ライフサイエンスコーパス: B-cell number

1 ction in peripheral T cells without reducing B cell number.

2 n cGVHD mice were not merely a reflection of B-cell number.

3 ure B cells, resulting in reduced peripheral B cell numbers.

4 small lymph nodes with marked reductions in B cell numbers.

5 py is associated with variable diminution in B cell numbers.

6 mmunoglobulin levels and in mature and total B cell numbers.

7 d, to a greater extent, germinal center (GC) B cell numbers.

8 nsgenic mice do not show increases in thymic B cell numbers.

9 effects on B cell survival and marginal zone B cell numbers.

10 ved that NKG2D deficiency affects peripheral B cell numbers.

11 n for BLyS/Bcmd signals regulates follicular B cell numbers.

12 ld leukocytosis, including elevated immature B cell numbers.

13 eased marginal zone and decreased follicular B cell numbers.

14 odeficiency in mice characterized by reduced B cell numbers.

15 anin and OVA, as well as reduced Ag-specific B cell numbers.

16 he numbers of peripheral T cells, but normal B cell numbers.

17 is suboptimal immune recovery with low T and B cell numbers.

18 pulp area with a significant decline in the B cell numbers.

19 s together with an increase in marginal zone B cell numbers.

20 lvap deletion has no effect on IgM(+)IgD(lo) B cell numbers.

21 e mature B cells, albeit at >20-fold reduced B cell numbers.

22 tween peripheral blood eosinophil levels and B cell numbers.

23 mpared to controls despite normal peripheral B cell numbers.

24 e also associated with decreased circulating B cell numbers.

25 +) depletion triggered a potent expansion of B cell numbers.

26 ntibody levels and disease flare even at low B cell numbers.

27 bone marrow in an attempt to maintain normal B cell numbers.

28 nses are supported by close correlation with B cell numbers.

29 deletion of FADD led to increased peripheral B cell numbers.

30 s and increased Tfh cell and germinal center B-cell numbers.

31 at is associated with a striking decrease in B-cell numbers.

32 luate a subset of patients with CVID and low B-cell numbers.

33 with significantly higher CSF CD4, CD8, and B-cell numbers.

34 with a concomitant increase in transitional B-cell numbers.

35 ularly of CD8(+) T cells, and reduced memory B-cell numbers.

36 ing memory Treg cells, but not higher IgE(+) B-cell numbers.

37 kewing, with increased myeloid and decreased B-cell numbers.

38 f WASp+ T cells and limited correction in MZ B-cell numbers.

39 tment when most patients had recovered total B-cell numbers.

40 l increase in transitional and marginal zone B-cell numbers.

41 had higher total B and CD27(+) IgA(+) memory B-cell numbers (15.2% [95% CI 3.2; 28.7], 22.5% [95% CI

42 tive flow cytometry (HSFC), which can define B cell numbers 50-100 times lower than conventional tech

43 3 (KLF3, BKLF) increases marginal zone (MZ) B cell numbers, a phenotype shared with mice lacking KLF

44 c MLNs contain a 4.3-fold expansion in total B cell number and a 2.5-fold increased percentage of CD4

45 ese findings demonstrate that Klf4 regulates B cell number and activation-induced B cell proliferatio

46 IL-4 treatment nearly normalized B cell number and greatly increased the percentage of ma

47 The factor(s) responsible for the reduced B cell number and increased T cell infiltrate in T-cell-

48 ar helper cells, resulting in an increase in B cell numbers and Ab production.

49 greater airway dysfunction, while increased B cell numbers and altered monocyte subsets were associa

50 gly reduced late transitional and follicular B cell numbers and are essentially devoid of marginal zo

51 Inc.) is suggested by its marked effects on B cell numbers and autoantibody formation as well as the

52 resulted in increased splenic and lymph node B cell numbers and decreased peritoneal B1 cell numbers.

53 We found increased splenic B cell numbers and decreased surface IgM levels on matur

54 resent finding that anti-4-1BB mAb decreases B cell numbers and function.

55 lize circulating IgE, but also reduce IgE(+) B cell numbers and H chain transcripts.

56 nity as demonstrated by augmented CD4 TFH/GC B cell numbers and hastened islet allograft rejection in

57 nted human BLyS-induced increases in splenic B cell numbers and IgA titers.

58 ll-specific deletion of Glut1 led to reduced B cell numbers and impaired Ab production in vivo.

59 in hematopoietic stem cells severely reduced B cell numbers and impaired B cell development in a hema

60 e recurrent infections, despite normal T and B cell numbers and intact in vitro lymphocyte function.

61 on of serum autoantibody levels, normal host B cell numbers and MHC class II expression, reduced dono

62 of IFN-gamma in vivo substantially restored B cell numbers and partly restored IgG1/IgE.

63 ivo BLyS inhibition profoundly reduced naive B cell numbers and primary immune responses, it had a ma

64 B cell numbers and response to T cell-dependent antigens

65 Here, we observe an increase in follicular B cell numbers and selective recovery of the MZ B cell c

66 a longitudinal study to evaluate changes in B cell numbers and subpopulations that occur during the

67 apy (ART)-induced decrease in HIV viremia on B cell numbers and subpopulations.

68 DeltaBAFF transgenic mice had reduced B cell numbers and T cell-dependent Ab responses, but no

69 At the B cell level, R788 reduced total B cell numbers and total Ig concentrations.

70 ficant correlation between peripheral memory B-cell numbers and antibody levels for five of the eight

71 HSC-GT led to a progressive improvement in B-cell numbers and development, along with increased lev

72 The changes in B-cell numbers and IgA levels were blocked by simultaneo

73 B-cell numbers and immunoglobulin (Ig) titers can increa

74 differed from that seen in circulating naive B-cell numbers and in a cross-platform biomarker analysi

75 ration of BAFFR-Fc in mice reduced pulmonary B-cell numbers and prevented CS-induced formation of lym

76 nfants' blood samples were also analyzed for B-cell numbers and proportions of CD5(+) and CD27(+) B c

77 rrent respiratory tract infections, very low B-cell numbers and serum IgA levels.

78 es, decreased T cell infiltration, increased B cell numbers, and decreased macrophage recruitment.

79 loped low white blood cell counts, decreased B-cell numbers, anemia, and reduced survival.

80 Less drastic reductions in marginal zone B cell numbers are also seen in the spleens of recombina

81 Variations in B cell numbers are associated with polycystic ovary synd

82 Although transitional immature type 1 (T1) B cell numbers are normal in Bim(-/-) mice, T2 and folli

83 Before immunization, bone marrow B cell numbers are very low, and peripheral lymphoid org

84 natural killer (NK)-cells are decreased but B-cell numbers are normal (T(-)B(+)NK(-)SCID).

85 his plasticity and despite constant renewal, B-cell numbers are stable in the absence of immunization

86 In HG patients, total B-cell numbers, as well as IgA + and IgG + switched memo

87 se model, we show that despite reduced total B cell numbers, B cell development in these mice occurs

88 e causes a progressive decline in peripheral B cell numbers, beginning at the transitional 1 developm

89 ted with B cell numbers, with flare at lower B cell numbers being associated with the highest BAFF le

90 in life, Rasgrp1-deficient mice have normal B cell numbers but are T lymphopenic, leading to defecti

91 D mice, btk deficiency only modestly reduces B cell numbers, but dramatically protects against diabet

92 y, the bone marrow (BM) had reduced immature B cell numbers, but normal numbers of pro-B cells.

93 s (82-99%), and reduced mature recirculating B cell numbers by 75-85%.

94 reatment in 5-wk-old NOD female mice reduced B cell numbers by approximately 95%, decreased subsequen

95 for the bone loss as well as the increase in B cell number caused by estrogen deficiency.

96 the patients in whom the marked decrease in B cell numbers characteristic of XLA could not be confir

97 t L chain receptor editing responses and had B cell numbers comparable to those found in animals lack

98 Treg, Treg-memory, and CD27(+) IgA(+) memory B-cell numbers compared to children without atopic disea

99 arly increases in regulatory IL-10-producing B-cell numbers compared with noncognate activation.

100 icant decrease in absolute live or total CLL B-cell numbers, confirming that trogocytosis occurs, rat

101 MLN B cell numbers correlate with ileitis severity in SAMP1/

102 of all mature B-cell subsets, but follicular B-cell numbers could be largely rescued by ectopic expre

103 Although total B-cell number did not differ significantly between cGVHD

104 or repeated vaccinations were common, memory B-cell numbers did not correlate with antibody titers.

105 While peripheral B-cell numbers do not decline with aging, the compositio

106 etion increases bacterial burden and reduces B cell numbers, IgG release, and neutrophil stimulation.

107 llowed for at least 24 months had sufficient B-cell numbers, IgM concentration, or IgM isohemagglutin

108 n Glut1 and Mcl-1 levels, glucose uptake and B cell number in the absence of TRAF3 were all dependent

109 ernative NF-kappaB activation and peripheral B cell numbers in a BAFF-R-dependent manner, whereas unc

110 d that conditions associated with reduced MZ B cell numbers in adult mice cause increased cDC2 occupa

111 ormal in TTT/AAA beta2-integrin KI mice, but B cell numbers in lymph nodes and IgG and IgM production

112 ciated with drastic reductions in peripheral B cell numbers in Mdm2(+/-)E micro -myc transgenics, and

113 tage onwards and severely diminished splenic B cell numbers in mice.

114 cy enhanced CD4 TFH and germinal center (GC) B cell numbers in naive mice and hastened islet allograf

115 analyzed various molecular markers of T and B cell numbers in neonatal dried blood spots of 99 child

116 hese changes produced a drastic reduction in B cell numbers in spleen and blood, and a novel increase

117 ion in Ab titers correlates with the reduced B cell numbers in the mutant mice.

118 Total B cell numbers in the periphery were not significantly a

119 ited to a single normal D(H) achieved normal B cell numbers in the periphery, mice forced to preferen

120 tro and limit T(FH) cell and germinal center B cell numbers in vivo.

121 trabecular bone (-61%), and markedly reduced B-cell number in the marrow (-52%) and blood (-36%) comp

122 CD4 T-cell and CD20 B-cell numbers in blood were determined.

123 Similar to CD4(+) but not CD8(+) T cells, B-cell numbers in both groups increased significantly af

124 sociations of higher Treg and CD27(+) IgA(+) B-cell numbers in children with food-allergic sensitizat

125 ch did not show decreases in CD4+, CD8+, and B-cell numbers in the pancreas and draining lymph nodes,

126 in the bone marrow and an increase in normal B-cell numbers in the peripheral blood.

127 atients had stable/improved cGVHD, and total B-cell numbers in these patients were significantly high

128 The cEmu(Delta/Delta) mice had reduced B cell numbers, in association with impaired D to J(H) a

129 In response to a high-cholesterol diet, IRA B cell numbers increase preferentially in secondary lymp

130 bers were also halved, whereas marginal zone B cell numbers increased.

131 The increase in splenic B cell number is IL-4 dose dependent, CD4+ T cell indepe

132 eover, they suggest that estrogen control of B cell number is indirect via osteocytes and that the in

133 Maintenance of thymic B cell number is strongly dependent on B cell-autonomous

134 e is delayed; however, a marked reduction in B-cell numbers is consistent in all patients.

135 igation activity and severely reduced mature B cell numbers, Lig4(R278H/R278H) (Lig4(R/R)) mice exhib

136 especially robust increases in transitional B cell number, marginal zone B cell proliferation, and C

137 with loss of serum Igs: 1) increased splenic B-cell numbers, mostly of the B1 and marginal zone (MZ)

138 t recirculation accounts for the decrease in B cell numbers observed in secondary lymphoid organs.

139 Recovery of CD27+ memory B cell number occurred in a median of 15.7 months (inter

140 en receptor alpha from B cells did not alter B cell number or bone mass and did not alter the respons

141 ions of autoreactive B cells, we found total B cell numbers paradoxically reduced in HCV-infected pat

142 /(-) mice was not due to reductions in early B cell numbers prior to disease onset.

143 Total B cell numbers, proportions of CD5(+) and CD27(+) B cell

144 e patients with the highest gene marking and B-cell numbers remain off immunoglobulin replacement the

145 loid cell numbers dramatically increased and B-cell numbers severely diminished.

146 H. pylori or A. lwoffii, the mucosal T- and B-cell numbers significantly increased.

147 Notch2(+/-)/NOD have MZ B cell numbers similar to those of wild-type C57BL/6, ye

148 l center formation and reduced marginal zone B cell numbers, similar to a pan-class I inhibitor.

149 Whereas in smokers B-cell numbers slightly increased, robust increases in B

150 ow, concomitant with the increase in splenic B cell number, suggest that redistribution of circulatin

151 n had a approximately 50% loss in follicular B cell numbers, suggesting that escape from central tole

152 The marked reduction in splenic B cell number suggests that selected LamH-Cmu H chain an

153 of antiviral Ab responses, including splenic B cell numbers, survival and function of adoptively tran

154 Ab treatment led to a 1000-fold reduction in B cell number that lasted 6 wk.

155 models lacking RANK or RANKL show defects in B cell number, the role of the RANKL-RANK axis on B phys

156 Thus, IL-4 increases splenic B cell number through two Stat6-independent effects: inc

157 of ER protein folding capacity and increased B-cell number through survival pathways and cell replica

158 tor 11 (GDF11), nodal], and the expansion of B-cell number through various mechanisms including trans

159 troduction of Rel protein restored wild-type B cell numbers to mice reconstituted with PU.1(+/-)Spi-B

160 with cOX6 significantly reduced circulating B cell numbers until day 5.

161 Finally, GzmB(+) B-cell number was dependent on IL-21 production, and B c

162 Although peripheral B cell numbers were markedly reduced, differentiation in

163 LNs and mature follicular and marginal zone B cell numbers were markedly reduced.

164 B cell numbers were measured by highly sensitive flow cy

165 Strikingly, while mature B cell numbers were normal, LNs were completely absent i

166 Although mature B cell numbers were only mildly reduced, bone marrow B c

167 Importantly, anti-insulin B cell numbers were reduced by Btk deficiency, but not N

168 While mature B cell numbers were significantly reduced in Ikka(Vav) m

169 IgM(+) (70-80%), but IgA(+) (and not IgG(+)) B-cell numbers were increased in LFs from severe COPD co

170 splantation, with no IS, CD4 T-cell and CD20 B-cell numbers were increased, but were reduced by IS.In

171 Blood transitional B-cell numbers were normal, but naive mature and memory

172 Total blood B-cell numbers were normal, CD27(+) memory B cells were

173 B cells was still abrogated, but follicular B-cell numbers were only mildly affected.

174 Still, blood memory B-cell numbers were reduced and showed impaired molecula

175 ers were normal, but naive mature and memory B-cell numbers were reduced despite slightly increased s

176 ffect of 5 days of IL-4 treatment on splenic B cell number when B lymphopoiesis is blocked with anti-

177 urvival was studied by evaluating changes in B cell number when lymphopoiesis was suppressed with ant

178 p300 led to surprisingly modest deficits in B-cell numbers, whereas inactivation of both genes was n

179 o a pronounced global reduction in mature B2 B cell numbers, which correlated with impaired survival

180 and influenza heamaglutinin-specific memory B-cell numbers, which phenotypically differs from vaccin

181 By contrast, DeltaBAFF/3H9 mice had reduced B cell numbers with a repertoire similar to that of 3H9

182 acteristic shift in dark zone and light zone B cell numbers, with an increase of B cells in the dark

183 m BAFF levels were inversely correlated with B cell numbers, with flare at lower B cell numbers being