ライフサイエンスコーパス: BK virus

1 nd in the polyomaviruses simian virus 40 and BK virus.

2 ation is believed to be primarily due to the BK virus.

3 mavirus family and is closely related to the BK virus.

4 ine of a kidney transplant patient and named BK virus.

5 s to investigate the immunologic response to BK virus.

6 und to exhibit elevated titers to the JC and BK viruses.

7 ed for replication of mouse polyomavirus and BK virus, a human polyomavirus associated with allograft

8 n blood and urine for JC virus reactivation; BK virus, a JC virus-related polyomavirus, was used as a

9 (early UTI; <3 months after transplant) and BK virus allograft nephropathy (BKVAN).

10 Published data for BK virus allograft nephropathy, a recently emerged graft

11 BK virus-allograft nephropathy (BKVAN) is an increasingl

12 Rates of BK virus and acute rejection were comparable, but a high

13 also inhibited large T antigen expression by BK virus and JC virus, two important, pathogenic human p

14 BK virus and other infections can induce damage that res

15 Human polyomaviruses (JC virus, BK virus and simian virus 40) are causative agents of so

16 gens, including cytomegalovirus, adenovirus, BK virus, and Epstein-Barr virus in the absence of acute

17 cidence of viral infection (cytomegalovirus, BK virus, and Epstein-Barr virus) and posttransplant lym

18 cussed in relation to human cytomegalovirus, BK virus, and Epstein-Barr virus, while the importance o

19 rgeted additional pathogens, including HHV6, BK virus, and JC virus.

20 s of cytomegalovirus disease, herpes zoster, BK virus, and nephropathy, which led to the discontinuat

21 ction with cytomegalovirus, EBV, adenovirus, BK virus, and/or human herpesvirus 6.

22 ipheral B cell subsets and revealed the anti-BK virus antibody repertoire as clonally complex with re

23 stimulation by overlapping peptide pools of BK virus antigen to determine frequency of CD8+ and CD4+

24 fic T-cell investigational therapy targeting BK virus, as well as five other opportunistic viruses: a

25 BK virus associated nephropathy (BKN) is an important ca

26 BK virus-associated hemorrhagic cystitis (BKV-HC) is a c

27 lantation after losing their renal grafts to BK virus-associated nephropathy (BKAN) are described.

28 BK virus-associated nephropathy (BKVAN) causes renal all

29 ansplant after allograft loss as a result of BK virus-associated nephropathy (BKVAN).

30 BK virus-associated nephropathy (BKVN) is associated wit

31 BK virus-associated nephropathy is an increasingly recog

32 BK virus infection are at risk of developing BK virus-associated nephropathy, allograft rejection, an

33 The differentiation of BK virus-associated renal allograft nephropathy (BKVAN)

34 d 369 renal transplant recipients tested for BK virus at serial time points after transplantation.

35 Classic human polyomaviruses (JC and BK viruses) become pathogenic when reactivating from lat

36 Polyomavirus BK virus (BKPyV) infection is an important complication

37 Quantitative testing of BK virus (BKPyV) nucleic acid has become the standard of

38 BK virus (BKV) allograft nephropathy (BKVAN) is a compli

39 cially produced secondary standards for both BK virus (BKV) and CMV, using digital polymerase chain r

40 ey, liver, and pancreas transplant patients, BK virus (BKV) and JC virus (JCV) DNAemia were observed

41 iously had only two disease-causing members (BK virus (BKV) and JC virus (JCV)) identified.

42 s of SV40 as well as of human polyomaviruses BK virus (BKV) and JC virus (JCV).

43 polyomavirus infect humans: JC virus (JCV), BK virus (BKV) and Simian Vacuolating virus-40.

44 immunofluorescence indicated the presence of BK virus (BKV) antigen.

45 PCR showed BK virus (BKV) DNA in all these and in an additional 18%

46 erassay variability in the quantification of BK virus (BKV) DNA precludes establishing broadly applic

47 Quantitative BK virus (BKV) DNA surveillance in plasma/urine was perf

48 was assayed in urine, and JC virus (JCV) and BK virus (BKV) DNAs were assayed in urine and PBMCs.

49 Infection with BK virus (BKV) generally occurs early during life, but i

50 BK virus (BKV) genotyping has been historically based on

51 id organ transplant recipients, particularly BK virus (BKV) in kidney transplant patients.

52 ated human polyomaviruses JC virus (JCV) and BK virus (BKV) in mesothelioma remained unclear.

53 d monitoring of Epstein-Barr virus (EBV) and BK virus (BKV) in solid organ and hematopoietic stem cel

54 tology for the detection and the role of the BK virus (BKV) in the carcinogenesis of urothelial carci

55 Posttransplant reactivation of BK virus (BKV) in the renal allograft progresses to poly

56 BK virus (BKV) in transplant patients can lead to advers

57 here are limited data on the epidemiology of BK virus (BKV) infection after alemtuzumab induction.

58 CoV-2 Omicron variant in 2022, against prior BK virus (BKV) infection and uninfected (without SARS-Co

59 BK virus (BKV) infection causing end-organ disease remai

60 Treatment of BK virus (BKV) infection in renal transplant recipients

61 BK virus (BKV) infection of kidney transplant patients i

62 BK virus (BKV) infection or reactivation in immunocompro

63 ssion is a widely recognized risk factor for BK virus (BKV) infection, particularly with the combinat

64 Cytomegalovirus (CMV) and BK virus (BKV) infections can cause significant morbidit

65 alogous viral genetic changes occur in human BK virus (BKV) interstitial nephritis (ISN).

66 BK virus (BKV) is a common human polyomavirus infecting

67 The human polyomavirus BK virus (BKV) is a common virus for which 80 to 90% of

68 BK virus (BKV) is a human polyomavirus that is generally

69 BK virus (BKV) is a nonenveloped, ubiquitous human polyo

70 BK virus (BKV) is a polyomavirus that establishes a life

71 BK virus (BKV) is a polyomavirus which infects a large p

72 BK virus (BKV) is a significant cause of nephropathy in

73 BK virus (BKV) is a ubiquitous pathogen that establishes

74 BK virus (BKV) is the infectious cause of polyomavirus-a

75 BK virus (BKV) is ubiquitous in the human population and

76 BK virus (BKV) is widely accepted to be the causative ag

77 In patients with PVAN, a high BK virus (BKV) load is detectable in plasma.

78 In recent years, BK virus (BKV) nephritis after renal transplantation has

79 Because the occurrence of BK virus (BKV) nephritis is far less frequent than BK vi

80 BK virus (BKV) nephropathy remains the main cause of ren

81 pathy has been attributed to reactivation of BK virus (BKV) or more rarely JC virus (JCV).

82 We compared the utility of BK virus (BKV) polymerase chain reaction (PCR) and urine

83 Identification of risk factors for BK virus (BKV) replication may improve transplant outcom

84 In the case of the human polyomaviruses, BK virus (BKV) replication occurs in the tubular epithel

85 In situ hybridization showed BK virus (BKV) to be the predominant species, but polyme

86 JC virus (JCV) viruria is more common than BK virus (BKV) viruria in healthy individuals but in kid

87 ison of antibody titers to JC virus (JCV) or BK virus (BKV) was made by hemagglutination inhibition (

88 BK virus (BKV), a human polyomavirus, causes BKV nephrit

89 comparisons, SA12 is most closely related to BK virus (BKV), a human polyomavirus.

90 megalovirus (CMV), Epstein-Barr virus (EBV), BK virus (BKV), adenovirus (ADV), and human herpesvirus

91 V), adenovirus (AdV), cytomegalovirus (CMV), BK virus (BKV), and human herpesvirus 6 (HHV-6).

92 human polyomaviruses (HPyV)-JC virus (JCV), BK virus (BKV), human polyomavirus 6 (HPyV6), and Merkel

93 Samples were analyzed for BK virus (BKV), JC virus (JCV), and simian virus 40 (SV4

94 Samples were analyzed for BK virus (BKV), JC virus (JCV), and simian virus 40 (SV4

95 mavirus (HPV), Epstein-Barr virus (EBV), and BK Virus (BKV), suggesting the involvement of these viru

96 the human polyomaviruses JC virus (JCV) and BK virus (BKV), the first step to a successful infection

97 the membrane receptor and entry pathway for BK virus (BKV), which can cause severe disease in immuno

98 to the hypothesis that a human virus such as BK virus (BKV), which establishes a persistent subclinic

99 BK virus (BKV), which infects a large percentage of the

100 The LAMP assay was developed for BK virus (BKV), which is a leading cause of morbidity in

101 the VP1 polypeptide of a human polyomavirus, BK virus (BKV), which is associated with polyomavirus-as

102 BK virus (BKV)-associated nephropathy (BKVAN) has been i

103 BK virus (BKV)-associated nephropathy is the second lead

104 uated the relationship of pretransplantation BK virus (BKV)-specific donor and recipient serostatus t

105 y (PML) and cross-recognize the polyomavirus BK virus (BKV).

106 lovirus (CMV), Epstein-Barr virus (EBV), and BK virus (BKV).

107 Epstein-Barr virus (EBV), and 64 (34.6%) for BK virus (BKV).

108 BK virus (BKV; human polyomavirus 1) infections are asym

109 ed the frequent detection of polyomaviruses (BK virus [BKV] or simian virus 40 [SV40]) in 46% of stoo

110 anded DNA (dsDNA) viruses (adenovirus [ADV], BK virus [BKV], cytomegalovirus [CMV], Epstein-Barr viru

111 ntibiotics have antiviral properties against BK virus but efficacy at preventing this infection has n

112 of polyomavirus nephropathy (PVN) is due to BK virus, but rare cases result from JC virus reactivati

113 Some infections, such as cytomegalovirus and BK virus, can promote inflammatory gene expression that

114 ly mimics the binding characteristics of the BK virus coat protein to cells.

115 in two separate pairs of samples containing BK virus collected from the same individual up to 302 da

116 BK virus controllers, defined as those with episodes of

117 a broad range of viral infections including BK virus, cytomegalovirus, adenovirus, human herpesvirus

118 5 urine specimens submitted for polyomavirus BK virus detection were used.

119 f BK DNA in plasma appears to be a marker of BK virus disease in HCT recipients.

120 Weekly plasma samples were tested for BK virus DNA by polymerase chain reaction (PCR).

121 It is concluded that quantitative PCR for BK virus DNA in serum is useful both for identifying tra

122 BK virus DNA was detected in serum samples from all 4 ca

123 me polymerase chain reaction (PCR) assay for BK virus DNA, a retrospective analysis was done of seque

124 an herpesvirus 6 and human herpesvirus 7 and BK virus DNA, CMV disease, and acute rejection.

125 by progressive decrease in the median plasma BK virus-DNA load, and undetectable levels at the last f

126 BK virus DNAemia (BKPyV) and nephropathy are common afte

127 o develop more effective and less toxic anti-BK virus drugs for clinical use.

128 immunocompromised individuals, JC virus and BK virus, encode miRNAs with the same function as that o

129 s known to have potent inhibitory effects on BK virus gene expression, both at the level of transcrip

130 The four BK virus genotypes have been demonstrated to behave as d

131 Finally, we found persistently elevated anti-BK virus IgG titers and a specific anti-BKPyV T cell res

132 ATG was associated with an increased risk of BK virus in low-PRA patients.

133 s with kidney transplantion and is caused by BK virus in more than 95% of cases.

134 ith clinical course and with the presence of BK virus in renal biopsy specimens.

135 avenous bolus steroids to five patients with BK virus in the plasma (BKP) (group 1) and also tried ot

136 antirejection therapies in 13 patients with BK virus in the urine (BKU) but no BKP (group 2).

137 BK virus incidence was 29.2%, with no graft losses due t

138 blood and urine (by PCR) remain negative for BK virus, indicating the absence of virus reactivation.

139 ctors significantly associated with PML were BK virus infection (22.2% vs. 1.1%), pretransplant trans

140 Kidney transplant recipients with BK virus infection are at risk of developing BK virus-as

141 with clinical consequences quite similar to BK virus infection in humans, including renal dysfunctio

142 tion must be paid to the higher incidence of BK virus infection in recipients of ABO-incompatible gra

143 BK virus infection is a significant complication of mode

144 This study demonstrates that BK virus infection is associated with younger age at tra

145 BK virus infection remains an important cause of loss of

146 s of cytomegalovirus infection, two cases of BK virus infection, and one case of Epstein-Barr virus i

147 is a useful tool in monitoring the course of BK virus infection.

148 utors to susceptibility to the activation of BK virus infection.

149 There are no approved treatments for BK virus infection.

150 e currently no therapies to prevent or treat BK virus infection.

151 se of levofloxacin to prevent posttransplant BK virus infection.

152 tely, however, the majority of patients with BK virus infections are asymptomatic.

153 virus 6, Epstein-Barr virus, adenovirus, and BK virus infections.

154 BK virus is a human polyomavirus associated with a range

155 opoietic cell transplantation (HCT), polyoma-BK virus is associated with hemorrhagic cystitis and als

156 A monoclonal antibody directed against the BK virus large T-antigen (clone BK.T-1) has previously b

157 r in the respiratory tract, but asymptomatic BK virus latency is established in the urothelium.

158 ingle-chain variable fragment complexed with BK virus-like particles revealed the quaternary nature o

159 BK virus load decreased in 3 of 3 patients after the red

160 renal transplantation, and we correlated the BK virus load with clinical course and with the presence

161 eveloped a real-time PCR assay to quantitate BK virus loads in the setting of renal transplantation,

162 BK virus loads were measured in urine, plasma, and kidne

163 s, and kidney and lung outcomes of BKPyV and BK virus native kidney nephropathy (BKVN) in lung transp

164 BK virus nephritis (BKN) in recipients of renal allograf

165 immunosuppressive agents as risk factors for BK virus nephropathy (BKN) has not been well studied.

166 titial fibrosis and tubular atrophy (14.4%); BK virus nephropathy (BKVAN) 9.9%; and acute tubular nec

167 BK virus nephropathy (BKVAN) causes about 10% of late ki

168 BK virus nephropathy (BKVN) is a recognized cause of gra

169 BK virus nephropathy (BKVN) is a significant cause of re

170 BK virus nephropathy (BKVN) is an important cause of ren

171 The course of BK virus nephropathy (BKVN) is difficult to predict.

172 BK virus nephropathy (BKVN) may cause renal allograft dy

173 Clinical outcome in BK virus nephropathy (BKVN) was examined in relation to

174 BK viremia, a prerequisite for BK virus nephropathy (BKVN), affects 5% to 16% of pediat

175 Unlike BK virus nephropathy (BKVN), our knowledge of clinicopat

176 e diagnostic accuracy and risk prediction in BK virus nephropathy (BKVN).

177 2.4 +/- 2.4; P=0.001) but no different from BK virus nephropathy (BKVN; 20.3+/-15.7; P=0.98).

178 dentifying transplant recipients at risk for BK virus nephropathy and for monitoring the response to

179 cipients with histopathologically documented BK virus nephropathy and from samples (n=76) from 16 tra

180 However, technical complications and BK virus nephropathy continue to be important causes of

181 BK virus nephropathy is one of the most common viral inf

182 Kidney transplant recipients with BK virus nephropathy or viremia are generally treated wi

183 ection (ACR), cytomegalovirus (CMV) disease, BK virus nephropathy, and kidney graft function.

184 essive multifocal leukoencephalopathy (PML), BK virus nephropathy, and Merkel cell carcinoma.

185 toxicity, chronic allograft nephropathy, and BK virus nephropathy, as well as donor and recipient fac

186 iciency was not associated with CMV disease, BK virus nephropathy, or kidney allograft function at 1

187 ide are used empirically in the treatment of BK virus nephropathy.

188 (range, 17-61 weeks) before the diagnosis of BK virus nephropathy.

189 a, and 29% (two of seven) patients developed BK virus nephropathy.

190 , we summarize accumulated knowledge on anti-BK virus neutralizing antibodies as well as their clinic

191 Studying the contribution of anti-BK virus neutralizing antibodies in viral control has lo

192 by addition of SV40 VLPs but not by VLPs for BK virus or JC virus, which are related human polyomavir

193 aft function, 1-year acute rejection, 1-year BK virus or patient death.

194 e incorporated site-specifically into a SV40/BK virus origin-based shuttle vector and replicated in x

195 , 0.991; P = .012) but not CMV (P = .31) and BK virus (P = .27).

196 ntrols and viremic KTR were stimulated using BK virus peptide libraries loaded or not on monocytes-de

197 gimens and with other cohorts not undergoing BK virus polymerase chain reaction surveillance.

198 06 (17.39%), cytomegalovirus 66 (3.75%), and BK virus polyoma virus 20 (1.13%) was low.

199 Polyoma BK virus produces an aggressively destructive nephropath

200 centage of renal transplant recipients, with BK virus reactivation as the main causative agent.

201 f graft-versus-host disease, whereas CMV and BK virus reactivation did not predict clinical outcomes.

202 omavirus-associated nephropathy (PVAN) after BK virus reactivation in kidney transplant recipients (K

203 Conversely, BK virus remained stable in urine and was undetectable i

204 BK virus renal allograft nephropathy (BKVAN) in the sett

205 kidney recipients had a higher incidence of BK virus replication (P = 0.04) and nephropathy (P = 0.0

206 plant has been significantly associated with BK virus replication after transplant.

207 ide insight into the mechanism of control of BK virus replication and may allow for future patient ri

208 of BKVN and (2) to identify risk factors for BK virus replication in the retransplant.

209 esvirus 6 (HHV6), cytomegalovirus (CMV), and BK virus screened weekly.

210 Posttransplant BK virus screening and treatment are essential tools to

211 BK virus seems to play a role in the development of HC a

212 iant culture system, we show that autologous BK virus-specific T cell lines can be reliably generated

213 that use of partly HLA-matched donor-derived BK virus-specific T cells for immunotherapy in progressi

214 an increase in the circulating frequency of BK virus-specific T cells in posoleucel recipients.

215 an increase in the circulating frequency of BK virus-specific T cells, and the presence and persiste

216 Nevertheless, the recovery of BK virus-specific T-cell immunity may require prolonged

217 onoclonal antibodies that broadly neutralize BK virus subtypes and the related JC polyomavirus.

218 ding to MPtV, bovine polyomavirus, Sa12, and BK virus, suggesting a combination of vertical and horiz

219 ates started collecting data on treatment of BK virus (TBKV) on the kidney follow-up forms.

220 l load in the urine was 400 times higher for BK virus than JC virus.

221 Different mechanisms exploited by the BK virus to evade neutralizing antibodies have been desc

222 as defined by surrogate markers (i.e., high BK virus viremia).

223 ts were screened for T-cell immunity to this BK virus VP1 epitope by in vitro stimulation of their pe

224 BK virus was detected by in situ hybridization in bladde

225 BK virus was grown in a cell-culture system.

226 While the BK virus was predominant in the BKV+ group, it was also

227 eings (simian virus 40 [SV40], JC virus, and BK virus) was associated with non-Hodgkin lymphoma.

228 VP1, an effective marker for diagnosing the BK virus, was amplified on an on-chip device in less tha

229 ge T antigen and major capsid protein VP1 of BK virus with high sequence homology to JC virus counter

230 tervention is the initial association of the BK virus with the host cell.