ライフサイエンスコーパス: AmpC beta-lactamase

1 n organisms lacking a chromosomally mediated AmpC beta-lactamase.

2 1 nM inhibitor (compound 1) in complex with AmpC beta-lactamase.

3 o detect phenotypically isolates that harbor AmpC beta-lactamase.

4 llowing detection of the beta-lactam, of the AmpC beta-lactamase.

5 spectively against hits from docking against AmpC beta-lactamase.

6 ve infections caused by organisms expressing AmpC beta-lactamases.

7 extended-spectrum beta-lactamases (ESBL) and AmpC beta-lactamases.

8 sensitive and specific for detecting SHV and AmpC beta-lactamases.

9 btained only for isolates producing ESBLs or AmpC beta-lactamases.

10 ach compound in the library, docking against AmpC beta-lactamase (AmpC) and the D(4) dopamine recepto

11 Using AmpC beta-lactamase, an enzyme that is well-characterize

12 revalence of AMR organisms, particularly for AmpC beta-lactamase and methicillin-resistant Staphyloco

13 ere obtained for seven of eight producers of AmpC beta-lactamase and no ESBL producers.

14 g/ml were obtained for all strains producing AmpC beta-lactamase and only 1 of 33 strains producing E

15 correlate well for isolates containing both AmpC beta-lactamases and ESBLs.

16 um beta-lactamases (ESBLs), plasmid-mediated AmpC beta-lactamases and KPC carbapenemases in Enterobac

17 o be very potent inhibitors of the TEM-1 and AmpC beta-lactamases and less so against the class B met

18 sistent with production of both a TEM and an AmpC beta-lactamase, and representative isolates of seve

19 ectrum beta-lactamases (ESBLs), transferable AmpC beta-lactamases, and carbapenemases are associated

20 isolates) producing non-MBL carbapenemases, AmpC beta-lactamases, and extended-spectrum beta-lactama

21 f extended-spectrum beta-lactamases (ESBLs), AmpC beta-lactamases, and one or multiple carbapenemases

22 ted antibiotic-resistant proteins, including AmpC, beta-lactamase, and carO, in clinical resistant st

23 AmpC beta-lactamases are cephalosporinases that confer r

24 gative organisms expressing plasmid-mediated AmpC beta-lactamases are limited because these organisms

25 Unlike ESBLs, however, AmpC beta-lactamases are not inhibited by clavulanic aci

26 AmpC beta-lactamases are related to the chromosomal enzy

27 For AmpC beta-lactamase, binding to aggregates of the small

28 MY-2 antibody was tested against a number of AmpC beta-lactamases by assaying known quantities of pur

29 e m-aminophenylboronic acid-Escherichia coli AmpC beta-lactamase complex to suggest modifications tha

30 tibiotic resistance genes, including a FOX-5 AmpC beta-lactamase encoded on a large IncA/C plasmid.

31 g family-specific ampC genes responsible for AmpC beta-lactamase expression in organisms with or with

32 deficient Q120L/Y150E variant of the class C AmpC beta-lactamase from Escherichia coli was solved at

33 The structures of AmpC beta-lactamase from Escherichia coli, alone and in

34 ositive isolates were positive by PCR for an AmpC beta-lactamase gene.

35 n in organisms with or without a chromosomal AmpC beta-lactamase gene.

36 Screening a deep mutant library of the bla(ampC) beta-lactamase gene of Escherichia coli, we identi

37 r the purpose of identifying family-specific AmpC beta-lactamase genes within gram-negative pathogens

38 Plasmid-mediated AmpC beta-lactamases have been associated with false in

39 Plasmid-mediated CMY-2 AmpC beta-lactamases have been identified in Salmonella

40 Six families of plasmid-mediated AmpC beta-lactamases have been identified, but no phenot

41 eumoniae bloodstream isolates harbor ESBL or AmpC beta-lactamases, (ii). confirmatory tests are neces

42 a 1.07 A X-ray crystallographic structure of AmpC beta-lactamase in complex with a boronic acid deacy

43 ng frequency, the true rate of occurrence of AmpC beta-lactamases in Escherichia coli, Klebsiella pne

44 in all gram-negative isolates, transferable AmpC beta-lactamases in Klebsiella pneumoniae, and carba

45 ere evaluated for detecting plasmid-mediated AmpC beta-lactamases in Klebsiella spp., Escherichia col

46 nient means of detection of plasmid-mediated AmpC beta-lactamases in organisms lacking a chromosomall

47 The diagnostic utility of the AmpC beta-lactamase inhibitors LN-2-128, 48-1220, and Sy

48 In particular, derepression of the AmpC beta-lactamase is a common mechanism of beta-lactam

49 Inducible expression of chromosomal AmpC beta-lactamase is a major cause of beta-lactam anti

50 boronic acid (BZB), a nanomolar inhibitor of AmpC beta-lactamase (K i = 27 nM), we have identified an

51 Understanding the nuances of AmpC beta-lactamase-mediated resistance can be challengi

52 ither the class C Citrobacter freundii CMY-2 AmpC beta-lactamase nor the class A TEM-1 beta-lactamase

53 ta-lactam antibiotics induce the chromosomal ampC beta-lactamase of many gram-negative bacteria.

54 ae P99, Klebsiella pneumoniae ACT-1, and the AmpC beta-lactamases of Enterobacter aerogenes, Morganel

55 wn quantities of purified enzymes in ELISAs (AmpC beta-lactamases of M. morganii, C. freundii, E. col

56 x, and periplasmic degradation (catalyzed by AmpC beta-lactamase) of these two compounds, and correla

57 m beta-lactamase (ESBL) and plasmid-mediated AmpC beta-lactamase (pAmpC) genes.

58 f Klebsiella spp. producing plasmid-mediated AmpC beta-lactamases (pAmpCs) was evaluated.

59 In patients with organisms hyperproducing AmpC beta-lactamases (positive by both methods), clinica

60 ity score matching of patients infected with AmpC beta-lactamase-positive organisms treated with cefe

61 extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase producers.

62 Lastly, we report the presence of the AmpC beta-lactamase producing gene (CITM) in 4.56% and 3

63 ctamase-producing Enterobacterales (ESBL-E), AmpC beta- lactamase-producing Enterobacterales (AmpC-E)

64 Here, guidance is provided for treating AmpC beta-lactamase-producing Enterobacterales (AmpC-E),

65 ctamase producing Enterobacterales (ESBL-E), AmpC beta-lactamase-producing Enterobacterales (AmpC-E),

66 Serratia marcescens is an opportunistic AmpC beta-lactamase-producing Enterobacterales associate

67 eam infections or pneumonia due to wild-type AmpC beta-lactamase-producing Enterobacterales, species

68 AmpC beta-lactamase-producing organisms are associated w

69 spectrum beta-lactamase-producing organisms, AmpC beta-lactamase-producing organisms, carbapenem-resi

70 the treatment of invasive infections due to AmpC beta-lactamase-producing organisms, particularly wh

71 eria, 96 (24%) had confirmed infections with AmpC beta-lactamase-producing organisms.

72 cloxacillin Etest to identify organisms with AmpC beta-lactamase production from February 2010 to Jan

73 vious microarray studies have shown that the AmpC beta-lactamase regulator AmpR, a member of the LysR

74 did not recognize TEM-1, K-1, OXA-1, or any AmpC beta-lactamase tested.

75 tion of organisms producing plasmid-mediated AmpC beta-lactamases, we evaluated the diagnostic utilit

76 Transferable AmpC beta-lactamases were detected in 3.3% of K. pneumon

77 Although plasmid-mediated AmpC beta-lactamases were first reported in the late 198

78 AmpC beta-lactamases were initially more dominant in Nor

79 , organisms producing ESBLs and transferable AmpC beta-lactamases were widespread.