ライフサイエンスコーパス: BMP receptor

1 MP9, and only these cells expressed the Alk1 BMP receptor.

2 matrix, preventing the activation of cognate BMP receptor.

3 he added synapse-stabilizing activity of the BMP receptor.

4 as chordin, that sequester ligands from the BMP receptor.

5 account for the stabilizing activity of the BMP receptor.

6 izing effects of Noggin or dominant-negative BMP receptor.

7 ion of wnt inhibitors with dominant-negative BMP receptor.

8 t on secreted BMP ligands through the type I BMP receptor.

9 hich expressed low to undetectable levels of BMP receptors.

10 signal through a hetero-oligomer complex of BMP receptors.

11 the restricted, basolateral localization of BMP receptors.

12 ecapitulate the effects of dominant negative BMP receptors.

13 ely Smad1, Smad5 and Smad8, are activated by BMP receptors.

14 nd ALK3) and two type II (ActRIIA and BMPR2) BMP receptors.

15 has overlapping functions with other type I BMP receptors.

16 ly by forming a plasma membrane complex with BMP receptors.

17 neutralizing antibody or the small molecule BMP receptor 1 inhibitor LDN-193189.

18 Surprisingly, sclerostin, noggin, and human BMP receptor 1A (BMPR1A)-FC fusion proteins blocked Wnt-

19 dy, we overexpressed a constitutively active BMP receptor 1A (caBmpr1a) in chondrocytes by using two

20 ng a heat shock-inducible, dominant-negative BMP receptor 1a [Tg(hs70I:dnBmpr1a-GFP)] to bypass early

21 PTHrP upregulates BMP receptor 1A expression in the mammary mesenchyme, en

22 tro/in vivo hybrid knockout assay, we ablate BMP receptor 1a in purified DP cells.

23 t Cre-mediated mutation of the gene encoding BMP receptor 1A in the surface epithelium and its deriva

24 Moreover, phospho-SMAD1/5 is altered and BMP receptor 1A is reduced in a XMC patient.

25 t BMP4 specifically induces proliferation of BMP receptor 1a-positive MP cells but has no effect on S

26 placeable by that of a constitutively active BMP receptor 1A.

27 r P2RY1, and the bone morphogenetic protein (BMP) receptor 1A (BMPR1A)/activin-like kinase 3 (ALK3),

28 ntains inter-myofibre progenitors expressing Bmp-receptor 1a (Bmpr1a) and Myf5 that respond to stimul

29 d conditional/conventional double KO mice of BMP-receptor 1a (BMPR1a; targeted to PV-INs) and 1b (BMP

30 ural crest-derived human melanocytes express BMP receptor-1A, -1B, and -2.

31 he same level of Bone Morphogenetic Protein (BMP) Receptor-1A as OAC but only 1/12 of Transforming Gr

32 co-express GDF5 and its preferred receptors, BMP receptor 1B and BMP receptor 2, during development.

33 iate into chondrocytes and that signaling of BMP receptor 1B in this context is replaceable by that o

34 of melanogenesis, down-regulated the mRNA of BMP receptor-1B in melanocytes.

35 ought to determine whether disruption of the BMP receptor 2 (BMPR2) would alter mammary tumor progres

36 This effect of BMP7 depended on BMPR2 (BMP receptor 2), and BMPR2 expression inversely correlat

37 its preferred receptors, BMP receptor 1B and BMP receptor 2, during development.

38 rmalities in the bone morphogenetic protein (BMP) receptor 2 (BMP-R2) signaling pathway are important

39 f the BMP type I receptors, we find that the BMP receptors act similarly to BMP4 in the gizzard when

40 entiation inhibitory signals by antagonizing BMP receptor-activated Smad activity while activating cr

41 ecifically increases nuclear localization of BMP receptor-activated SMADs (R-SMADs) confirming a func

42 onstrate that Gata-2 functions downstream of BMP receptor activation in these same cells, and is a di

43 ding to two types of serine/threonine kinase BMP receptors, activation of which leads to phosphorylat

44 Here we show that the BMP receptor activin-like kinase 3 (Alk3) is elevated ea

45 ontribution of EPDCs to the AV junction, the Bmp receptor activin-like kinase 3 (Alk3; or Bmpr1a) was

46 The type I BMP receptors activin-like kinase (ALK)3 and ALK6 share

47 Further reduction of Bmp receptor activity by removing one functional copy of

48 was to analyze the function(s) of the type 1 BMP receptor, Acvr1, in lens development.

49 not the liver bud, acting through the type I BMP receptor Acvr1l, is required for PE specification.

50 Thus, the type I BMP receptor ALK2 plays an essential cell-autonomous rol

51 FOP-associated mutations in the BMP receptor ALK2 reduce binding of the inhibitor FKBP12

52 FKBP12 preferentially targets the BMP receptor ALK2.

53 basal hepcidin expression, whereas 2 type I BMP receptors, Alk2 and Alk3, are required for regulatio

54 Conditional deletion of the BMP receptor Alk3 from venous pole SHF cells leads to im

55 wild-type mice showed an upregulation of the BMP receptors Alk3 and BMPR-II, and of their ligand BMP4

56 ese observations demonstrate that one type I BMP receptor, Alk3, is critically responsible for basal

57 iac myocyte-specific deletion of the type IA BMP receptor, ALK3.

58 This may represent a novel BMP receptor and is the first to be characterized in pri

59 from the complex and permits it to bind the BMP receptor and signal.

60 bition of Dab2 attenuates internalization of BMP receptors and abrogates the proangiogenic effects of

61 Overall, our results show that BMP receptors and beta3 integrin work together to contro

62 tion by their activation of different type I BMP receptors and distinct modulations of the cell cycle

63 MP) signaling in pulmonary vascular disease, BMP receptors and downstream phospho-Smad1/5/8 were redu

64 ecycling pathways for the type I and type II BMP receptors and highlights the importance of tetraspan

65 d that the geometric compartmentalization of BMP receptors and ligands creates a signaling gradient t

66 The requirement of various BMP receptors and members of the SMAD signal transductio

67 Spict interacts with BMP receptors and promotes their internalization from th

68 However, whereas these BMP receptors and signaling components are required in t

69 re similar to those we observe in mutants of BMP receptors and Smad transcription factors.

70 Flk-1(+) progenitors coexpressed TGFbeta and BMP receptors and target genes.

71 Using siRNAs to type I and II BMP receptors and the signaling intermediaries (Smads),

72 BMPs are mediated by the canonical family of BMP receptors and then regulated by specific inhibitory

73 We show here that several BMP ligands, all BMP receptors, and BMP-associated Smad1/5/8 are expresse

74 nsferrin receptor 2, matriptase-2, neogenin, BMP receptors, and transferrin.

75 alling in vivo using either a small molecule BMP receptor antagonist or a solubilized BMPR1a-FC recep

76 s period in vitro or in vivo, using either a BMP receptor antagonist or noggin (Nog).

77 Importantly, blocking BMP activity by BMP receptor antagonist, noggin, reverse the effects of

78 BMP receptor antagonists also decreased clonogenic cell

79 BMP receptor antagonists and silencing of BMP type I rec

80 We find that the BMP receptors are differentially expressed in distinct r

81 The CAF cells express type I and type II BMP receptors as well as the receptor for SDF-1, CXCR4.

82 alk6b, a type IB bone morphogenetic protein (BMP) receptor, as the cause of the zebrafish GCT phenoty

83 BMP receptor association with membrane microdomains, whi

84 overexpressing a dominant-negative form of a Bmp receptor at various embryonic stages, we determined

85 x (Chd-Tsg-BMP) forms relatively quickly and BMP receptor binding is relatively slow.

86 A BMP-receptor binding assay revealed that Tsg has two dis

87 BMP antagonist, noggin, or dominant negative BMP receptors blocked the effects of elevated intracellu

88 arried out to evaluate the potential role of BMP receptor (BMP-R) types IA, IB, and II in bladder tra

89 d-circulating NK cells express type I and II BMP receptors, BMP-2 and BMP-6 ligands, and phosphorylat

90 pite the importance of endocytosis-regulated BMP receptor (BMPR) control of this developmental signal

91 phogenetic protein 2 (BMP2), which activates BMP receptor (BMPR) expressed by enteric neurons.

92 ermore, a dynamic expression profile for the BMP receptor (BMPR) isoform IB was observed, with dramat

93 s of the TGF-beta family that signal via the BMP receptor (BMPR) signaling cascade, distinct from can

94 udies, we have demonstrated that the type IB BMP receptor (BMPR-IB) plays an essential and specific r

95 ncer, we examined the expression of BMPs and BMP receptors (BMPR) as well as the responsiveness to re

96 on by examining whether either of the type I BMP receptors (Bmpr), BmprIa and BmprIb, have a role con

97 s of function of bone morphogenetic protein (BMP) receptor (BMPR)II, observed in pulmonary arterial h

98 We revealed the presence of mRNA of Type I BMP receptors, BMPR-1A (ALK3), BMPR-1B (ALK6) and ALK2 i

99 analyzed the expression and function of two BMP receptors, BMPR-IA and BMPR-IB, in neural precursor

100 n and regulation of the mRNAs for the type I BMP receptors, BMPR-IA and BMPR-IB, in quail embryos in

101 ing, we conditionally inactivated the type 1 Bmp receptor Bmpr1a in the facial primordia, using the N

102 expressed type I bone morphogenetic protein (BMP) receptor Bmpr1a (also known as Alk3) in the mesench

103 Genetic ablation of the type 1A BMP receptor (Bmpr1a) in brown adipogenic progenitor cel

104 xpressing progenitors, we ablated the Type I Bmp receptor, Bmpr1a utilizing Isl1Cre/+.

105 ns, we deleted the genes encoding the type I BMP receptors, Bmpr1a and Acvr1, and the canonical trans

106 eviously found that disruption of two type I BMP receptors, Bmpr1a and Acvr1, respectively, in an ost

107 AMOT130 interacts with the BMP receptor BMPR2 and facilitates SMAD activation and t

108 Loss of function mutations in the type II BMP receptor BMPR2 are the leading cause of pulmonary ar

109 trathymic progenitors expressing the type IA BMP receptor (BMPRIA) and provide evidence that CD34(+)C

110 A role for the type I BMP receptor BmprIB as a regulator of ovulation rates in

111 NIPA1 physically interacts with the type II BMP receptor (BMPRII) and we demonstrate that this inter

112 We show that the type II BMP receptor (BMPRII) is a novel target of miR-302.

113 The type II BMP receptor (BMPRII) is expressed as two alternatively

114 s in the Type II Bone morphogenetic protein (Bmp) receptor, BmpRII, in families with PAH has implicat

115 Signaling is transduced by BMP receptors (BMPRs) of type I and type II that are ser

116 demonstrated that the loss of expression of BMP receptors (BMPRs) type IA, -IB, and -II (BMP-RIA, -R

117 ts of the BMP signalling pathway, the type I BMP receptors (BMPRs), are both necessary and sufficient

118 P signaling loops, we first localized Type I BMP receptors (BMPRs), BMPR-1A (ALK3), -1B (ALK6) and AL

119 ssociation is dependent on the expression of BMP receptors but not transforming growth factor beta re

120 of beta1-integrin reduced overall levels of BMP receptors but significantly increased partitioning o

121 Therefore, potentiation of the BMP receptor by H11K promotes an activation of the PI3K/

122 ts BMP signalling involves downregulation of BMP receptors by promoting their endocytosis and lysosom

123 Activation of BMP receptors by their ligands leads to induction of sev

124 Further, ectopic BMP receptors cause an upregulation of Nkx2.5, the pylor

125 r alone or together with a dominant-negative BMP receptor, Chordin and/or Noggin in competent epiblas

126 to loss-of-function mutation of the TGF-beta/BMP receptor complex and the second to increased signali

127 This paper visualizes time-resolved BMP receptor complex formation and demonstrates that the

128 affold to facilitate assembly of the HJV.BMP.BMP receptor complex to induce hepcidin expression.

129 cts as a BMP2/BMP4 co-receptor, recruits the BMP receptor complexes into raft microdomains, and posit

130 ecycling endosomes and increased mobility of BMP receptor-containing compartments at the NMJ.

131 However, how postendocytic trafficking of BMP receptors contributes to the regulation of signal tr

132 Surprisingly, we find that the type II BMP receptor, DAF-4 (dauer formation-defective-4), is re

133 BMP receptors determine the intensity of BMP signals via

134 lopment, yet mice lacking type II or type IA BMP receptors die at gastrulation and cannot be used to

135 , Noggin, as well as a chemical inhibitor of BMP receptors, DMH1, and described the inputs from BMP s

136 Importantly, a specific kinase inhibitor of BMP receptors drastically attenuated chondrogenesis in r

137 the avian embryo with constitutively active Bmp receptors driven by promoters of varying strengths.

138 emonstrating functional redundancy of type I BMP receptors during cerebellar development.

139 has broadly overlapping functions with other BMP receptors during skeletal development.

140 partially rescued TDP-43-induced defects in BMP receptor dynamics and distribution and suppressed BM

141 tive manner to prevent binding to the type I BMP receptor ectodomain, and inhibited BMP-dependent ind

142 Based on the BMP receptor expression pattern, we examined the functio

143 endothelial-specific member of the TGF-beta/BMP receptor family that is inactivated in patients with

144 oprecipitated with ALK3, an essential type-I BMP receptor for hepatic hepcidin expression.

145 pe I and type II bone morphogenetic protein (BMP) receptors for binding to BMPs, decreased BMP signal

146 cription factors activated by TGF-beta or by BMP receptors form trimeric complexes with Smad4 to targ

147 nd Smad8 are phosphorylated by the activated BMP receptors, form a complex with Smad4, and translocat

148 Further, we observed a shift of BMP receptors from early to recycling endosomes and incr

149 , we have used a Cre-loxP strategy to delete Bmp receptor function specifically within the developing

150 e studies show the effects of alterations in BMP receptor function targeted to the osteoblast lineage

151 However, the mechanisms by which BMP receptors function in vertebrate development are inc

152 e find that mutation of the zebrafish type I BMP receptor gene alk8 causes reduction of atrial size w

153 Here, we inactivated the mouse BMP receptor gene Bmpr1a specifically in the limb bud ap

154 sexpression or inactivating mutations of the BMP receptor gene can lead to dedifferentiation of vSMC

155 xpression and up-regulated HOXB4, BMP-4, and BMP receptor gene expressions.

156 A transcribed from the only type II TGF-beta/BMP receptor gene in Caenorhabditis elegans.

157 In mutants containing either single BMP receptor gene mutation alone, cerebellar histogenesi

158 In the present study, deletion of the BMP receptor genes, Bmpr1b and Bmpr1a, in the mouse tele

159 ning a heatshock-inducible dominant-negative Bmp receptor-GFP fusion.

160 ngs are consistent with the observation that BMP receptor hyperactivation correlates with bone abnorm

161 Similarly, BMP receptor I expression is increased and its downstrea

162 Finally, c-Abl associates with BMP receptor IA and regulates phosphorylation of Smad in

163 itional gene targeting in mice, we show that BMP receptor IA is essential for the differentiation of

164 in in the epithelium and mesenchyme, and the BMP receptor IA is prominently expressed in the follicul

165 us requirement of SNS development, the Alk3 (BMP receptor IA) was deleted in the NC lineage.

166 xpression of a constitutively active form of BMP receptor-Ia (caBmprIa) in CNC lineage did not produc

167 nt of G8neg cells with a soluble form of the BMP receptor-IA or Noggin promoted N-cadherin synthesis

168 al wall progenitors with a dominant-negative BMP receptor Ib (dnBMPIb) virus increased their producti

169 he exposure of immature cells overexpressing BMP receptor Ib to BMP2 and BMP4.

170 negative and constitutively active forms of BMP receptors IB (BMPRIB), we show that BMPs, possibly a

171 hh expression by BMP4 may not be mediated by BMP receptor-IB.

172 he roles of TGFbeta receptor II (TGFBR2) and BMP receptor II (BMPR2) using a Pten-null prostate cance

173 sults showed that type II receptors, such as BMP receptor II, activin receptor IIA, and activin recep

174 Mutations in bone morphogenetic protein (BMP) receptor II (BMPRII) are associated with pulmonary

175 Activation of bone morphogenetic protein (BMP) receptor II (BMPRII) promotes pulmonary artery endo

176 d pathway by dorsomorphin, which targets the BMP receptors, improves the hepcidin responsiveness to E

177 conditional genetic deletion of the type II BMP receptor in Ascl1-expressing cells promoted neurogen

178 ies show enhanced activity downstream of the Bmp receptor in cells where Fmn1 is perturbed, suggestin

179 Noggin in hair follicles or deletion of the BMP receptor in myofibroblasts prevented adipocyte forma

180 BMP antagonist noggin or a dominant-negative BMP receptor in normal EBs leads to increased apoptosis.

181 ion experiments, conditional deletion of the BMP receptor in Shh-Cre;Bmpr1a(flox/flox) embryos allows

182 Knockdown of the BMP receptor in SMAD4-negative cells reduced their invas

183 ntagonist Noggin or an activated form of the BMP receptor in the chick limb, we demonstrate that BMP

184 quired for the EMT and the activation of the BMP receptor in the endocardium can promote AV EMT in th

185 protein, alphaA-crystallin were regulated by BMP receptors in a Smad-independent manner.

186 teins (BMPs) is suggested by the presence of BMP receptors in chicken embryo lenses.

187 appear to mediate neogenin interaction with BMP receptors in chondrocytes.

188 rrent loss of SMAD4 and normal expression of BMP receptors in colorectal tumors was associated with r

189 negative Type I (tALK3) or Type II (tBMPRII) BMP receptors in developing Xenopus embryos results in r

190 ng the expression of BMP7 or the activity of BMP receptors in muscles induced hypertrophy that was de

191 Moreover, blocking endogenous BMP receptors in progenitors with a virus transducing dn

192 ts did not induce differential expression of BMP receptors in RPE.

193 lecular mechanism consistent with a role for BMP receptors in the establishment of early morphogen gr

194 re, we describe the pattern of expression of BMP receptors, including Bmpr-Ia, Bmpr-Ib, Bmpr-II, Actr

195 cur via a distinct subset of BMP ligands and BMP receptors, independently of neogenin.

196 or by overexpression of a dominant-negative BMP receptor, indicates that BMPs regulate cell cleavage

197 y in the presence of a constitutively active BMP receptor, indicating a mechanism of action downstrea

198 D/P-SMAD)1 and 5, which could be reversed by BMP receptor inhibitors and ALK3 knockdown.

199 , or visualization of the spatial pattern of BMP-receptor interactions reveals a spatially bistable p

200 lar feedback to produce two stable states of BMP-receptor interactions, a spatial bistability in whic

201 sitive feedback circuit that promotes future BMP-receptor interactions.

202 Signaling by Bmp receptors is mediated mainly by Smad proteins.

203 TGF-beta signaling acting through the BMP receptors is necessary for the generation of several

204 li is still required by a ligand-independent BMP receptor, its function likely occurs between recepto

205 ation reduces Smad interaction with TGF-beta/BMP receptor kinase and affects all receptor-activated S

206 ssion patterns of BMP-2, -4, -5, -6, and -7, BMP receptor kinases (BRKs) -1, -2, and -3, and BMP bind

207 TGF-beta and BMP receptor kinases activate Smad transcription factors

208 phorylation, which is mediated by the type I BMP receptor kinases in response to BMP stimulation, is

209 Bone morphogenetic protein (BMP) receptor kinases are tightly regulated to control d

210 The effect of bone morphogenetic protein (BMP) receptor knockdown on BMP-6-stimulated hepcidin pro

211 1 of the type II bone morphogenetic protein (BMP) receptor ligands, BMP4, is widely expressed in the

212 regulation of the relative concentrations of BMP receptors, ligands and antagonists.

213 of a transgenic inducible dominant-negative Bmp receptor line to examine the temporal roles of Bmp s

214 ted SMAD1, an indicator of signaling through BMP receptors, localizes to the nuclei of elongating len

215 al. and Marques et al. present evidence that BMP receptors may also influence the development of syna

216 is required both upstream and downstream of Bmp receptor-mediated Smad1 phosphorylation for inductio

217 Neither noggin nor dominant negative BMP receptor misexpression causes similar vascular pheno

218 duced by the thymic stroma and the requisite BMP receptor molecules (BMPR-1A, BMPR-1B, BMPR-II), and

219 d lamina cribrosa (LC) cells express BMP and BMP receptor mRNA and proteins.

220 In addition, type I and type II BMP receptor mRNA levels were also increased in P19 cell

221 ted after the identification of heterozygous BMP receptor mutations as the underlying defect in the r

222 Additionally, BMPR1, a type I BMP receptor normally required for BMP-mediated patterni

223 gnaling by expression of a dominant-negative BMP receptor or Noggin allows other animal blastomeres t

224 a expression of constitutively active type I BMP receptors or by reducing retrograde transport in mot

225 Constitutively active BMP receptors or constitutively active Smad1 mimicked th

226 forms of either bone morphogenetic protein (BMP) receptor or fibroblast growth factor (FGF) receptor

227 ndings of a modulating effect of ROR2 on the BMP-receptor pathway through the formation of a heterome

228 itutively active bone morphogenetic protein (BMP) receptors prevents pdfr mutants misrouting phenotyp

229 Vegfa is transcriptionally regulated by the Bmp receptor-regulated Smad.

230 , and suppressed activation of intracellular BMP receptor-regulated Smads (R-Smads) and Erk1/2 was id

231 urf1), which results in the stabilization of BMP receptor-regulated Smads and potentiation of the Sma

232 ly supports the role of Laf/Alk8 as a type I BMP receptor required for the specification of ventral c

233 ly, the causative amino acid mutation of the BMP receptor responds to activin, thereby turning soft t

234 ansmitted through HFE, TfR2, and HJV augment BMP receptor sensitivity to BMPs.

235 rovide the first evidence that activation of BMP receptor serine/threonine kinase stimulates the PI 3

236 tion results from the combined inhibition of BMP receptor serine/threonine kinases and activation of

237 nalysis of compound mutants of Alk3/6 type I BMP receptors shows that BMP signaling is necessary for

238 BMP receptors signal through C-terminal phosphorylation

239 B and MAP kinase activation during TGF-b and BMP receptor signaling and upon overexpression.

240 Studies on BMP receptor signaling during organogenesis have been ha

241 To determine the role of BMP receptor signaling in bone formation in vivo, we gen

242 lineage and demonstrate a necessary role of BMP receptor signaling in postnatal bone growth and bone

243 d by cadherin-6B was found to be mediated by BMP receptor signaling independent of BMP.

244 A key function of Smad-independent BMP receptor signaling may be reorganization of actin cy

245 -derived astrogenesis from the SVZ niche via BMP receptor signaling pathway following injury.

246 promoting astrogenesis via activation of the BMP receptor signaling pathway.

247 We present evidence that BMP receptor signaling regulates vascular remodeling dur

248 ase (TAK)1, a "noncanonical" mediator of the BMP receptor signaling.

249 using dorsomorphin, a chemical inhibitor of Bmp receptors, significantly increased beta-cell neogene

250 c-Abl contributed to BMP receptor-specific Smad-dependent transcription of CS

251 ized and secreted BMP-4 as well as expressed BMP receptor subtypes BMPRI and BMPRII.

252 Expression of BMP-2 and BMP-4, BMPR-IA (BMP receptor subunit), BMPR-IB, and BMPR-II, and the BMP

253 When coinjected with dominant-negative BMP receptor (tBR) in the ventral side of the embryo, XR

254 BmprIa and BmprIb encode two type I BMP receptors that are primarily responsible for BMP sig

255 e examined the effects of loss of one of the BMP receptors, the BmprIb, on the development of the eye

256 Genes encoding two type I BMP receptors, the type II TGFbeta receptor, two BMP- or

257 We investigated the roles of the BMP receptor Thickveins (Tkv) and the BMP inhibitor Shor

258 Germline-specific expression of an activated BMP receptor thickveins (Tkv) or E-cadherin can partiall

259 Cv-2 binds the type I BMP receptor Thickveins (Tkv), and we demonstrate how th

260 correlate with the expression of the type I BMP receptor thickveins (tkv).

261 nges in the expression pattern of the type I BMP receptor thickveins (tkv).

262 naling through a direct interaction with the BMP receptor, thickveins.

263 tagonists that prevent BMP interactions with BMP receptors thus modulating BMP effects in tissues.

264 gnals synergistically through the two type I BMP receptors Tkv and Sax.

265 The bone morphogenetic protein (BMP) receptor Tkv localizes to microtubule-based nanotub

266 itogenesis, by targeting a dominant-negative BMP receptor to Lmo2+ cells in developing zebrafish embr

267 onformational change, which denies access of BMP receptors to the growth factor.

268 that it inhibits BMP signaling by regulating BMP receptor traffic.

269 tly elevated, possibly due to alterations in BMP receptor trafficking.

270 ed BMP-2 expression, and showed no effect on BMP receptor transcripts.

271 ation action of the constitutively activated BMP receptor type 1A, ca-ALK-3.

272 ciprocal feedback loop, miR-21 downregulates BMP receptor type 2 expression.

273 predictions, we have found that hypoxia and BMP receptor type 2 signaling independently upregulate m

274 lammation, and genetic haploinsufficiency of BMP receptor type 2.

275 cle tracking microscopy, we demonstrate that BMP receptor type I and II (BMPRI and BMPRII) have disti

276 epithelium, we have exploited the fact that Bmp receptor type Ia (Alk3) is expressed in the epitheli

277 mutant mice with conditional inactivation of BMP receptor type IA (BMPRIA).

278 e protein kinase casein kinase II (CK2) as a BMP receptor type Ia (BRIa) interacting protein.

279 scle cells, BMP2 and BMP4 signaling required BMP receptor type II (BMPRII), but not activin receptor

280 d knockdown experiments, we demonstrate that BMP receptor type II and activin-like kinase-2 are neces

281 y co-immunoprecipitates with BMP-15, whereas BMP receptor type II extracellular domain was most effec

282 structure-function analysis of the BMP-Alk3-BMP receptor, type 2 (BMPR2) ligand-receptor complex, al

283 BMP receptor-type 2 (BMPR2) knockdown in HepG2 cells inc

284 ic day 7.5 (E7.5), phenotypes that mimic the Bmp receptor type1a (Bmpr1a) null mutant.

285 to suggest that SMOC acts downstream of the BMP receptor via MAPK-mediated phosphorylation of the Sm

286 2, alk3, and alk6 and inhibition of a single BMP receptor was not sufficient to decrease signaling.

287 mRNA for the type II BMP receptor was observed in freshly isolated and cultur

288 The expression of both type I BMP receptors was inhibited by exogenous TGF-beta1.

289 The effect of IL-1beta on BMP receptors was studied by reverse transcription-polym

290 m injection of noggin or a dominant negative BMP receptor, was transplanted into the non-neural ectod

291 an physically interact with ACVRL1, a type I BMP receptor, we generated cartilage-specific Acvrl1 (Ac

292 the functional redundancies among the Type I BMP receptors, we applied dominant-negative (dn) BMPR-1B

293 ring RNAs to inhibit the expression of other BMP receptors, we found that wild-type cells transduce B

294 Finally, expression of a dominant-negative BMP receptor (which induces a P-to-O fate change in the

295 bb) in muscle, and alternatively the type II BMP receptor Wishful Thinking (Wit) in the motoneuron.

296 Here, we demonstrate that the BMP receptor Wishful Thinking (Wit) is required for syna

297 Furthermore, we demonstrate that presynaptic BMP receptor wishful thinking is required for the retrog

298 Here, we demonstrate that the BMP receptor (Wit) and ligand (Gbb) are necessary for th

299 ion of cells with BMPR1A and ligation of the BMP receptor with BMP-2 also activated GTP-Rho A of thes

300 neous misexpression of constitutively active BMP receptors with Smad7 suppresses the Smad7-induced ph