ライフサイエンスコーパス: B-cell activating factor

1 ble cluster of differentiation 27) and BAFF (B-cell activating factor).

2 ifferentiation are substantially enhanced by B cell-activating factor.

3 family protein, which is inhibited by excess B cell-activating factor.

4 ion and an inflammatory milieu with elevated B cell-activating factor.

5 associated with liver inflammation and serum B cell-activating factor.

6 nance therapy with belimumab, an antibody to B-cell activating factor.

7 ly prolonged survival ex vivo independent of B cell activating factor and showed increased amounts of

8 Remarkably, both B cell-activating factor and CD40 ligand do not signific

9 eads to systemic inflammation with increased B cell-activating factor and IFN levels and induction of

10 for an abrogation of tolerance, no increased B cell-activating factor and IFN, and no IFN signature.

11 d B-cell counts, B-cell subset distribution, B cell-activating factor and immunoglobulin levels, and

12 d salivary glands and abnormal expression of B cell-activating factor and its receptors.

13 he formation of ectopic lymphoid structures (B-cell activating factor and B cell-attracting chemokine

14 ls are activated and primed for survival via B-cell activating factor and B-cell receptor-associated

15 The emergence of B-cell-activating factor and its related family members

16 incorporating the molecular adjuvants BAFF (B cell activating factor) and APRIL (a proliferation-ind

17 r necrosis factor (TNF) family ligands BAFF (B cell-activating factor) and APRIL (a proliferation-ind

18 ers, as well as B-cell survival factor BAFF (B-cell activating factor) and antiapoptotic molecule Bcl

19 lammation, splenic plasma cells, circulating B cell activating factor, and intragraft transcripts for

20 , including anti-CD20 monoclonal antibodies, B-cell-activating factor, and a proliferation-inducing l

21 or activator of NF-kB (RANK)-RANK ligand and B cell-activating factor-APRIL (a proliferation-inducing

22 We identified B-cell-activating factor as a protein that promoted B-ce

23 FLD, such as increased hepatic expression of B-cell-activating factor, augmented oxidative stress, an

24 Activation of the type I interferon/B cell-activating factor axis in SS has recently attract

25 ently to wild type in response to IgM, CD40, B cell-activating factor/B lymphocyte stimulator, CpG, a

26 At 2 years from transplantation, the B-cell activating factor/B-cell ratio was significantly

27 The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a t

28 mbinant RABV-based vaccine expressing murine B cell activating factor (BAFF) (rRABV-mBAFF).

29 The cytokine B cell activating factor (BAFF) and its receptor, BAFF r

30 he tumor necrosis factor (TNF) family member B cell activating factor (BAFF) binds B cells and enhanc

31 mbination excision circles (KRECs) and serum B cell activating factor (BAFF) in patients with humoral

32 The B cell activating factor (BAFF) inhibitor, belimumab, is

33 B cell activating factor (BAFF) is a crucial survival fa

34 B cell activating factor (BAFF) is essential for B cells

35 B cell activating factor (BAFF) plays a central role in

36 gulation of signals received through BCR and B cell activating factor (BAFF) receptor.

37 Cd138(+) plasma cells mediated by IL-10 and B cell activating factor (BAFF) signalling.

38 B cell activating factor (BAFF) signals through BAFF-R t

39 B cell activating factor (BAFF) stimulation of the BAFF

40 member 13B (B lymphocyte stimulator (BLyS), B cell activating factor (BAFF)) promotes primary B cell

41 B cell activating factor (BAFF), a ligand belonging to t

42 entiated a multimodal mechanism dependent on B cell activating factor (BAFF), leading to a proinflamm

43 neration of pathogenic ICOSL(+) B cell via a B cell activating factor (BAFF)-non-canonical NF-kappaB

44 gnaling serendipitously uncovered a role for B cell activating factor (BAFF).

45 ular cells (MRCs) rather than FDCs expressed B cell activating factor (BAFF).

46 cells proliferate to the prosurvival factor B cell activating factor (BAFF).

47 We show here that B cell-activating factor (BAFF) activates this second pa

48 roteins and B cell tropic factors, including B cell-activating factor (BAFF) and a proliferation-indu

49 periodontitis lesions, require the cytokines B cell-activating factor (BAFF) and A proliferation-indu

50 iated IgG-PB differentiation is dependent on B cell-activating factor (BAFF) and IL-10, whereas IgA-P

51 B cell-activating factor (BAFF) binds the three receptor

52 mpaired receptor editing and increased serum B cell-activating factor (BAFF) concentrations.

53 The B cell-activating factor (BAFF) cytokine family is a key

54 Given that B cell-activating factor (BAFF) is an integral aspect of

55 The B cell-activating factor (BAFF) is critical for B cell d

56 ents with cGVHD have significantly increased B cell-activating factor (BAFF) levels and that their B

57 e presence of alloantibodies and high plasma B cell-activating factor (BAFF) levels in patients with

58 t-versus-host disease (cGVHD) have increased B cell-activating factor (BAFF) levels, but whether BAFF

59 plasma cells, and a post-treatment surge in B cell-activating factor (BAFF) levels.

60 show that Btk also couples the receptor for B cell-activating factor (BAFF) of the TNF family (BAFF-

61 independent survival signals provided by the B cell-activating factor (BAFF) receptor (BAFF-R).

62 am of both the B cell receptor (BCR) and the B cell-activating factor (BAFF) receptor.

63 ets, elevated IgG autoantibody reactivity to B cell-activating factor (BAFF) was associated with SLE

64 ey found autoantibodies directed against the B cell-activating factor (BAFF) were associated with gre

65 als, the approval of belimumab (which blocks B cell-activating factor (BAFF)) for use in patients wit

66 Expression of B cell-activating factor (BAFF), a critical B cell survi

67 cathelicidin, interleukin 1 (IL-1), IL-4 and B cell-activating factor (BAFF), after IgD crosslinking.

68 B cell-activating factor (BAFF), part of a tumor necrosi

69 a proliferation-inducing ligand (APRIL) and B cell-activating factor (BAFF), tumor necrosis factor l

70 : belimumab, a monoclonal antibody targeting B cell-activating factor (BAFF).

71 1 monoclonal antibody targeting the cytokine B cell-activating factor (BAFF).

72 B cell dysfunctions, and one of these is the B cell-activating factor (BAFF).

73 ubsets, mirroring deficiency of the cytokine B cell-activating factor (BAFF).

74 is a novel splicing isoform of the regulator B cell-activating factor (BAFF, BLyS), a TNF family prot

75 The cytokine TNF family member B cell-activating factor (BAFF; also termed BLyS) is ess

76 B-cell activating factor (BAFF) and A proliferation-indu

77 The production of B-cell activating factor (BAFF) and other B-cell surviva

78 ectively evaluated B-cell subpopulations and B-cell activating factor (BAFF) in 136 patients (46 BOS,

79 We measured serum B-cell activating factor (BAFF) in 46 cGVHD patients rec

80 B-cell activating factor (BAFF) is an important cytokine

81 We hypothesized that high B-cell activating factor (BAFF) levels after rituximab c

82 B-cell activating factor (BAFF) single nucleotide polymo

83 B-cell activating factor (BAFF), a member of the TNF fam

84 pa B ligand (sRANKL), osteoprotegerin (OPG), B-cell activating factor (BAFF), and a proliferation-ind

85 ns, a proliferation-inducing ligand (APRIL), B-cell activating factor (BAFF), and soluble CD40 ligand

86 G), a proliferation-inducing ligand (APRIL), B-cell activating factor (BAFF), interleukin (IL)-6, and

87 of APRIL (a proliferation-inducing ligand), B-cell activating factor (BAFF), tumor necrosis factor-a

88 SF13B, encoding the cytokine and drug target B-cell activating factor (BAFF), was associated with mul

89 apoptosis and access to the B-cell cytokine, B-cell activating factor (BAFF), were essential.

90 tor receptor (BAFFR) expression and inhibits B-cell activating factor (BAFF)-induced B-cell survival

91 e genes included Tnfsf13b, which encodes the B-cell activating factor (BAFF).

92 e stimulator (BLyS), also referred to as the B-cell activating factor (BAFF).

93 ion between B/plasma cells, neutrophils, and B-cell activating factor (BAFF, aka TNFSF13B).

94 Emerging evidence indicates B-cell activating factor (BAFF, Tnfsf13b) to be an impor

95 However, the B-cell activating factor (BAFF/BlyS) may also be an impo

96 B-cell-activating factor (BAFF) and its receptor BAFF-R

97 B-cell-activating factor (BAFF) is associated with donor

98 Sustained increase in B-cell-activating factor (BAFF) mRNA in the CNS and BAFF

99 As a result, mutant TWEAK associated with B-cell-activating factor (BAFF) protein and down-regulat

100 -142(-/-) B cells express elevated levels of B-cell-activating factor (BAFF) receptor (BAFF-R) and as

101 ivation, as well as a defect in BCR-mediated B-cell-activating factor (BAFF) receptor up-regulation a

102 Recent studies have underscored the role of B-cell-activating factor (BAFF), a member of the tumor n

103 a proliferation-inducing ligand (APRIL) and B-cell-activating factor (BAFF), whereas removal of term

104 apacity of a therapeutic mAb and blockade of B-cell-activating factor (BAFF)-BR3 B-cell survival.

105 The B-cell-activating factor (BAFF)-receptor (BAFF-R) is res

106 Elevated B-cell-activating factor (BAFF; TNFSF13B) levels have be

107 e mated with mice transgenic (Tg) for CD257 (B-cell activating factor, BAFF) developed CD5(+) B-cell

108 The B cell activating factor belonging to the tumor necrosis

109 B cell-activating factor belonging to the TNF family (BA

110 ly sensitive to the combination of IL-21 and B cell-activating factor belonging to the TNF family (BA

111 Constitutive overexpression of B cell-activating factor belonging to the TNF family (BA

112 3dg-binding CD21/CD19 costimulatory complex, B cell-activating factor belonging to the TNF family (BA

113 The TNF-related ligand, B cell-activating factor belonging to the TNF family (BA

114 B cell-activating factor belonging to the TNF family (BA

115 The TNF family cytokine B cell-activating factor belonging to the TNF family (BA

116 B cell-activating factor belonging to the TNF family (BA

117 to influence Mvarphi phenotype by mediating B cell-activating factor belonging to the TNF family (BA

118 pecificity, NF-kappaB activation through the B cell-activating factor belonging to the TNF family (BA

119 The effects of B cell-activating factor belonging to the TNF family (BA

120 B cell-activating factor belonging to the TNF family rec

121 y, superimposing genetic deficiency of BAFF (B cell-activating factor belonging to the TNF family) on

122 nd is resistant to the survival factor BAFF (B cell-activating factor belonging to the TNF family).

123 microenvironment, including signals from the B cell-activating factor belonging to the TNF family/BLy

124 BAFF (B cell-activating factor belonging to the tumor necrosis

125 studies have defined a crucial role for the B cell-activating factor belonging to TNF family (BAFF;

126 pril (a proliferation-inducing ligand)/BAFF (B cell-activating factor belonging to TNF), albumin, cho

127 2 cells released the B-cell survival factor, B-cell activating factor belonging to the TNF family (BA

128 B-cell activating factor belonging to the tumor necrosis

129 ults suggest that macrophage- and DC-derived B-cell-activating factor belonging to the TNF family (BA

130 ith the potent B-cell survival factor BAFF ('B-cell-activating factor belonging to the TNF family') p

131 B-cell survival and maturation factor BAFF (B-cell-activating factor belonging to the tumor necrosis

132 w discusses some of the pertinent aspects of B-cell-activating factor biology and considers how recen

133 involved in B lymphocyte development, BAFF (B cell activating factor, BlyS, TALL-1, CD257, TNFSF13B)

134 ection from spontaneous apoptosis induced by B cell-activating factors CD40L, TNF-alpha, and fibronec

135 Total airway IgE correlated with B-cell activating factor concentrations.

136 Serum levels of B-cell activating factor correlate with laboratory indic

137 s were maintained in a manner different from B-cell-activating-factor-dependent p52/RelB regulation.

138 ction of the immunomodulatory cytokine BAFF (B-cell activating factor; encoded by the TNFSF13B gene),

139 its absence relieved B cells of the need for B cell activating factor for survival.

140 ession, and rendering B cells independent of B cell activating factor for survival.

141 family kinases, whereas it is independent of B-cell activating factor, IFN, and Toll-like receptor si

142 By neutralizing B cell-activating factor in vivo, we found an arrest in

143 n the role of APRIL and the related cytokine B-cell activating factor in several glomerular diseases,

144 eals a novel role for P62 in mediating BAFF (B-cell activating factor)-induced B1b cell proliferation

145 ction after B-cell receptor stimulation, and B-cell activating factor-induced nuclear factor kappaB2/

146 eukin-2 receptor alpha (sIL-2Ralpha), sCD27, B-cell activating factor, interferon gamma-induced prote

147 fic cytokines (insulin-like growth factor-1, B-cell activating factor, interleukin-6, interleukin-10)

148 (-) and CD21(low) B cells and a reduction in B cell-activating factor levels.

149 s against double-stranded DNA, and increased B cell-activating factor levels.

150 ere reduced despite slightly increased serum B cell-activating factor levels.

151 (eg, zoledronic acid, anti-DKK-1 MoAb, anti-B-cell activating factor MoAb and bortezomib, Btk inhibi

152 Mice overexpressing B cell activating factor of the TNF family (BAFF) develo

153 B cell activating factor of the TNF family (BAFF), also

154 BAFF (B cell activating factor of the TNF family, also known a

155 B cell activating factor of the tumor necrosis factor fa

156 e mice results in the elevated production of B cell-activating factor of the TNF family ((BAFF) also

157 d the functions of the TNF family cytokines, B cell-activating factor of the TNF family (BAFF) and a

158 non-Hodgkin's lymphoma (NHL) B cells express B cell-activating factor of the TNF family (BAFF) and a

159 The TNF family members B cell-activating factor of the TNF family (BAFF) and it

160 a proliferation-inducing ligand (APRIL) and B cell-activating factor of the TNF family (BAFF) but th

161 ther augmentation in mitogenic responses and B cell-activating factor of the TNF family (BAFF) recept

162 Herein we demonstrate that B cell-activating factor of the TNF family (BAFF), a B c

163 volved in the immunopathology of RA, such as B cell-activating factor of the TNF family (BAFF), ICOS

164 n requires additional signals from BCR and a B cell-activating factor of the TNF family (BAFF), produ

165 that they stained with mAb specific for the B cell-activating factor of the TNF family (BAFF; also c

166 is also associated with increased levels of B cell-activating factor of the TNF family (BAFF; also k

167 DC-produced survival factors such as B cell-activating factor of the TNF family and a prolife

168 B cell-activating factor of the TNF family and a prolife

169 In addition, LMP1 induces B cells to express B cell-activating factor of the TNF family and a prolife

170 The B cell-activating factor of the TNF family receptor (BAF

171 function are completely independent of BAFF (B cell-activating factor of the TNF family) or APRIL (a

172 IgG and IgA production was enhanced by BAFF (B cell-activating factor of the TNF family), an innate m

173 -4 or IL-10, whereas Ab secretion requires a B cell-activating factor of the TNF family.

174 nate and adaptive immune systems through the B cell-activating factor of the TNF family.

175 We examined expression of B cell-activating factor of the tumor necrosis factor (T

176 The ASC survival factors B cell-activating factor of the tumor necrosis factor (T

177 cell life depends critically on the cytokine B cell-activating factor of the tumor necrosis factor fa

178 rs of the B cell-activating TNF superfamily (B cell-activating factor of TNF family (BAFF) and a prol

179 we show that NF-kappaB activation induced by B cell-activating factor of tumor necrosis factor family

180 s express BR3, the specific receptor for the B cell-activating factor of tumor necrosis factor family

181 B cell-activating factor of tumor necrosis factor family

182 )) for APRIL and the closely related ligand, B-cell activating factor of the TNF family (BAFF), bind

183 The B-cell activating factor of the TNF family (BAFF), nucle

184 aling from the B-cell receptor (BCR) and the B-cell activating factor of the TNF family receptor (BAF

185 n of the effects of rituximab (anti-CD20) on B-cell-activating factor of the tumor necrosis factor fa

186 ein expression of NIK is steadily induced by B cell-activating factor or CD40 ligand, two major physi

187 lls (IgG(+)); and (5) both TNFRSF17 mRNA and B cell-activating factor protein were up-regulated.

188 Signaling from the BCR and B cell activating factor receptor (BAFF-R or BR3) differ

189 w here that PTP1B negatively regulates CD40, B cell activating factor receptor (BAFF-R), and TLR4 sig

190 eptors sensitive to trophic factors, such as B cell-activating factor receptor (BAFF-R or BR3) during

191 CD40 enhanced proliferation, whereas B cell-activating factor receptor (BAFF-R) and transmemb

192 ltaneous targeting of BCMA together with the B cell-activating factor receptor (BAFF-R).

193 quires cooperative signaling through BCR and B cell-activating factor receptor 3 (BR3).

194 pha activation lowered surface BCR, CD19 and B cell-activating factor receptor and increased expressi

195 ne production, proliferation of T cells, and B cell-activating factor receptor expression on B cells.

196 e Ptpn22, we show evidence for enhanced BCR, B cell-activating factor receptor, and CD40 coreceptor p

197 induced IL-15 production in B cells through B cell-activating factor receptor, whereas IL-15, a pote

198 sing functional itBreg cells in a CD40L- and B cell-activating factor receptor-dependent manner.

199 ing the myeloma-associated antigens BCMA and B-cell activating factor receptor (BAFF-R) failed to eli

200 Rather, high CD45 expression reduces B-cell activating factor receptor (BAFFR) expression and

201 (dpi) was more dominantly controlled by the B-cell-activating factor receptor (BAFF-R), a gene that

202 40, lymphotoxin beta receptor (LTbetaR), and B-cell-activating factor receptor (BAFF-R).

203 nalling of B-cell activation molecules CD69, B-cell-activating factor receptor, and transmembrane act

204 High-level soluble B-cell activating factor (sBAFF) was observed in kidney

205 The recruited neutrophils secreted a B cell-activating factor that highly accelerated plasma

206 The approval of anti-B cell activating factor therapy and an increasing body

207 Fo cells responded to AgR stimulation and to B cell activating factor, they displayed decreased survi

208 rated mediators, matrix metalloproteinase-9, B-cell activating factor, transforming growth factor-bet

209 of CLL or normal B cells with CD40-ligand or B-cell-activating factor upregulated miR-155 and enhance

210 ant CXCL13 was up-regulated >1,000-fold, and B cell-activating factor was also detected.

211 chemokines (CXCL13, CCL19, CCL21, CCL1, and B-cell-activating factor) was increased in pancreatic an

212 s such as a proliferation-inducing ligand or B cell-activating factor, which were constitutively expr