ライフサイエンスコーパス: BAFF

1 BAFF (TNF superfamily [TNFSF] 13B/Blys) and APRIL (TNFSF

2 BAFF also contributed to the maintenance and/or expansio

3 BAFF and a proliferation-inducing ligand (APRIL), which

4 BAFF and APRIL enhanced the immune reaction, improved an

5 BAFF and its homolog APRIL are TNF-like cytokines that s

6 BAFF expression was significantly increased in lungs of

7 BAFF is a B cell survival and maturation factor implicat

8 BAFF is a crucial survival factor for transitional and m

9 BAFF is a cytokine critical for development and proper s

10 BAFF is an ideal molecule to improve early pathways of B

11 BAFF is critical for the survival and maturation of matu

12 BAFF is significantly increased in lungs of patients wit

13 BAFF levels were also higher in blood and bronchoalveola

14 BAFF produced by Nphs and cDCs is regulated differently

15 BAFF staining in lymphoid follicles was observed around

16 BAFF stimulation, in contrast to CD40 activation, was un

17 BAFF, via BAFFR, activates multiple signaling pathways i

18 BAFF-mediated atheroprotection required B cells and was

19 A BAFF/APRIL-like relative called BAFF- and APRIL-like mol

20 c inquiry, we identified and characterized a BAFF-like gene in lampreys, which, with hagfish, are the

21 d bony fishes, and we report in this study a BAFF-like gene in lampreys.

22 OLD stage IV COPD, characterized by abundant BAFF-positive cells but few apoptotic cells (mostly B ce

23 In addition, BAFF augments innate B cell responses via complex intera

24 The N and C termini of adjacent BAFF or APRIL monomers are spatially close and can be li

25 accine incorporating the molecular adjuvants BAFF (B cell activating factor) and APRIL (a proliferati

26 red survival of ERK5-deficient B cells after BAFF stimulation.

27 However, ERK5 deficiency did not alter BAFF activation of the PI3-kinase-Akt or NF-kappaB signa

28 The HIV-infected children had an altered BAFF profile that could have affected their B cell compa

29 Although BAFF-depleting therapy with belimumab achieved approval

30 To determine the relationships among BAFF, B cells, and Treg cells, a panel of C57BL/6 (B6) c

31 previously unknown synergy between AngII and BAFF in inducing IL-10 production by B cells, resulting

32 r IgG-immune complexes (ICs), FcgammaRs, and BAFF during the formation of memory B cells in mice.

33 rmation of B cell memory through IgG-ICs and BAFF.

34 smembrane activator and CAML interactor, and BAFF receptor, in sorted human immune cell subsets, we f

35 We analyzed serum BAFF levels and BAFF expression in B cells in blood and bronchoalveolar

36 reduces Aiolos and Ikaros protein levels and BAFF- and CD40L-induced proliferation, plasmablast diffe

37 ssing/B cell-deficient B6.BTg.muMT mice, and BAFF-deficient/B cell-deficient B6.Baff(-/-) muMT mice d

38 ion mainly in neutrophils and monocytes, and BAFF expression in neutrophils from pSS patients strongl

39 BAFF increased in CD8(-) cDCs and Nphs, and BAFF(+) CD11b(hi) NK cells expanded in draining lymph no

40 proliferation, such as BCL6, MYC, PIK3CA and BAFF-R.

41 enotype status affects HIV-1 replication and BAFF induction, as both were abrogated in MDMs displayin

42 levels of IP-10, TNF-alpha, CRP, sCD14, and BAFF than United States neonates.

43 ate the role of BAFF in COPD, we antagonized BAFF by prophylactic or therapeutic administration of a

44 Antagonizing BAFF in CS-exposed mice attenuates pulmonary inflammatio

45 Moreover, antagonizing BAFF altered the phenotype of alveolar and interstitial

46 Anti-BAFF antibody was injected on days 3, 17, 31, and 45 aft

47 Anti-BAFF treatment interferes with humoral responses at mult

48 Anti-BAFF treatment reduced the frequency of B cells in allog

49 Naive B cells were strongly reduced by anti-BAFF treatment in all compartments.

50 However, anti-BAFF treatment did not attenuate hepatic fibrosis as mea

51 asmablasts/plasma cell numbers lower in anti-BAFF-treated rats, which was reflected by less DSA in ce

52 tor ligand was significantly reduced in anti-BAFF-treated rats.

53 Interestingly, the administration of anti-BAFF mAb in Mdr2(-/-) mice altered the BCR repertoire on

54 We examined the effects of anti-BAFF treatment on B cells, expression of costimulatory m

55 APRIL, BAFF, TNF-alpha, IL-6, and IL-10 levels in serum and sal

56 Serum and saliva levels of TNF-alpha, APRIL, BAFF, IL-6, and IL-10 were similar in CP and AgP groups.

57 In multiple sclerosis (MS), combined APRIL/BAFF blockade led to unexpected exacerbated inflammation

58 Here, we investigate the role of the APRIL/BAFF axis in the CNS.

59 hich nonetheless display a very strong basal BAFF production.

60 We report also that basal BAFF secretion was higher in monocytes obtained from fem

61 Because BAFF promotes B cell class-switch recombination and humo

62 roles for NIK in additional pathways beyond BAFF signaling.

63 are both specific and redundant: BAFFR binds BAFF, whereas BCMA and TACI bind to either BAFF or APRIL

64 g B cells in patients with lupus by blocking BAFF, type I interferon, or TLR7 to TLR9.

65 ase at 18 months of age had lower cord blood BAFF levels than nonallergic children.

66 Both BAFF and APRIL assemble as homotrimers that bind and act

67 A BAFF/APRIL-like relative called BAFF- and APRIL-like molecule (BALM) has also been ident

68 ough B-lymphocyte receptors, including CD40, BAFF receptor, and Toll-like receptors, and also plays a

69 gnaling pathway and the receptors for CD40L, BAFF and TLR ligands.

70 garette smoke extract (CSE) increases B-cell BAFF expression and (2) recombinant BAFF (rBAFF) rescues

71 Our data support the hypothesis that B-cell BAFF expression creates a self-perpetuating loop contrib

72 Single-chain BAFF (BBB) and to a lesser extent single-chain ABB, but

73 Circulating BAFF levels were maximal at birth, and farmers' children

74 ensitive detection of endogenous circulating BAFF by ELISA or using a homogenous assay.

75 Therapeutically, BAFF and combined BAFF/APRIL inhibition delays disease onset in diverse mu

76 In conclusion, BAFF-APRIL heteromers of different stoichiometries have

77 In contrast, BAFF overexpression markedly reduced hypercholesterolemi

78 We correlated BAFF immunostaining in LFs in lung explants or biopsies

79 better understand BAFF functions, we created BAFF reporter (BAFF-RFP) mice and Baff floxed (Baff(fl/f

80 eatment of wild-type cells with the cytokine BAFF, a known attenuator of p18(INK4c) function in B lym

81 B lymphocytes via production of the cytokine BAFF.

82 ment was diminished in both B cell-deficient BAFF-Tg chimeras, but also B cell-deficient wild-type ch

83 Loss of CD16, hematopoietic cell-derived BAFF, or blocking IC:FcgammaR regions in vivo diminished

84 mportance of pDC/monocyte crosstalk to drive BAFF secretion.

85 We demonstrate here that HIV-1 drives BAFF production in MDMs in a type-I IFN- and TLR-indepen

86 s BAFF, whereas BCMA and TACI bind to either BAFF or APRIL.

87 IL-2, whereas SLE patients exhibit elevated BAFF and DN B cells and reduced IL-21.

88 cating IFN induction as a factor in elevated BAFF levels in CGVHD.

89 The elevated BAFF and ANA titers were also detected in human patients

90 nization of mice with a DNA vaccine encoding BAFF or APRIL multitrimers, together with interleukin 12

91 ow that DNA or DNA-protein vaccines encoding BAFF or APRIL multitrimers, IL-12p70, and membrane-bound

92 ing recombinant BAFF in vitro and endogenous BAFF in vivo These tools will prove useful for the detec

93 is usually limited to mature B cells, excess BAFF promotes the expansion of TACI-expressing transitio

94 I-dependent activation in settings of excess BAFF remain unclear.

95 al autoimmunity, we hypothesized that excess BAFF would accelerate atherosclerosis.

96 G-ICs prior to significant B cell expansion, BAFF secretion, and lupus nephritis.

97 ells still respond to the prosurvival factor BAFF in culture and require BAFF-R signaling for their i

98 for a limited supply of the survival factor BAFF.

99 n antibody against the B cell trophic factor BAFF, was ineffective in phase III trials, and efgartigi

100 expressing murine B cell activating factor (BAFF) (rRABV-mBAFF).

101 The B cell activating factor (BAFF) inhibitor, belimumab, is the first biologic drug a

102 B-cell activating factor (BAFF) is an important cytokine for B-cell maturation.

103 B-cell-activating factor (BAFF) is associated with donor-specific antibodies (DSA)

104 The B cell-activating factor (BAFF) is critical for B cell development and humoral imm

105 B cell activating factor (BAFF) is essential for B cells to develop and respond to

106 elevated levels of B-cell-activating factor (BAFF) receptor (BAFF-R) and as a result proliferate more

107 ls provided by the B cell-activating factor (BAFF) receptor (BAFF-R).

108 ptor (BCR) and the B cell-activating factor (BAFF) receptor.

109 B cell activating factor (BAFF) stimulation of the BAFF receptor (BAFF-R) is essen

110 umab (which blocks B cell-activating factor (BAFF)) for use in patients with lupus nephritis in the U

111 oprotegerin (OPG), B-cell activating factor (BAFF), and a proliferation-inducing ligand (APRIL) were

112 ng ligand (APRIL), B-cell activating factor (BAFF), interleukin (IL)-6, and IL-8 in biofluids of pati

113 ne and drug target B-cell activating factor (BAFF), was associated with multiple sclerosis as well as

114 ne of these is the B cell-activating factor (BAFF).

115 eting the cytokine B cell-activating factor (BAFF).

116 TNF family ligands B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) serve

117 ligand (APRIL) and B-cell activation factor (BAFF) are currently targeted in autoimmune diseases as B

118 The observation that the soluble factors BAFF, IL-2, and IL-21 induce memory and DN B cell activa

119 ting factor of tumor necrosis factor family (BAFF) regulates B cells in health, but its role in COPD

120 tivating factor belonging to the TNF family (BAFF) and a proliferation inducing ligand (APRIL) signal

121 B cell activating factor of the TNF family (BAFF) develop systemic autoimmunity characterized by cla

122 B cell activating factor of the TNF family (BAFF), also known as B lymphocyte stimulator, is a ligan

123 B-cell activating factor of the TNF family (BAFF), nucleic acid-sensing Toll-like receptors (TLRs),

124 onging to the tumor necrosis factor family" [BAFF]).

125 characterized by abundant apoptotic but few BAFF-positive cells (mostly B cells); and (2) type B, th

126 Finally, BAFF and APRIL support plasma cell survival, with differ

127 Correspondingly, we find BAFF orthologs in all of the jawed vertebrate representa

128 L interactor (TACI) signals are critical for BAFF-mediated autoimmunity, but the B cell developmental

129 aling pathways, which are also important for BAFF to promote mature B cell survival.

130 Median GCF, serum, and saliva levels for BAFF (P <0.001) and IL-6 and IL-8 (P <0.005) were higher

131 n of ERK 1 and 2 MAP kinases is required for BAFF-R to promote B cell survival.

132 TACI(+) transitional cells from BAFF-transgenic mice are characterized by an activated,

133 oimmunity, TACI(+) transitional B cells from BAFF-transgenic mice spontaneously produce class-switche

134 enic and bone marrow neutrophils (Nphs) from BAFF-RFP mice expressed the highest constitutive levels

135 Serum and GCF BAFF (P <0.0001), serum, saliva, and GCF APRIL (P <0.000

136 Higher BAFF levels at birth were positively associated with pro

137 At birth, girls had higher BAFF levels and lower proportions of CD5(+) B cells than

138 l at birth, and farmers' children had higher BAFF levels than nonfarmers' children.

139 Consistent with the higher BAFF levels, liver-specific selection of the focused BCR

140 Little is known about when, where, and how BAFF is produced in vivo and about which BAFF-producing

141 portionately contracted in mice deficient in BAFF (B6.Baff(-/-) ).

142 IV-1 Nef accessory protein is dispensable in BAFF upregulation as a nef-deleted HIV-1 strain is still

143 nges strongly correlated with an increase in BAFF and APRIL expression in the IFN-high BM.

144 The cell- and tissue-specific increases in BAFF expression were dependent on type I IFN signaling.

145 B cells could be infected in BAFF-R(-/-) mice, but virus loads remained low.

146 rescued BAFFR-dependent B cell maturation in BAFF-deficient mice.

147 s, down to levels close to those observed in BAFF-deficient mice.

148 he MEK5-ERK5 MAP kinase signaling pathway in BAFF-induced mature B cell survival and homeostatic main

149 pathway, in addition to its critical role in BAFF-mediated cell survival, may control the expression

150 factor (TNF) superfamily ligands, including BAFF and APRIL, can be multitrimerized using the lung pr

151 leted HIV-1 strain is still able to increase BAFF at levels similar to the wild type strain.

152 th polyinosinic:polycytidylic acid increased BAFF expression in splenic Ly6C(hi) inflammatory MOs, CD

153 el mechanistic explanation for the increased BAFF levels observed during HIV-1 infection and highligh

154 fully competent (R5-tropic) HIV-1 to induce BAFF production by monocyte-derived macrophages (MDMs).

155 exposure during pregnancy appears to induce BAFF production in the newborn child, and high neonatal

156 IFN-beta injections induced BAFF expression mainly in neutrophils and monocytes, and

157 els and promoted lupus nephritis by inducing BAFF production in the kidneys, and the formation of ren

158 It functioned as a decoy receptor inhibiting BAFF- and APRIL-mediated B cell survival and NF-kappaB a

159 ition, and address whether new insights into BAFF/APRIL family complexity can be exploited to improve

160 igger B cell activation, and one of these is BAFF.

161 Like mammalian BAFF and APRIL, the lamprey BAFF-like gene is expressed in T-like, B-like, and innat

162 In vitro analyses indicated that the lamprey BAFF-like protein can bind to a BCMA-like receptor Ig fu

163 The TNF superfamily ligands BAFF and APRIL interact with three receptors, BAFFR, BCM

164 We quantified and localized BAFF expression in lungs of never-smokers, smokers witho

165 Mechanistically, lowering BAFF levels also diminished the number of T cells positi

166 Like mammalian BAFF and APRIL, the lamprey BAFF-like gene is expressed

167 ts higher sequence similarity with mammalian BAFF than APRIL.

168 In this manner, BAFF impacts autoreactive B cell activation via extrafol

169 farming and nonfarming families, we measured BAFF levels in plasma from mothers and their children at

170 tion of tumor necrosis factor family members BAFF and APRIL and increased expression of FAS on circul

171 cl2(Tg) mice, B cell-deficient B6.muMT mice, BAFF-overexpressing/B cell-deficient B6.BTg.muMT mice, a

172 Moreover, BAFF directly promotes the differentiation of Th17 cells

173 ies to recognize, inhibit, or activate mouse BAFF was investigated.

174 functional manipulation of endogenous mouse BAFF and provide an alternative to the widely used BAFF

175 ometric ratio; blocked the activity of mouse BAFF on a variety of cell-based reporter assays; and ant

176 tion in the newborn child, and high neonatal BAFF levels were associated with more accelerated postna

177 Notably, BAFF and APRIL did not cause indiscriminate B cell expan

178 s; and antagonized the prosurvival action of BAFF on primary mouse B cells in vitro A single administ

179 RNA-sequencing analysis of BAFF-stimulated nfkb2-deleted versus normal B cells sugg

180 lection accounts for therapeutic benefits of BAFF inhibition, and address whether new insights into B

181 IgG1 named Sandy-2, prevented the binding of BAFF to all of its receptors, BAFF receptor, transmembra

182 similar to what is observed upon blockade of BAFF.

183 isease, we investigated the contributions of BAFF to aberrant IgG autoantibody production and hepatic

184 decoy receptor for the specific depletion of BAFF in mice.

185 pSS patients will lead to downregulation of BAFF and a consequential reduction of autoreactive B cel

186 hway, which plays a vital role downstream of BAFF, CD40L, lymphotoxin, and other inflammatory mediato

187 teers, we therefore examined the dynamics of BAFF induction and B cell subset activation and composit

188 Dysregulation of BAFF contributes to the development of some autoimmune d

189 n a host that harbors B cells, the effect of BAFF on Treg cells goes beyond its ability to expand the

190 ined plasma levels of BAFF and expression of BAFF receptors on B cells.

191 ory factors (IRFs) control the expression of BAFF.

192 However, heteromers of BAFF and APRIL that occur in patients with autoimmune di

193 uggest that, whereas an ancestral homolog of BAFF and APRIL was already present in a common ancestor

194 (which harbor B cells largely independent of BAFF because of expression of a Bcl2 transgene) than in

195 activation and, in particular, induction of BAFF.

196 The interaction of BAFF, also known as BLyS, with its receptors BAFFR and T

197 e treatment of SLE, where elevated levels of BAFF and Aiolos may prime CD27(+) memory and DN memory-l

198 We also determined plasma levels of BAFF and expression of BAFF receptors on B cells.

199 ul information about the increased levels of BAFF observed during HIV-1 infection and highlights the

200 ich correlated with elevated serum levels of BAFF, antinuclear Abs (ANA) and immune complexes.

201 expressed the highest constitutive levels of BAFF; other myeloid subsets, including conventional dend

202 NA plasmids encoding soluble multitrimers of BAFF and APRIL using surfactant protein D as a scaffold,

203 with disease severity, and overexpression of BAFF has been demonstrated within lymphoid follicles of

204 romoting B cell expansion, overexpression of BAFF promotes expansion of T cells, including T regulato

205 Ab-producing plasmablasts in the presence of BAFF and proinflammatory cytokines.

206 enic transitional B cells in the presence of BAFF.

207 e show that the virus-mediated production of BAFF by monocytes relies on a type I IFN response by a s

208 eas IRF4 and IRF8 are negative regulators of BAFF expression.

209 tify IRF1 and IRF2 as positive regulators of BAFF transcription and IRF4 and IRF8 as potent repressor

210 While the role of BAFF in B cells has been widely described, its role in i

211 Next, to investigate the role of BAFF in COPD, we antagonized BAFF by prophylactic or the

212 These findings suggest an important role of BAFF in facilitating B cell subset proliferation and red

213 the importance of macrophages as a source of BAFF, a phenomenon that might contribute to B cell dysfu

214 r selection of B cells, and the targeting of BAFF has emerged as a successful treatment strategy of S

215 Treatment of BAFF-RFP mice with polyinosinic:polycytidylic acid incre

216 nesis, of particular relevance to the use of BAFF-targeted therapies in systemic lupus erythematosus.

217 milar to APRIL, heteromers consisting of one BAFF and two APRILs (BAA) bind to the receptors B cell m

218 and serum levels of IL-6, IL-8, sRANKL, OPG, BAFF, and APRIL were determined by enzyme-linked immunos

219 ERK5 was required for optimal BAFF up-regulation of Mcl1 and Bcl2a1, which are prosurv

220 0L, anti-IgM, IL-21, CpG, IFN-alpha, IL-6 or BAFF induces miR-155 and decreases PU.1 expression.

221 nable to secrete Igs in response to APRIL or BAFF.

222 ransplant proportion of any B-cell subset or BAFF serum levels.

223 belimumab achieved approval for lupus, other BAFF inhibitors were much less beneficial in clinical tr

224 B cells promoted BAFF-independent Treg cell expansion in vivo, as evidenc

225 tor (BAFF) stimulation of the BAFF receptor (BAFF-R) is essential for the homeostatic survival of mat

226 of B-cell-activating factor (BAFF) receptor (BAFF-R) and as a result proliferate more robustly in res

227 he B cell-activating factor (BAFF) receptor (BAFF-R).

228 the binding of BAFF to all of its receptors, BAFF receptor, transmembrane activator and calcium modul

229 s B-cell BAFF expression and (2) recombinant BAFF (rBAFF) rescues B cells from CSE-induced apoptosis

230 o that of Sandy-2 by stimulating recombinant BAFF in vitro and endogenous BAFF in vivo These tools wi

231 Reducing BAFF in vivo prevented the formation of TLSs and lupus n

232 physiological role might be to down-regulate BAFF activity.

233 ubsets plays an important role in regulating BAFF production and TI-2 Ab responses.

234 nd BAFF functions, we created BAFF reporter (BAFF-RFP) mice and Baff floxed (Baff(fl/fl) ) mice.

235 osurvival factor BAFF in culture and require BAFF-R signaling for their in vivo maintenance.

236 ents show that Syk-deficient B cells require BAFF receptor and CD19/PI3K signaling for their long-ter

237 tions that induce dendritic cells to secrete BAFF, which acts at or upstream of Bcl-6 in activated B

238 We analyzed serum BAFF levels and BAFF expression in B cells in blood and

239 in B6 wild-type mice despite the lower serum BAFF levels in the former than in the latter.

240 Clinical periodontal recordings, serum BAFF, IL-8, and saliva sRANKL levels were higher in the

241 immunity through increased levels of soluble BAFF, B lymphocytes, and immunoglobulins.

242 hibition and increased production of soluble BAFF, which in turn up-regulated humoral immunity.

243 his in vitro study, we describe that soluble BAFF in combination with IL-2 and IL-21 is a T cell cont

244 identified a novel role for B cell-specific, BAFF-dependent transmembrane activator and CAML interact

245 c targets for hepatic fibrosis and targeting BAFF specifically for attenuating the autoantibody produ

246 rvation that heteromers are less active than BAFF, we speculate that their physiological role might b

247 We demonstrate that BAFF accumulates in macrophages in vivo and that it is p

248 In this article, we demonstrate that BAFF is a bona fide ISG and that IFN regulatory factors

249 Moreover, we demonstrated that BAFF is able to drive Th17 responses both indirectly, by

250 In the present study, we demonstrated that BAFF-induced B cell survival was actually independent of

251 cient and wild-type mice, demonstrating that BAFF modulated immunity through the extrafollicular and

252 Our composite results imply that BAFF-based mechanisms for B cell regulation evolved befo

253 We propose that BAFF and APRIL multitrimers are promising molecular adju

254 In summary, we show that BAFF expression is directly induced by type I IFNs via I

255 In this manuscript, we show that BAFF promotes events leading to lupus nephritis.

256 Previous reports have suggested that BAFF expression is directly induced by type I IFNs, but

257 the B-cell expansion defect, suggesting that BAFF-R is a bona fide miR-142 target through which it co

258 The BAFF-APRIL system is best known for its control of B cel

259 recise binding site for these factors in the BAFF promoter.

260 Lowering the BAFF-R gene dose in miR-142(-/-) mice rescues the B-cell

261 activating factor (BAFF) stimulation of the BAFF receptor (BAFF-R) is essential for the homeostatic

262 n containing the extracellular domain of the BAFF-APRIL receptor TACI, was applied in clinical trials

263 ases with established hyperactivation of the BAFF-APRIL system.

264 istration of a soluble fusion protein of the BAFF-receptor, BAFFR-Fc, in mice exposed to air or CS fo

265 ic strategies based on the inhibition of the BAFF/IL-17 response.

266 reduced atherosclerosis was dependent on the BAFF family receptor transmembrane activator and CAML in

267 or and CAML interactor (TACI) but not to the BAFF receptor (BAFFR).

268 e B cell population and is additional to the BAFF-independent effect of B cells on Treg cells.

269 Therapeutically, BAFF and combined BAFF/APRIL inhibition delays disease o

270 These BAFF and APRIL effects coincided with an enhanced germin

271 The predicted protein encoded by this BAFF-like gene in lampreys exhibits higher sequence simi

272 Thus, BAFF plays a previously unappreciated role in lupus neph

273 esponses after NP-Ficoll immunization; thus, BAFF produced by both cDCs and Nphs contributes to T cel

274 the IFN-inducible genes CXCL10 and TNFSF13B (BAFF) were correlated at both the gene and the plasma le

275 y [TNFSF] members TNFSF11 [RANKL], TNFSF13B [BAFF], and TNFSF14 [LIGHT]) produced by reactive cholang

276 MAVS also was required or contributed to BAFF expression in dendritic cell and MO subsets, respec

277 Consistent with a potential contribution to BAFF-mediated humoral autoimmunity, TACI(+) transitional

278 ch NIK is acutely deleted fail to respond to BAFF stimulation in vitro and in vivo.

279 tion, IL-6 production, growth in response to BAFF or APRIL, and AID/Bcl-6 expression, as well as foll

280 ult proliferate more robustly in response to BAFF stimulation.

281 ne lupus strains, although responsiveness to BAFF inhibition is model dependent, in keeping with hete

282 NOD mice receiving transient BAFF blockade were characterized by an enrichment of reg

283 HIV-1-induced type I IFN by pDCs triggers BAFF production in both classical and intermediate monoc

284 Heteromers consisting of one APRIL and two BAFF (ABB) bind to TACI and BCMA and weakly to BAFFR in

285 To better understand BAFF functions, we created BAFF reporter (BAFF-RFP) mice

286 y that HIV-1 (X4- and R5-tropic) upregulates BAFF expression and secretion by human monocytes.

287 nd provide an alternative to the widely used BAFF receptor-Fc decoy receptor for the specific depleti

288 Using BAFF receptor (BAFFR)-deficient mice, we characterized B

289 8) at the expense of memory B cells, as were BAFF serum levels (1,651 +/- 1,297 vs. 1,139 +/- 693 pg/

290 is review, we discuss the mechanisms whereby BAFF/APRIL signals promote autoreactive B cell activatio

291 ng pregnancy and early childhood and whether BAFF levels are associated with postnatal B-cell maturat

292 We sought to investigate whether BAFF levels are related to environmental exposures durin

293 how BAFF is produced in vivo and about which BAFF-producing cells contribute to B cell responses.

294 gs highlight a novel mechanism through which BAFF promotes humoral autoimmunity via direct, TACI-depe

295 Experiments with BAFF-deficient B6.Baff(-/-) Bcl2(Tg) mice, B cell-defici

296 Moreover, treatment of Muvarphis with BAFF or APRIL enhanced the clearance of Leishmania from

297 This protective activity is not shared with BAFF.

298 with the in vivo data, AngII synergized with BAFF to induce IL-10 production by B cells in vitro via

299 this role is in the proper folding of Wnt3a, BAFF, IL-7, and perhaps other factors produced by the ex

300 Postinfection with West Nile virus (WNV), BAFF increased in CD8(-) cDCs and Nphs, and BAFF(+) CD11