ライフサイエンスコーパス: BLIMP1

1 l Z(+) cells in oral hairy leukoplakia being BLIMP1(+).

2 r B lymphocyte-induced maturation protein 1 (Blimp1).

3 r B-lymphocyte-induced maturation protein 1 (BLIMP1).

4 s in B-cell differentiation: LMO2 and PRDM1 (Blimp1).

5 ation (ie, E4BP4, TXNIP, TBET, GATA3, HOBIT, BLIMP1).

6 tion of the transcription repressor PRD1-BF1/Blimp1.

7 ises results in sustained elevated levels of Blimp1.

8 ty factor Pax5 and the plasma cell regulator Blimp1.

9 hen they differentiate and express wild-type BLIMP1.

10 ng electroporation abolished the function of Blimp1.

11 lasma cells due to impaired up-regulation of BLIMP1.

12 ctional activity of the transcription factor Blimp1.

13 ession of the transcription factors Tbet and Blimp1.

14 of physiological repressors such as BCL6 or BLIMP1.

15 f the microRNA let-7c, which is regulated by BLIMP1.

16 asmacytoid differentiation, notably IRF4 and BLIMP1.

17 essed genes including Chordin, Cerberus, and Blimp1.

18 ied an extended set of promoters occupied by BLIMP1.

19 -7 maturation and consequential induction of BLIMP1.

20 SG and express the transcriptional repressor Blimp1.

21 cells was also largely rectified by ablating Blimp1.

22 ry T cells occurs normally in the absence of Blimp1.

23 BCL6 (26%), CD10 (0%), BCL2 (31%), Blimp1 (0.02%), and Epstein-Barr virus (EBV) (20%) showe

24 B cells had elevated TLR9 and PAX5, but not BLIMP1 (a gene-expression pattern associated with mature

25 show that the cellular transcription factor BLIMP1, a key player in both epithelial and B-cell diffe

26 itiated by signals that induce expression of Blimp1, a key regulator of the germ cell, in a few epibl

27 r cell mass (ICM)-generated cells expressing Blimp1, a key transcriptional repressor of the somatic p

28 Ets-1 negatively regulates the expression of Blimp1, a known suppressor of IL-2 expression, ablation

29 Blimp1, a transcriptional repressor, has a crucial role

30 Blimp1 ablation in E12.5 mouse dermal fibroblasts delaye

31 ranscription factors such as IRF4, XBP1, and BLIMP1 accompanied by a strong inhibition of proliferati

32 To explore Blimp1 activities at later stages in the embryo proper,

33 BLIMP1 addition was sufficient to induce reactivation in

34 In all cases studied, both BLIMP1 alleles were inactivated by deletions or mutation

35 Furthermore, we show that Blimp1 (also called Prdm1), a let-7 target and a master

36 ma cells expressing the transcription factor Blimp1 (also known as Prdm1).

37 zinc finger transcriptional repressor Prdm1/Blimp1, an essential regulator of placenta development,

38 s respond to IL-27 and IL-12 by upregulating Blimp1 and adopt a Tr-1-like phenotype characterized by

39 Let-7c reciprocally inhibited Blimp1 and also blocked LPS-induced suppressor of cytoki

40 tes the transcription factors gatae and krox/blimp1 and both of these transcription factors also feed

41 Blimp1 and E2A directly regulated Cxcr5 expression and,

42 confirm and extend the competitive model of BLIMP1 and IRF interaction.

43 transient period of il10 transcription, the blimp1 and irf4 transcription factors were induced in B1

44 At such sites, BLIMP1 and IRFs can antagonistically regulate promoter a

45 with Foxp3(+) Treg-cell specific deletion of Blimp1 and other approaches, here we show that Foxp3(+)

46 to regulate Blimp1 expression via B108, and Blimp1 and Otx2 were shown to form a negative feedback l

47 creting cells by controlling the activity of Blimp1 and Pax5 and may be required for B cell tolerance

48 ession of IRF8 and Bcl6 which are targets of Blimp1 and potent osteoclastogenic transcriptional repre

49 und genes encoding the transcription factors Blimp1 and Runx3 and acted by antagonizing their express

50 IRF4 promoted the expression and function of Blimp1 and T-bet, two transcription factors required for

51 important for suppressing the expression of Blimp1 and TH1-associated genes and for positively regul

52 fferentiation possibly through repression of Blimp1 and that Fancc(-/-) B cells are hypersensitive to

53 ls, including altered expression of BCL6 and BLIMP1 and unique expression of chemokine receptors that

54 this circuit generates an expanding torus of blimp1 and wnt8 expression.

55 Thus even-skipped and hox11/13b, along with blimp1 and wnt8, are members of a cohort of torus genes

56 ring the long isoform had significantly less BLIMP1 and XBP1 mRNA and, for human pre-B cells, remaine

57 and CD138 positive, demonstrated upregulated BLIMP1 and XBP1 mRNA, and acquired the morphology of pla

58 , TBX21 (T-bet), NFIL3 (E4BP4), ZEB2, PRDM1 (BLIMP1), and RORA mRNA levels are higher in CD56(dim) ce

59 rectly bound to the promoter region of IRF4, BLIMP1, and BCL2.

60 tion of key osteoclastogenic factors NFATc1, BLIMP1, and c-FOS by inhibiting ITAM-mediated expression

61 ss the zinc finger transcriptional repressor Blimp1, and demonstrate that this subset of highly clono

62 is was marked by higher expression of EOMES, blimp1, and Glut1 in Gal-9(+) versus Gal-9(-) T cells, w

63 ation by inhibiting the transcription factor Blimp1, and in wild-type (WT) cells cRel was dynamically

64 n-regulates the expression of IRF4 and PRDM1/BLIMP1, and memory B cell-enriched hsa-miR-223 down-regu

65 ion factors IFN regulatory factor (IRF)4 and Blimp1, and paradoxically also activation-induced deamin

66 n MHC II and plasma cell markers MUM1, PRDM1/Blimp1, and XBP1s.

67 luding this bi-stable circuit of mutual cRel-Blimp1 antagonism into a multi-scale model revealed that

68 nal network, with mutually antagonistic Bcl6-Blimp1 as a core regulatory axis.

69 These results identify Blimp1 as a critical regulator of tissue remodelling and

70 analyzed in transgenic embryos, establishing Blimp1 as a direct Gli target and identifying Gli activa

71 These findings point to a role for BLIMP1 as a tumor suppressor gene, whose inactivation ma

72 re we identify the transcriptional regulator Blimp1 as crucial to induce IL-10 in inflammatory T help

73 colleagues have identified FOXO3 and PRDM1 (Blimp1) as tumor suppressor genes with a potentially cri

74 tory reconstruction experiment revealed that blimp1 autorepression accounts for progressive extinctio

75 Here, we show that the HPK1-NFkappaB-Blimp1 axis mediates T cell dysfunction.

76 ression of the zinc finger repressor protein Blimp1 (B-lymphocyte-induced maturation protein), the cr

77 chromatin accessibility surrounding IRF4 and BLIMP1 binding motifs and epigenetic remodeling of IL21R

78 tiple motif variants are required to capture BLIMP1 binding specificity.

79 ally repressed during ASC differentiation by Blimp1 binding the Rel locus.

80 s, and mice with T cell-specific deletion of Blimp1 (Blimp1CKO mice) spontaneously develop severe int

81 trikingly, Zbtb20 induction does not require Blimp1 but depends directly on Irf4, acting at a newly i

82 more about functional contributions made by Blimp1+ cell lineages here we perform the first single-c

83 Prdm1.Cre-LacZ allele demonstrate that these Blimp1(+) cells give rise to the mature SpA-TGCs, canal

84 We observed that Blimp1+ cells gave rise to all photoreceptors, but also

85 Transcriptome analysis of Blimp1 CKO macrophages identified the murine chemokine (

86 the precociously generated bipolar cells in Blimp1 CKO mice co-expressed GFP, suggesting that rods b

87 ed elevated levels of Ccl8, and consequently Blimp1 CKO mice had higher levels of circulating CCL8, r

88 Birthdating analyses in control and Blimp1 CKO mice showed that bipolar cells were birthdate

89 O) of Blimp1 in myeloid cells and found that Blimp1 CKO mice were protected from lethal infection ind

90 r cells were birthdated as early as E13.5 in Blimp1 CKO mice, five days before this cell type was gen

91 oked for transitioning rod photoreceptors in Blimp1 conditional knock-out (CKO) mice carrying the NRL

92 The transcriptional repressor Blimp1 controls cell fate decisions in the developing em

93 In addition, we show that Blimp1 controls common and unique aspects of Treg and Te

94 We demonstrate that KLF4 and BLIMP1 cooperatively induce the expression of LMP1, even

95 Alternatively, Blimp1 could be expressed broadly in Otx2+ cells and sil

96 In principle, Blimp1 could be expressed only in Otx2+ cells that are c

97 Using a Blimp1-Cre germline conditional knockout, we discovered

98 ed the fate of Blimp1 expressing cells using Blimp1-Cre mice and Lox-Stop-Lox reporter strains.

99 A Blimp1-Cre transgenic strain was also exploited to gener

100 Blimp1-deficient DCs exhibited elevated expression of MH

101 re we explored further phenotypic changes in Blimp1-deficient DCs, the molecular mechanism underlying

102 ributing to the proinflammatory phenotype of Blimp1-deficient DCs.

103 Accordingly, Blimp1-deficient effector T cells fail to produce IL-10,

104 BLIMP1-deficient macrophages expressed elevated levels o

105 ficient Treg cells are more susceptible, and Blimp1-deficient Treg cells are resistant, to acquiring

106 Blimp1 deletion results in excess bipolar cell formation

107 context of allergic airway inflammation are Blimp1 dependent, express type 2 cytokines, and share fe

108 g) cell-derived IL-10 and IL-35 in promoting BLIMP1-dependent exhaustion of CD8(+) TILs that limits e

109 gh PI3Kdelta-AKT-GSK3, which in turn promote BLIMP1-dependent IL-10 production.

110 quisition of pluripotency does not require a Blimp1-dependent PGC intermediate state.

111 We propose that Blimp1-dependent recruitment of Tle4 to the Ifng locus c

112 ew insights into the chromatin landscape and Blimp1-dependent regulatory networks governing trophobla

113 trophoblast stem cells allow us to identify Blimp1-dependent transcripts enriched in SpA-TGCs.

114 ng domain was required for reactivation, but BLIMP1 did not directly bind the nucleotide (nt) -660 Rp

115 y, we identify a population of proliferating Blimp1(+) diploid cells present within the spongiotropho

116 Loss of Blimp1 disrupts epithelial architecture and lumen format

117 CpG content, leading to the observation that BLIMP1 DNA-binding is methylation sensitive.

118 The mechanism by which BLIMP1 does so involves strongly turning on expression o

119 f B lymphocyte-induced maturation protein 1 (Blimp1) does not rescue the expression of IL-2 by Ets-1-

120 Additionally we find that beside Blimp1, down-regulated phospho-Smad159 levels also disti

121 regulatory network, established by SOX17 and BLIMP1, drives comprehensive germline DNA demethylation

122 d the secretion of IgM without up-regulating Blimp1, driving the cells towards an intermediate activa

123 e polarization between Bcl6(+) Tfh cells and Blimp1(+) effector Th cell populations developed by 72 h

124 Finally, we used IgM1:eGFP and cd45DsRed;blimp1:eGFP zebrafish to characterize plasma B cells and

125 cers of Prdm1 and Prdm14 in EpiLCs in vitro; BLIMP1 (encoded by Prdm1) then directly induces Tfap2c.

126 While expression of BLIMP1 (encoded by Prdm1) was a common target, IL-10 and

127 t induces expression of transcription factor BLIMP1 (encoded by Prdm1), which regulates plasma cell d

128 r B lymphocyte-induced maturation protein-1 (Blimp1) exhibit a lupus-like phenotype, secondary to enh

129 these alternatives, we followed the fate of Blimp1 expressing cells using Blimp1-Cre mice and Lox-St

130 was also exploited to generate a fate map of Blimp1-expressing cells.

131 Here we describe Blimp1 expression and functional requirements within mat

132 On the molecular level, Fra1 represses Blimp1 expression and interferes with binding of the act

133 ation domains, we propose that Fra1 inhibits Blimp1 expression and negatively controls plasma cell di

134 in culture significantly increased CD138 and Blimp1 expression and PC-specific IgM, but did not affec

135 n of activated B cells is required to foster Blimp1 expression but needs to be terminated to avoid ov

136 ed with increased AgR signaling capacity and Blimp1 expression by B-1b cells.

137 Thus, Blimp1 expression defines a mammary stem cell subpopulat

138 east cancer models, shows that the increased Blimp1 expression depends on both MAPK activation and mi

139 IFN-gammaR signaling induced Blimp1 expression in B cells but also initiated an infla

140 asm that is inherited from the egg; in mice, Blimp1 expression in the epiblast mediates the commitmen

141 ession of VEGF signaling diminishes PRD1-BF1/Blimp1 expression in tumor vasculature and inhibits intr

142 Previous reports showed that ectopic BLIMP1 expression induces reactivation in some EBV-posit

143 Thus, we conclude that BLIMP1 expression is both necessary and sufficient to in

144 c germ cells that are derived from PGCs when Blimp1 expression is lost.

145 Indeed, high Blimp1 expression levels are detected in invasive p130Ca

146 Blimp1 expression marks a rare subpopulation of unipoten

147 Our results suggest that Blimp1 expression stabilizes immature photoreceptors by

148 whereas IL2Ralpha(hi) cells exhibited strong Blimp1 expression that repressed Bcl6 (effector Th cell

149 Otx2 and RORbeta were found to regulate Blimp1 expression via B108, and Blimp1 and Otx2 were sho

150 Thus, the association of Blimp1 expression with ESC development furthers understa

151 SOX11 silencing downregulates PAX5, induces BLIMP1 expression, and promotes the shift from a mature

152 es over a broad physiological range, AID and Blimp1 expression, CSR, somatic hypermutation and plasma

153 gous phenotypic changes, including decreased BLIMP1 expression, increased let-7c expression, and incr

154 nt BACH2 and IRF8 downregulation, sustaining BLIMP1 expression, the master regulator for PC different

155 nerate a beta-catenin/Tcf input required for blimp1 expression, while the wnt8 gene in turn requires

156 s-regulatory module (CRM), B108, that mimics Blimp1 expression.

157 ls plasma cell differentiation by repressing Blimp1 expression.

158 RBPJ expression, resulting in a decrease of Blimp1 expression.

159 ivates a feed-forward loop in which KLF4 and BLIMP1 first activate LMP1 expression and then cooperate

160 wild-type, Bcl6(fl/fl) Foxp3-Cre, and Prdm1 (Blimp1)(fl/fl) Foxp3-Cre mice to study the reciprocal ro

161 ory conditions, the intrinsic requirement of Blimp1 for homeostatic maintenance of these T cell subse

162 ntified two strong Tcf1 binding sites in the Blimp1 gene at a 24-kb upstream and an intron-3 element.

163 ic program and regulated by a balanced SOX17-BLIMP1 gene dosage.

164 We report here that the BLIMP1 gene is inactivated by structural alterations in

165 The blimp1 gene is itself linked into a feedback circuit tha

166 BLIMP1 gene transcription was activated by TGF-beta1 via

167 able fraction of ABC-DLBCL carry an inactive BLIMP1 gene, and suggest that the same gene is inactivat

168 ork subcircuit comprising the otx, wnt8, and blimp1 genes accounts for a moving torus of gene express

169 subcircuit that includes the otx, wnt8, and blimp1 genes, the cis-regulatory control systems of whic

170 tal abnormalities, whereas transheterozygous Blimp1(gfp/-) embryos with further reduced expression le

171 Here, we show that Blimp1 has a novel interaction with Prmt5, an arginine-s

172 Blimp1 has been shown to function as a direct activator

173 functional annotation analysis revealed that Blimp1 has broadly shared as well as cell type-specific

174 antigen-specific CD8(+) T cells, including a Blimp1(hi)Id3(lo) tissue-resident effector cell populati

175 inhibited by the transcriptional regulators Blimp1, Id2 and Id3.

176 ce to study the reciprocal roles of Bcl6 and Blimp1 in allergic airway inflammation.

177 To examine the role of BLIMP1 in innate immunity, we used a conditional knockou

178 s DC phenotype and confirm the importance of BLIMP1 in maintaining tolerogenic DCs in both mice and h

179 ely, these data reveal an important role for BLIMP1 in modulating host defenses by suppressing expres

180 ity, we used a conditional knockout (CKO) of Blimp1 in myeloid cells and found that Blimp1 CKO mice w

181 ll, our study reveals the functional role of Blimp1 in promoting the dermal papilla inductive signali

182 last by sequential upregulation of SOX17 and BLIMP1 in response to WNT and BMP signalling.

183 inflammation, indicating a crucial role for Blimp1 in T cell homeostasis regulation.

184 We analyzed the function of Blimp1 in the mouse retina using a conditional deletion

185 The DNA motif bound by BLIMP1 in vitro overlaps with that of interferon regulat

186 anscription factor Prdm1 (also called Ubo or Blimp1) in response to Hedgehog (Hh) signalling, express

187 Interestingly Blimp1 inactivation results in up-regulated Csf1 express

188 dent cellular transcription factors KLF4 and BLIMP1 induce lytic EBV reactivation in epithelial cells

189 siRNA knockdown of BLIMP1 inhibited 12-O-tetradecanoyl-phorbol-13-acetate (

190 consistent with the latter alternative: that Blimp1 inhibits bipolar competence in Otx2+ cells and mu

191 sion, while the wnt8 gene in turn requires a Blimp1 input.

192 phocyte-Induced Maturation Protein 1 (BLMP-1/BLIMP1), involved in differentiation of mammalian secret

193 to occupied promoters containing overlapping BLIMP1/IRF motifs (e.g. AIM2, SP110, BTN3A3) are shown t

194 The transcription factor BLIMP1 is a master regulator of primordial germ cell (PG

195 rst time, that the transcriptional repressor Blimp1 is a novel mediator of p130Cas/ErbB2-mediated inv

196 Notably, Blimp1 is also dispensable for reprogramming epiSCs to E

197 experimental validation we demonstrated that Blimp1 is both a target and a mediator of key dermal pap

198 sing a genetic approach, we demonstrate that Blimp1 is dispensable for the derivation and maintenance

199 Blimp1 is dynamically expressed at diverse tissue sites

200 Here we show that Blimp1 is dynamically regulated in dermal papilla cells

201 s been postulated that repression of Pax5 by Blimp1 is essential for plasma cell development.

202 zinc finger transcriptional repressor Prdm1/Blimp1 is essential for specification of spiral artery t

203 In T cells, Blimp1 is expressed in both effector (Teff) and regulato

204 Although in the epidermis Blimp1 is important for keratinocyte and sebocyte differ

205 Our study demonstrates that Blimp1 is involved in a novel transcriptional regulatory

206 Thus, although Blimp1 is obligatory for PGC specification, it is not re

207 t Foxp3(+) Treg cell-intrinsic expression of Blimp1 is required to control Treg and Teff cells homeos

208 Collectively, these results demonstrate that Blimp1 is required to maintain a highly proliferative lu

209 e pluripotent state, it is not known whether Blimp1 is similarly involved.

210 Blimp1 is transiently expressed in Otx2+ cells.

211 r B lymphocyte-induced maturation protein 1 (BLIMP1) is a master regulator of B and T cell differenti

212 )/B lymphocyte-induced maturation protein 1 (BLIMP1) is a transcriptional repressor expressed in a su

213 B-lymphocyte-induced maturation protein 1 (Blimp1) is a transcriptional repressor that regulates ce

214 get set which is preferentially activated by BLIMP1 knock-down.

215 During cleavage stages the blimp1/krox gene is expressed in the large micromeres an

216 The blimp1/krox gene of Strongylocentrotus purpuratus, forme

217 The MASO perturbation analysis also revealed blimp1/krox inputs into other genes of the endomesoderm

218 The expression of blimp1/krox is dynamic, and involves several distinct sp

219 A different splice variant, blimp1/krox1a, is expressed only from gastrula stage onw

220 Blimp1 likely forms a cross-repressive network with pro-

221 ially dependent on the transcription factor, BLIMP1, linking plasma cell commitment and cessation of

222 terial infections and a molecularly distinct Blimp1(lo)Id3(hi) tissue-resident memory population that

223 The BLIMP1 locus lies on chromosome 6q21-q22.1, a region fre

224 enhancers and a distal element at the Prdm1 (Blimp1) locus, E-proteins contributed to Igk, Igh, and P

225 and impaired differentiation resulting from Blimp1 loss in ABC-DLBCL lymphomagenesis.

226 Blimp1(+) luminal stem cells give rise to Blimp1(-) prog

227 Blimp1 may also have a role in the maintenance of early

228 death into T cell-independent proliferation, Blimp1-mediated plasmablast differentiation, and autoant

229 motif) ligand 8, CCL8, as a direct target of Blimp1-mediated transcriptional repression in these cell

230 nhancer-targeted IRF2 protected LCLs against Blimp1-mediated tumor suppression.

231 In occupied promoters, only a subset of BLIMP1 motifs overlap with IRF motifs.

232 protein expression, despite the presence of BLIMP1 mRNA.

233 its functional role remains unknown because Blimp1 mutant embryos arrest at E10.5 due to placental i

234 tenin was able to override the HF defects in Blimp1 mutant mice, underlining the close reciprocal rel

235 Importantly, Blimp1 not only silences TSC gene expression but also pr

236 is unknown, since an unbiased assessment of BLIMP1 occupancy in vivo is lacking.

237 The GRN centers on Blimp1, one of the transcription factors (TFs) that regu

238 ow the conserved transcription factor BLMP-1/Blimp1 operates as a pioneer factor to decompact chromat

239 TG resulted in sustained BCL6 but not BLIMP1 or CD138 expression, which is consistent with mai

240 tif selection predicts that only a subset of BLIMP1 or IRF sites is subject to antagonistic regulatio

241 uring allergic airway inflammation, Bcl6 and Blimp1 play dual roles in regulating Tfr-cell activity i

242 The transcriptional regulator Blimp1 plays crucial roles in controlling terminal diffe

243 Blimp1 plays essential roles in multipotent progenitor c

244 entified role that transcriptional repressor Blimp1 plays in the control of breast cancer invasivenes

245 ssion profiling indicated that many of these Blimp1-positive cells coexpress other genes typically as

246 may not entail an obligatory route through a Blimp1-positive PGC-like state.

247 ments revealed that ESCs commonly arise from Blimp1-positive precursors; indeed, prospective sorting

248 ells can become ESCs without first acquiring Blimp1 positivity.

249 The zinc-finger transcriptional repressor Blimp1 (Prdm1) controls gene expression patterns during

250 toreceptor fate determination, we found that Blimp1 (Prdm1) is expressed transiently in developing ph

251 Blimp1 (Prdm1), the key determinant of primordial germ c

252 Commensurately higher Blimp1/PRDM1 expression was detected in ERalpha-negative

253 of the zinc finger transcriptional repressor Blimp1/PRDM1 is essential for the establishment of epith

254 In sum, the transcriptional repressor Blimp1/Prdm1 is required for terminal differentiation of

255 Developmental arrest of Blimp1/Prdm1 mutant embryos at around embryonic day 10.5

256 Here we investigate Blimp1/Prdm1 requirements in the trophoblast cell lineag

257 Blimp1-Prmt5 colocalization results in high levels of H2

258 ubsequently, Dhx38, a putative target of the Blimp1-Prmt5 complex, is upregulated.

259 Blimp1(+) luminal stem cells give rise to Blimp1(-) progeny that are invariably Elf5(+)ERalpha(-)P

260 g of the activating AP-1 member c-Fos to the Blimp1 promoter.

261 cell differentiation through binding to the Blimp1 promoter.

262 on-GC type DLBCL cases (n = 20/26, 77%) lack BLIMP1 protein expression, despite the presence of BLIMP

263 Blimp1 protein repressed ERalpha (ESR1) gene transcripti

264 Thus, Blimp1 regulates proliferation, apoptosis and alveolar c

265 We conclude that Blimp1 regulates the decision between photoreceptor and

266 r B lymphocyte-induced maturation protein-1 (BLIMP1) regulates gene expression and cell fate.

267 Thus, the induction of Blimp1 represents a novel mechanism whereby the RelB NF-

268 the key regulator of hPGC-like fate, whereas BLIMP1 represses endodermal and other somatic genes duri

269 Blimp1 represses the incipient somatic program in these

270 Our data demonstrate that Tcf1-mediated Blimp1 repression is functionally critical for safeguard

271 of c-Fos in Fra1 transgenic B cells releases Blimp1 repression.

272 of the hesC gene, however, is controlled by Blimp1 repression.

273 e include activation by beta-catenin/Tcf and Blimp1, repression within the torus by Hox11/13b, and re

274 ly, the present experiments demonstrate that Blimp1 requirements in diverse cell types are exquisitel

275 e being three or more synergistically acting BLIMP1-responsive elements (BRE) within Rp.

276 TGFB1 and BLIMP1 RNA levels were correlated in patient breast tumo

277 BLIMP1's DNA-binding domain was required for reactivatio

278 Here, we examined BLIMP1's role in inducing EBV lytic gene expression in n

279 document previously unappreciated aspects of Blimp1's role in T cell biology and shed light on the in

280 DCs from Blimp1 SLE-risk allele carriers exhibited analogous phen

281 BLIMP1 strongly induced transcription from Rp as well as

282 rential roles for transcriptional regulators Blimp1, T-bet, Id2, and Id3 in supporting and maintainin

283 ore, cellular transcription factors, such as BLIMP1, that are key mediators of differentiation likely

284 Blimp1 thus represses the repressor of delta, thereby pe

285 nctions with the master germline determinant BLIMP1 to promote primordial germ cell (PGC) specificati

286 ggest that PRDM14 cooperates with TFAP2C and BLIMP1 to upregulate germ cell and pluripotency genes, w

287 r B lymphocyte-induced maturation protein 1 (BLIMP1) to promote MHC-II expression.

288 B, increased IgM secretion, up-regulation of Blimp1 transcription and decreased MHC-II surface expres

289 landscape of VAT-resident T(reg) cells in a BLIMP1 transcription factor-dependent manner.

290 Moreover, we demonstrate that Blimp1 triggers cell invasion and metastasis formation v

291 We identified Hrd1-mediated BLIMP1 ubiquitination as a previously unknown mechanism

292 T-bet did not affect Blimp1 upregulation in IFN-gamma-activated B cells but i

293 The latter gene, coding for BLIMP1, was inactivated by multiple mechanisms, more fre

294 two cellular transcription factors (KLF4 and BLIMP1) which cooperatively activate the two LMP1 promot

295 EZH2 inhibition in NHL cells induced BLIMP1, which impaired tumor growth.

296 Cell Stem Cell, Bao et al. demonstrate that Blimp1, which is required for primordial germ cell (PGC)

297 master regulator of plasma cell development, Blimp1 will in turn suppress AID expression and drive th

298 nse to viral infection, compound deletion of Blimp1 with Tcf1 restored T(FH) cell frequency, numbers,

299 ontrolled at the cis-regulatory level by the blimp1-wnt8 torus-generating subcircuit now explains the

300 xpression of multiple key factors, including Blimp1, Xbp1, and CXCR4, and is therefore critical for e