ライフサイエンスコーパス: Amp

1 Amp-Seq and length-polymorphism based genotyping were co

2 Amp-Seq based genotyping of longitudinal samples improve

3 Amp-Seq markers were superior to length-polymorphic mark

4 Amp-Seq permits tracking of clone density over time to s

5 urrent output (0.6+/-0.02 versus 0.56+/-0.02 Amp; P<0.0001) and greater impedance drop (16.8+/-3.0 Om

6 nems 4-7 with beta-lactamases (TEM-1, SHV-1, Amp-C) were characterized by electrospray ionization mas

7 M), or cyclo[Asp(5)-/Glu(5)-/Asp(5)(Gly(5'))-Amp(8)] (19, K(i) = 1.3 nM; 22, K(i) = 3.3 nM; and 23, K

8 mino-3-(7-methoxy-4-coumaryl)propionic acid (Amp) or L- or D-2-amino-3-(6,7-dimethoxy-4-coumaryl)prop

9 ate that in vervet monkey striatum, an acute Amp or MeAmp drug dosage produces extensive striatal dop

10 trand salt bridge between (4S)-aminoproline (Amp) and aspartic acid (Asp) that directs the compositio

11 /kg, i.m., 4 h apart) of either amphetamine (Amp), n = 3, or methamphetamine (MeAmp), n = 3.

12 ene for CMS 514A derived from an amphiploid (Amp H. angustifolius/P 21, 2n = 68).

13 oring the beta-lactam antibiotic ampicillin (Amp) against multiple pathogenic Gram-negative bacterial

14 here the beta-lactam antibiotics ampicillin (Amp) and amoxicillin (Amx) are linked to a monofunctiona

15 bp integrons added resistance to ampicillin (Amp) and chloramphenicol (Cm), and the 1,600-bp integron

16 imals were then given water with ampicillin (Amp; 5 g/liter) ad libitum.

17 implicit time (IT) Z-score, mfERG amplitude (Amp) Z-score, sex, diabetes duration, diabetes type, blo

18 ratory duration, inspiratory peak amplitude (Amp), and phase were different at higher ( 2.5 Hz) vs. l

19 ratory duration, inspiratory peak amplitude (Amp), and phase were different at higher (>=2.5 Hz) vs.

20 At 1-2 weeks postdrug, both Amp and MeAmp exposure effected similar decreases (60-70

21 one densities were tracked longitudinally by Amp-Seq despite MOI > 1, thus providing an additional pa

22 Multiplicity of infection (MOI) by Amp-Seq was 2.32 versus 1.73 for msp2.

23 red APD at 90% repolarization (APD(90)), CaT(Amp) and reduced alternans susceptibility, whereas femal

24 to AP duration (APD) and CaT amplitude (CaT(Amp)) alternans.

25 ly one combination improving APD(90) and CaT(Amp) but with minimal impact on DAD risk.

26 ntegron; the beta-lactamase gene, conferring Amp resistance in the 1,200-bp integron; and the aadA an

27 Since both the donors (Amp(s)-Tet(r)) and recipients (Amp(r)-Tet(s)) were resis

28 b) Adp has a larger Stokes shift than either Amp or Lys(Mca) and thus has less chance of self-quenchi

29 TC-Amp and Ent-Amp exhibit potency comparable to that of the FDA-approv

30 ecies such as Staphylococcus aureus, and Ent-Amp exhibits low cytotoxicity against human T84 intestin

31 obactin-antibiotic conjugates, hereafter Ent-Amp/Amx, where the beta-lactam antibiotics ampicillin (A

32 Moreover, Ent-Amp and Ent-Amx selectively kill E. coli CFT073 co-cultu

33 hat TC-Amp and its Ent-based predecessor Ent-Amp achieve enhanced antibacterial activity against dive

34 me-kill kinetic studies demonstrate that Ent-Amp/Amx kill this strain more rapidly at 10-fold lower c

35 ctively, for St Spc Su Tet; 0.95 and 1.0 for Amp Cm St Spc Su Tet; and 1.0 and 0.99 for Gen Kan St Sp

36 9-dTK-T2-pac(Flox) helper which assists H129(Amp) tracer's propagation and transneuronal monosynaptic

37 ultiple-copy of expression cassettes in H129(Amp) tracer.

38 e developed an anterograde monosynaptic H129(Amp) tracer system based on HSV-1 strain H129.

39 These improvements of H129(Amp) tracer system shorten experiment duration from 28-d

40 The lack of toxic viral genes in the H129(Amp) tracer minimizes toxicity in postsynaptic neurons,

41 The H129(Amp) tracer system consists of two components: an H129-d

42 The H129(Amp) tracer system is a powerful tracing tool for reveal

43 moxia, hypoxia or hypercapnia, and increased Amp and produced a phase advance, which was similar to t

44 moxia, hypoxia or hypercapnia, and increased Amp and produced a phase advance, which was similar to t

45 The C227-11-infected, Amp-treated C57BL/6 mice exhibited both morbidity and mo

46 ichment using Droplet Pre-Amplification (MED-Amp) method, which combines single-molecule emulsificati

47 The MED-Amp assay increased mutant signal by over 50-fold with m

48 The MED-Amp assay successfully detected KRAS mutant ctDNA in 86%

49 The mfERG Amp, mfERG IT, SBP, and sex were together predictive of

50 used to calculate the maximum IT and minimum Amp Z-scores for each zone.

51 The recently developed ATONA (Atto- to Nano-Amp) amplification system paired with Faraday cup detect

52 ion-free long-read sequencing technology: No-Amp sequencing.

53 n together, our findings demonstrate that No-Amp sequencing is a powerful tool that enables the disco

54 on between expansion sizes obtained using No-Amp sequencing and Southern blotting (P = 5.0 x 10-4).

55 demonstrated that the shorter side chain of Amp or Adp was better tolerated by MMP-1 and MMP-2.

56 Conjugation of Amp to a new monofunctionalized TC scaffold affords TC-A

57 The sensitivity of Amp-Seq for relative quantification of clones was invest

58 els, and in 100 uninfected persons by use of Amp-RT, an ultrasensitive RT assay.

59 eks, by 25% at 10-12 weeks and by 16% in one Amp-treated subject at 32 weeks.

60 Using our Amp-seq approach, we screened 80 An. funestus field isol

61 pcDNA-89 or with the plasmid backbone pcDNAI/Amp (pcDNA) and then challenged 2 weeks later with eithe

62 ed sequences were C6-(Gly-Pro-Hyp)5-Gly-Pro-[Amp/Adp]-Gly-Pro-Gln-Gly approximately Leu-Arg-Gly-Gln-L

63 h the donors (Amp(s)-Tet(r)) and recipients (Amp(r)-Tet(s)) were resistant to erythromycin, the trans

64 p2 in detecting minority clones (sensitivity Amp-Seq: 95%, msp2: 85%).

65 Amplicon deep sequencing (Amp-Seq) offers a tool to address this knowledge gap.

66 study, we developed an amplicon sequencing ("Amp-seq") approach targeting An. funestus, and using mul

67 TC-Amp and Ent-Amp exhibit potency comparable to that of th

68 ew monofunctionalized TC scaffold affords TC-Amp, which displays markedly enhanced antibacterial acti

69 h STm show that the TC moiety facilitates TC-Amp uptake by the OM receptors FepA and IroN and that th

70 Moreover, TC-Amp achieves targeted activity, selectively killing STm

71 Remarkably, we uncover that TC-Amp and its Ent-based predecessor Ent-Amp achieve enhanc

72 ined in significantly higher yields than the Amp-containing fTHPs, (b) Adp has a larger Stokes shift

73 the OM receptors FepA and IroN and that the Amp warhead inhibits penicillin-binding proteins.

74 This Amp-Asp salt bridge allowed for the rational design of s

75 for uropathogenic E. coli CFT073 relative to Amp/Amx, and time-kill kinetic studies demonstrate that

76 r Typhimurium (STm) compared with unmodified Amp.

77 Of the 50 clinical samples, 38 (76%) were Amp-RT positive, while all uninfected controls were nega

78 titutions in this series, such as those with Amp (25, 26), Orn (27), or IAmp (29) at position 7, were