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1 from S. coelicolor WhiD (ScWhiD) only at the C terminus.
2 ame-shifted protein product with an extended C terminus.
3 interaction by sequestering copper from the C terminus.
4 leavage about 450 residues upstream from the C terminus.
5 ing the recruitment of a key loop by the XIP C terminus.
6 road set of chimeric GPCRs harboring the V2R C terminus.
7 l as a novel Art v 3-specific epitope at the C terminus.
8 tion, S6 kinase undergoes acetylation at the C terminus.
9 range and increasing rigidity from the N to C terminus.
10 ing a coreceptor-mimetic sulfopeptide to its C terminus.
11 tion and reveal a dimer mediated by the Ku80 C terminus.
12 uences in eukaryotes, including the Hedgehog C terminus.
13 ne with 16 histidines and 2 cysteines at its C terminus.
14 cated N terminus and cytoplasmically located C terminus.
15 nts that have been fused onto the receptor's C terminus.
16 ing to truncation of ~300 amino acids in the C terminus.
17 ia evolutionarily conserved sequences in its C-terminus.
18 m, P2RX7E, which in addition has a truncated C-terminus.
19 to mimic constitutive acetylation of the p53 C-terminus.
20 and trimers, each including SpyTag at their C-terminus.
21 tetratricopeptide repeat (TPR) domain at the C-terminus.
22 tion to the polarity requires an intact RecA C-terminus.
23 viously proposed to be auto-inhibited by its C-terminus.
24 r CyRPA), with SnoopTagJr fused at the N- or C-terminus.
25 horylation of either Ser396 or Ser404 in the C-terminus.
26 the PDZ domain and its interaction with DVL C-terminus.
27 hich contained an aromatic tryptophan at its C-terminus.
28 ctural feature upstream of the ebolavirus NP C-terminus.
29 t Bif-1 interacted with prohibitin-2 via its C-terminus.
30 d in DBLepsilon and DBLzeta domains near the C-terminus.
31 ylate specific serine sites located near its C-terminus.
32 horylation of serine 261 residue on the AQP2 C-terminus.
33 mon N-terminus with P and V but has a unique C-terminus.
34 ith Vac14 in a manner that requires the Fig4 C-terminus.
35 sed with a double (V5-HA) epitope tag at the C-terminus.
36 quential folding pathway initiating from the C-terminus.
37 zone targeting depended on the intracellular C-terminus.
38 factors, while the GAIP interacting protein C-terminus 1 (GIPC1, aka Synectin) interacts with the ne
39 vaccination (p < 0.001), higher in NANP than C-terminus (2855 vs 1297 proportional change between mea
40 (2-(diphenylphosphanyl)phenyl)methanol as a C-terminus activator has been demonstrated at simple and
41 ta suggest that overexpression of the Spc110 C terminus acts as a dominant-negative mutant that titra
45 of the GAL4 DNA-binding domain to the BRCA1 C terminus (amino acids 1396-1863), we assessed the func
46 RM peptide externalizes from the capsid, its C-terminus (amino acids 28-40) anchors into the membrane
47 s moved the linker closer to the tropomyosin C terminus, an effect that was more pronounced in the pr
48 and 4R isoforms, underrepresentation of the C terminus, an increase in negative charge in the prolin
49 l nuclear localization signal in the extreme C terminus and a nuclear retention element (NRE) in the
51 agenesis, we map phosphorylation to the Env7 C terminus and confirm that Ser-331 is a primary and pre
53 d in the gp120 trimer association domain and C terminus and in the gp41 heptad repeat 1 (HR1) region.
54 tabilized by a helix-loop-helix motif at the C terminus and interactions between the beta-sheets of t
55 FFA4-L phosphorylation occurs on the distal C terminus and is directly responsible for recruitment a
57 indlin plus-tip localization depended on the C-terminus and a putative EB1-interaction motif (hxxPTxh
58 two different catcher domains at the N- and C-terminus and by combining two corresponding Tag-fused
59 osphopeptide analogues of the GPCR rhodopsin C-terminus and determine the ability of these peptides t
60 eceptor phyB interacts with SPA1 through its C-terminus and enhances the recruitment of PIF1 for phos
64 ke cytoplasmic kinase phosphorylates RBOHD's C-terminus and two phosphorylated residues (S862 and T91
65 phosphorylate different residues in the AQP2 C-terminus, and suggest new strategies to target distinc
66 te that specific residues within the tatM2NX C terminus are required to confer antagonism on TRPM2.
68 the highest positive charge density at their C-terminus are overwhelmingly ribosomal proteins, sugges
70 ed transmembrane region closest to the APOL1 C terminus as the pore-lining segment of this novel chan
75 es CcrM degradation by Lon and that the CcrM C terminus both binds to its DNA substrate and is recogn
76 the central region of the cavity and has its C terminus bound in an allosteric pocket of domain IV th
81 us with a carboxybenzyl group (Z) and at the C-terminus carried either a carboxylic acid or an isopht
84 residues (S325/S328/S330) in the regulatory C-terminus contributes to multiple features of the cardi
85 -interacting protein kinase 1 (RIPK1) to its C terminus (CT), independent of its ion-conducting funct
86 tg8-interacting motifs (AIMs) located at the C-terminus, cytoplasmic loop, and within the transmembra
89 in part through its intrinsically disordered C terminus, directly binds to WT cTnC, and we find that
94 nding partner proteins on its N-terminus and C-terminus domains and creating a supercomplex that prom
95 finity Ca(2+)-binding sites contained in the C-terminus domains, RCK1 and RCK2, contribute equally to
96 ed in negatively charged residues near their C-terminus eject the fastest, while nascent chains enric
98 in wound around the thin filaments, with its C-terminus embedded within the Z-disk and its N-terminus
99 M1 variants with enhanced flexibility in the C terminus failed to support its store-independent activ
100 interactions evidently involve both the Ras C terminus for lipid anchoring and its G-protein domain.
101 dition to covalent thioester linkage to Ub's C terminus for Ub transfer reactions, conjugation enzyme
102 binding/tetramerization element whereas the C-terminus forms an intrinsically disordered linker (IDL
103 e rotation of the helix switch dislodges the C-terminus from the regulatory region, activating the fl
104 ylases NEIL1 and NEIL2, Xenopus laevis NEIL3 C terminus has two highly conserved zinc finger motifs c
106 R), phosphorylation of multiple sites on the C-terminus has been recognized as a critical step underl
107 re specifically, a 0.58 kbp deletion, at the C-terminus has been reported in high frequencies in Sene
108 hat the binding of calcium-calmodulin to the C-terminus has long-range allosteric effects on the extr
109 features are a catalytic homologous to E6AP C terminus (HECT) domain and 3 central WW domains that b
110 , revealed that the residues at the HIV-1 MA C terminus help stabilize protein-protein interactions w
111 e data also suggest the participation of the C terminus in membrane localization, which is generally
112 nduces a conformational heterogeneity at the C terminus in the fibril state, whereas the overall fibr
113 -S781R or a CGEP variant with an unprocessed C-terminus in a cgep clpr2-1 background was used to demo
114 chitecture and suggests a role for the Ctf19 C-terminus in mediating CPC-binding and accurate chromos
115 ity of the N-terminus and cationicity of the C-terminus in temporin B improves its membrane activity
116 Deletion of 25 amino acids (aa) from the C terminus inactivated MGAT4D-L, but deletion of 20 aa d
117 mutant protein bearing an alteration in the C-terminus indicated that light stabilizes ACS5 by inhib
120 he N-terminus of aSyn occurs upon release of C-terminus interactions when calcium binds, but the leve
122 s of truncated Inp1 variants showed that the C terminus is important for association to the peroxisom
124 Further, the HigA structure reveals that the C terminus is ordered and does not transition between di
128 binding, demonstrating that alpha-catenin's C-terminus is a modular detector of F-actin tension.
129 Prph2 (termed RRCT), we find that the Prph2 C-terminus is necessary and sufficient for the initiatio
130 ggested that a charge carrier residue at the C-terminus is promoting the formation of diagnostic w io
135 g an additional 25-45 amino acids at the Rca C terminus, known as the C-terminal extension (CTE).
137 ing protein calmodulin (CaM) to the proximal C-terminus leads to the boosting of channel activity and
141 l stability assays, we demonstrated that the C terminus maintains ACLY tetramerization, a conserved a
142 Furthermore, interactions at the peptide C terminus modulated DM-binding affinity, suggesting dis
143 omain (Ala-Ser-Lys) within the intracellular C terminus of 5-HT(2A)R severely diminished internalizat
145 vented when the Gbetagamma sink betaARK1-ct (C terminus of beta-adrenergic receptor kinase-1) was coe
146 y probed the effects of substitutions in the C terminus of BRCA1: the N- and C-terminal borders of it
147 Y102E are similar in that neither binds the C terminus of Brd4, but in all other aspects the mutant
150 emonstrate this utility, we fused TTR to the C terminus of conatumumab, an antibody that targets tumo
152 RAS alpha4-alpha5 while state B involved the C terminus of CRD, beta3-5 of RBD, and part of KRAS alph
153 Red) cassette was inserted in-frame with the C terminus of CSF1R, separated by a T2A-cleavable linker
154 We propose that the intrinsically disordered C terminus of cTnT directly interacts with the regulator
157 highly-conserved histidine residues near the C terminus of each microtubule-binding repeat are pH sen
158 t stem cells, we show that a mutation at the C terminus of eIF2gamma impairs CDC123 promotion of eIF2
164 uced conformational fit to both the proximal C terminus of KCNQ4 channels and CaM, likely underlying
167 tions of all 11 phosphorylation sites on the C terminus of MORs almost completely abolished desensiti
168 natively spliced gag RNA, interacts with the C terminus of mouse APOBEC3 and prevents its packaging w
169 ectroscopy, show that the interaction of the C terminus of Neuroligin-2 with Collybistin-2 induces a
171 ative splicing and show that the full-length C terminus of p73 is essential for hippocampal developme
172 43, the two cysteine residues closest to the C terminus of pejvakin, for reactive oxygen species-indu
173 via several PxDLS-like motifs located at the C terminus of Piccolino, which can connect multiple RIBE
174 ld allowed cryo-EM tomography mapping of the C terminus of protein A to the apical lobe, which correl
175 ng studies on the role of the H2 alpha-helix C terminus of PrP, we found that deletion of the highly
176 e first 3 aa linked to N-fMet as well as the C terminus of PSMalpha2 in promoting FPR2 to recruit bet
177 ed 69-residue (Asn(81)-Asn(149)) fragment at C terminus of Rhi o 2 was identified as crucial for IgE-
180 Here, we show that overexpression of the C terminus of Spc110 is toxic to cells and correlates wi
183 identified a short conserved sequence at the C terminus of the Acm1 D-box that was necessary and suff
184 etin/TonB, short N-terminal subdomain at the C terminus of the CCSSD, a previously unobserved topolog
185 k, including D165 in motif F and R416 at the C terminus of the FMDV 3D(pol) and RNA template-primer.
186 observed that when mim6 was appended to the C terminus of the heavy chains of bNAbs, this sulfopepti
189 ed that the degree of phosphorylation on the C terminus of the mu-opioid receptor alters acute desens
192 ling is terminated by phosphorylation of the C terminus of the receptor by GPCR kinases (GRKs) and by
193 th most of the pore-forming domain (PFD) and C terminus of the Serum Resistance Associated-interactin
194 ocus on the mechanism by which the cytosolic C terminus of the synaptic cell adhesion protein Neuroli
195 on the exposure of a cryptic epitope on the C terminus of the transmembrane portion of pro-TNF on cl
196 identified a 49-amino-acid-long motif in the C terminus of the two channels that regulates expression
198 al, backbone-extended monomers at the N- and C- terminus of peptides using wild-type and engineered r
199 noncanonical amino acid either at the N- or C-terminus of a protein or microprotein of interest for
200 tRNA ligase (PEARL) adds amino acids to the C-terminus of a small peptide scaffold in an ATP- and tR
202 e end-to-end bonds formed between the N- and C-terminus of adjacent Tpm molecules define Tpm continui
203 Further mechanistic probing revealed that C-terminus of c-Cbl interacted with the cytoplasmic tail
204 into the CENP-H/K complex by binding to the C-terminus of CENP-H, leading to formation of the ternar
205 ions that completely or partially remove the C-terminus of CFTR at the same time as keeping an intact
206 s of W1282X-CFTR, whose PTC is closer to the C-terminus of CFTR, suggest the presence of both C-termi
208 tandem affinity tag was conjugated with the C-terminus of endogenous HSP90beta protein over the pare
211 ies reveal that the engagement of the distal C-terminus of Galphai/o with the receptor differentiates
213 tional binding region was revealed to be the C-terminus of helix B of IL-7, highlighting the value of
214 uitination by the Hsp70-associated E3 ligase c-terminus of Hsp70-interacting protein (CHIP) and subse
217 Fusion of the peptide to either the N- or C-terminus of IN results in maximal stimulation of conce
218 inds to a phosphorylated serine motif on the C-terminus of Kv1.2; and that loss of this interaction i
222 patially-restricted delivery of PP1 near the C-terminus of Ndc80, a core kinetochore-microtubule link
224 rotein comprised of the body of Rom1 and the C-terminus of Prph2 (termed RRCT), we find that the Prph
225 hough post-translational modification of the C-terminus of RAS has been studied extensively, little i
226 e S4-S5 linker (S4-S5(L)) interacts with the C-terminus of S6 (S6(T)) to stabilize the gate in the op
227 ions are located in the extended cytoplasmic C-terminus of Slack channels and result in increased Sla
228 Previous experiments have shown that the C-terminus of Slack channels binds a number of cytoplasm
229 onnative structure in a peptide model of the C-terminus of SOD1, a sequence that might serve as a pot
233 -binding peptide (DSARGFKKPGKR) fused to the C-terminus of superfolder green fluorescent protein (sfG
234 izes several important residues close to the C-terminus of TglA to perform its activity and is tolera
235 eadthrough-reducing mutations at the extreme C-terminus of the a/Tif32 subunit of eIF3 either suppres
236 contains a five-amino acid insertion at the C-terminus of the C-terminal zinc finger and has no obse
237 we inserted an endogenous 3X-FLAG tag at the C-terminus of the canonical DISC1 gene in human induced
239 used to attach an EGFP coding module to the C-terminus of the endogenous NME1 gene in melanoma cell
243 osomes and adds an ssrA tag or degron to the C-terminus of the incomplete protein, which directs degr
244 erved phosphorylated Ser/Thr residues at the C-terminus of the nucleolar phosphoprotein Treacle.
246 RL that catalyzes the addition of Cys to the C-terminus of the peptide TglA in the biosynthesis of 3-
247 preferential membrane orientation, where the C-terminus of the peptide traverses the plasma membrane
250 seven transmembrane helices, with the N- and C-terminus of the protein located at the extracellular s
251 ons to the intermediate state, the hand-like C-terminus of the VSD-pore linker (S4-S5L) interacts wit
252 t target the two adjacent PPXY motifs at the C-terminus of the Warts polypeptide and additional WW do
254 ontaining a tetrazole-derived warhead at the C-terminus of ubiquitin and employed a cyclic polyargini
257 y also in vivo Furthermore, we show that the C terminus, only in the context of the full-length enzym
259 The location of this interaction on the C terminus overlaps with the sites of human pathogenic m
264 find that the intrinsically disordered SIRT6 C-terminus promotes binding at the higher affinity site
266 rectly with CypD via its acidic proline-rich C-terminus region and binding at the putative ligand bin
268 acidic N-terminus (residues 1-40) and basic C-terminus (residues 264-303), whereas NMR signals from
269 s a conformational change that dislodges the C terminus, resulting in a cis-to-trans switch that is l
273 The long isoform (BRD4L) has an extended C terminus that binds transcription cofactors, while the
275 fluorescent protein attached directly to the C-terminus that is similar to fusions used in previous s
276 a-helical assembly at the nucleoprotein (NP) C-terminus that was conserved through half a century of
277 udied responses to the repeat region and the C-terminus, the antibody response against the N-terminal
278 erminus is a toxic effector regulated by the C terminus, there is an emerging consensus that this cis
280 nt-associated protein, localized through its C terminus to distinct regions (C-zones) of the sarcomer
281 e that ACLY forms a homotetramer through the C terminus to facilitate CoA binding and acetyl-CoA prod
284 and photo-manipulation of the crucial Galpha C terminus, to demonstrate the temporal coupling of cogn
286 rminus of CFTR, suggest the presence of both C-terminus truncated CFTR proteins that are poorly funct
287 g of melanopsin mutants including a proximal C-terminus truncation (at residue 365) and proline mutat
288 rd cytoplasmic loop, which is increased upon C-terminus truncation, supporting the idea that these tw
289 otein (AKAP) 79/150, which binds to the LTCC C-terminus via a modified leucine-zipper (LZ) interactio
290 hate (PIP(2)) binding domains, or the entire C terminus, was without effect on the forskolin response
292 xposed on the cytoplasmic face of the folded C terminus, where it might interact with other channel p
293 ible regions of the gH N terminus and the gL C terminus, while the fifth was placed around gL residue
294 eracted with COMA in vitro through the Ctf19 C-terminus whose deletion affected chromosome segregatio
296 of three tyrosine residues in the alpha-dbn C terminus with phenylalanine compromising the alphakap-
297 ed its interaction through its intracellular C terminus with Rab4, which was increased by l-PGDS.
298 n to site-specifically label proteins at the C-terminus with a variety of cysteine-lysine dipeptide c
299 onfocal microscopy of the Glbs tagged at the C-terminus with green fluorescent protein was used to de
300 d by the viral protein Gag and tagged at its C-terminus with the fluorescent protein Dendra2 have the