genotype infected w

94 We find cross-population signals of African ancestry enrichment at the major histocompatibil

95 APOL1 genotyping in donors with recent African ancestry is considered.

96 (minor allele frequencies<0.05) in Asian and African ancestry populations.

97 c/P variants were identified in Non-Hispanic African ancestry probands.

98 s patient reports have described patients of African ancestry who developed nephrotic-range proteinur

99 Combining results from the samples with African ancestry with summary statistics from the Psychi

100 10 individuals (6644 of European and 2166 of African ancestry) from the Collaborative Study on the Ge

101 le-genome sequencing data among survivors of African ancestry, first based on ejection fraction (EF)

102 L1 gene, found only in individuals of recent African ancestry, greatly increase risk of multiple type

103 4.2%; P = 2.8 x 10(-8)) in 246 survivors of African ancestry, which was successfully replicated in 1

104 These African ancestry-predominant alleles may help explain th

105 l living kidney donors self-reporting recent African ancestry.

106 nce and up-front cancer care for patients of African ancestry.

107 at TET2 that was specific to individuals of African ancestry.

108 , but remains unexplored in populations with African ancestry.

109 0.07; P = 6.62 x 10(-8)) with each allele of African ancestry.

110 body mass index, or type 2 diabetes risk in African-ancestry populations.

111 animals from lethal challenge with both the African and Asian lineages of ZIKV, impairing virus diss

112 the second sublineage primarily consisted of African and Australian isolates.

113 s from primary monocytes from individuals of African and European ancestry following activation of th

114 The South African and Ugandan cohorts included 701 and 106 individ

115 was consistent across quartiles of European, African, and Native American genetic ancestry.

116 oms into the transatlantic trade in enslaved Africans, and the overrepresentation of Yoruba peoples i

117 and escalating resistance to pyrethroids in African Anopheles populations, threatening to reverse th

118 the last common ancestor (LCA) of humans and African apes is still a divisive issue.

119 of long-term temporal trends of POPs in the African atmosphere.

120 The African baobab (Adansonia digitata L.), also referred to

121 African Bicyclus butterflies show strong seasonal polyph

122 In the African Breast Cancer-Disparities in Outcomes Study, a p

123 metabolites were under polygenic control in African calves.

124 Despite the past stability of the African carbon sink, our most intensively monitored plot

125 African Caribbean heritage was associated with increased

126 Over the 5 decades, South African cases of blastomycosis were caused by species th

127 demiologically-linked cases were sent to the African Centre of Excellence for Genomics of Infectious

128 om an Indian cheetah museum specimen and two African cheetah, one modern and one historic, imported i

129 to test higher transfusion thresholds among African children with severe malaria complicated by thes

130 Vdelta3(+) TRD sequences in the majority of African children.

131 thods for examining the AVT system in female African cichlid fish Astatotilapia burtoni, including im

132 We used females of the mouth brooding African cichlid fish, Astatotilapia burtoni, to test for

133 o one another but distantly related to other African clade organisms recovered in the United States o

134 ith ClinicalTrials.gov, NCT03271307, and Pan African Clinical Trials, PACTR201711002697316.

135 hood support and economic stability for East African coastal communities-a region of least developed

136 to three empirical datasets: Apicomplexa and African coelacanth genomes as well as sequences of hemag

137 As rural African communities experience more frequent and extreme

138 and Saudi Arabia), the northern part of the African continent (Algeria and Libya) and the Horn of Af

139 Due to yet unknown reasons, the African continent has remained relatively unaffected.

140 The African continent is regarded as the cradle of modern hu

141 Central African countries have the most diverse HIV epidemics.

142 were lower in populations living in northern African countries or South Africa compared with sub-Saha

143 Central African countries such as Chad, Democratic Republic of t

144 129 studies with 21 474 participants from 23 African countries were included in the systematic review

145 highest in countries with older populations, African countries with high HIV/AIDS prevalence, and sma

146 basic sanitation services, in 10 Sub-Saharan African countries, are the same magnitude as nutrients d

147 In some African countries, more than one-half of 45- to 49-y-old

148 In five southern African countries, the prevalence of children who were H

149 We identified 96 studies representing 39 African countries, with a median cohort size of 370 part

150 nes circulated on the market particularly in African countries.

151 ween November 2006 and December 2018 from 23 African countries.

152 lment among 10-14-year-olds in 7 sub-Saharan African countries.

153 Lassa virus (LASV), which is endemic to West African countries.

154 has already been detected in many Asian and African countries.

155 ccine implementation has recently begun in 3 African countries.

156 or COVID-19 in the absence of integration of African data and leadership by African institutions.

157 (MAPS; development cohort, n = 151), and the African Descent and Glaucoma Evaluation Study (ADAGES; v

158 cy that mainly afflicts young individuals of African descent and is resistant to all targeted agents

159 s143185769) present in ~9% of individuals of African descent may regulate ACE2 expression and may be

160 ma disproportionately affects individuals of African descent.

161 The Pro47Ser variant of p53 (S47) exists in African-descent populations and is associated with incre

162 Social determinants of health in the African diaspora drive the lack of disease testing, incr

163 y associated with the passage of atmospheric African Easterly Waves.

164 rgency conditions (based on the 2013-16 west African Ebola virus disease epidemic).

165 Remarkably, African elephants (Loxodonta africana) have been found a

166 necessary to combat poaching and to conserve African elephants.

167 aps of Africa, the contributions of multiple African empires and kingdoms into the transatlantic trad

168 We identify 16 loci linked to African environmental adaptations across crossbred anima

169 MLT approach achieves skillful prediction of African fire one month in advance and can be generalized

170 environmental drivers and predictability of African fire using the analytical framework of Stepwise

171 as they do for long-distance exchanges among African foragers more broadly.

172 eening of potential bushmeat samples in East African forensic science pipelines.

173 A new study of African fossils spanning seven million years shows that

174 ime sleepiness, anxiety and depression among African gamers, (2) the association between these condit

175 regarded as the cradle of modern humans and African genomes contain more genetic variation than thos

176 icans reflects pronounced limitations in the African genomic database, the artificiality of the colon

177 validated trait architecture consistency in African germplasm and investigated further evidence for

178 ied six novel SHELL alleles in noncommercial African germplasm populations from the Malaysian Palm Oi

179 Lineage 8 (L8), seemingly restricted to the African Great Lakes region.

180 ers and 4 tissue samples from a NiV-infected African green monkey with viral loads as low as 52 genom

181 inistered within 2-6 hours of fever onset in African green monkeys (AGM).

182 A model was developed in African green monkeys (AGMs) after challenge with a leth

183 We show that African green monkeys (AGMs) support robust SARS-CoV-2 r

184 ial of NiV delivered by the aerosol route in African green monkeys (AGMs) used the Malaysia strain (N

185 Hamsters and African green monkeys received a primary intranasal infe

186 The West African Group (WAG) B. anthracis have mutations renderin

187 South African guidelines recommend repeat viral load testing w

188 received treatment in accordance with South African guidelines.

189 lowing expansion primarily in New Guinea and African Guinea.

190 first appeared in hominins, all known South African hominins show morphological adaptations to biped

191 tic for severe infection in many sub-Saharan African hospitals.

192 first GWAS of serum uric acid in continental Africans identified three associations at two loci, SLC2

193 wildlife species that are common in the East African illegal wildlife products trade based on their u

194 In conclusion, Sub-Saharan African immigrant women have a two-fold higher risk of d

195 the existing limited representation of West Africans in public genomic databases.

196 cience, Embase, African Journals Online, and African Index Medicus for studies on vitamin D prevalenc

197 ying a new subspecies predominantly found in African individuals and showing that closely related non

198 Strikingly, we find that African individuals carry a stronger signal of Neanderth

199 ly a fraction of the genetic diversity among African individuals has been surveyed(1).

200 using data from more than 10,000 sub-Saharan African individuals recruited from Ghana, Burkina Faso,

201 characterization of the genomic diversity of African individuals to understand human ancestry and imp

202 Legume supplementation in breastfed, rural African infants did not affect the structure of the gut

203 ntegration of African data and leadership by African institutions.

204 utralizing activity of bNAbs against primary African isolates differs from their activity against pse

205 s of these virus isolates has shown that the African isolates form a single disparate clade, rather t

206 we searched PubMed, Web of Science, Embase, African Journals Online, and African Index Medicus for s

207 into ecological patterns of snakes within an African landscape half a century ago.

208 on phenolic compounds and bioactivity of the African leafy green vegetable, Bidens pilosa, known as B

209 logy in the African lion (Panthera leo leo), African leopard (Panthera pardus pardus), and cheetah (A

210 examines cortical neuronal morphology in the African lion (Panthera leo leo), African leopard (Panthe

211 Although neurons in the African lion were insufficiently impregnated for accurat

212 of mammals, including bovine, Asian buffalo, African lion, and goat.

213 inancial constraints and low-quality forage, African livestock are rarely fed at 100% maintenance ene

214 ting the threat of insecticide resistance in African malaria vector populations requires comprehensiv

215 Free-ranging African mammals are exposed to diverse IAV subtypes.

216 The quality of the honey on the South African market was evaluated using the Agricultural Prod

217 th, Swiss National Science Foundation, South African Medical Research Council.

218 f African women to the gene pool compared to African men varies across the Americas, consistent with

219 ional Research on Obesity and Diabetes among African Migrants (RODAM) study.

220 g the mid- to late Holocene, coincident with African monsoon failure during the end of the Green Saha

221 in collections of colonized and wild-derived African mosquitoes do not prevent cleavage in vitro by t

222 s-ancestry meta-analysis results for admixed African (Nagelkerke's R(2) = 0.032; liability R(2) = 0.0

223 African naked mole-rats were likely the first mammals to

224 South African National Clinical Trial Register (DOH-27-0913-41

225 inicalTrials.gov (NCT01187979) and the South African National Clinical Trials Registry (SANCTR) (DOH-

226 d mortality surveillance data from the South African National Population Register up to Dec 31, 2017.

227 ntrolled field experiment conducted in South African neighbourhoods in which individuals with a low s

228 c metabolites or anti-nutritive compounds in African nightshade leaves during moist cooking.

229 inutritive phytochemical aglycones in edible African nightshade leaves, an underutilized food resourc

230 A comprehensive understanding of African North American biohistory is a prerequisite for

231 d overrepresentation of Nigerian lineages in African North Americans reflects pronounced limitations

232 ment in which seedlings of 12 European/North African oaks were grown under two watering treatments, a

233 This adversely affects individuals of African or Middle Eastern ancestries who have on average

234 nfidence interval {CI}, 1.3-6.4]; P = .008), African origin (mOR, 3.0 [95% CI, 1.0-9.2]; P = .047), c

235 This discovery further supports an East African origin for the MTBC and provides additional mole

236 rt evidence for a third mammalian lineage of African origin in the Paleogene of South America-a newly

237 PBRM1 mutations in renal cancer patients of African origin, and decreased immune activity in bladder

238 ded increased FBXW7 mutations in patients of African origin, decreased VHL and PBRM1 mutations in ren

239 sis of CAEBV in 22 patients of Caucasian and African origins was established.

240 During the 2014 West African outbreak, a dilemma emerged about the ethics of

241 odel.Methods: We recruited 106 healthy South African participants with varying degrees of tuberculosi

242 ces is at the root of the present success of African pastoralism.

243 implant diseases are prevalent in this North African patient population.

244 C, and D HIV isolates derived from cells of African patients living with HIV and produced in periphe

245 taneously as cradles and museums of tropical African plant biodiversity.

246 PIMMS43 genetic structure across African Plasmodium falciparum populations indicates alle

247 ions have overlooked a high-risk Sub-Saharan African population: adolescent girls and young women (AG

248 African populations provide a unique opportunity to inte

249 election has, however, been under-studied in African populations, despite their diversity and importa

250 In African populations, infant immunisation has been fundam

251 d with LP in ancient and present-day eastern African populations, the contexts for selection for LP a

252 revalence of vitamin D deficiency is high in African populations.

253 rt genome sequence and annotation of a South African QPM line K0326Y, which is assembled from single-

254 al cancer (CRC) (~91:100,000), whereas rural African (RA) people have the lowest risk (<5:100,000).

255 E756del is highly prevalent and enriched in Africans, raising the possibility that it is under posit

256 The African region had the highest median prevented fraction

257 The WHO African region is expected to gain the greatest health b

258 ia region, Eastern Mediterranean region, and African region.

259 cur extensively along the flanks of the East African Rift System, including an offshore branch in the

260 entrates deep carbon below parts of the East African Rift System.

261 rge mammalian herbivores in a semi-arid East African savanna.

262 We studied tree rooting patterns in Southern African savannas to ask: how tree rooting strategies aff

263 However, many African settings treat with FLU monotherapy, and the cos

264 third of vertical HIV transmission cases in African settings.

265 but the decline was entirely due to Eastern African sites.

266 n against pathogenic trypanosomes that cause African sleeping sickness.

267 ly sourced nightshade leaves, comprising two African species Solanum scabrum and S. nigrum, and from

268 results suggest that during the 1990s, South African SRWs foraged on prey isotopically similar to Sou

269 we compared LTL measured in 1295 sub-Saharan Africans (SSAs) with 559 African-Americans (AAms) and 24

270 ons of leaves and edible parts of three East African staple crops: Zea mays, Manihot esculenta, and M

271 emonstrated the lack of clonal evolution for African strains which conclusively support the significa

272 urrence of B. tabaci over 2 years across the African study area.

273 African swine fever (ASF) is a severe viral disease that

274 In the absence of any available vaccines, African swine fever (ASF) outbreak containment relies on

275 o combat this devastating disease.IMPORTANCE African swine fever virus (ASFV) causes incurable and of

276 African swine fever virus (ASFV) is a complex nucleocyto

277 African swine fever virus (ASFV) is among the most compl

278 n phase, and isothermal detection system for African Swine Fever Virus (ASFV).

279 ntra-familial relationships for the southern African Synlestidae.

280 Gambiense human African trypanosomiasis ([gHAT] sleeping sickness) is a

281 Human African trypanosomiasis (HAT), or sleeping sickness, is

282 Human African trypanosomiasis is causing thousands of deaths e

283 ucei is a kinetoplastid parasite that causes African trypanosomiasis, which is fatal if left untreate

284 We grew 24 tree species occurring in five African vegetation types, varying from dry savanna to mo

285 orea appears to be more similar to the known African viruses than to any other Asian viruses.

286 served for clade 5 genomes, but only for non-African viruses.

287 pinnae and extensive vocal repertoire of the African wild dog (Lycaon pictus) has led to the assumpti

288 uditory information, within the brain of the African wild dog closely resembles that observed in othe

289 zation quotient of 1.73, indicating that the African wild dog has a relatively large brain size.

290 f other mammals, the olfactory system of the African wild dog has certain features that appear to cor

291 ighly social group structure observed in the African wild dog.

292 main and accessory olfactory systems of the African wild dog.

293 and between-pack dynamics in a population of African wild dogs (Lycaon pictus) to test these contrast

294 the semantic content of the vocalizations of African wild dogs, and the behaviors generated, occurs b

295 Obese, black South African women (n = 45) were randomized into exercise (n

296 Furthermore, the greater contribution of African women to the gene pool compared to African men v

297 al microbiota and immune factors in pregnant African women who were HIV-uninfected (n = 314) versus H

298 In our study of pregnant South African women with accurately dated pregnancies, we show

299 is a high-risk period for HIV acquisition in African women, and pregnant women who become acutely inf

300 estricted feeding on the rumen microbiome of African Zebu cattle remains largely unexplored.