ライフサイエンスコーパス: C termini

1 tratricopeptide repeat (TPR) domain at their C termini.

2 buted at the confluence of cytoplasmic N and C termini.

3 gered proximity between their TIR domain and C termini.

4 antiparallel beta-sheet with flexible N and C termini.

5 sible binding event involving both the N and C termini.

6 helical structure in LPS with extended N and C termini.

7 62-133) due to the intertwining of its N and C termini.

8 cted by transversal filaments by their N and C termini.

9 highly conserved Rab-binding domain at their C termini.

10 acts to basic sequence motifs near the N and C termini.

11 entrally to enable contact between the N and C termini.

12 rved alpha-helical domains at both the N and C termini.

13 trating intermolecular interactions at their C termini.

14 pha, beta, and gamma) with cytoplasmic N and C termini.

15 The coiled coil was unzipped from its N and C termini.

16 domains are widely separated at their N and C termini.

17 e of apoA-IV that was truncated at its N and C termini.

18 helical structure flanked by flexible N and C termini.

19 with H2AX through domains at both its N and C termini.

20 cids (basic motifs) are present in p17 N and C termini.

21 lices (TM1 and TM2), and extracellular N and C termini.

22 TI or large truncations are made at the N or C termini.

23 stabilized by interactions between the N and C termini.

24 a conserved Ras-like core and extended N and C termini.

25 st multiple FH epitopes located at the N and C termini.

26 n protein aggregates with solvent-accessible C termini.

27 S(E/D)V amino acid sequence located at their C termini.

28 n 148 GPCRs and all 11 unique Galpha subunit C termini.

29 t in no other protein, one each in the N and C termini.

30 Rs), principally by receptors binding Galpha C termini.

31 ued in DAT chimeras encoding both SERT N and C termini.

32 se fold with degraded kinase motifs at their C termini.

33 charged domains (Pro-Arg-Gly) at both N- and C-termini.

34 creasing lengths and functionalizable N- and C-termini.

35 through their third intracellular loops and C-termini.

36 oligomers dictated by features of the N- and C-termini.

37 unbiased ladder sequencing of protein N- and C-termini.

38 c cytosol have four residues, EEVD, at their C-termini.

39 ic packing interactions with extended N- and C-termini.

40 ultiple stages from the N-termini toward the C-termini.

41 otubule, at least partly through the tubulin C-termini.

42 out of alignment by two residues toward the C-termini.

43 ein-coupled receptor (GPCR), fused via their C-termini.

44 ides containing an arginine residue at their C-termini.

45 oteins recruit and anchor Ca(V)2s via Ca(V)2 C-termini.

46 al G domain flanked by more divergent N- and C-termini.

47 ns are tagged for degradation at both N- and C-termini.

48 evisiae, identifying 2190 N-termini and 1562 C-termini.

49 renyl and methyl groups at their free N- and C-termini.

50 cross-linked peptides via (18)O-labeling at C-termini; (2) determination of the putative partial seq

51 receptor is composed of intracellular N and C termini, a large extracellular domain containing the A

52 for DAT, because replacing the SERT N and/or C termini affected neither substrate nor inhibitor affin

53 nnotations of proteomes, while proteome-wide C termini analysis still poses substantial challenges.

54 effectively and selectively isolate protein C termini and contributes to the global annotation of C

55 sistent with Kir channel crystal structures: C termini and M2 domains are centrally located relative

56 emoval of the intrinsically disordered N and C termini and the hook region of beta1a prevented oligom

57 ts show that a few amino acid changes at the C-termini and active sites of Nasonia vitripennis SDRs l

58 have mapped proteolysis sites at the N- and C-termini and at a limited internal segment, while other

59 od, and tissues by removing cleavable N- and C-termini and by shielding components from metabolic enz

60 el beta-sheets, flanked by disordered N- and C-termini and Ser13 phosphorylation creates a network of

61 ly been ascribed to the receptor cytoplasmic C-termini and to AMPAR-associated auxiliary subunits, bo

62 e autoinhibitory contacts between the N- and C-termini and unmask UvrA recognition determinants.

63 st kinesins transport cargoes bound to their C-termini and use N-terminal motor domains to move along

64 FP or cyan fluorescent protein (CFP) at N or C termini, and all such constructs, including double-tag

65 cular interactions between its charged N and C termini, and between its hydrophobic region and the C

66 clusters of polar residues at both the N and C termini, and deletion of up to 11 C-terminal residues

67 tructural similarities between TssA1 and gp6 C-termini, and propose that TssA1 could be a baseplate c

68 glycosylases from diverse sources, where the C termini are disordered and do not form comparable intr

69 The N and C termini are highly dynamic and are involved in the int

70 The peptide C termini are located close to the main fibril axis, whe

71 We also found that NIP4;1 and NIP4;2 C termini are phosphorylated by a pollen-specific CPK th

72 eptide binding cleft, upon which the peptide C termini are tested for their capacity to dislodge the

73 The N and C termini are unexpectedly close, providing clues for sp

74 ed), and highly acidic environments in which C-termini are also protonated.

75 bile, the core is highly structured, and the C-termini are flexible but restrained by their contact w

76 In contrast, the sequences of the C-termini are highly conserved, consistent with them enc

77 To examine how many C-termini are needed for SSB function, we engineered cov

78 on experiments show that that GCC185's N-and C-termini are within <40 nm of each other on the Golgi.

79 forms (EAAT2a and EAAT2b) that vary at their C termini as a consequence of alternative RNA splicing.

80 hemoselective capture step merging the N and C termini as a covalently linked O/S-ester intermediate

81 hese properties are not common to all formin C termini, as those of mDia1 and INF2 do not behave simi

82 e exception of a few residues near the N and C termini, as well as three hydrophilic residues within

83 t strategy for specific isolation of protein C termini based on LysC digestion and site-selective dim

84 ase cleavage, degenerate conservation of the C-termini between classes precludes pinpointing the anal

85 loss, likely due to differences in the N-and C-termini between the catenins.

86 by 2 autoinhibitory domains within its N and C termini, both of which were found to play critical rol

87 e domain only constructs, when tagged at the C termini but not at the N termini.

88 gamma isoforms are highly conserved at their C-termini but have unique N-terminal sequences, and we h

89 plains activity of PPAD against arginines at C-termini but not within peptides.

90 ecursor (pVI) that is cleaved at both N- and C-termini by AVP.

91 these peptides are protected at their N- and C-termini by macrocyclization.

92 igomerization of Ca(v)1.2 channels via their C termini can result in the amplification of Ca(2+) infl

93 more compact and rigid sites at their N and C termini compared with WT alpha-Syn that may facilitate

94 bodies at the cell surface and extracellular C termini comprised most or all of those present at the

95 OD4.2.2 structure, though with altered N and C termini conformations.

96 These peptides have atypically diverse C termini consisting of residues not recognized by eithe

97 The SSB C-termini contain a 9 residue acidic tip and a 56 residu

98 lical membrane domains and large cytoplasmic C-termini containing two cystathionine-beta-synthase dom

99 udy, we conducted mutational analysis of the C termini (containing the conserved Jas motif) of two JA

100 verexpression of SynGAP alpha1 versus alpha2 C-termini-containing proteins in hippocampal neurons has

101 ole the highly divergent intracellular N and C termini contribute to these processes.

102 proteins to test whether DAT and SERT N and C termini contribute to transporter substrate and inhibi

103 e allosteric sites located at the PKAc N and C termini coordinately regulate the phosphatase sensitiv

104 ysis in mammals suggested that expanded NF-M C termini correlated with larger-diameter axons.

105 fication efficiency by obtaining the largest C termini data set of the human proteome with the least

106 PilA proteins with diverse and/or truncated C termini decreased native pilA transcription, suggestin

107 meric building blocks, while flanking N- and C-termini direct the formation of larger sHSP oligomers.

108 One mouse truncated all C termini downstream of Oprm1 exon 3 (mE3M mice), while

109 tical in their N termini but unique in their C termini due to a -1 ribosomal frameshift during transl

110 ted by a cytosolic loop, and has both N- and C- termini exposed to the endoplasmic reticulum (ER) lum

111 ed by a three-residue break with both N- and C-termini exposed to the cytoplasm.

112 n intramembrane protein where both the N and C termini face the cytoplasm.

113 f two PABPs on a poly(A) streak in which the C-termini face toward or away from each other).

114 The septin C-termini face, namely the C-terminal extension of Cdc12

115 ntrinsic function of both proteins, requires C termini facing the cytoplasmic leaflet of the plasma m

116 two equally active isoforms with alternative C-termini, Fes1L and Fes1S.

117 So far, sequencing of protein N- and C-termini has been limited to single purified protein sp

118 in which the V1, V2, and V3 loops and N and C termini have been truncated) have indicated that a hal

119 AP, alpha1 and alpha2, which differ in their C-termini, have opposing effects on synaptic strength.

120 ved for subclasses having homologous F(ab')2 C termini (IgG1/3/4).

121 nerated 3 mutant mouse models with truncated C termini in 2 different mouse strains, C57BL/6J (B6) an

122 eolysis to investigate the role of the N and C termini in ATP hydrolysis and auto-inhibition of the y

123 a lipid bilayer, implicating both the N and C termini in membrane binding.

124 these mice revealed divergent roles for the C termini in morphine-induced behaviors, highlighting th

125 The unanchored ubiquitin C termini in the aggregates are generated in situ by agg

126 hin the cytoplasmic membrane, with the N and C termini in the cytoplasm and periplasm, respectively.

127 termini of the ssSPTs in the cytosol, their C termini in the lumen, and showed that they contain a s

128 by determining the orientation of the N- and C-termini in the amyloidogenic protein alpha-synuclein.

129 n response along the line joining the N- and C-termini) increased upon SBM binding from approximately

130 This N/C-termini interaction is a biomarker assay for the undes

131 beta(2)-AR-Galpha C termini interactions alter receptor conformation, whic

132 Analysis of protein C termini is very important for functional annotations o

133 lacking the intrinsically disordered N- and C-termini, loses specificity for DNA lesions and shows l

134 to the human 43-mer inhibitory tract (N and C termini, mAbinhibit, and mAb4C11) and the neoepitope g

135 -electron microscopy, we show that the GroEL C-termini make physical contact with the PepQ folding in

136 The C termini may function as homodimerisation domains.

137 t stable proteoforms with undocumented N- or C-termini, meaning these proteoforms are stable function

138 /IAA and ARF proteins share highly conserved C-termini mediating homotypic and heterotypic interactio

139 To understand how the distinct C termini might affect transporter trafficking and surfa

140 large movement between two positions in the C termini of a dimeric cotransporter.

141 The N and C termini of adjacent BAFF or APRIL monomers are spatial

142 onstrate that CryAB interacts with the N and C termini of Ago2, not the catalytic site defined by the

143 Thus, proteolytic modifications of the N and C termini of alpha2AP constitute major regulatory mechan

144 This novel interface involves the C termini of alpha3 and alpha5 helices.

145 Although the C termini of ARF and Aux/IAA proteins facilitate their h

146 Thus, the hydrophobic regions in the C termini of BH3-only members associated in distinct way

147 tion structures of the ANK repeat-containing C termini of both kidney-type glutaminase (KGA) and GLS2

148 The noncore C termini of both RAG1 and RAG2 are also required for AT

149 ly invariant residues that bind to the N and C termini of bound peptide found in most vertebrae class

150 Surprisingly, both the N and C termini of csGRP78 were necessary for this profibrotic

151 ibitor-induced dimers but suggested that the C termini of domain IV of the two monomers were in close

152 cisely determined the locations of the N and C termini of DRC3 and the C terminus of DRC4 within the

153 rrestins and specific phosphoresidues in the C termini of each receptor are crucial for determining t

154 ion resides in short acidic regions near the C termini of each subunit.

155 vered by yeast two-hybrid screening that the C termini of ENaC alpha and beta subunits bind filamin A

156 These results illustrate that the C termini of formins are highly diverse in their interac

157 ies against linear epitopes within the N and C termini of gD2.

158 We show that STEP(61) binds to the C termini of GluA2 and GluA3 as well as endogenous AMPAR

159 y applied to the characterization of protein C termini of HeLa cells.

160 is constitutively bound to IQ domains of the C termini of human Kv7 (hKv7, KCNQ) channels to mediate

161 raction requires sequences in both the N and C termini of ICP27.

162 at are predicted to modify the intracellular C termini of IL-15Ralpha, and another N-terminal exon "E

163 mbers of the IL-1 family, both the N and the C termini of IL-37 are extended, and we show they are di

164 ation away from the cell surface, moving the C termini of IL-7Ralpha and gamma(c) from a distance of

165 The region at the C termini of integrin beta(1) and beta(3) tails recogniz

166 istance to the known separation of the N and C termini of MBP than FRET.

167 drial matrix, suggesting that both the N and C termini of MCU face the matrix.

168 -dependent conformational variation near the C termini of molecules within PrP(Sc) multimers.

169 Moreover, the N and C termini of one Hsp90 molecule simultaneously bound to

170 iple glutamate residues from side chains and C termini of paclitaxel-stabilized microtubules.

171 f complexes with Fab fragments bound to N or C termini of PDE6gamma revealed that PDE6gamma stretches

172 toxin 2 (Stx2A1) interact with the conserved C termini of ribosomal-stalk P-proteins to remove a spec

173 high affinity interaction between the N and C termini of S. mutans P1 creates a non-adherent phenoty

174 , sorting motifs have been identified in the C termini of several GPCRs that facilitate correct traff

175 al transcriptional activation domains in the C termini of several tail module subunits of Saccharomyc

176 of nNOS binds with very low affinity to the C termini of target proteins, and a necessary simultaneo

177 y or through the interface between the N and C termini of the channel.

178 ive modification of numerous residues in the C termini of the D1 and D2 proteins on the donor side of

179 ally modulated by small regions in the N and C termini of the Gle2 binding domain sequence, suggestin

180 onfirm that conserved sequences in the N and C termini of the Mfa1 fimbrial subunit protein perform c

181 We find that the nucleoporin Nup62 and the C termini of the nephronophthisis (NPHP) proteins NPHP4

182 f Mcl-1 deletion mutants from both the N and C termini of the protein, including one that contained a

183 cular organization and location of the N and C termini of the transient receptor potential vanilloid

184 looking down onto the cell surface with the C termini of the two chains separated by 110 A and the d

185 e system, we identified regions in the N and C termini of the V protein that inhibit viral RNA synthe

186 These observations suggest that the N and C termini of the Vik1 MHD form a discrete folding motif

187 g N-terminal helices positioned to match the C termini of the viral glycoproteins.

188 Analysis with antibodies targeting the N and C termini of the VZV SCP indicates that the hexon-cappin

189 ed to structural rearrangements of the N and C termini of their motor domain upon nucleotide binding.

190 While the C termini of these orthologs are not conserved in amino

191 and the synthetic peptides representing the C termini of these proteins were in the 1- to 40-muM ran

192 enzymatic removal of the negatively charged C termini of tubulin.

193 Dimeric Grb2 binds to the C termini of two FGFR2 molecules.

194 The C termini of various cellular proteins insert within the

195 rmed between SpyCatcher (-sc; encoded at the C'-termini of recombinant proteins) and SpyTag.

196 tifs (ERret) are incorporated into the N- or C- termini of Shaker monomers or within sodium channels

197 roduced cysteine residue pairs to the N- and C- termini of the cpRFP scaffold, and subsequently optim

198 e Galphao interacts with both the N- and the C- termini of TRPM1, Gbetagamma interacts only with the

199 ble with this approach and modify the N- and C-termini of a single substrate protein in a sequential,

200 Recombinant C-termini of ADAMTS10 and ADAMTS6, both of which induce

201 Separate analyses of domains near the N- and C-termini of agrin, laminin, and collagen IV in mouse an

202 The C-termini of all isoforms localize to the active zone.

203 near interactions play a role in capping the C-termini of alpha-helices and 310-helices.

204 This strategy was used to modify the C-termini of an antibody scFv construct and of Protein L

205 wo L-terminase protomers projecting from the C-termini of an S-terminase ring.

206 with mass spectrometry show that the N- and C-termini of AtHsp18.5 are highly accessible and lack st

207 of Rpn11 dimerizes with that of Rpn8 and the C-termini of both subunits form long helices, which are

208 pha-helical bundles formed from the extended C-termini of capsid protein VP4B and VP4C protrude from

209 s selected from phage libraries to the N- or C-termini of core streptavidin and used them to setup ph

210 The C-termini of E2 [amino acids (aa) 890-1053] and MEK2 (aa

211 the 'alpha3/alpha5' interface, in which the C-termini of helices alpha3 and alpha5 are in close prox

212 emonstrate following proteolysis that N- and C-termini of IP3 R1 remain associated, presumably throug

213 T) between fluorescent proteins fused to the C-termini of LRRC8 subunits.

214 o bind to negatively charged residues at the C-termini of P-proteins.

215 of a fuzzy complex in which both the N- and C-termini of p27 interact with Cdk2/cyclin A in multiple

216 ues that project into solution from the N or C-termini of peptide and protein substrates.

217 ons of mRNA sequences that correspond to the C-termini of protein domains, suggesting ribosome protec

218 Specifically, the N- and C-termini of Rev contribute to protein stability; mutati

219 nteracting mainly with the disordered N- and C-termini of specific CCT subunits of both rings.

220 hesin, but flanking sequences at both N- and C-termini of SpyCatcher were disordered.

221 ion distances of neighboring residues at the C-termini of the alpha1 and alpha2 helices are consisten

222 The C-termini of the Gtgamma- and Gtalpha-subunits (GalphaCT

223 eering has been applied: the original N- and C-termini of the minichaperone were linked together by a

224 dies for pS319 and pY359+pS362 at the N- and C-termini of the P-domain, respectively.

225 ult in multiple peaks for the exposed N- and C-termini of the peptide and in inhomogeneous line-broad

226 linkers, leading to outward movements of the C-termini of the pore-lining M3 helices and opening of t

227 t interactions involving the L3 loop, N- and C-termini of the RRM domain are collectively important f

228 immunodominant antigenic sites in the N- and C-termini of the RSV-G protein, that were boosted >10-fo

229 with a phosphoserine/phosphothreonine at the C-termini of the target protein.

230 hosphatase BL (PDZ2) interacts and binds the C-termini of the tumour suppressor protein APC and of th

231 formation of non-native contacts between the C-termini of the two helices.

232 , describing a possible mechanism of how the C-termini of these homologous Hsp70 variants can differe

233 Using peptides derived from the N- or C-termini of this sequence, as well as Ambn variants tha

234 r attaching isotopic tags to both the N- and C-termini of tryptic peptides, and second, a search engi

235 ructurally distinct, representing the N- and C-termini of TSC1; a "pincer" is formed by the highly fl

236 Most of these modifications occur on the C-termini of tubulin and may directly affect the binding

237 ized to investigate the effects of different C termini on the process of biomineralization.

238 bent TIA-1 shape, which organizes the N- and C-termini on the same side of the protein, are discussed

239 formation of intermolecular hydrogen bonds: C-termini or internal linear motifs of proteins bind as

240 embrane domains (TMDs), with both the N- and C-termini orientated toward the lumen of the ER.

241 Within the highly diverged N- and C-termini, posttranslational modifications are scattered

242 osylated because of the fact that the mutant C termini project extracellularly.

243 eas in 3'-terminal exons that encode protein C-termini, protein-level selection is significantly stro

244 cterized by a beta-turn structure near their C termini rather than the alpha-helical structure common

245 kely attributed to the changes in the N- and C-termini rather than in the RNA-binding region.

246 earrangements that facilitate their flexible C-termini refolding to engage distinct interfaces.

247 e the proteome-wide identification of N- and C-termini relies on the generation of single, terminal p

248 d 11 and 19 amino acid residues at the N and C termini, respectively, exhibited no significant change

249 3- and 10-amino-acid extensions at the N and C termini, respectively.

250 e lacking 104 and 65 residues from its N and C termini, respectively.

251 otease-resistant and has cysteine-rich N and C termini responsible for polymerization.

252 Importantly, removal of the C termini results in slower overall folding, reducing th

253 arginine(R)-phenylalanine(F) motif at their C-termini (RFamide peptides).

254 o as to juxtapose the amino (N) and carboxy (C) termini; several of these designed structures have be

255 nternal PrP fragments, cleaved at both N and C termini, similar to those found in PrP-CAA and GSS bra

256 played by oligomerization, disordered N and C termini, subunit exchange, and variable dimer interfac

257 pelling experimental evidence that DAT N and C termini synergistically contribute to substrate and in

258 g and immunolocalization of two dual, N- and C-termini-tagged APP constructs: CFP-APP-YFP [containing

259 Unfortunately, the structures of the N and C termini that are important for lipid binding were not

260 r DNA cleavage inhibition and have divergent C termini that are required in each case for inhibition

261 t main transition states placed at the N and C termini that dictate the direction in which unfolding

262 ative opportunities within the ebolavirus NP C-termini that might be leveraged for diagnostics and no

263 four- to two-helix packing transition at the C-termini that send opposing signals in bacterial chemor

264 f arrestins bound to phosphorylated receptor C-termini, the functional role of each phosphorylation s

265 ifference between the two peptides is at the C-termini, the N-terminal segment plays a key role in th

266 II-III loop (residue 626) and both the N and C termini; the I-II loop (residue 406) showed weak FRET

267 oteins with subsequent ligation of the N and C termini to form a continuous peptide backbone.

268 tly to two helical regions at the GRK5 N and C termini to inhibit GPCR phosphorylation, though only t

269 Lys motifs were moved from the extreme N and C termini to the interior next to the cleavage site sequ

270 ) and polycystin-2 (PC2), interact via their C-termini to form a receptor-ion channel complex whose f

271 vable Fmoc or acetylated N-termini via their C-termini to produce active peptide SPR sensors that wer

272 ASIC subunits contain intracellular N and C termini, two transmembrane domains that constitute the

273 used two full-sized IgG antibodies via their C termini using sortase transpeptidation and click chemi

274 ain potential phosphorylation sites at their C termini, we propose that preventing phosphorylation at

275 disrupt intramolecular interactions of STIM C termini, we show that the increased flexibility of the

276 A total of 781 protein C termini were identified with a 300 mug digest in our s

277 The N and C termini were intrinsically disordered in both the full

278 ether by a polypeptide linker and new N- and C-termini were made at desired parts of the protein surf

279 9 as well as the distance between the N- and C-termini were monitored to estimate the strength and or

280 -specific linkage of proteins via their N or C termini, when a remaining free terminus is required fo

281 epitopes, and gradually separate toward the C termini, where they associate with the membrane.

282 n endo conformation oriented toward the 3SCC C-termini, whereas the cysteines are predisposed for tri

283 -binding motifs, known as IQ motifs in their C termini, which associate with calmodulin (CaM), a univ

284 base was first introduced to analyze protein C termini, which effectively improved the accuracy and s

285 possesses multiple CaMBDs at cytosolic N and C termini, which is reminiscent of animal CNGCs and unli

286 find that Nod1 and Gef2 interact through the C-termini, which is important for their localization.

287 readthrough generates proteins with extended C-termini, which often possess distinct properties.

288 unfolding is initiated from both the N- and C-termini, while three-state unfolding is initiated only

289 t-translationally modified to join the N and C termini with a peptide bond.

290 ruits tRNA(Ala(UGC)) to modify nascent-chain C termini with a polyalanine degron.

291 ic proteins, we have modified their N and/or C termini with a short peptide sequence that interacts w

292 o confirm the exact orientation of its N and C termini with respect to the plasma membrane to get clu

293 that interactions of the Galphas and Galphaq C termini with the beta(2)-adrenergic receptor (beta(2)-

294 Interaction of Galphas or Galphaq C termini with the GPCR increases signaling potency, sug

295 We also found that swapping PLB N and C termini with those from SLN caused the resulting chime

296 ith the potential to interact at both N- and C-termini with adjacent membrane-bound divisome componen

297 ing pathway, where the exposure of ubiquitin C termini within protein aggregates enables HDAC6 recogn

298 ed forms of SSB that possess only one or two C-termini within a four-OB-fold "tetramer".

299 ligases, only differ by one residue at their C-termini; yet each has its specific E1 for the activati

300 results in two isoforms that differ at their C termini: ZAPL (long) encodes a poly(ADP-ribose) polyme