ライフサイエンスコーパス: Babesia

1 n the model of acute babesiosis with the WA1 Babesia.

2 aerythrocytic organisms typical of the genus Babesia.

3 wo species of the related protozoan parasite Babesia.

4 mptomatic blood donors who test positive for Babesia.

5 tebrate hosts and change the epidemiology of Babesia.

6 omplexan pathogens, including Toxoplasma and Babesia.

7 nd selected for resistance in two species of Babesia.

8 lopment of protozoa parasites from the genus Babesia.

9 f the invasion machinery between malaria and Babesia.

10 a diversity of EBP belonging to Rickettsia, Babesia, Anaplasma, Bartonella, and Ehrlichia species.

11 Targeted pathogens were Borrelia, Babesia, Anaplasma, Rickettsia, Ehrlichia, Bartonella, F

12 eptor interactions must occur for successful Babesia and Plasmodium invasion of the human red cell.

13 Intracellular parasites, including Babesia and Plasmodium, the agents of human babesiosis a

14 uperfamily of the Piroplasmida hemoparasites Babesia and Theileria (pRAP-1) is structurally conserved

15 urrently known piroplasmida, including other Babesia and Theileria species, in lacking two conserved

16 a new database supporting Piroplasmida (i.e. Babesia and Theileria), the addition of large amounts of

17 terinary relevance, such as West-Nile virus, Babesia and Trypanosoma species.

18 es (Stat4KO mice) were infected with the WA1 Babesia, and observations were made on the course of inf

19 rrelia burgdorferi sensu lato, 11 species of Babesia, and the virus causing severe fever with thrombo

20 Pathogens such as Plasmodium, Babesia, and Theileria invade and multiply within host r

21 found in mature erythrocytes that expressed Babesia antigens but not the transferrin receptor CD71.

22 ntained Babesia nuclei and failed to express Babesia antigens.

23 e zoonosis caused by protozoans of the genus Babesia, apicomplexan parasites that replicate within er

24 of cattle, but only in the last 30 years has Babesia been recognized as an important pathogen in huma

25 gondii, responsible for human toxoplasmosis, Babesia belongs to the Apicomplexa family.

26 1 (RAP-1) and which come from the parasites Babesia bigemina and Babesia bovis, is a target for vacc

27 The rhoptry-associated protein 1 (RAP-1) of Babesia bigemina induces partial protective immunity and

28 Babesia bigemina infection of mature bovine erythrocytes

29 rgeted vaccine antigen for Babesia bovis and Babesia bigemina infections of cattle.

30 ction against challenge using the homologous Babesia bigemina strain.

31 iated protein 1 (RAP-1) of Babesia bovis and Babesia bigemina to confer partial protective immunity i

32 in mice makes it a unique pathogen to study Babesia biology and pathogenesis.

33 A comprehensive understanding of Babesia biology necessitates the application of advanced

34 dant and previously unrecognized elements of Babesia biology, with evolutionary dynamics consistently

35 ng rhoptry-associated protein 1 (RAP-1) from Babesia bovis and B. bigemina, which have been shown to

36 1 (RAP-1) is a targeted vaccine antigen for Babesia bovis and Babesia bigemina infections of cattle.

37 y of rhoptry-associated protein 1 (RAP-1) of Babesia bovis and Babesia bigemina to confer partial pro

38 ozoite surface antigen 2 (MSA-2) proteins of Babesia bovis are members of the variable merozoite surf

39 The tick-transmitted hemoparasite Babesia bovis causes an acute infection that results in

40 The tick-borne apicomplexan parasite Babesia bovis causes bovine babesiosis which leads to en

41 n part attributable to parasite DNA and that Babesia bovis DNA is directly mitogenic for bovine B cel

42 ozoite surface antigen (vmsa) gene family of Babesia bovis encode membrane proteins involved in eryth

43 activity of DNA from the protozoan parasite Babesia bovis for bovine B lymphocytes.

44 Serial blood passage of virulent Babesia bovis in splenectomized cattle results in attenu

45 Babesia bovis is a deadly disease of cattle resulting in

46 Antigenic variation in Babesia bovis is one aspect of a multifunctional virulen

47 The Babesia bovis merozoite surface antigen 1 (MSA-1) is an

48 The Babesia bovis merozoite surface antigen 1 (MSA-1), a mem

49 The Babesia bovis merozoite surface antigen 2 (MSA-2) locus

50 Babesia bovis parasites present a serious and significan

51 A 225-kDa Babesia bovis protein occurs on the cytoplasmic side of

52 Babesia bovis rhoptry-associated protein 1 (RAP-1), whic

53 Babesia bovis small heat shock protein (Hsp20) is recogn

54 We examined Babesia bovis sporozoites for the expression of two mole

55 believed to play a key role in resistance to Babesia bovis through parasite suppression by macrophage

56 morphism is a defining characteristic of the Babesia bovis variable merozoite surface antigen (VMSA)

57 ied in the carboxy-terminal one-third of the Babesia bovis variable merozoite surface antigen family

58 d on the small-subunit rRNA gene sequence of Babesia bovis were compared in a blind study of experime

59 imed to develop a synchronization method for Babesia bovis which causes the most pathogenic form of b

60 The protozoan parasite Babesia bovis, a reemerging threat to U.S. cattle, is ac

61 rofolate reductase/thymidylate synthase from Babesia bovis, against 48 different reagents at five dif

62 Babesia bovis, an intraerythrocytic parasite of cattle,

63 come from the parasites Babesia bigemina and Babesia bovis, is a target for vaccine development.

64 Babesia bovis, the causative agent of severe babesiosis

65 Sequestration of Babesia bovis-infected erythrocytes (IRBCs) in the host

66 , Cryptosporidium and Theileria species, and Babesia bovis.

67 rofolate reductase/thymidylate synthase from Babesia bovis.

68 of equine piroplasmosis tested negative for Babesia caballi and Babesia equi in the complement fixat

69 detection of equine antibodies specific for Babesia caballi.

70 f two protozoan parasites, Theileria equi or Babesia caballi.

71 cannot be distinguished microscopically, and Babesia can also be confused with the early trophozoite

72 Thus, Babesia can also be transmitted by infected blood, and i

73 Whereas several species of Babesia can cause severe disease in humans, the ability

74 The major merozoite surface antigens of Babesia canis have been described as a 28-kDa membrane p

75 Babesia canis is the agent of the canine babesiosis in E

76 were seroreactive to an Ehrlichia sp., 16 to Babesia canis, and 25 to Bartonella vinsonii, and 22 ser

77 mitted pathogens, including Ehrlichia canis, Babesia canis, Babesia gibsonii, or spotted fever group

78 However, even in asymptomatic people, a Babesia carriage state can be established that can last

79 individuals, tick-transmitted infection with Babesia causes no specific clinical manifestations, with

80 ell leukemia-lymphoma virus, Chagas, dengue, Babesia, cytomegalovirus, malaria, and other infections.

81 Here we identify the RON2 proteins of Babesia divergens (BdRON2) and B. microti (BmRON2) and s

82 we present a detailed characterization of a Babesia divergens homolog of AMA1 (BdAMA1), and taking a

83 n of erythrocytes is an integral part of the Babesia divergens life cycle.

84 and clinically mutant cells, we showed that Babesia divergens uses neuraminidase- and trypsin-sensit

85 7, the major antigenic adhesion protein from Babesia divergens, the agent of bovine babesiosis, was a

86 e patient's serum had strong reactivity with Babesia divergens, which causes babesiosis in cattle and

87 nsfusions acquired babesiosis infection with Babesia divergens-like/MO-1 organisms and not Babesia mi

88 e identify spermidine as a key polyamine for Babesia duncani and Plasmodium falciparum for intraeryth

89 disease in humans, the ability to propagate Babesia duncani both in vitro in human erythrocytes and

90 Babesia duncani causes severe to lethal infection in hum

91 This review spotlights the Babesia duncani in culture-in mouse (ICIM) model as a pr

92 highly effective against Babesia microti and Babesia duncani in mice and protects animals from lethal

93 Babesia duncani is the causative agent of babesiosis in

94 and heart failure, as a potent inhibitor of Babesia duncani parasite development within human erythr

95 advancements in gene editing technologies of Babesia, emphasizing the foundational importance of in v

96 in deploying blood donor screening assays in Babesia endemic regions, identifying changing risks for

97 s efficiently acquire the protozoal pathogen Babesia equi during acute and persistent infections and

98 osis tested negative for Babesia caballi and Babesia equi in the complement fixation test before impo

99 zoite antigens 1 and 2 (EMA-1 and EMA-2) are Babesia equi proteins expressed on the parasite surface

100 The protozoan parasite Babesia equi replicates within erythrocytes.

101 ial in providing protective immunity against Babesia following parasite clearance.

102 and technical guidance for future studies in Babesia genetics, highlighting the transformative potent

103 a seminested PCR to detect and differentiate Babesia gibsoni (Asian genotype), B. canis subsp. vogeli

104 s, including Ehrlichia canis, Babesia canis, Babesia gibsonii, or spotted fever group rickettsiae, wa

105 Coinfection with other pathogens such as Babesia has been shown to alter the clinical course of L

106 mans are dead-end hosts for tick-transmitted Babesia, human-to-human transmission of Babesia spp. fro

107 f the relatively understudied zoonotic genus Babesia In humans, babesiosis, particularly transfusion-

108 Despite the importance of Babesia in livestock industry and emerging cases in huma

109 emic regions, identifying changing risks for Babesia in non-endemic areas, investigating recipients o

110 guidance for the management of asymptomatic Babesia-infected blood donors.

111 m a single blood donation by an asymptomatic Babesia-infected donor.

112 e the risk of collecting blood products from Babesia-infected donors and describe how investigations

113 Forty-six babesia-infected subjects were identified from 1991 thro

114 isms that clear, or occasionally exacerbate, Babesia infection and those pathological processes that

115 the immunologic and pathologic responses to Babesia infection are similar in animals and humans.

116 Human Babesia infection can cause asymptomatic infection, mild

117 a central role in determining the course of Babesia infection in these strains.

118 In this study, we evaluated the course of Babesia infection in three strains of mice, C57BL/6J, BA

119 ated Plasmodium species, the pathogenesis of Babesia infection remains poorly understood.

120 shington DC have been routinely screened for Babesia infection using highly sensitive and specific nu

121 C biomechanical properties, before and after Babesia infection, reside on a spectrum of severity, wit

122 healthy, immunocompetent adults in whom most Babesia infections are self-limited based on studies sho

123 and reliable way to diagnose Plasmodium and Babesia infections in a low prevalence setting.

124 al changes in blood that are associated with Babesia infections.

125 HS's performance in detecting Plasmodium and Babesia infections.

126 Babesia is a genus of apicomplexan parasites that infect

127 Recognizing that Babesia is an expanding blood safety threat, there shoul

128 ion of babesiosis and as the epidemiology of Babesia is impacted by climate change.

129 e the current gold standard for detection of Babesia is microscopic examination of blood smears, accu

130 d by intraerythrocytic protozoa of the genus babesia, is characterized by nonimmune hemolytic anemia

131 her and with the Missouri and Kentucky human Babesia isolates.

132 n of erythrocytes is an integral part of the Babesia life cycle.

133 A newly identified intraerythrocytic Babesia-like organism, WA1, and its relatives were recen

134 % to Ehrlichia chaffeensis, and 17.8% to the Babesia-like piroplasm WA1.

135 In rare cases, infection with Babesia may be associated with marked pancytopenia.

136 nfections with Borrelia burgdorferi (33.6%), Babesia microti (8.4%), Anaplasma phagocytophila (1.9%),

137 this parasite to be most closely related to Babesia microti (97.9% sequence similarity); sera from i

138 nsient as well as stable transfection of the Babesia microti (B. microti) in the in vivo conditions.

139 A new strain of Babesia microti (KR-1) was isolated from a Connecticut r

140 rently infected with Borrelia burgdorferi or Babesia microti (or both).

141 A point mutation in the Babesia microti 23S rRNA gene predicted resistance to az

142 ding West Nile virus, Zika virus (ZIKV), and Babesia microti Although there is continual need to moni

143 nel detected three coinfections, with two of Babesia microti and A. phagocytophilum and one of B. mic

144 Borellia burgdorferi, Babesia microti and Anaplasma phagocytophilum rely almos

145 pecies in vitro, is highly effective against Babesia microti and Babesia duncani in mice and protects

146 east and upper Midwest of the United States, Babesia microti and Borrelia burgdorferi use Ixodes scap

147 ly caused by the intraerythrocytic parasite, Babesia microti and transmitted by the same tick as Lyme

148 in indirect fluorescent-antibody tests with Babesia microti antigen, however, suggesting that they r

149 ansplant recipient who survived infection by Babesia microti contracted through blood transfusion.

150 s and fatalities of babesiosis are caused by Babesia microti Current treatment for human babesiosis c

151 Serologic evidence of exposure to Babesia microti did not significantly impact the clinica

152 arasites could be seen on microscopy, and no Babesia microti DNA was detected in the blood of any sub

153 The Babesia microti genome showed a classical Rabl organizat

154 sitive, and accurate method for detection of Babesia microti in patient specimens.

155 um vivax malaria, has shown activity against Babesia microti in several animal models of acute infect

156 testing were used to confirm the presence of Babesia microti in the donor's blood and to establish th

157 aneous infection of Borrelia burgdorferi and Babesia microti in the northeastern and northern midwest

158 of coinfection with Borrelia burgdorferi and Babesia microti in tick vectors, reservoir hosts, and pa

159 valuated the efficacy of TQ for treatment of Babesia microti infection in mice with severe combined i

160 y who were suspected of local acquisition of Babesia microti infection.

161 t surveyed B. miyamotoi, B. burgdorferi, and Babesia microti infections.

162 - and transfusion-transmitted human pathogen Babesia microti infects host erythrocytes to cause the p

163 Babesia microti is a tick-borne red blood cell parasite

164 Human babesiosis caused by Babesia microti is an emerging tick-borne zoonosis of in

165 Babesia microti is an intraerythrocytic parasite and the

166 long-term carriers of the zoonotic parasite Babesia microti is evidenced by numerous reported cases

167 Although infection by the protozoan Babesia microti is rarely symptomatic in immunocompetent

168 The apicomplexan pathogen Babesia microti is responsible for most cases of human b

169 Babesia microti is the cause of a potentially fatal emer

170 Crystal structures of Babesia microti lactate dehydrogenase BmLDH reveal a cri

171 Tickborne transmission of Babesia microti mainly occurs in 7 states in the Northea

172 Here, we show that a mutation in the Babesia microti mitochondrial cytochrome b (Cytb) that c

173 atment of babesiosis, including clearance of Babesia microti parasitemia.

174 acted from whole-blood specimens and detects Babesia microti with a limit of detection of approximate

175 the United States is caused predominantly by Babesia microti, a tick-transmitted blood parasite.

176 Babesia microti, a tick-transmitted, intraerythrocytic p

177 Babesia microti, a tickborne intraerythrocytic parasite

178 Babesia microti, a zoonotic intraerythrocytic parasite,

179 Babesia microti, an emerging human pathogen, is primaril

180 s including Borrelia burgdorferi sensu lato, Babesia microti, and Anaplasma phagocytophilum.

181 agent of human monocytic ehrlichiosis (HME), Babesia microti, and Borrelia burgdorferi.

182 burgdorferi, babesiosis, which is caused by Babesia microti, and human granulocytic ehrlichiosis (HG

183 ty of infection with a common microparasite, Babesia microti, in females - with females carrying the

184 babesiosis, which is caused by the piroplasm Babesia microti, is made by microscopic identification o

185 The major species, Babesia microti, is readily transmissible via blood tran

186 besiosis, a zoonosis caused by the protozoan Babesia microti, is usually not treated when the symptom

187 gainst a panel of 24 organisms consisting of Babesia microti, other Babesia species, Plasmodium speci

188 abesia divergens-like/MO-1 organisms and not Babesia microti, the common United States species.

189 ime PCR assay targeting the 18S rRNA gene of Babesia microti, the dominant babesiosis pathogen in the

190 ted States have been tickborne and caused by Babesia microti, the etiologic agent of all previously d

191 The intraerythrocytic apicomplexan Babesia microti, the primary causative agent of human ba

192 For Borrelia burgdorferi and Babesia microti, the sensitivity of TBDCapSeq was compar

193 burgdorferi, Anaplasma phagocytophilum, and Babesia microti.

194 and molecular tests for the causative agent, Babesia microti.

195 gnosed by peripheral red blood cell smear as Babesia microti.

196 tic Ehrlichia sp., Borrelia burgdorferi, and Babesia microti.

197 ere coinfected with Borrelia burgdorferi and Babesia microti.

198 re highly efficacious against B. duncani and Babesia microti.

199 ic cycle, including Borrelia burgdorferi and Babesia microti.

200 sfection method has not been established for Babesia microti.

201 The expert panel recommends that all Babesia NAT positive blood donors should be referred for

202 We also describe how microbiologists in Babesia non-endemic regions can assess for changing risk

203 CD71-positive reticulocytes rarely contained Babesia nuclei and failed to express Babesia antigens.

204 hemoglobin mediated) and secondary changes (Babesia parasite infection mediated) to the RBC membrane

205 Babesia parasite invades exclusively red blood cell (RBC

206 ection with the recently identified WA1-type Babesia parasite is described.

207 The diversity of Babesia parasites and the lack of specific drugs necessi

208 ng tick-borne malaria-like illness caused by Babesia parasites following their development in erythro

209 ich develops through cyclical replication of Babesia parasites in host erythrocytes.

210 most severe clinical signs of all the large Babesia parasites infecting dogs.

211 lness caused by tick-borne intraerythrocytic Babesia parasites of the Apicomplexa phylum.

212 October 2021, confirmed by identification of Babesia parasites on thin blood smear and/or by polymera

213 methods do not identify infected donors, and Babesia parasites survive blood-banking procedures and s

214 Due to limitations in synchronizing Babesia parasites, fine-scale time-course transcriptomic

215 the biology, pathogenicity, and virulence of Babesia parasites, there is still no well-defined, adequ

216 ck-borne disease caused by intraerythrocytic Babesia parasites.

217 terinary infection caused by 100+ species of Babesia parasites.

218 ck-borne disease caused by intraerythrocytic Babesia parasites.

219 apidly emerging tick-borne illness caused by Babesia parasites.

220 s the identification of novel stage-specific Babesia proteins for testing transmission-blocking immun

221 s four cysteine residues conserved among all Babesia RAP-1 family members and a C-terminal (CT) regio

222 Current knowledge of Babesia replication cycle progression and regulation is

223 intra-erythrocyte protozoal parasites, with Babesia rossi causing the most severe clinical signs of

224 ever, there are no exoerythrocytic stages in Babesia, so targeting of the blood stage and associated

225 A Babesia sp. found in eastern cottontail rabbits (Sylvila

226 of an underrecognized, but highly enzootic, Babesia sp. in baboons may result in substantial, unanti

227 irst identification of antigens expressed in Babesia sp. sporozoites and establishes that, at least i

228 of severe combined immunodeficient mice with Babesia sp. strain WA1 was studied to assess the contrib

229 Two continuous lines of the zoonotic Babesia sp. were established and confirmed to share iden

230 , we applied single-cell RNA sequencing to 3 Babesia species (B. divergens, B. bovis, and B. bigemina

231 ing of 130 slides positive for Plasmodium or Babesia species and 151 negative controls.

232 Babesia species are tick-borne intracellular parasites t

233 tafenoquine inhibits the growth of different Babesia species in vitro, is highly effective against Ba

234 More than 100 Babesia species infect a wide array of wild and domestic

235 c characteristics; MO1 probably represents a Babesia species not previously recognized to have infect

236 s a tick-borne multisystem disease caused by Babesia species of the apicomplexan phylum.

237 mpared the detection rates of Plasmodium and Babesia species on peripheral blood smears utilizing the

238 We also show that B. duncani and other Babesia species use an ancestral spermidine synthase-lik

239 omparative analysis within and between three Babesia species, (B. bigemina, B. divergens and B. bovis

240 toparasite-borne pathogens (EBP) followed by Babesia species, and with fewer species of Anaplasma, Ba

241 ganisms consisting of Babesia microti, other Babesia species, Plasmodium species, tick-borne and othe

242 ease in humans and animals that is caused by Babesia species, which are tick-transmitted apicomplexan

243 rious Ehrlichia, Bartonella, Rickettsia, and Babesia species.

244 nalysis was done to compare MO1 with various Babesia species.

245 on for reactivity with antigens from various Babesia species.

246 ne inducing immunity against different human Babesia species.

247 entified BdPhoD as a resistance mechanism in Babesia species.

248 Plasmodium, Toxoplasma, Cryptosporidium and Babesia species.

249 spp., Candidatus Neoehrlichia mikurensis and Babesia spp.

250 pp., Candidatus Neoehrlichia mikurensis, and Babesia spp.

251 has been identified and characterized in any Babesia spp.

252 of resistance in independent populations of Babesia spp. (B. bovis and B. divergens).

253 extension of the geographic range of various Babesia spp. and the movement of donors and blood produc

254 Several Babesia spp. are increasingly being recognized as zoonot

255 Babesia spp. are tick-borne parasites with a global dist

256 Babesia spp. are tick-borne, intraerythrocytic hemoparas

257 Babesia spp. are tick-transmitted intra-erythrocytic pro

258 tted Babesia, human-to-human transmission of Babesia spp. from transfusion of red blood cells and who

259 ion at 56% (5 of 9); Plasmodium malariae and Babesia spp. had the highest rate of detection at 100% (

260 phic range of B. microti is expanding, other Babesia spp. have been implicated in transfusion transmi

261 Babesia spp. have complex life cycles involving multiple

262 Babesia spp. infect a wide range of mammalian species an

263 transgenic systems available for a range of Babesia spp. should encourage further biological and tra

264 id diagnostic technique for the detection of Babesia spp. that has not yet been systematically evalua

265 ling pathways and environmental stimuli that Babesia spp. utilize in the bloodstream and for transmis

266 B. miyamotoi, A. phagocytophilum, and Babesia spp. were not detected in any patient.

267 ia miyamotoi, Anaplasma phagocytophilum, and Babesia spp. were not detected in any patient.

268 r Ehrlichia spp., Anaplasma phagocytophilum, Babesia spp., or Lyme Borrelia spp.

269 er 1933 is synonymous with that of the genus Babesia Starcovici 1893 and that the morphological varia

270 No Babesia test for screening blood donors has been license

271 ch as Crimean Congo hemorrhagic fever virus, Babesia, Theileria, and Anaplasma species, identifies ar

272 Piroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted

273 Here, we describe recent progress in Babesia transfection, different gene manipulation system

274 In most patients, transfusion-transmitted Babesia (TTB) results in a moderate-to-severe illness.

275 Here, we present a whole-parasite Babesia vaccine.

276 es suggest that the development of such anti-Babesia vaccines should be feasible, many others identif

277 In this study, the prevalence of Babesia vogeli (B. vogeli) was investigated in dogs from

278 toparvum in 21.2%, Ehrlichia canis in 20.3%, Babesia vogeli in 2.0% and Candidatus Mycoplasma turicen

279 e response that protects from the pathogenic Babesia WA1 is mediated by macrophages and NK cells, pro