ライフサイエンスコーパス: BRCA2 protein

1 ere has been very little characterization of BRCA2 protein.

2 2% similarity), respectively, with the human BRCA2 protein.

3 tations predicted to cause truncation of the BRCA2 protein.

4 lic mutations in BRCA2 and express truncated BRCA2 proteins.

5 use cDNA sequence predicts a 3328-amino-acid Brca2 protein, 90 amino acids shorter than the human pro

6 Proximate to the COOH terminus of the BRCA2 protein, a conserved and DNA binding domain (BRCA2

7 BRCA2 protein, a product of the breast cancer susceptibi

8 Our results demonstrate that BRCA2 proteins acetylate primarily H3 and H4 of free his

9 The Brca2 proteins also share a potential nuclear localizati

10 Because of the presence of C-terminal BRCA2 protein and atypical clinical features of the misc

11 Skp2 overexpression reduced BRCA2 protein and promoted cell growth and migration.

12 equenced cDNA for the entire 3329 amino acid Brca2 protein and this has revealed that, like Brca1, Br

13 shift mutations leading to truncation of the BRCA2 protein are typically considered pathogenic; howev

14 The BRCA1 and BRCA2 proteins are important in maintaining genomic stab

15 The BRCA1 and BRCA2 proteins are involved in the maintenance of genome

16 Purified RAD52 and BRCA2 proteins both block the DNA polymerase function of

17 ow functional significance of restoration of BRCA2 protein by secondary BRCA2 mutations in acquired d

18 This study suggests a requirement of BRCA2 protein for the IR-induced assembly of Rad51 compl

19 ells expressing a carboxy-terminal truncated BRCA2 protein form IR-inducible BRCA2 and FANCD2 foci, b

20 This region is highly conserved in BRCA2 proteins from a variety of mammalian species, but

21 The BRCA2 protein has been proposed to function in the repai

22 Both BRCA1 and BRCA2 proteins have been implicated in the repair of dou

23 ds, which is poorly conserved with mammalian BRCA2 proteins, having only 37% amino acid identity over

24 The mechanistic link between the BRCA2 protein, homologous recombination, and genomic ins

25 appears to diagnose the biochemical loss of BRCA2 protein in cancers (ie, BRCA2-mutant genotype), wh

26 e results demonstrated that the stability of BRCA2 protein in mammalian cells depends on the presence

27 tudies provide evidence for key roles of the BRCA2 protein in mammalian gametogenesis and meiotic suc

28 tissue truncation test to identify truncated BRCA2 proteins in breast cancer tissue biopsies in vivo

29 BRCA2 protein interacts directly with the RAD51 recombin

30 eight BRC repeats would affect the way that BRCA2 protein interacts with the RAD51 filament.

31 er development, at least in part because the BRCA2 protein is required for the maintenance of genomic

32 ss either phospho-Ser7-FANCG, or full length BRCA2 protein, lack the interactions amongst the four co

33 of EP300 results in decreased expression of BRCA2 protein leading to sensitivity to treatments that

34 ssibility, we examined the alteration of the BRCA2 protein level in human cell lines after UV irradia

35 Mitomycin C (MMC) led to decreased BRCA2 protein levels associated with increased ubiquitin

36 ar phenotype was observed after reduction of BRCA2 protein levels using specific BRCA2 small-interfer

37 able of binding to two separate sites in the BRCA2 protein, located either side of the BRC repeats.

38 in human cell lines led to dramatic loss of BRCA2 protein, mainly due to its increased degradation.

39 We demonstrated that Brca2 protein prevents single-stranded DNA gap accumulat

40 based molecule (35d) that disrupts the RAD51-BRCA2 protein-protein interaction, thus mimicking the ef

41 BRCA2 protein regulates recombinational repair by intera

42 Although the function of the BRCA2 protein remains to be determined, murine cells hom

43 n-truncating mutations, a test for truncated BRCA2 proteins should identify most BRCA2 hereditary can

44 Lastly, we demonstrate that full-length BRCA2 protein stimulates DMC1-mediated DNA strand exchan

45 f human Rad51 to the conserved BRC repeat of BRCA2 protein, the RecB-domain may be one of several str

46 iduals by promoting degradation of wild-type BRCA2 protein, thereby predisposing them to genomic inst

47 utation, low-level expression of full-length BRCA2 protein was detectable in these cells by immunoblo

48 e in the cancer, which indicated that intact BRCA2 protein was present in this cancer.

49 s this question, the expression of wild-type BRCA2 protein was reconstituted, in an either constituti

50 Residues 3196-3232 of the murine BRCA2 protein were shown to be involved in this interact

51 re are hotspots in the structures of ATM and BRCA2 proteins where pathogenic germline, and recurrent

52 ript lacking exons 4-7, encoding an in-frame BRCA2 protein with an internal deletion of 105 amino aci

53 defined and an interaction identified of the Brca2 protein with the DNA-repair protein Rad51.