ライフサイエンスコーパス: BSP

1 BSP and Col11a1 co-purify upon ion-exchange chromatograp

2 BSP contains numerous substituents which are anionic in

3 BSP expression in mineralized tissues is upregulated at

4 BSP includes functional domains implicated in collagen b

5 BSP is further validated by substantiated biological dis

6 BSP is multifunctional, affecting cell attachment and si

7 BSP is present in cementum, the hard tissue covering the

8 BSP modulation of MMP-2 activity and inhibition may defi

9 BSP with theta (~4-7Hz) peak intraburst spectral power a

10 BSP, OPN, and DMP1 were invariably co-expressed with the

11 BSP-GSH (2mM), which cis-inhibits sinusoidal GSH uptake

12 BSP-i's extent performed better than the 2017 WWC extent

13 g precipitously with an increase in pH >6.0; BSP influx was independent of pH.

14 TGF-beta signaling protein-1 (BSP-1) is rapidly phosphorylated in response to TGF-beta

15 ely diffusable substrate and purified MMP-2, BSP, and natural (tissue inhibitor of matrix metalloprot

16 P-2 alone, MMP-2 and BSP, or preformed MMP-2-BSP complexes and solving a general linear mixed inhibit

17 esent study, we examined the expression of a BSP-GFPtpz reporter mouse line during odontoblast differ

18 rates of response and remission than adding BSP or continuing MEDS alone.

19 After organophosphate addition, BSP accumulates within these BAG-75-containing BMF precu

20 bone marker gene (OPN, Cbfa1, Col I alpha1, BSP, ALP) expression in vivo.

21 Native OPN incorporated 1.07 and BSP 2.46 mol of phosphate/mol by factor-independent prot

22 Expression levels of BMP-2 and BSP were significantly upregulated by OIM and Si (25 mug

23 ncentrations added to MMP-2 alone, MMP-2 and BSP, or preformed MMP-2-BSP complexes and solving a gene

24 r the first time that cleavage of BAG-75 and BSP by an AEBSF-sensitive, osteoblast-derived serine pro

25 a hypothetical mechanism in which BAG-75 and BSP function actively in nucleation of apatite within BM

26 Cleavage of BAG-75 and BSP was also inhibited at the minimum dosage of AEBSF su

27 We show here that BAG-75 and BSP, biomarkers for these foci, are specifically enriche

28 finally into osteoblasts expressing Col1 and BSP during postnatal day 7-10, when serum levels of thyr

29 ast transformation dually marked by COL2 and BSP or RUNX2 within the vascular bundles.

30 es-such as OPN, DMP1, DMP2, DMP3 (DSPP), and BSP-have been mapped to the same locus.

31 DTT and BSP-GSH affect GSH transport only in cells expressing th

32 ver, the upregulation of MMP9, MMP2, FN, and BSP was observed.

33 Ibsp messenger RNA (mRNA) and BSP protein were strongly expressed during alveolar bone

34 expression vectors demonstrated that OC and BSP gene transcription was down-regulated by Cx45 cotran

35 Cx43 in UMR 106-01 cells up-regulated OC and BSP gene transcription.

36 both cell coupling and expression of OC and BSP.

37 ments of in vitro phosphorylation of OPN and BSP by several other known protein kinases were carried

38 Recombinant OPN and BSP can protect murine erythroleukemia cells from attack

39 eptides efficiently, suggesting that OPN and BSP contain sites that are specific for ppGalNAcT-1.

40 uced about 1 mol of phosphate/mol of OPN and BSP molecule.

41 eral synthetic peptides derived from OPN and BSP sequences were designed to include either known or p

42 groups presented higher staining of OPN and BSP than both untreated groups (P < 0.05).

43 These data led to calculations that OPN and BSP, respectively, contain 7.83 and 4.14 mol of phosphat

44 ific sites of the bone glycoproteins OPN and BSP.

45 er proteins such as alkaline phosphatase and BSP.

46 resented higher numbers of PCNA-positive and BSP-positive cells than control at 10 and 30 days post-s

47 nions, including biliverdin, bile salts, and BSP, were predominantly excreted by way of the kidney, w

48 peridine/trifluoromethanesulfonic anhydride (BSP), diphenyl sulfoxide/trifluoromethanesulfonic anhydr

49 ne formation which were co-labeled with anti-BSP antibodies.

50 eased calcium deposition in vitro as well as BSP, collagen type 1 and integrin beta1 protein expressi

51 dy, we found that the blood-based biomarkers BSP, OMD, ACY1, and GHR robustly associated with PD acro

52 nk rate (BR) in patients with blepharospasm (BSP) and increased blinking (IB).

53 ng specific peptides and antibodies to block BSP and OPN protective activity.

54 y cementoblasts gave strong signals for both BSP and OCN genes, confirming its nature as cementum or

55 and in vivo phosphorylation sites of bovine BSP by a combination of state-of-the-art techniques and

56 Both the purified bovine BSP and OPN were radiolabeled by [32P]ATP and factor-ind

57 intravenously injected bromosulfophthalein (BSP) was eliminated over a 72-hour period.

58 n the OATP1B3 substrate bromosulfophthalein (BSP) was coincubated with encorafenib or vemurafenib com

59 lial uptake exhibited a strong inhibition by BSP-GSH at 0.05 mM (55%) and 2 mM (64%), whereas cortica

60 Ct-OATP1B3-mediated uptake into lysosomes by BSP.

61 ), whereas cortical uptake was unaffected by BSP-GSH.

62 sed as the particle backscatter coefficient (BSP), and PM10 particulate mass concentration-on the occ

63 phosphorylation of native and deglycosylated BSPs by casein kinase II identified seven phosphorylatio

64 ce of a hitherto unreported Na(+)-dependent, BSP-GSH inhibitable GSH transporter in the lens epitheli

65 dioactivity incorporated on dephosphorylated BSP and OPN provided 6.6 and 8.9 mol of phosphate incorp

66 ~4-7Hz) feature dominating the bursts during BSP in these patients.

67 Expression of the endogenous BSP gene in Gallus osteoblasts was similarly downregulat

68 lowest dose of amelogenin slightly enhanced BSP expression, whereas at the highest dose, a dramatic

69 Both controllers used the estimated BSP as feedback.

70 ropathogenic bacteria-secreted particles (ET-BSPs) stimulate intestinal epithelium to produce IDENs (

71 that undifferentiated cells did not express BSP or osteocalcin.

72 ed that tubule formation by cells expressing BSP could be inhibited by an activity blocking antibody

73 dothelial cells (HUVECs) were used to follow BSP modulation of MMP-2 inhibition and tubule formation.

74 vascular endothelial cells were positive for BSP, DPP, DMP1, and AP; MEPE was not detected.

75 MethPrimer can design primers for BSP and MSP.

76 the follicle cells expressed transcripts for BSP, OCN, and osteopontin (OPN).

77 t, the high affinity of this transporter for BSP relative to antifolates seems to be intrinsic to its

78 Responsiveness of the 1.2-kb Gallus BSP promoter to Cbfa factors Cbfa1, Cbfa2, and Cbfa3 was

79 nt of Cbfa sites in expression of the Gallus BSP gene.

80 The effect of 2 mM bromosulfophthalein-GSH (BSP-GSH) on GSH uptake in the lens epithelium and cortex

81 the seven Cbfa sites in the Gallus and human BSP promoters, suggest that suppressor activity by Cbfa

82 Three weeks following implantation, human BSP could be identified in RNAs isolated from the retrie

83 study identifies structural domains in human BSP and MMP-2 that contribute to these interactions.

84 For every implant from which human BSP cDNA was amplified, parallel implants harvested at 6

85 assessment of human actin, collagen type I, BSP, and osteocalcin indicated that undifferentiated cel

86 ntin (Spp1/OPN), and bone sialoprotein (Ibsp/BSP).

87 e first nonantibody-based method to identify BSP on western blots and in/on cells.

88 In the Ad/PDGF-1308 treated implants, BSP, OC, and OPN were all downregulated at 3 weeks.

89 ognostic capability of BSP's implementation (BSP-i) compared with the 2017 WWC, using periodontal-rel

90 BR was increased in patients with IB and in BSP patients with clonic spasms but not in BSP patients

91 BR in BSP and IB patients was compared with that from a group

92 Ex vivo overexpression of RCAS-Dlx5WT in BSP/TVA calvarial cells promoted, whereas that of RCAS-D

93 oxyapatite deposition which were enriched in BSP and Col11a1 containing an alternatively spliced "6b"

94 st dose, a dramatic decrease (three-fold) in BSP expression was observed.

95 accharides, sulfate, and phosphate groups in BSP isolated from human bone.

96 l resorption-stimulating bone matrix high in BSP content.

97 explore the molecular mechanisms involved in BSP regulation, a clonal population of immortalized muri

98 n BSP patients with clonic spasms but not in BSP patients with tonic spasms.

99 n of BSP by Cbfa factors was not observed in BSP promoters in which Cbfa sites were deleted or mutate

100 neralized tissue-associated genes, including BSP and RunX2, between the P-MSCs and the PDL-MSCs.

101 properties of skeletal cell types, including BSP as one component of that phenotype, is the result of

102 emistry indicated that RCAS-Dlx5WT increased BSP and osteopontin (OPN) expression, whereas it decreas

103 RvE1 increased BSP, RunX2, and ALP compared with the RvD1 dose and time

104 Indeed, BSP has been shown to be a positive indicator of the inv

105 The Na(+)-independent, BSP-GSH insensitive RcGshT may function as an apical GSH

106 hrough its importance to cementum integrity, BSP is essential for periodontal function.

107 Here we introduce BSP (big-small patch), a non-parametric model by compari

108 onstrated that FAM-peptide 3 bound to 90 kDa BSP and its 18 to 60 kDa fragments, as well as to 110 kD

109 Thrombin digests of 32P-labeled BSP showed radioactivity to be associated with fragment

110 an ossicle implant model where cells lacking BSP-RGD showed substantial defects as compared with cont

111 duce the phenotypic severity of mice lacking BSP-RGD in vivo.

112 in roots and stems of Picea mariana (Mill.) BSP.

113 Furthermore, use of native BSP and matrix-assisted laser desorption ionization time

114 last marker genes, including Runx2, ALP, OC, BSP, OPG, and DMP-1, with concurrent upregulation of RAN

115 d CREB target gene expression, including OC, BSP, cyclin A, cyclin D1, and vascular endothelial growt

116 OSX, RUNX2, BMP2, ALP, OCN, BSP and CX43 genes were expressed in hDFC cultured for 1

117 he 26 amino acid domain encoded by exon 4 of BSP is shown by a series of binding and activity assays

118 Genetic ablation of BSP in Ibsp knockout (Ibsp(-/-)) mice results in develop

119 resence of inhibitors, while the addition of BSP restored vessel formation.

120 significant reduction in the total amount of BSP synthesized and secreted.

121 ng-term (>10 years) prognostic capability of BSP's implementation (BSP-i) compared with the 2017 WWC,

122 MP analog treatment blocks the deposition of BSP in the extracellular matrix without a significant re

123 ralizing cultures, with matrix deposition of BSP temporally preceding that of apatite.

124 both amino- and carboxy-terminal domains of BSP contribute to restoration of activity to TIMP2-inhib

125 ssibly due to the observed downregulation of BSP and OC and a persistence of stimulation of MNGCs.

126 The effect of BSP on MMP-2 modulation by inhibitors was determined wit

127 e of a greater than 500-fold molar excess of BSP.

128 wn to reduce melatonin-induced expression of BSP and ALP.

129 The expression of BSP and OPN in tumor cells provides a selective advantag

130 ouse model was used to examine expression of BSP and other markers, including Type I collagen, in tis

131 Melatonin increased gene expression of BSP and the other bone marker proteins, including alkali

132 y contribute to spatiotemporal expression of BSP during bone development.

133 n could similarly modulate the expression of BSP in two cell lines, the MC3T3-E1(MC3T3) pre-osteoblas

134 vealed a dramatic reduction in expression of BSP mRNA and protein in cementoblasts and surrounding os

135 gain of function by tumor cell expression of BSP or OPN has been defined using specific peptides and

136 d displayed an increase in the expression of BSP, ALP, and osteocalcin genes within 1 h of exposure t

137 ese experimental contexts, the expression of BSP-GFPtpz was still exclusive to DSPP-Cerulean, an odon

138 ies regarding the expression and function of BSP by odontoblasts and dentin.

139 is for further understanding the function of BSP in bone nucleation.

140 eth, although the expression and function of BSP in the formation of acellular cementum and periodont

141 probability of observing NPF as functions of BSP and PM10.

142 These data demonstrate the importance of BSP in maintaining proper periodontal function and alveo

143 Loss of BSP caused progressively disorganized PDL and significan

144 The singular prognostic performance of BSP stage was slightly higher than that of 2017 WWC stag

145 resent study the state of phosphorylation of BSP and OPN was evaluated by in vitro 32P labeling using

146 The presence of BSP increased the competitive K I values between 15- and

147 The role of BSP in alveolar bone healing has not been studied.

148 Thus, the proposed role of BSP in hydroxyapatite nucleation and growth may depend o

149 RGD of DMP1 with corresponding sequences of BSP did not enhance the ability of DMP1 to bind alphaVbe

150 localized to biomineralization foci (site of BSP) and to nucleoli (site of nucleolin).

151 Suppression of BSP by Cbfa factors was not observed in BSP promoters in

152 ons of nicotine decreased the transcripts of BSP and COL-I in a dose- and time-dependent manner (P <0

153 ctrometry with selective enzyme treatment of BSP to provide new information on the precise distributi

154 Major type of BSP fragments was composed of 45 amino acid including pa

155 ipts for OCN and OPN with an upregulation of BSP mRNA noted at 72 hours.

156 This suggests that the combinatorial use of BSP-GFPtpz and DSPP-Cerulean can be a valuable experimen

157 nvolvement of covalently bound phosphates on BSP in receptor mediated "outside-in" signaling via tran

158 However, HSG cells could not migrate onto BSP in a modified Boyden chamber assay.

159 we found that PDL cells did not express OPN, BSP, OCN, or ALP under any of the conditions used in thi

160 y were randomized to receive either CBASP or BSP stratified by phase 1 response, ie, as nonresponders

161 ostn/Osf2, and the bone sialoprotein gene or BSP), genes that are expressed in the developing brain (

162 n kinase showed no phosphorylation of OPN or BSP, while protein kinase C and cGMP-dependent protein k

163 during prominent burst suppression patterns (BSP) present in all 3 patients.

164 R methods, such as bisulfite sequencing PCR (BSP) and methylation specific PCR (MSP), remain the most

165 DIP-Seq results by bisulfite sequencing PCR (BSP) in some of the differentially methylated promoters.

166 ngly, we found BBF2H7-derived small peptide (BSP) fragments located between the S1P and S2P cleavage

167 The British Society of Periodontology (BSP) implemented a simplified version of the 2017 World

168 N,N'-Bis(salicylidene)-1,2-phenylenediamine (BSP).

169 nophore 4-(trifluoromethoxy)phenylhydrazone; BSP influx was also suppressed at pH 7.4.

170 se (SVP) or bovine spleen phosphodiesterase (BSP), clearly slows as the digestion approaches the abas

171 combination of 1-benzenesulfinyl piperidine (BSP) and trifluoromethanesulfonic anhydride (Tf(2)O) for

172 ritia neritea, using Bayesian skyline plots (BSP), multivariate analyses and Bayesian clustering.

173 These results indicate that although poplar BSP is encoded by a multigene family, transcriptional ac

174 of poplar share some similarities to poplar BSP, the observed developmental expression patterns in t

175 Poplar BSPs are encoded by a multigene family and one member, b

176 oral dynamics of the body surface potential (BSP) during atrial excitation.

177 atients with a clinical diagnosis of primary BSP (19 patients had tonic orbicularis oculi (OO) spasms

178 ol signal the burst suppression probability (BSP), the brain's instantaneous probability of being in

179 g cortical injury but demonstrated prominent BSP on EEG.

180 cumulation of a 32 kDa bark storage protein (BSP) in the inner bark parenchyma and xylem rays.

181 Bone sialoprotein (gene: Ibsp; protein: BSP) is a multifunctional extracellular matrix protein p

182 nd the presence of the bone matrix proteins, BSP and BAG-75.

183 2 (200 received CBASP and MEDS, 195 received BSP and MEDS, and 96 received MEDS only).

184 distal bsp promoter sequences act to repress BSP expression in cancer cells and that most of the prom

185 Bone sialoprotein (BSP) and apatite co-localize in the extracellular matrix

186 omoted gene expression of bone sialoprotein (BSP) and OPN.

187 Bone sialoprotein (BSP) and osteocalcein (OCN) markers were upregulated 3-f

188 resulted in a decrease in bone sialoprotein (BSP) and osteocalcin (OCN) mRNAs while PDGF-BB also incr

189 n, for gene expression of bone sialoprotein (BSP) and osteocalcin (OCN), and histomorphometric analys

190 pressed the expression of bone sialoprotein (BSP) and osteonectin in both femurs and bone marrow oste

191 with mineralized tissues, bone sialoprotein (BSP) and osteopontin (OPN), and a cell-surface receptor

192 Bone sialoprotein (BSP) and osteopontin (OPN, ETA-1) are expressed by troph

193 between the expression of bone sialoprotein (BSP) and skeletal metastasis of breast cancers.

194 thods were used to detect bone sialoprotein (BSP) distribution in Hyp and WT mouse molar tissues, and

195 the relationship between bone sialoprotein (BSP) expression and osteocalcin expression with subseque

196 nced osteocalcin (OC) and bone sialoprotein (BSP) gene expression in human prostate cancer cells by a

197 Expression of the bone sialoprotein (BSP) gene, a marker of bone formation, is largely restri

198 Bone sialoprotein (BSP) has been shown to induce limited gelatinase activit

199 ins osteopontin (OPN) and bone sialoprotein (BSP) have been implicated in biological functions such a

200 s), osteopontin (OPN) and bone sialoprotein (BSP) in the Galnt1-null mice relative to those of the wi

201 Bone sialoprotein (BSP) is a member of the SIBLING family with essential ro

202 Bone sialoprotein (BSP) is a multifunctional, highly phosphorylated, and gl

203 Bone sialoprotein (BSP) is a secreted glycophosphoprotein normally restrict

204 Bone sialoprotein (BSP) is an acidic 301 amino acid protein expressed by os

205 Bone sialoprotein (BSP) is an acidic phosphoprotein with collagen-binding,

206 Bone sialoprotein (BSP) is an extracellular matrix (ECM) protein associated

207 Bone sialoprotein (BSP) is an extracellular matrix protein found in mineral

208 ot cultures of UMR-106-01 Bone Sialoprotein (BSP) osteoblast cells.

209 i.e., osteopontin (OPN), bone sialoprotein (BSP), alkaline phosphatase (ALP), osteocalcin (OCN), alp

210 glycoprotein-75 (BAG-75), bone sialoprotein (BSP), and alkaline phosphatase that are the exclusive si

211 ription factor 2 (RunX2), bone sialoprotein (BSP), and osteocalcin (OCN) messenger RNA (mRNA), was ev

212 matrix protein-1 (DMP1), bone sialoprotein (BSP), and osteopontin (OPN) are three SIBLINGs (small in

213 The mRNA expressions of bone sialoprotein (BSP), collagen type I (COL-I), osteocalcin (OCN), runt-r

214 length osteopontin (OPN), bone sialoprotein (BSP), dentin matrix protein 1 (DMP1), dentin phosphoprot

215 n of osteocalcin (OC) and bone sialoprotein (BSP), genes pivotal to bone matrix formation and calcifi

216 d tissue-specific marker, bone sialoprotein (BSP), indicating that epithelial products can regulate t

217 Immunohistochemistry for bone sialoprotein (BSP), integrin beta1 and collagen type 1 and histologica

218 ssociated genes including bone sialoprotein (BSP), OC, and osteopontin (OPN) in the cell-implant spec

219 l nuclear antigen (PCNA), bone sialoprotein (BSP), osteocalcin (OCN), and tartrate-resistant acid pho

220 ulation (OC/CM) expressed bone sialoprotein (BSP), osteopontin (OPN), and OC, markers selective to ce

221 sue-associated markers of bone sialoprotein (BSP), Type I collagen (COL I), osteocalcin (OCN), osteop

222 .g., osteocalcin (OCN) or bone sialoprotein (BSP).

223 e response element of rat bone sialoprotein (BSP).

224 potentially nucleated by bone sialoprotein (BSP).

225 is, we infected 5-day-old bone sialoprotein (BSP)/avian retroviral receptor gene (TVA) transgenic mic

226 ood-based biomarkers were bone sialoprotein (BSP, Discovery false discovery rate [FDR]-corrected p =

227 g factor alpha-1 [Cbfa1], bone sialoprotein [BSP], osteocalcin [OCN], and osteopontin [OPN], markers

228 [OCN], osteopontin [OPN], bone sialoprotein [BSP], osteoprotegerin [OPG] and receptor activator of NF

229 nchymal stem cell, BMMSC; bone sialoprotein, BSP; hydroxyapatite/tricalcium phosphate, HA/TCP; Hertwi

230 ing phosphoglycoproteins (bone sialoprotein, BSP; osteopontin, OPN; and dentin matrix protein-1, DMP1

231 Simulated BSP maps during normal atrial excitation (i.e. sinoatria

232 ce uptake of bilirubin, sulfobromophthalein (BSP), and taurocholate, had any influence on 55Fe-heme u

233 s property with that of sulfobromophthalein (BSP), a preferred OATP2B1 substrate.

234 Accumulating evidence supports BSP as a key regulator of mineralized tissue formation v

235 ed osteoblast differentiation and suppressed BSP gene expression.

236 In the developing teeth, BSP-GFPtpz was expressed at high levels in cementoblasts

237 de showed a slightly better performance than BSP grade (0.9175 versus 0.9155).

238 We conclude that BSP is a critical and nonredundant factor for alveolar b

239 To test our hypothesis that BSP plays an important role in cementogenesis, we analyz

240 We hypothesized that BSP ablation would cause defective alveolar bone healing

241 We hypothesized that BSP-RGD plays an important role in cementum and alveolar

242 In this report, we show that BSP and OPN form rapid and tight complexes with compleme

243 estingly, our recent publication showed that BSP and type XI collagen form complexes in mineralizing

244 Previous work has shown that BSP can bind to matrix metalloproteinase-2 (MMP-2).

245 Results collected here suggest that BSP plays a non-redundant role in acellular cementum for

246 These data suggest that BSP-1 is the prototype of a new class of signaling molec

247 The BSP and Ph(2)SO methods give comparable results in all t

248 The BSP framework revealed population expansions, dated afte

249 diagnosis according to the 2017 WWC and the BSP-i guidelines for implementation.

250 esian binary filter algorithm to compute the BSP from the EEG and controllers using a linear-quadrati

251 undary element method is used to compute the BSP resulting from atrial excitation.

252 nd dental pulp during tooth development, the BSP-GFPtpz transgene was detected during in vitro minera

253 ur data indicate that Cbfa repression of the BSP promoter does not involve the transducin-like enhanc

254 cids 362 to 513) relieved suppression of the BSP promoter.

255 We show that the BSP at 08 h on a given day is a reliable indicator of an

256 In total, the BSP-RGD domain is implicated in periodontal development,

257 PF event was greater than 0.5 (95%) when the BSP at 08 h was less than 6.8 Mm(-1).

258 electron microscopy, which included thinner BSP-positive staining within the cementum, discontinuous

259 alphaVbeta5 integrin, HSG cells attached to BSP but not to DMP1 or OPN.

260 ic migration-enhancing properties of DMP1 to BSP and OPN were performed using human skeletal (MG63 an

261 afenib in DLD1 cells additionally exposed to BSP.

262 factors mediated repression of the wild-type BSP promoter, in contrast to their well known activation

263 yl 4-DP donors with glycosyl acceptors using BSP/Tf2O activation, whereas beta-linked 4'-DP disacchar

264 We have investigated whether BSP and OPN may play a similar role in tumor cell comple

265 activates a mineralization program in which BSP localizes to extracellular matrix sites where hydrox

266 resorption fronts and reversal lines, while BSP was localized to reversal lines.

267 differentially modulates BR in patients with BSP and IB depending on the baseline BR.

268 significantly reduced BSDI in patients with BSP and IB.

269 ients with favorable outcomes; patients with BSP and unfavorable outcomes showed either no features,