ライフサイエンスコーパス: BRCA1 gene

1 ighly sensitive electrochemical detection of BRCA1 gene.

2 regulation that may modulate the activity of BRCA1 gene.

3 ne to identify any 185delAG mutations of the BRCA1 gene.

4 n close proximity to the recently identified BRCA1 gene.

5 q21 region of human chromosome 17, near the BRCA1 gene.

6 NA sequence variants is demonstrated for the BRCA1 gene.

7 mple of sections of the wild-type and mutant BRCA1 gene.

8 ts in the approximately 4 Mb surrounding the BRCA1 gene.

9 nfer the opposite phenotype to the wild-type BRCA1 gene.

10 1860, which is at least 470 kb distal to the BRCA1 gene.

11 tein lacking the first 17 amino acids of the BRCA1 gene.

12 rrying a targeted deletion of exon 11 of the Brca1 gene.

13 1 gene) and which lies head to head with the BRCA1 gene.

14 oximately 30 kb between the BRCA1 and pseudo-BRCA1 genes.

15 d a possible functional link between p53 and BRCA1 genes.

16 homozygous for mutations in both the p53 and Brca1 genes.

17 d to attomolar detection of breast cancer 1 (BRCA1) gene.

18 p62, binding neighbor of BRCA1 gene 1 (NBR1) and STING, triggers the IFN cascade

19 ubiquitin-associated-like and NBR1 [next to BRCA1 gene 1 protein]-like domains) gene are genome-wide

20 tion of Brca1 expression or mutations of the Brca1 gene activate the Akt oncogenic pathway.

21 dicates that it maps less than 1 kb from the Brca1 gene and that, unlike that in human, this region i

22 With the identification of the BRCA1 gene and the observation that most mutations in th

23 between the position of the mutation in the BRCA1 gene and the presence of ovarian cancer in a famil

24 mor analyses confirmed loss of the wild-type BRCA1 gene and/or protein expression in all 3 available

25 ning and sequencing of the canine and murine BRCA1 genes and contrast the sequences with human BRCA1.

26 and mapping directly adjacent to the pseudo-BRCA1 gene) and which lies head to head with the BRCA1 g

27 nvolved in transcriptional regulation of the BRCA1 gene, and their overexpression may have a role in

28 Inherited mutations in the BRCA1 gene are associated with a high risk of breast and

29 Germline mutations in the BRCA1 gene are associated with an increased susceptibili

30 ct that women carrying a mutated copy of the BRCA1 gene are at increased risk of developing breast an

31 Germline mutations of the breast cancer 1 (BRCA1) gene are a major cause of familial breast and ova

32 In addition, using the BRCA1 gene as an example, we explore the physiological i

33 nt point mutations; insertion C mutations in BRCA1 genes associated with breast cancer were analyzed

34 known to be obligate carriers of the mutant BRCA1 gene because of their parental relationships with

35 on and immediate cis-control elements of the BRCA1 gene between humans and mice.

36 ifetime risk of cancer with mutations of the BRCA1 gene, BRCA2 is the more important gene for men.

37 y, cancers with BRCT domain mutations harbor BRCA1 gene breakpoints within or adjacent to Alu element

38 pe and spectrum of germline mutations on the BRCA1 gene, but do not provide guidance to women with mo

39 A1 is able to downregulate the expression of BRCA1 gene by binding directly to its promoter region.

40 We also show the involvement of BRCA1 gene by promoter hypermethylation or down-regulate

41 Although transcriptional activation of the BRCA1 gene can account for induction of BRCA1 expression

42 ce that function and regulation of the human BRCA1 gene can be studied and manipulated in a genetical

43 xpression of truncated or mutant full-length BRCA1 genes can abrogate certain phenotypic characterist

44 Mutations in the BRCA1 gene cause an extremely high lifetime risk of brea

45 Mutations in a germ-line allele of the BRCA1 gene contribute to the familial breast cancer synd

46 Jewish origin, a frameshift mutation of the BRCA1 gene, designated 185delAG, occurs with a carrier f

47 Thus the most common polymorphisms of the BRCA1 gene do not make a significant contribution to bre

48 The BRCA1 gene encodes a large multidomain protein of 1863 r

49 The BRCA1 gene encodes a tumor suppressor that has been impl

50 The BRCA1 gene encodes a tumor suppressor that is mutated in

51 ith the HMGA1b cDNA results in a decrease of BRCA1 gene expression and in a lack of BRCA1 induction a

52 To study the regulation of BRCA1 gene expression and the potential importance of dy

53 xtensively studied, the relationship between BRCA1 gene expression and tumor aggressiveness remains c

54 of BAT3, as well as SET1A, decreased Myc and BRCA1 gene expression but did not affect the binding pro

55 A drastic reduction in BRCA1 gene expression is a characteristic feature of agg

56 The BRCA1 gene expression level in highly proliferative lumi

57 3 are mediated, in part, by the induction of BRCA1 gene expression via transcriptional activation by

58 , may also be involved in the suppression of BRCA1 gene expression/function in breast cancers.

59 of the hereditary breast and ovarian cancer BRCA1 gene for all possible sequence changes in the homo

60 high sensitive detection of breast cancer 1 (BRCA1) gene for the first time.

61 We have cloned a homologue of the human BRCA1 gene from chicken; the gene encodes a 1749 amino a

62 The BRCA1 gene from individuals at risk of breast and ovaria

63 Although the function of the BRCA1 gene has been extensively studied, the relationshi

64 d that women with germ-line mutations in the BRCA1 gene have a greatly increased lifetime incidence o

65 ho have inherited a germline mutation in the BRCA1 gene have a greatly increased risk of developing b

66 copies of the murine homologue of the human BRCA1 gene have been disrupted by gene targeting.

67 ber of mouse lines carrying mutations in the Brca1 gene have been generated, and mice homozygous for

68 Numerous missense mutations in human BRCA1 gene have been linked to predisposition to breast

69 pant, including 1 frameshift deletion in the BRCA1 gene implicated in hereditary breast and ovarian c

70 latory mechanism for the inactivation of the BRCA1 gene in both hereditary and sporadic breast cancer

71 ve analyzed the promoter region of the human BRCA1 gene in detail and demonstrate that the expression

72 we have examined the 5' region of the human BRCA1 gene in detail.

73 re, we show that indeed, inactivation of the Brca1 gene in granulosa cells led to the development of

74 y using the Cre-lox system to inactivate the Brca1 gene in mouse ovarian granulosa cells.

75 noticed deletions-insertions (>50 bp) at the BRCA1 genes in BRCA1 patients.

76 Germ line mutations of the BRCA1 gene increase the risk of breast and ovarian cance

77 Mutation of Brca1 gene increases the phosphorylation and the kinase

78 ow that retroviral transfer of the wild-type BRCA1 gene inhibits growth in vitro of all breast and ov

79 expression of the 90 kb genomic copy of the BRCA1 gene into BRCA1-deficient human cells.

80 BRCA1 gene is a tumor suppressor for breast and ovarian

81 Mutation in the BRCA1 gene is associated with an increased risk of breas

82 The BRCA1 gene is closely apposed to a gene structure that i

83 The Brca1 gene is identified as an in vivo target of E2F1 in

84 l and demonstrate that the expression of the BRCA1 gene is under complex regulation.

85 he transcription start sites of the NBR2 and BRCA1 genes is 218 bp, suggesting that regulation of the

86 However, the reasons why silencing the Brca1 gene leads to tumorigenesis are not clearly unders

87 A mutation in the BRCA1 gene may confer substantial risk for breast and/or

88 ese results suggest that inactivation of the BRCA1 gene may not be responsible for the development of

89 These results indicate that BRCA1 genes may play a critical role in the regulation o

90 suppressor gene, located centromeric to the BRCA1 gene, may play a role in sporadic ovarian cancer d

91 ild-type BRCA1 gene (wt-BRCA1) and a mutated BRCA1 gene (mt-BRCA1), in which the first initiation sit

92 hift mutations by using the detection of the BRCA1 gene mutations 185delAG and 5382insC as examples.

93 y of breast cancer patients with and without BRCA1 gene mutations found significantly lower levels of

94 BRCA1 gene mutations impair homologous recombination (HR

95 Among carriers of BRCA1 gene mutations, the data are conflicting.

96 nd mutant-type sequences of four deleterious BRCA1 gene mutations.

97 The BRCA1 gene, mutations of which contribute significantly

98 The neighbor of Brca1 gene (Nbr1) functions as an autophagy receptor inv

99 p62/sequestosome 1 (SQSTM1) and neighbor of BRCA1 gene (NBR1).

100 The recently identified BRCA1 gene on 17q21, involved in the development of fami

101 n unaccounted for by mutations in either the BRCA1 gene or the BRCA2 gene.

102 Germ-line mutations in the BRCA1 gene predispose affected individuals to breast and

103 Germ-line mutations of the BRCA1 gene predispose women to early-onset breast and ov

104 Inherited mutations in the BRCA1 gene, presumably leading to loss of function, conf

105 c is that many detectable changes within the BRCA1 gene produce subtle alterations to the protein tha

106 gnized both the rodent and human form of the BRCA1 gene product (Mr 215 kDa, p215BRCA1) were develope

107 The BRCA1 gene product and its stoichiometric binding partne

108 We have characterized the BRCA1 gene product by using four polyclonal antibodies r

109 The BRCA1 gene product is a nuclear phosphoprotein that is a

110 The tumor suppressor activity of the BRCA1 gene product is due, in part, to functional intera

111 Recent studies have shown that the BRCA1 gene product may be important in mediating respons

112 The BRCA1 gene product plays numerous roles in regulating ge

113 r explanation for some of the effects of the BRCA1 gene product.

114 manner, such that low steady-state levels of BRCA1 gene products are found in resting cells and early

115 We have characterized the BRCA1 gene products by Western blot and immunoprecipitat

116 of epigenetic heterogeneity at p14(ARF) and BRCA1 gene-promoter loci in liquid biopsies obtained fro

117 Taken together, Alu-mediated BRCA1 gene rearrangements are responsible for generating

118 rochip approach, we could directly visualize BRCA1 gene regulatory complexes from patient-derived can

119 blished that inheritance of mutations in the Brca1 gene significantly increases the chances of develo

120 ed mutations in familial cancers but also by BRCA1 gene silencing in sporadic cancers.

121 e induced genetic ablation of exon 11 in the Brca1 gene specifically in the skeletal muscle of adult

122 We found that an exogenous BRCA1 gene strongly inhibited telomerase enzymatic activ

123 Cancers due to germline mutations in the BRCA1 gene tend to lack targets for approved chemopreven

124 creened for a possible point mutation in the BRCA1 gene that is associated with breast cancer.

125 were generated for the RB1 , TP53 , MLH1 and BRCA1 genes that can be readily implemented in research

126 ach, we designed three assays, targeting the BRCA1 gene, the entire 4-Mb major histocompatibility com

127 med at increasing the apoptotic threshold by BRCA1 gene therapy may have the potential to prevent the

128 the expression of the murine Brca1 and human BRCA1 genes through its ability to modulate E2F transcri

129 Furthermore, the potential relationship of BRCA1 gene to ovarian tumors of borderline malignancy re

130 The BRCA1 gene was previously found to inhibit the transcrip

131 e a CpG island is found at the 5' end of the BRCA1 gene, we hypothesized that the decreased BRCA1 mRN

132 To investigate the function of the BRCA1 gene, we performed DNA microarray and confirmatory

133 efficacy of this approach, the exons of the BRCA1 gene were amplified by PCR using primers 5'-labele

134 ted region, or 3' untranslated region of the BRCA1 gene were analyzed in cases, and selected variants

135 Selected sequences specific to the BRCA1 gene were used as a test platform.

136 nucleotide polymorphisms (SNPs) spanning the BRCA1 gene were used to define patterns of common variat

137 here are several common polymorphisms in the BRCA1 gene which generate amino acid substitutions.

138 E2F site is conserved in the promoter of the BRCA1 gene, which is also regulated by a similar mechani

139 ensor exhibited a fine capability of sensing BRCA1 gene with linear range of 10attomolar (aM) to 1nan

140 ng the second exon of BRCA1 of the wild-type BRCA1 gene (wt-BRCA1) and a mutated BRCA1 gene (mt-BRCA1