ライフサイエンスコーパス: BK

1 BK antagonists normalized neuronal excitability in both

2 BK channels are tetrameric.

3 BK inhibition by PAX is best characterized by the idea t

4 BK polyomavirus (BKPyV) is a small DNA virus that establ

5 BK polyomavirus (BKPyV) is a ubiquitous human pathogen,

6 BK polyomavirus (BKPyV) is associated with symptomatic h

7 BK polyomavirus (BKPyV)-associated cancer after transpla

8 BK polyomavirus (PyV) is a major source of kidney failur

9 BK polyomavirus-associated nephropathy (BKPyVAN) constit

10 BK seems to permit the protective effects triggered by c

11 BK viruria was observed in 15.4% (6/39) of living donors

12 BK virus (BKV) is a significant cause of nephropathy in

13 BK virus (BKV)-associated nephropathy is the second lead

14 BK virus controllers, defined as those with episodes of

15 BK/BK mice live longer than WT littermates, and have hei

16 BK/Kv were mostly closed at rest in normoxia.

17 00 cells/mm (pOR = 6.29[3.56, 11.13], I 0%), BK-related diseases (pOR = 2.59[1.22, 5.49], I 0%), HLA

18 calcium-activated potassium channel (KCa1.1; BK, Slo1, MaxiK, KCNMA1) is the predominant potassium ch

19 oligomers migration (for caprolactam n = 3: BK = 0.050 +/- 0.004 mg/Kg; AOX = 0.019 +/- 0.001 mg/Kg)

20 titial fibrosis and tubular atrophy (14.4%); BK virus nephropathy (BKVAN) 9.9%; and acute tubular nec

21 In this exploratory study, we evaluated 45 BK patients and 20 healthy controls by optical coherence

22 eatment of the patient with chlorzoxazone, a BK/SK channel activator, partially improved motor functi

23 MetMb(AOX) = 25.9 +/- 0.8%), CIE L*a*b* (a*(BK) = 15.0 +/- 0.4 and a*(AOX) = 16.6 +/- 0.3) and TBARS

24 Accordingly, BK-beta1subunit increased the localization of BKDEC (i.e

25 on reduced the function of calcium-activated BK potassium channels, whose activation depends on their

26 Large conductance calcium-activated (BK) channels are broadly expressed in neurons and muscle

27 anded DNA (dsDNA) viruses (adenovirus [ADV], BK virus [BKV], cytomegalovirus [CMV], Epstein-Barr viru

28 the S-acylated S0-S1 domain conserved in all BK channels that controls membrane trafficking and is de

29 ght the importance of not only CFTR but also BK channel function in maintaining ASL homeostasis and e

30 s failed graft (71%) than for FECD (97%) and BK (92%).

31 elevated membrane expression of BKalpha and BK channel current.

32 y those including the pH-independent CaV and BK module or proportionate mixed scenarios.

33 One patient developed cytomegalovirus and BK and 2 others EBV and BK viremia.

34 cytomegalovirus and BK and 2 others EBV and BK viremia.

35 mavirus (HPV), Epstein-Barr virus (EBV), and BK Virus (BKV), suggesting the involvement of these viru

36 difference in BCVA outcome between FECD and BK eyes (P = .170), or between phakic and pseudophakic F

37 high visual acuity levels for both FECD and BK eyes.

38 Patients who underwent DMEK for FECD and BK had better graft survival compared to DSAEK and PK.

39 Patients with FECD and BK who underwent DMEK (121 eyes), DSAEK (423 eyes), or P

40 ECD were observed between eyes with FECD and BK, but ECD was significantly lower in eyes with previou

41 cases of DSAEK (423) or PK (405) for FED and BK from the Singapore Cornea Transplant Registry perform

42 enteric viruses [human adenoviruses, JC and BK polyomaviruses, Aichi virus 1 (AiV-1), enteroviruses,

43 n human brain, 2) coexpression of LINGO1 and BK channels resulted in rapidly inactivating BK currents

44 ntains functional coupling between RyR2s and BK channels and is critically important for cerebral art

45 ividual VGCCs, of A-type VGKCs and of SK and BK channels.

46 hannels (VGKCs), and Ca(2+)-activated SK and BK K(+) channels.

47 wed diminished spontaneous Ca(2+) sparks and BK channel activity in bladder and urethra SMCs.

48 Importantly, both paxilline-treated and BK-beta1 KO mitochondria displayed a more rapid Ca(2+) o

49 On the other hand, activating TRPML1 and BK channels enhanced cellular degradation of exogenous T

50 The functional expression of both VGCCs and BK channels, as well as their localization with respect

51 ype VGCCs, high-voltage activated VGKCs, and BK channels, leading to Ca(2+) spikes.

52 ipheral B cell subsets and revealed the anti-BK virus antibody repertoire as clonally complex with re

53 anded (open) and metal-free (closed) Aplysia BK channel structures.

54 tive membrane potentials and for appropriate BK channel positioning.

55 the Ca(2+)-activated K(+) channels, known as BK and SK channels, the physiological importance of Ca(2

56 In certain ligand-gated channels, such as BK channels and MthK, a Ca(2+)-activated K(+) channel fr

57 duced the sensitization of TRPA1, as well as BK- and CFA-induced hypersensitivity.

58 We provide evidence that augmented BK channel activity manifests as increased intrinsic exc

59 iant culture system, we show that autologous BK virus-specific T cell lines can be reliably generated

60 lasma membrane BK(Ca) channel with auxiliary BK-beta1-4 subunits profoundly affects the regulatory me

61 les in mediating allosteric coupling between BK domains than previously assumed.

62 way and oral application in the bloodstream: BK dysfunction recovered acutely and over time (the latt

63 as prostaglandin E(2) (PGE(2)), bradykinin (BK), and nerve growth factor (NGF) as well as multiple k

64 itochondrial BK(Ca) channel (mitoBK(Ca) ) by BK-beta subunits is not established.

65 channels (VGCCs) and negatively regulated by BK potassium channels activated by Ca(2+) influx through

66 cell-specific, physiological roles served by BK channels of different subunit composition.

67 e conductance Ca(2+)-activated K(+) channel (BK) current is prominent, and in mammalian inner hair ce

68 al CaV-like channel and a potassium channel, BK (Slo1), whereas the second module relies on pHi-depen

69 ctance calcium-activated potassium channels (BK) are composed of pore-forming BKalpha and auxiliary b

70 Chronic BK polyomavirus (BKPyV) infection is recognized as a pot

71 This PAX-binding pose in closed BK channels is supported by additional functional result

72 Given that clustered BK channels are functionally coupled to, and localize ne

73 al, depression of excitability via clustered BK channels.

74 ge-gated K(+) channels of large conductance (BK channels) are expressed in a diverse variety of both

75 Importantly, ABHD17a deacylates BK channels in a site-specific manner because it has no

76 regulatory subunits, beta and gamma, define BK channels that span a diverse range of functional prop

77 the expression of VGCCs and Ca(2+)-dependent BK K(+) channels coupled to ACh release at the MOC-OHC s

78 e-conductance, voltage- and Ca(2+)-dependent BK-type K(+) channel.

79 say based on CRISPR-Cas13 accurately detects BK polyomavirus DNA and cytomegalovirus DNA from patient

80 K viruric donors were more likely to develop BK viruria (66.6% vs 7.8%; P < .001) and viremia (66.6%

81 ters were higher in recipients who developed BK viremia, pretransplant donor, recipient, and combined

82 Furthermore, the absence of LRRC52 disrupted BK channel localization in the IHCs.

83 Donor BK viruria is associated with early BK viruria and virem

84 Donor BK viruria is associated with early BK viruria and viremia in kidney transplant recipients.

85 We identified the Caenorhabditis elegans BK channel SLO-1 as a molecular target of the Mel recept

86 ibition of S-acylation attenuated endogenous BK channel currents independently of changes in cell sur

87 erfering RNA (siRNA) knockdown of endogenous BK channels had similar effects.

88 f RCK activation by Ca(2+) in the eukaryotic BK and bacterial MthK K(+) channels are well understood.

89 wo enzymes, ABHD17a and ABHD17c, that excise BK channel lipid groups with remarkable precision.

90 lpha10nAChRs) in OHCs and I(K,n) and I(K,f) (BK channels) in IHCs.

91 First, BK currents activate at unprecedentedly negative membran

92 ic FECD eyes (39%; P = .852), but higher for BK eyes than for FECD eyes (46% vs 39%, P = .001).

93 taining 26), the gamma subunit mandatory for BK function in the airways.

94 s undergoing immunosuppression reduction for BK viremia had 10-year outcomes similar to those without

95 alizing serostatus had the greatest risk for BK viremia (odds ratio, 4.9; 95% confidence interval, 1.

96 was more often required in eyes treated for BK vs FECD eyes (12.4% vs 7.4%, P = .022).

97 isengagement of the gamma1-F273S mutant from BK channels.

98 n and turnover of large T (LT) proteins from BK, JC, Merkel cell, HPyV7 and trichodysplasia spinulosa

99 ual role: they both support release and fuel BK channels, suggesting that at immature stages presynap

100 ese studies indicate that a loss-of-function BK channel mutation causes ataxia and acts by reducing m

101 Furthermore, BK channels as well as purinergic receptors were shown t

102 a calcium-activated potassium conductance, G(BK) , and a low-voltage-activating delayed rectifier, G(

103 e calcium-activated potassium conductance, G(BK) , that can be blocked by agents that disrupt calcium

104 Efflux of K(+) through G(BK) can rapidly elevate [K(+) ](c) , which speeds the ac

105 expansion offers the possibility to generate BK-specific T cell lines for adoptive immunotherapy.

106 terize a clinical-scale protocol to generate BK-specific T cell lines from viremic KTR.

107 Global BK knockouts and CMBK knockouts, in contrast with SMBK k

108 ompared with litter-matched controls, global BK knockout, and wild-type mice.

109 rgeted additional pathogens, including HHV6, BK virus, and JC virus.

110 g the pore of heterologously expressed human BK channels.

111 To determine the linker's role in human BK activation, we designed a series of linker sequence s

112 s expression system, Mel activates the human BK channel (hSlo1) in a membrane-delimited manner in the

113 nables quantal transmission also activates I(BK) , an effect that can be blocked internally by BAPTA,

114 t additional factors may help define the IHC BK gating range.

115 cally target BKPyV-infected cells.IMPORTANCE BK polyomavirus (BKPyV) is an emerging pathogen that rea

116 sponses in a sophisticated manner.IMPORTANCE BK polyomavirus can cause serious problems in immune-sup

117 In BK-beta1 knockout mice, cardiac mitoBK(Ca) displayed a l

118 90 mV, to account for the profound change in BK activation range caused by removal of LRRC52, we sugg

119 Although some diversity in BK channel function, localization, and regulation appare

120 ild-type mice but are profoundly impaired in BK channel-null mice.

121 voltage-dependent gating and pore opening in BK channels is modulated to a great extent by the intera

122 e diagnostic accuracy and risk prediction in BK virus nephropathy (BKVN).

123 firing rate potentiation, and reductions in BK currents in vestibular nucleus neurons.

124 .001-.026) in FED, but only over 3 years in BK (P < .001-.031).

125 BK channels resulted in rapidly inactivating BK currents, and 3) LINGO1 reduced the membrane surface

126 Ethanol also increased BK channel open probability measured in single-channel r

127 nt ex vivo studies implicated that increased BK activity favors the survival of the myocardium at isc

128 Hypoxia did not inhibit BK in inside-out patches.

129 ownregulates CFTR activity but also inhibits BK channel function, thereby causing ASL depletion.

130 o not support the view that hypoxia inhibits BK/Kv to initiate or maintain the hypoxic response.

131 PAX inhibits BK channels by selective interaction with closed states.

132 molecular events downstream of cGMP involve BK channels present in cardiomyocytes or in other cardia

133 between mitochondrial BK(Ca) -alpha and its BK-beta1 subunit.

134 d, large-conductance, Ca(2+)-activated K(+) (BK) channel currents.

135 nductance voltage and Ca(2+)-activated K(+) (BK) channel have a key role in the ethanol effect on GPe

136 ammalian Ca(2+)- and voltage-activated K(+) (BK) channel opening.

137 of large conductance Ca(2+)-activated K(+) (BK) channels also result in tremor and motor disorders.

138 nductance Ca(2+) and voltage-activated K(+) (BK) channels control membrane excitability in many cell

139 mal large-conductance Ca(2+)-activated K(+) (BK) channels, a critical negative feedback mechanism tha

140 uctance, voltage- and Ca(2+)-activated K(+) (BK) channels.

141 Ca(2+)-activated and voltage-dependent K(+) (BK) channels, critical for mucociliary function in the a

142 hat of large conductance, Ca(2+)-gated K(+) (BK) channels despite the lack of sequence similarity.

143 uctance, calcium- and voltage-activated K(+)(BK) channel consists of the pore-forming alpha subunits

144 -conductance Ca2+- and voltage-activated K+ (BK) potassium channel alpha-subunit, and pathogenic gain

145 Bacterial keratitis (BK) is an ocular disorder associated with poor visual pr

146 trophy (FECD; 85.3%) or bullous keratopathy (BK; 10.5%).

147 trophy [FECD]: n = 111; bullous keratopathy [BK]: n = 24; and failed graft: n = 18).

148 Kim BK, Hong SJ, Cho YH, et al.

149 VAN (defined as sustained [>3 wk] high-level BK viremia >10 copies/mL) within 5 years posttransplant

150 nsidered in SOT recipients with lymphopenia, BK-related infections and rituximab exposure in addition

151 4 and a*(AOX) = 16.6 +/- 0.3) and TBARS (MDA(BK) = 0.0060 +/- 0.0003 ug/g and MDA(AOX) = 0.0044 +/- 0

152 ugh direct interaction, how ethanol-mediated BK channel activation causes behavioral intoxication is

153 Association of the plasma membrane BK(Ca) channel with auxiliary BK-beta1-4 subunits profou

154 Association of plasma membrane BK(Ca) channels with BK-beta subunits shapes their bioph

155 roperties similar to that of plasma membrane BK(Ca) when associated with BK-beta1 (left-shifted volta

156 V, n = 7) resembling that of plasma membrane BK(Ca) when associated with its regulatory BK-beta1 subu

157 After 23 days metmyoglobin (MetMb(BK) = 31.3 +/- 2.9% and MetMb(AOX) = 25.9 +/- 0.8%), CIE

158 ered in IHCs from Lrrc26 knockout (KO) mice, BK current activation was shifted more than +200 mV in I

159 strated an interaction between mitochondrial BK(Ca) -alpha and its BK-beta1 subunit.

160 ver, functional association of mitochondrial BK (mitoBK(Ca) ) with regulatory subunits is unknown.

161 , functional modulation of the mitochondrial BK(Ca) channel (mitoBK(Ca) ) by BK-beta subunits is not

162 with membrane alone could directly modulate BK activation.

163 Mallotoxin is a potent small-molecule BK channel activator.

164 kl/kl mice was rescued in the double-mutant BK/BK;kl/kl mice exhibiting lower plasma Pi, improved we

165 g was used to assess functionality of mutant BK channels.

166 (AAV) viral transfection in mice, the mutant BK(G354S) channel, but not the BK(WT) channel, caused pr

167 We describe a mutation (BK(G354S)) in KCNMA1, in a child with congenital and pro

168 onoclonal antibodies that broadly neutralize BK virus subtypes and the related JC polyomavirus.

169 90.6% for the BK group and 83.9% for the non-BK group.

170 Here we report a novel BK channel-targeted peptide with functional activity in

171 CaV-channel dependent activation of BK channels is critical for feedback control of both cal

172 ppeared to be mediated through activation of BK channels, because the effects of ML-SA1 on Tat-mediat

173 components essential both for activation of BK currents at negative membrane potentials and for appr

174 udy supports a scheme in which activation of BK/Kv strongly limits the magnitude of hypoxia-induced [

175 effect on GPe neurons, as the application of BK channel inhibitors blocked the ethanol-induced firing

176 Our study thus indicates that the control of BK channel trafficking is a critical regulatory mechanis

177 T-cell epitopes that influence the course of BK polyomavirus (BKPyV) infection after kidney transplan

178 subunit in HeLa cells doubled the density of BK(Ca) in mitochondria.

179 -recipient serostatus and the development of BK viremia, specific risk factors for BKV-related compli

180 acological inhibitors or shRNA knock-down of BK channels.

181 -beta pre-treatment amplified the effects of BK on RhoA translocation and MYPT1/MLC20 phosphorylation

182 osphorylation, but suppressed the effects of BK on RhoA-GTP content, SrcFK auto-phosphorylation and c

183 ntrollers, defined as those with episodes of BK viremia of 3 months or less, had an 11-fold increase

184 red with patients with prolonged episodes of BK viremia.

185 1 reduced the membrane surface expression of BK channels.

186 (Ca) was accompanied by a high expression of BK(Ca) transcript in the BK-beta1 KO, suggesting a lower

187 mV at 12 um matrix Ca(2+) ) Co-expression of BK(Ca) with the BK-beta1 subunit in HeLa cells doubled t

188 r cytokine measurements in the management of BK.

189 Furthermore, positive modulation of BK channels in vivo can enhance short-term habituation.

190 MP pathway and by using direct modulators of BK.

191 The number of BK channels progressively decreases with age in the IHCs

192 may provide insight into the pathogenesis of BK and guide treatment options.

193 erassay variability in the quantification of BK virus (BKV) DNA precludes establishing broadly applic

194 Recipients of BK viruric donors were more likely to develop BK viruria

195 esults suggest that LINGO1 is a regulator of BK channels, which causes a "functional knockdown" of th

196 ansplant after allograft loss as a result of BK virus-associated nephropathy (BKVAN).

197 results revealed a surprising sensitivity of BK activation to the linker sequence.

198 luated in samples representing a spectrum of BK infection (n = 25), followed by a multicenter validat

199 duration by changing alternative splicing of BK channels; this requires nuclear export of the splicin

200 ization of BKDEC (i.e. the splice variant of BK(Ca) that specifically targets mitochondria) into mito

201 estigating the effects of internal Ca(2+) on BK channel gating currents.

202 de that functional effects of S-acylation on BK channels depend on the presence of beta1-subunits.

203 he Ca(2+)- and voltage-sensing mechanisms on BK channel gating is still debated.

204 ifying endolysosomes by activating TRPML1 or BK channels may provide therapeutic benefit against late

205 ecoy" cells, and/or significant polyomavirus BK viremia.

206 Three recipients developed polyomavirus (BK) viremia near or >10,000 copies/ml that resolved afte

207 Nile virus, as well the human polyomaviruses BK/JC/MCV, human adenoviruses, and human papillomaviruse

208 onse between Gram-negative and Gram-positive BK and to determine the diagnostic value of corneal thic

209 gnificantly with incidence of posttransplant BK viremia.

210 big conductance Ca(2+)-activated potassium (BK) channel in regulating endolysosome pH, as well as Ta

211 rge-conductance calcium-activated potassium (BK) channels and Kv3.3 voltage-gated potassium channels

212 ce calcium- and voltage-activated potassium (BK) channels are potently modified by their functional c

213 arge conductance Ca(2+)-activated potassium (BK) channels are S-acylated at two sites that impart dis

214 ce voltage- and calcium-activated potassium (BK) channels inhibiting channel activity independently o

215 2+)- and voltage-gated (Slo1) big potassium (BK) channel.

216 ant two-pore domain (K2P) and big potassium (BK) channels.

217 alcium- and voltage-dependent big potassium (BK) channels.

218 Large-conductance potassium (BK) channels are transmembrane (TM) proteins that can be

219 Ca(2+))-activated big-conductance potassium (BK)-type channels.

220 Thus, a potent BK channel peptide modulator is open to neurological app

221 The effect of polyomavirus reactivation (BK viremia or JC viruria) on antibodies to kidney-specif

222 With current immunosuppressive regimens, BK polyomavirus-associated nephropathy (BKPyVAN) is stil

223 We hypothesized that LINGO1 is a regulatory BK channel subunit.

224 at mitoBK(Ca) associates with its regulatory BK-beta1 subunit in cardiac mitochondria, ensuring prope

225 e BK(Ca) when associated with its regulatory BK-beta1 subunit.

226 MitoBK(Ca) -alpha and the regulatory BK-beta1 subunit associate in mouse cardiac mitochondria

227 n's antiinflammatory effectiveness to rescue BK activity and thus mucociliary function was tested in

228 The BK activator, NS1619, rescued BK(G354S) cells but not siRNA-treated cells, by selectiv

229 Second, BK channels are positioned in clusters away from the vol

230 sion of LRRC52 with BK alpha subunits shifts BK current gating about -90 mV, to account for the profo

231 ET-1 inhibited single BK channels and transient BK currents in myocytes and st

232 e is established using gap junctions and SLO BK potassium channels to repress a calcium-activated pro

233 he maintenance of AWC asymmetry, couples SLO BK potassium channels to transactivation of sox-2 expres

234 chanistic insight into how NSY-7 couples SLO BK potassium channels to transactivation of sox-2 expres

235 experiments showed that loss of Ca(2+) spark-BK channel signaling in Mcoln1 (-/-) mice rendered both

236 nally associates with its regulatory subunit BK-beta1 in adult rodent cardiomyocytes.

237 tion, surface trafficking of beta1 subunits, BK channel and transient BK current activation, and vaso

238 s expressing both alpha- and beta1-subunits, BK channel alpha-subunits were endogenously S-acylated.

239 late the multisubunit composition of surface BK channels to stimulate contraction is unclear.

240 mediate its behavioral effects by targeting BK channels and their coupled calcium channels.

241 Although ethanol targets BK channels through direct interaction, how ethanol-medi

242 l outcomes of DSAEK for FED were better than BK.

243 e, with Kv having a much greater effect than BK.

244 While it is known that BK channels are activated by voltage and Ca(2+), and tha

245 exploratory subgroup analysis revealed that BK-induced coronary artery vasorelaxation was greater (P

246 Our findings suggest that BK channelopathy underlies epilepsy in AS and support th

247 The BK activator, NS1619, rescued BK(G354S) cells but not si

248 The BK(G354S) channel trafficked normally to plasma, nuclear

249 C. elegans, loss of function in SLO-1, the BK channel ortholog, confers profound ethanol resistance

250 p.(Asn449fs) and p.(Ile663Val) abolished the BK current, whereas p.(Cys413Tyr) and p.(Pro805Leu) redu

251 st that Mel promotes sleep by activating the BK channel through a specific Mel receptor and Gbetalamb

252 ge-activated potassium channel, known as the BK channel, is one of the central proteins that mediate

253 Ca) channel is functionally modulated by the BK-beta1 subunit; proper targeting and activation of mit

254 VP1, an effective marker for diagnosing the BK virus, was amplified on an on-chip device in less tha

255 specific causes for first graft failure, the BK group had better graft survival than patients who had

256 the second renal allograft was 90.6% for the BK group and 83.9% for the non-BK group.

257 es, we identified a peptide derived from the BK polyomavirus (BKV) minor structural proteins VP2/3 th

258 Mitochondria from the BK-beta1 knockout (KO) mice showed sparse mitoBK(Ca) cur

259 nome-size primary transcripts.IMPORTANCE The BK polyomavirus (BKPyV) miRNA plays an important role in

260 The mutation in the BK channel selectivity filter dramatically reduced singl

261 The better allograft survival in the BK group over acute rejection and disease recurrence rem

262 high expression of BK(Ca) transcript in the BK-beta1 KO, suggesting a lower abundance of mitoBK(Ca)

263 i diet which also shortened life span in the BK/BK;kl/kl mice.

264 e, the mutant BK(G354S) channel, but not the BK(WT) channel, caused progressive impairment of several

265 ne KCNMA1, encoding the alpha-subunit of the BK channel have emerged as responsible for a variety of

266 eins, of the intracellular S0-S1 loop of the BK channel pore-forming alpha-subunit controls functiona

267 he channel through the central cavity of the BK channel, and that only a single PAX molecule can inte

268 Although the size of the BK current decreased with age, IHCs retained a normal KC

269 ge and Ca(2+)-activated K(+) channels of the BK type are stimulated by cGMP/cGMP-dependent protein ki

270 p.(Cys413Tyr) and p.(Pro805Leu) reduced the BK current amplitude and shifted the activation curves t

271 Pi, autophagy, and alphaKlotho, we used the BK/BK mouse (homozygous for mutant Becn1(F121A) ) with i

272 a single PAX molecule can interact with the BK channel at a time.

273 analysis of the interaction of PAX with the BK channel pore gate domain guided by recently available

274 tential sites of interaction of PAX with the BK channel, we undertook a computational analysis of the

275 ix Ca(2+) ) Co-expression of BK(Ca) with the BK-beta1 subunit in HeLa cells doubled the density of BK

276 alling pathways such as K(+) release through BK channels, and the production and release of arachidon

277 Thus, BK and Kv were mostly closed at rest and activated by de

278 s had significantly better BSCVA compared to BK eyes (P = .006 at 4-year follow-up).

279 latory gamma subunits, LRRC26 and LRRC52, to BK channel function and localization in mouse IHCs.

280 lization of calcium channels with respect to BK channels and presynaptic release components significa

281 dy screen to examine the humoral response to BK polyomavirus.

282 ope of the ESPVR and dp/dtmax in response to BK, indicating a poor contractile response to CSAR activ

283 our hypothesis, vasorelaxation responses to BK and sodium nitroprusside were similar before and 219+

284 imal endothelium-dependent vasorelaxation to BK (bradykinin; 10(-)(6)-10(-)(10) M) was blunted (P<0.0

285 of beta1 subunits, BK channel and transient BK current activation, and vasodilation did not involve

286 1 inhibited single BK channels and transient BK currents in myocytes and stimulated vasoconstriction

287 rolled, but 9 patients experienced transient BK viremia during the first year.

288 After kidney transplantation, uncontrolled BK polyomavirus (BKPyV) replication causes kidney graft

289 ntrols and viremic KTR were stimulated using BK virus peptide libraries loaded or not on monocytes-de

290 ate thickness (IT) in distinguishing Gram-ve BK in a clinical cohort.

291 Whereas BK currents and channel localization were unaltered in I

292 cortical/medullary collecting duct, whereas BK channel abundance increased in principal cells of the

293 ient serology status was not associated with BK viremia (P = .31, P = .75, and P = .51, respectively)

294 plasma membrane BK(Ca) when associated with BK-beta1 (left-shifted voltage dependence of activation,

295 tion of plasma membrane BK(Ca) channels with BK-beta subunits shapes their biophysical properties and

296 Here we report that CaCCs coexist with BK and SK channels in inferior olivary (IO) neurons that

297 how that 1) LINGO1 coimmunoprecipitated with BK channels in human brain, 2) coexpression of LINGO1 an

298 ingle-chain variable fragment complexed with BK virus-like particles revealed the quaternary nature o

299 The graft survival in eyes with BK was poorer overall; however, the DMEK group still had

300 hat heterologous coexpression of LRRC52 with BK alpha subunits shifts BK current gating about -90 mV,