ライフサイエンスコーパス: B-cell subset

1 revealed that they were enriched in a CD9(+) B cell subset.

2 e activation and temporary expansion of this B cell subset.

3 strong orientation toward the marginal zone B cell subset.

4 ting in a reduction in the size of the naive B cell subset.

5 ecognized CD5(+)CD27(+) post-germinal center B cell subset.

6 cells, suggesting an important role for this B cell subset.

7 L) are highly suggestive that they are a new B cell subset.

8 organ cellularity, most prominent among the B-cell subset.

9 is associated with the apoptosis of multiple B cell subsets.

10 7(-)IgM(+), CD27(+)IgM(+), and CD27(+)IgG(+) B cell subsets.

11 inders from the follicular and marginal zone B cell subsets.

12 rongest proliferative response of all memory B cell subsets.

13 ing a chemotactic effect of eotaxin on these B cell subsets.

14 turation status of human CD21/CD24 nonmemory B cell subsets.

15 sequent changes in proportions of individual B cell subsets.

16 are expressed at different levels by various B cell subsets.

17 elatively constant level throughout numerous B cell subsets.

18 transitional and anergic IgD(+)IgM(-)CD27(-) B cell subsets.

19 4(high)CD21(low)) and T2 (CD24(high)CD21(+)) B cell subsets.

20 duced the highest c-Rel protein levels among B cell subsets.

21 ng fungal load that was independent of T and B cell subsets.

22 vely selected into the marginal zone and B-1 B cell subsets.

23 on sites in Ab V regions of naive and memory B cell subsets.

24 shape the epigenome of expanded SLE effector B cell subsets.

25 etermine how CD19 affects CNS recruitment of B cell subsets.

26 mainly derive from T cell-independent innate B cell subsets.

27 hat seen in old follicular and marginal zone B cell subsets.

28 ies have mainly focused on B1 and follicular B cell subsets.

29 B1 cell BCR signaling is distinct from other B cell subsets.

30 related genes and the relative expansions of B cell subsets.

31 the four main human IgM(+) and IgG(+) memory B-cell subsets.

32 ression of IL-10 and are enriched in various B-cell subsets.

33 ing plasma cells and 2 IgE-expressing memory B-cell subsets.

34 uppressive capacity of both memory and naive B-cell subsets.

35 n and internalization of cross-linked BCR in B-cell subsets.

36 ancreatic and splenic suppressive FasL(high) B-cell subsets.

37 regulated signatures compared with the other B-cell subsets.

38 g in vivo BAFF dependence of these 2 CD27(+) B-cell subsets.

39 ular kinases identified activation status of B-cell subsets.

40 4(+) T-cell reduction, and changes in T- and B-cell subsets.

41 to determine the frequencies of circulating B-cell subsets.

42 eceptor expression in newly formed and naive B-cell subsets.

43 lular immunity, involving various T-cell and B-cell subsets.

44 WM patients in relation to normal plasma and B-cell subsets.

45 ptor after CD40 engagement compared to other B-cell subsets.

46 BCR-mediated apoptosis of the T1 B cell subset, a major checkpoint for negative selection

47 nct kinetics of proliferation for individual B cell subsets across all developmental stages.

48 examined the dynamics of BAFF induction and B cell subset activation and composition, to investigate

49 both the CD27(+) memory population and naive B cell subset after only a brief stimulation in vitro.

50 A newly discovered B cell subset, age-associated B cells, expresses the tra

51 ndard immunophenotyping of circulating human B cell subsets, an in vitro CFSE dilution assay was used

52 dies to polysaccharide antigens by the human B-cell subset analog to murine B-1 cells was reported in

53 The B cell subset analysis confirmed earlier reports of high

54 signaling, demonstrate dependence of the T3 B cell subset and IgM surface expression on BTK activity

55 2B low/neg cells in the CD27(+)IgD(-) memory B cell subset and that these changes are associated with

56 s associated with normalization of activated B cell subsets and allows age-dependent accumulation of

57 ress the highest levels of FcgammaRIIb among B cell subsets and are highly susceptible to FcgammaRIIb

58 ich is suitable for longitudinal studies and B cell subsets and biomarkers discovery.

59 ptosis and is shared by all preimmune murine B cell subsets and CD27- human B cells.

60 surface expression of BTLA on various human B cell subsets and confirm its ability to attenuate B ce

61 (T1) stage and leads to a decrease in mature B cell subsets and deficits in T cell-dependent antibody

62 We determined the proportion of B cell subsets and frequencies of Ag-specific memory B c

63 develop normal B1 and B2 immature and mature B cell subsets and have normal levels of naive serum Abs

64 , several correlations were observed between B cell subsets and liver function.

65 ht the phenotypic heterogeneity of innate B1 B cell subsets and of their possible fates in a relevant

66 and activated NK cells, differentiated T and B cell subsets and proinflammatory monocytes, suggesting

67 isolation of antibodies from all peripheral B cell subsets and revealed the anti-BK virus antibody r

68 ar to a previously described FCRL4(+) memory B-cell subset and to an "exhausted," anergic CD21(low) m

69 ns and thymi from 3-week-old pups for T- and B-cell subsets and epithelial cells did not show any sig

70 identified differential effects of different B-cell subsets and helped to clarify the still poorly un

71 n of anti-PS antibodies or anemia with other B-cell subsets and no association of other antibody spec

72 authors studied by flow cytometry peripheral B-cell subsets and serum levels of BAFF, the main homeos

73 intain stable relative levels of circulating B cell subsets, and a potential mechanism for viral rese

74 atory biomarkers, the proportions of various B cell subsets, and fetal priming to tetanus vaccination

75 ntly up-regulated on monocytes, neutrophils, B cell subsets, and plasma cells in multiple murine mode

76 y receptor on T cells, natural killer cells, B cell subsets, and some dendritic cells.

77 Leukocytes, B-cell subsets, and DSA were measured using flow cytomet

78 chemistry of tissue, flow cytometry of blood B-cell subsets, and serum immunoglobulin levels.

79 ggressive B-cell lymphomas (n = 138), normal B-cell subsets, and stromal cells.

80 replasma and plasma B cells, newly developed B-cell subsets, and their apoptosis was performed 30-60

81 tors regulating Ab production by this unique B cell subset are not well understood.

82 iral replication and alterations in distinct B cell subsets are largely unknown.

83 peripheral B cell compartment, although all B cell subsets are present in relatively normal ratios.

84 asmablast B-cell development, and that these B-cell subsets are dependent on T-cell-derived signals t

85 g cells resided mainly in the CD19(+) CD5(-) B cell subset, as assessed by enzyme-linked immunosorben

86 We sought to define the frequency of B-cell subsets associated with progressive B-cell matura

87 study characterizes longitudinal changes in B cell subsets at both infected anatomical sites.

88 tic stem cell (HSC) gives rise to all of the B-cell subsets [B-1a, B-1b, B-2, and marginal zone (MZ)

89 IL-10-producing CD1d(high)CD5(+) regulatory B cell subset (B10 cells) have been identified during th

90 epleted, particularly a rare IL-10-producing B cell subset (B10 cells) known to regulate inflammation

91 a rare IL-10-producing CD1dhiCD5+ regulatory B cell subset (B10 cells), since the adoptive transfer o

92 Of the major peripheral B cell subsets, B1a cells were most prominently affected

93 Flow cytometry was used to analyze CD19(+) B cell subsets based on the expression of CD24 and CD38.

94 aluated phenotypic definition of circulating B-cell subsets before and after standard of care and B-c

95 trols, but there was no difference in memory B cells subsets between controls and splenectomized subj

96 This results in significant loss of B cell subsets beyond the T1 stage and disrupted humoral

97 ll compartment with a normal distribution of B-cell subsets both in bone marrow and the periphery, sh

98 t change other previously defined regulatory B-cell subsets (Breg), including CD5CD1d Breg or express

99 antibody results in significant depletion of B cell subsets but does not affect anti-peanut IgE level

100 shared with other mature perinatal or adult B cell subsets but were either unique or variably shared

101 onfer regulatory functions to various mature B-cell subsets but immature B-cell progenitors endowed w

102 L-10 production was not confined to a single B-cell subset, but enriched in both the CD24(hi)CD27(+)

103 erely inhibited the generation of all mature B-cell subsets, but follicular B-cell numbers could be l

104 Thy-1 autoreactive (ATA) BCR cells in the B1 B cell subset by transgenic expression yielded spontaneo

105 were used to identify C. neoformans-binding B cell subsets by flow cytometry.

106 on at the protein level was confirmed in UCB B cell subsets by intracellular staining and flow cytome

107 cent studies in Hep-2 cells; quantitation of B-cell subsets by means of flow cytometry; assessments o

108 depletion of the IL-10-producing regulatory B cell subset called B10 cells.

109 However, specific B-cell subsets can also negatively regulate T-cell immun

110 Specific B-cell subsets can regulate T-cell immune responses, and

111 B cells in three circulating naive or memory B cell subsets (CD19+IgD+CD27-, CD19+IgD+CD27+, or CD19+

112 , depletion of the prominent IL-10-producing B-cell subset, CD1d(hi) cells, resulted in less IL-10(+)

113 characterized a distinct, late transitional B cell subset, CD21(int) transitional 2 (T2) B cells.

114 longitudinal study of its kind, we measured B cell subset composition, as well as PfEMP1-specific Ab

115 We studied blood B-cell subset composition, replication history, somatic

116 ve immune cells, including myriad T-cell and B-cell subsets, compound these complexities.

117 ormed high-throughput VH sequencing of human B cell subsets defined by IgD and CD27 expression: IgD(+

118 tometry analysis of the splenic transitional B cell subsets demonstrated that MZ B cell development w

119 tuted with T2-MZP B cells but not with other B cell subsets displayed accelerated tumor growth, demon

120 We evaluated B-cell counts, B-cell subset distribution, B cell-activating factor and

121 cells contributed to the alterations in the B-cell subset distribution.

122 to analyze the potential association between B-cell subsets distribution and anti-HLA antibodies befo

123 e study aimed to verify the relation between B cell subsets' distribution and liver disease progressi

124 Distinct skin-associated B cell subsets drive or suppress cutaneous inflammatory

125 Localized functions of skin-associated B cell subsets during inflammation comprise Ab productio

126 on signals driving CNS migration of distinct B cell subsets during neuroinflammatory insults is criti

127 egulating differentiation and maintenance of B-cell subsets during an immune response is unclear.

128 nse to this virus is contributed by multiple B cell subsets, each generating qualitatively distinct r

129 for the existence of different transitional B-cell subsets, each displaying unique phenotypic and re

130 Among B cell subsets, elevated frequencies of memory and plasm

131 Importantly, not all B cell subsets enhance immune responses.

132 ntrast, ATA B-CLL did not develop from other B cell subsets, even when the identical ATA BCR was expr

133 ction in each of the major mature peripheral B-cell subsets, exerting the greatest impact on marginal

134 Furthermore, these B cell subsets exhibited an increased steady state dwell

135 in which the major immunoglobulin M (IgM(+)) B-cell subset expresses green fluorescence protein (GFP)

136 B cell subsets expressing the transcription factor T-bet

137 Here we report a novel B-cell subset expressing 4-1BBL, which increases with ag

138 CD19 B-cell subsets expressing cell surface kappa and lambda

139 The predominant B-cell subset found in trout NALT are IgT(+) B cells, si

140 Immature transitional and mature activated B cell subset frequencies were increased in HCV-infected

141 re activated, tissue-like memory, and plasma B cell subset frequencies, cell cycling, and intrinsic a

142 nd malaria exposure and also correlated with B cell subset frequencies.

143 ne cells, we performed RNA-seq in T cell and B cell subsets from either healthy donors or patients wi

144 criptome analyses of CLL and the main normal B cell subsets from human blood and spleen revealed that

145 B-cell subsets from healthy individuals and patients wit

146 e markedly impaired in both naive and memory B-cell subsets from HIV-infected persons.

147 subsets, including a newly defined effector B cell subset, from subjects with SLE and healthy contro

148 For clarity, this regulatory B cell subset has been labeled as B10 cells, because the

149 The age-associated B cell subset has been the focus of increasing interest

150 A number of different B cell subsets have been shown to exhibit regulatory act

151 The normal B-cell subsets have well-defined miRNA signatures.

152 es that altered distribution of transitional B-cell subsets highlights different regulatory defects i

153 studied lncRNA expression patterns in normal B-cell subsets, HL cell lines, and tissues.

154 he role of serum Igs in maintaining specific B-cell subset homeostasis at steady state.

155 ciated with an accumulation of heterogeneous B cell subsets; however, their influence on viral load a

156 of two major, functionally distinct, mature B cell subsets, i.e., follicular mature (FM) and margina

157 Mature B-cell subsets, immune responses, and memory B-cell and

158 ave been shown to be an important regulatory B cell subset in humans.

159 l features revealed activation of T cell and B cell subsets in a proportion of patients.

160 s, the proportions of naive and memory T and B cell subsets in A-T patients did not vary in relation

161 Examination of splenic and BM B cell subsets in CD22 and ST6Gal-I knockout mice reveal

162 the characterization of autoantigen-specific B cell subsets in different models of autoimmunity and,

163 hat different Borrelia can activate the same B cell subsets in distinct ways and they each elicit a c

164 g cytokine-producing regulatory and effector B cell subsets in health and disease and discuss how fut

165 ow that changes in P. falciparum Ag-specific B cell subsets in HIV-infected individuals mirror those

166 d CD24 distinguishes transitional and mature B cell subsets in mice.

167 Additionally, the monitoring of individual B cell subsets in patients may lead to the discovery of

168 well as the proportion and numbers of major B cell subsets in peripheral lymphoid organs, was unaffe

169 serologic activity and reduce BLyS-dependent B cell subsets in serologically and clinically active SL

170 a B cells are greatly expanded into effector B cell subsets in some autoimmune mice, thus indicating

171 plex interplay of MZ and multiple peritoneal B cell subsets in the early response to infection.

172 e findings demonstrate the plasticity of the B cell subsets in virus-infected hosts and show for the

173 to an "exhausted," anergic CD21(low) memory B-cell subset in HIV(+) patients.

174 However, the significance of this B-cell subset in humans is poorly understood.

175 ound that IgT(+) B cells represent the major B-cell subset in the skin epidermis and that IgT is main

176 linked immunospot assay (ELISPOT) to examine B-cell subsets in 59 subjects, including 28 with PBC, 13

177 We analyzed the reconstitution kinetics of B-cell subsets in adult leukemic patients within 6 month

178 t in our understanding of the role of T- and B-cell subsets in atherosclerosis and addresses the role

179 eriphery, (ii) expansion of CD80+ and CD62L- B-cell subsets in BM and the periphery, and (iii) a sign

180 ory and CD19(+)CD24(hi)CD38(hi) transitional B-cell subsets in healthy human donors.

181 The role of B-cell subsets in human leukocyte antigen (HLA)-specific

182 d heavy-chain genes from immature and mature B-cell subsets in mice, we demonstrate a striking gradie

183 mpaired humoral response, we assessed memory B-cell subsets in paired samples collected before and af

184 We studied the distribution of peripheral B-cell subsets in patients deficient for key factors of

185 ic differentiation is skewed toward specific B-cell subsets in the embryo are unanswered questions, b

186 ant early depletion of both naive and memory B-cell subsets in the peripheral blood, with differentia

187 itors in the bone marrow and of transitional B-cell subsets in the spleen.

188 ore, the altered numbers of naive and memory B-cell subsets in these animals corresponded with increa

189 , whereas they clearly populate 1% of mature B-cell subsets in VH125Tg/NOD mice.

190 profiles and transcriptomes from five human B cell subsets, including a newly defined effector B cel

191 Remarkably, all B cell subsets, including even transitional 1 B cells, w

192 rations were associated with an imbalance in B-cell subsets, including a significant decrease in memo

193 with CD19-Cre and found that all peripheral B-cell subsets, including B1 B cells, require YY1 for th

194 inct DNA methylation signatures specific for B-cell subsets, including memory B cells (MBCs) and plas

195 HISmice contain several B-cell subsets, including those with the phenotype CD20(

196 rthermore, B2 cells, in the absence of other B-cell subsets, increase splenic regulatory T-cell popul

197 dicated by a marked disruption of peripheral B cell subsets, increased levels of PD-1 expression, and

198 of ART restored the typical distribution of B cell subsets, increasing the proportion of naive B cel

199 variably designed to deplete specific T and B cell subsets, interrupt receptor-ligand interactions,

200 Thus, by bolstering the IgM(+)IgD(+)CD27(+) B-cell subset, IRAK-4 and MyD88 promote optimal T-indepe

201 In addition, the percentage of a B cell subset is significantly lower in the non-responde

202 This B-cell subset is IgM(+), but due to low/negative IgD cel

203 ever, proinflammatory cytokine expression in B-cell subsets is largely unexplored.

204 partment and the relationship between memory B-cell subsets is still limited, although these are cent

205 -17, interferon-gamma and differential T and B cell subset lymphopenia.

206 ocystis challenge, suggesting that different B cell subsets may be responsible for the generation of

207 The reported microarray analysis of human B cell subsets may now be used to delineate B cell defec

208 und humoral immunodeficiency and lack mature B cell subsets, mirroring deficiency of the cytokine B c

209 In transcriptionally profiled normal B-cell subsets (naive, germinal center, and memory B cel

210 munity, neither the initiating event nor the B cell subset necessary for WP formation has been identi

211 for autoreactivity, and an expansion of this B cell subset occurs in several mouse models of lupus.

212 boost of 2 clonally and functionally related B-cell subsets of short-lived IgE(+) plasmablasts and Ig

213 proliferation and differentiation of various B cell subsets on TLR stimulation.

214 ejection and pretransplant proportion of any B-cell subset or BAFF serum levels.

215 specifically in CLL but not in normal mature B-cell subsets or after B-cell activation.

216 n), proportion of Bm2 cells but not of other B-cell subsets or BAFF levels was independently associat

217 e global quantitative recovery of T-cell and B-cell subsets or in global T-cell and B-cell function.

218 e or particulation, selective recruitment of B cell subsets, or activation and recruitment of Pn prot

219 The roles distinct B cell subsets play in clonal expansion, isotype switchi

220 B cells play in establishing, and the roles B cell subsets play in maintaining lifelong anti-peanut

221 ctions with regard to dynamics of the memory B cell subsets point to their role in the pathogenesis o

222 Gene expression profiling of different B-cell subsets positioned the phenotype of putative B-1

223 n leads to an abnormally expanded CD5(+) B1a B-cell subset (present as early as 4 days after birth),

224 re enriched in the IgM(high)CD5(+)CD1d(high) B cell subset previously reported to contain a higher fr

225 To investigate whether perturbation of B cell subsets prior to immunization with recombinant En

226 are still unknown, we studied five precursor B cell subsets (ProB, PreBI, PreBII large, PreBII small,

227 In allergy, some regulatory B-cell subsets producing IL-10 have been recently descri

228 st an important role of BAFF in facilitating B cell subset proliferation and redistribution as a cons

229 rine B-1b and primate IgM(+)CD27(+) "memory" B cell subsets proposed to produce TI-2 Ab responses may

230 Some B cell subsets provide extensive cross-protection agains

231 However, specific regulatory B cell subsets recently were identified that downregulat

232 One functional B cell subset, regulatory B cells (Bregs), has recently

233 l and mature B cell recovery, whereas memory B cell subsets remained significantly depleted.

234 We studied peripheral B- and T-cell subsets, B-cell subset replication history, somatic hypermutation

235 mory T and B cells may limit MS, rapid CD19+ B-cell subset repopulation in the absence of effective T

236 low cytometric analysis of tetramer-reactive B cell subsets revealed a significantly higher frequency

237 Further, paired CSF and blood B cell subsets (RRMS; n = 7) were isolated using fluores

238 In NOD, btk deficiency mirrors changes in B cell subsets seen in other strains, but also improves

239 memory B cells and the activation of sorted B cell subsets shows that GA-dependent increased Breg ce

240 In chronic viral infections, the deranged B cell subset signifies uncontrolled disease.

241 infection, a state of activation results in B cell subset skewing that is likely the result of alter

242 Second, we examined colonization by EBV of B-cell subsets sorted from a unique collection of IM ton

243 on, the peripheral CD19CD24CD38 transitional B cell subset strongly declined, regardless of the subse

244 vels of eotaxin receptor CCR3 than the other B cell subsets, suggesting a chemotactic effect of eotax

245 s impaired TLR-induced proliferation of this B-cell subset, suggesting a means by which loss of this

246 identified IL-10-competent CD1d(high)CD5(+) B cell subset termed B10 cells that represents 1-3% of a

247 a cells and also the enigmatic marginal zone B cell subset that is poorly understood in humans.

248 Marginal zone B cells (MZB) are a mature B cell subset that rapidly respond to blood-borne pathog

249 al center fate, and we identified a CD11c(+) B cell subset that was not capable of producing IL-10 ev

250 erstanding of the abundance and phenotype of B cell subsets that are induced or perturbed by exogenou

251 Better understanding of the B cell subsets that are responsible for the development

252 ere is also mounting evidence for regulatory B cell subsets that may play a protective role.

253 We have discovered a distinct mature B-cell subset that accumulates with age, which we have t

254 Thus, we have identified a new B-cell subset that is critical for immunological toleran

255 in this issue of Blood, identified a pre-pro-B-cell subset that marks the earliest stages of B-cell l

256 and genetic approaches, we discovered a new B-cell subset that, upon adoptive transfer into B cell-d

257 cted individuals, focusing on the skewing of B-cell subsets that circulate in the peripheral blood an

258 Phenotype of T- and B-cell subsets that expand during the early stages of nu

259 by the functional balance between different B-cell subsets that may be generated by this therapeutic

260 epleting antibody rituximab, the size of all B cell subsets, the T1/T2-ratio, and the cyroglobulin le

261 pite sharing some features with other mature B-cell subsets, they are refractory to BCR and CD40 stim

262 clones in MC and lymphomas derive from this B-cell subset, this establishes IgM(+) memory B cells as

263 e cells self-renew and persist as a minor B1 B cell subset throughout life.

264 tics of LANA/EBNA-1 expression in individual B-cell subsets throughout a course of infection has not

265 ll lymphomas, indicating sensitivity of this B cell subset to transformation caused by p53 deficiency

266 Indeed, disturbances in the ability of B cell subsets to present antigen, produce cytokines, an

267 how viral gene products function in specific B cell subsets to regulate this process is incomplete.

268 The contribution of MZ and Fo B cell subsets to this antiviral TI-2 response, however,

269 nerated IgE(+) cells, the capacity of tonsil B-cell subsets to generate IgE(+) PCs and the class swit

270 Here we demonstrate that memory B cell subsets unexpectedly diverged across antibody cla

271 mononuclear cells were quantified for T and B cell subsets using flow cytometry, and serum cytokine

272 skewing (lower T1/T2-ratio) of the immature B cell subset was noted in MC patients, suggesting that

273 ution of HIV-specific responses among memory B cell subsets was corroborated by transcriptional analy

274 study, a role for LSD1 in the development of B cell subsets was examined.

275 Characterization of B-cell subsets was performed by flow cytometry.

276 HSFC, including analysis of B cell subsets, was performed.

277 Consistent with an increased number of these B cell subsets, we detected elevated levels of IgG3 natu

278 Using large-scale imaging across B cell subsets, we found that, in contrast with naive an

279 n those SLE patients occurred throughout all B cell subsets, we hypothesized that ARID3a expression i

280 whole-genome bisulfite sequencing of normal B cell subsets, we observed broad epigenetic programming

281 ther B-cell lymphomas, cHL lines, and normal B-cell subsets, we show that they differ extensively fro

282 Effects of prolactin on splenic B cell subsets were studied in female BALB/c mice.

283 Using fluorescence-activated cell sorting, B-cell subsets were analyzed.

284 B-cell subsets were predominantly associated with sex, b

285 Various B-cell subsets were purified and characterized by flow c

286 B-cell subsets were quantified by flow cytometry; annexi

287 phenotype, specificity, and functionality of B-cell subsets were studied in a cohort of pregnant wome

288 oper development and function of the various B cell subsets while counteracting lymphomagenesis.

289 ional B cells, including a late transitional B cell subset with a phenotype intermediate between T2 a

290 The spleen regulatory B cell subset with the functional capacity to express IL

291 EBV infection induced redistribution between B cell subsets with enrichment of IgD(+)CD27(+) cells (c

292 B cell subsets with phenotypes characteristic of naive,

293 The discovery of B cell subsets with regulatory properties, dependent on

294 Distinct human IL-10-producing B-cell subsets with immunoregulatory properties have bee

295 KDM6B expression increases in B-cell subsets with increasing stage of differentiation,

296 y similar to each other and to IgG(+) memory B cell subsets, with typical upregulation of activation

297 plasmablasts and plasma cells than in other B-cell subsets, with higher levels in patients with SLE

298 Chemokine-dependent localization of specific B cell subsets within the immune microarchitecture is es

299 t the pathologic cytokine-producing effector B cell subsets without impacting the protective regulato

300 he maturation and functionality of all major B cell subsets, yet the molecular players in these signa