ライフサイエンスコーパス: C-terminal

1 ified, from which four are containing Trp at C-terminal.

2 The C-terminal 11 transmembrane portion of PC1 undergoes thr

3 SpxA2 but remained stable when fused to the C-terminal acidic tail of SpxA1.

4 ow-dependent force transfer required talin's C-terminal actin binding site, ABS3, but not vinculin.

5 ines leaf marking formation depending on its C-terminal activation motif.

6 lyproline II helix, while segment 2 of ArkA (C-terminal) adopts a 310 helix, but is far less structur

7 H2B acidic patch regions through the SMARCB1 C-terminal alpha-helix and the SMARCA4/2 C-terminal SnAc

8 B recognizes such ribosomes by inserting its C-terminal alpha-helix into the vacant mRNA tunnel.

9 native cysteine pair at the groove (C55) and C-terminal alpha9 helix (C175) of BFL-1 operates as a re

10 P-inhibitory activity, we propose that those C-terminal amino acid residues are a potentially targeta

11 Here, we demonstrate that the 9 C-terminal amino acid residues of TIMP-1 and the large e

12 owed by an O-N acyl migration to install the C-terminal amino alcohol, a different strategy was requi

13 MLXIP/MondoA and MLXIPL/ChREBP bind LDs via C-terminal amphipathic helices.

14 ved partial ordering of the core histone H2A C-terminal and H3 N-terminal tails in the chromatosomes.

15 on of PTPN14 binding through mutation of the C-terminal arginine did not impact the ability of severa

16 PTPN14 binds to a C-terminal arginine highly conserved in diverse HPV E7.

17 The C-terminal basic domain of APC (APC-B) directly nucleate

18 This suggests that a well-ordered C-terminal beta-barrel domain is not required for TerS(P

19 TerS(P76-26) structure lacked the conserved C-terminal beta-barrel domain used by other TerS protein

20 The cocrystal structure of the W C-terminal binding motif with 14-3-3 provides only the s

21 ated that AN, a plant homologue of mammalian C-TERMINAL BINDING PROTEIN (CtBP), antagonistically regu

22 The C-terminal BON domain binds anionic phospholipids throug

23 While studying C-terminal (C-tail) deletion mutants of Mtf1 and TFB2M,

24 a central linker region, and contains tandem C-terminal C2 domains (C2A and C2B) with affinity for ph

25 P-A/H4 through multiple physical contacts, a C-terminal CAL1 fragment directly binds a CENP-C cupin d

26 wever, the molecular mechanisms by which the C-terminal cassette modulates the activities of the N-te

27 tes that binding of inhibited Rubisco to the C-terminal CbbO VWA domain initiates a signal toward the

28 veals that it blocks alignment of the N- and C-terminal CD73 domains necessary for catalysis.

29 It shows that the C-terminal cleaved product of apple RIN4 (MdRIN4) but no

30 ired for microtubule localization, while the C-terminal coiled-coil CC2 domain is sufficient to inter

31 To test for a functionally critical C-terminal conformation, calcium imaging of melanopsin m

32 ers on both N-terminal CX(13)CX(2)CX(5)C and C-terminal CPXC motifs of NUBP1 in the presence of gluta

33 d a potent cA4 ring nuclease activity in the C-terminal Crn2 domain.

34 structure of the periplasmic complex of the C-terminal CSS domain (CCSSD) of PupR, the sigma regulat

35 Its C-terminal cupin domain then rearranges the triply modif

36 Interestingly, the 4Fe-4S cluster in the C-terminal CysB domain of Pol3 forms the central interfa

37 nsense mutations that partially truncate its C-terminal cytoplasmic regulatory domain impair NHE6 act

38 se mutant CLN3(R334C) and for a JNCL-related C-terminal deletion mutant (CLN3DeltaC).

39 l diaphanous inhibitory domain (DID) and its C-terminal diaphanous autoregulatory domain (DAD).

40 domain (M) that interacts with clients and a C-terminal dimerization domain (C).

41 nonical Sp1 molecule in the highly conserved C-terminal DNA-binding zinc finger domains.

42 analyzed homology-directed mutations in the C-terminal, DNA-wrapping domain of the GyrA subunit of E

43 proteins that lack the characteristic nexin C terminal domain.

44 The methyltransferase (MTase) domain and the C-terminal domain (CTD) of L adopt a unique conformation

45 Interest in the C-terminal domain (CTD) of the RPB1 subunit of the RNA p

46 bstrate; an interfacial site between TMD and C-terminal domain (CTD) that modulates the Zn(2+) transp

47 merase II (RNA Pol II) contains a disordered C-terminal domain (CTD) whose length enigmatically corre

48 ported through, and a regulatory cytoplasmic C-terminal domain (CTD).

49 polymerase II by hyperphosphorylation of its C-terminal domain (CTD).

50 The other is the NP C-terminal domain (NP-Ct), whose function has not previo

51 of TRADD (TRADD-N), which interacts with the C-terminal domain (TRADD-C) and TRAF2 to modulate the ub

52 contractile tail phages, such as T4, and its C-terminal domain adopt an Ig-like fold of unknown funct

53 frameshift mutations, including those in the C-terminal domain and a large number of patient-associat

54 n (PrP(C)) comprises two domains: a globular C-terminal domain and an unstructured N-terminal domain.

55 Nascent C-terminal domain clusters at primed genomic loci lower

56 bound a hydrophobic pocket within the GSDMD C-terminal domain distal to its N-terminal domain.

57 The C-terminal domain facilitates ER export of proSP-B.

58 scription start site and phosphorylating the C-terminal domain for RNA polymerase II (RNAPII) for act

59 ifies the site of LC3 lipidation, includes a C-terminal domain formed by 7 WD40-type repeats (WD40 do

60 HIV-1 particles, and we identify a distinct C-terminal domain in CLASP2 that promotes both MT stabil

61 t an N-terminal domain that wraps around the C-terminal domain in the oligomer.

62 confirmed that phosphorylation of SK2 in the C-terminal domain increases its ubiquitination and endoc

63 oinositide lipid content is reduced, and the C-terminal domain is key to determining agonist response

64 A from S. aureus strain RN6390 indicates its C-terminal domain is toxic when targeted to the Escheric

65 ng multimerization and explained why several C-terminal domain mutations are remarkably resistant to

66 atalyzes isomerization of proline 128 in the C-terminal domain of alpha-synuclein.

67 rogeneity in determining the activity of the C-terminal domain of bacterial Enzyme I (EIC).

68 athway-driven hemolysis, suggesting that the C-terminal domain of C3b has an important function in cl

69 n alpha-helix and develops contacts with the C-terminal domain of CaM in about 2 ms.

70 t a highly conserved arginine residue in the C-terminal domain of diverse HPV E7 mediates the interac

71 Domain swapping in the alpha-helical C-terminal domain of M(pro) (M(pro)C) locks M(pro) into

72 ined and solved the crystal structure of the C-terminal domain of NP (NP-Ct), but its role in virus r

73 The C-terminal domain of RecA binds to dsDNA and directs it

74 SSUP-72 would normally remodel the C-terminal domain of RNA polymerase in anticipation of t

75 and the biochemical characterization of the C-terminal domain of S. aureus OatA.

76 ngation; however, molecular details like the C-terminal domain of the alpha-chain, the heparin-bindin

77 t structural and biophysical analyses of the C-terminal domain of the bacteriophage phi29 ATPase (CTD

78 (alpha-MoRE) of the intrinsically disordered C-terminal domain of the measles virus nucleoprotein (N(

79 ed by nutritional stress, affect the RNAP II C-terminal domain phosphorylation at Ser2, and control r

80 sitic, and antiinvasive activities, with the C-terminal domain potentiating the 2 latter activities.

81 The C-terminal domain showed strong PPIase activity, no role

82 so showed that deletion of the 1B domain and C-terminal domain significantly reduced the helicase act

83 fused to a degenerate polymerase fold and a C-terminal domain structurally similar to Cas11.

84 d directly interacts with Nup98-Rae1 via its C-terminal domain to impair docking of cargo-receptor (k

85 amer bound to promoter DNA reveals that YefM C-terminal domain undergoes disorder to order transition

86 n which the N-terminal domain I (DI) and the C-terminal domain V (DV) are exposed to the solvent.

87 onal activation activity, due to a divergent C-terminal domain, but retains the ability to interact w

88 ase A (PKA), which phosphorylates SK2 in its C-terminal domain, facilitating its endocytosis.

89 sphorylation of threonine in the cytoplasmic C-terminal domain, providing the first direct evidence o

90 In contrast, we found two residues in the C-terminal domain, tyrosine 351 and glutamate 355, that

91 ts inclusion in the complex depends upon its C-terminal domain, which contains highly conserved cyste

92 D zinc finger domain, as well as an extended C-terminal domain.

93 recognize different DNA motifs, via diverged C-terminal domains (CTDs).

94 o central domains synapse the ends while two C-terminal domains form a separate dimer that contacts o

95 iously shown that one likely function of the C-terminal domains of OPG is to bind cell surface hepara

96 the exact biological functions of the three C-terminal domains of OPG remain uncertain.

97 We identified N- and C-terminal domains on TRPV1 responsible for TRPA1-TRPV1

98 This allows the C-terminal domains to capture one strand of underwound n

99 the catalytic core to the flexibly attached C-terminal domains, thereby fixing a conformation that i

100 ong RNA, which is held in place by auxiliary C-terminal domains.

101 nus, near the middle, and near the inserting C-terminal end of the pHLIP transmembrane helix.

102 mong them, the 10-mer epitope located at the C-terminal end of the signal peptide was found to be the

103 a coli cells fused or not to a HisTag at the C-terminal end.

104 amide family peptides due to their conserved C-terminal end.

105 healthy donors were primarily active against C-terminal epitopes in the spike protein, which show a h

106 stalled, triggering RQC and CAT-tailing-like C-terminal extension (CTE).

107 deletion at the N-terminus and a 16-residue C-terminal extension containing a histidine tag.

108 Our findings suggest that the Glu-rich long C-terminal extension of insect TnT functions as a myofil

109 Structures of pre-ribosomes lacking the C-terminal extension of Nog1 demonstrate that this exten

110 ture consisting of a long glutamic acid-rich C-terminal extension of ~70 residues with unknown functi

111 CopG consists of a thioredoxin domain with a C-terminal extension that contributes to metal binding.

112 a(2)-sigma(4) architecture and an additional C-terminal extension that encodes a SnoaL_2 domain, whic

113 d-coil tetramerization domain of P, and long C-terminal extensions projecting from these two helices,

114 The C-terminal 'fastener' helix retains PAF and is followed

115 the association of baseline plasma levels of C-terminal FGF23 with time to first hospitalization with

116 Complementation studies indicate that the C-terminal filamentous actin (F-actin)-binding domains a

117 to bridge hexon MCP subunits and possesses a C-terminal flexible half emanating from the inner rim of

118 The C-terminal fragment localizes to the cell body irrespect

119 n this manuscript, we propose that the 99-aa C-terminal fragment of APP (C99), when delivered to the

120 Endorepellin, the C-terminal fragment of the heparan sulfate proteoglycan

121 in rapid cleavage and secretion of a POLGARF C-terminal fragment.

122 n interactions during the lag phase, whereas C-terminal fragments (20-32 and 26-32) showed limited in

123 lytically cleaved form, as membrane-spanning C-terminal fragments of the proteins.

124 ast and other tumors characterized by PIK3CA C-terminal frameshift mutations may derive benefit from

125 Its C-terminal functional domain exhibits autophosphorylatio

126 ivity, while some also exert activity of the C'-terminal fusion partner.

127 terial protein, ALC), contains a distinctive C-terminal fusion resembling the small-subunit of rubisc

128 the N-terminal myristoylation signal and the C-terminal FXXF motif in PKAc regulate its thermal stabi

129 rogenic peptides indicated that P1'-P4', the C-terminal gasdermin D region adjacent to the cleavage s

130 eral membrane attachment of the protein, the C-terminal GOLD domain directs it to the plasma membrane

131 on incorporation reveals that the tip of the C-terminal hairpin (residues 125-145) is stably folded i

132 aptotagmin-1, or by a peptide that spans the C-terminal half of the synaptobrevin SNARE motif.

133 e disordered region that connects the N- and C-terminal halves in many eukaryotic ABC transporters, a

134 Ts OLD lacks the C-terminal helical domain present in Class 2 OLD homolog

135 ction mutations in BRCA1 interacting protein C-terminal helicase 1 (BRIP1) are associated with ovaria

136 This activity is provided by the C-terminal helicase domain of viral nonstructural protei

137 embly and heteromerization are controlled by C-terminal helices.

138 However, the C-terminal helix alphaN, implicated in assembly of synap

139 formation is a domain swap of the conserved C-terminal helix of Ku80.

140 ubstrates in the PHDs are conserved, but the C-terminal helix of the PHDs is strikingly absent.

141 e discovered that binding and release of the C-terminal helix of transducin is coupled to hydration c

142 decameric core aggregates via its conserved C-terminal histidine cluster (HisC).

143 main, a central Src homology 3 domain, and a C-terminal histidine phosphatase domain.

144 independent domains: N-terminal, middle and C-terminal (HsOrc6-N, HsOrc6-M and HsOrc6-C).

145 , while the folded N-terminal domain and the C-terminal IDR are not required.

146 0 residues (NTD) of FIP200 interact with the C-terminal IDR of ATG13.

147 rs a transmembrane domain (TMD) and extended C-terminal intracellular domain containing a degron.

148 of a 30 kDa fragment comprising most of L1's C-terminal, intracellular domain.

149 The C-terminal intrinsically disordered region (C-IDR), rema

150 A C-terminal IQGAP1 region was responsible for its associa

151 ice to replace the most abundantly expressed C-terminal isoform, p73alpha, with a shorter product of

152 s single nucleotide variant (SNV) within the C-terminal leucine rich repeat (LRR) domain is responsib

153 ut the protein originating in the peripheral C-terminal ligand binding site and culminating in pore o

154 the tyrosine residues (Y954) located in the C-terminal lobe of the activator kinase domain was impor

155 reveals that the cluster organizes the FBXL5 C-terminal loop responsible for recruiting IRP2.

156 Previous work established that the C-terminal low-complexity domain (LCD) of hnRNPA2 fibril

157 ns three RNA recognition motifs (RRMs) and a C-terminal low-complexity domain, sometimes referred to

158 tention through a mechanism dependent on its C-terminal lysine residue; its deletion led to modest re

159 lock binding between Hop TPR2A and the Hsp90 C-terminal MEEVD peptide.

160 utinin (HBHA) is a protein Ag with a complex C-terminal methylation pattern and is recognized by T ce

161 ent to confer binding to FGF14, altering the C-terminal moiety from methoxy (21a) to pai bond-contain

162 ic proteins uncovered a novel six-amino-acid C-terminal motif (CTM) flanking the homeodomain that ser

163 AC9 directly binds ERK7 through a conserved C-terminal motif and that this interaction is essential

164 while the [4Fe-4S](2+) cluster bound at the C-terminal motif is labile.

165 In this process, cluster binding to the C-terminal motif of NUBP1 promotes protein dimerization,

166 However, unlike WT CLASP2, the CLASP2 C-terminal mutant is unable to induce MT stabilization o

167 tionic currents in cultured cells, the first C-terminal mutant to do so.

168 ith one encoding Kcnt1(R455H), a cytoplasmic C-terminal mutation homologous to a human R474H variant

169 calculations of the last 21 residues of the C terminals of G(i) and G(s) were performed to shed ligh

170 e at least two epitope regions in the N- and C-terminals of PLA(2)R1 at diagnosis, contradicting the

171 nd central-linker IDR, as well as the folded C-terminal oligomerization domain, while the folded N-te

172 terminal p63 isoforms, it is unclear how the C-terminal p63 isoforms are regulated.

173 uggest that PABPN1 is a key regulator of the C-terminal p63 isoforms through APA in coding sequence a

174 reading frame, adding a common proline rich C-terminal part instead of the last KH RNA binding domai

175 Rcd4 interacts with the C-terminal part of Ana3, which loads onto the procentrio

176 Modeling of the structure of the C-terminal part of Opi3 was consistent with the topology

177 Atg16L1(153-210) comprises the C-terminal part of the Atg16L1 coiled-coil domain.

178 ordered linker (IDL), and a highly conserved C-terminal peptide (CTP) motif that mediates a wide arra

179 Thrombin-derived C-terminal peptides (TCPs), including a major 11-kDa fra

180 interaction with the vasopressin V2 receptor C-terminal phosphopeptide (V2Rpp).

181 In cancers, C-terminal phosphorylation alters p27 protein-protein in

182 deactivation have been characterized (i.e., C-terminal phosphorylation and beta-arrestin binding), b

183 Here we show that RBOHD is regulated by C-terminal phosphorylation and ubiquitination.

184 e N-terminal Pol module is catalytic and the C-terminal Pol module is non-catalytic.

185 The C-terminal portion of M13 becomes alpha-helical and deve

186 The C-terminal portion of titin is closely associated with t

187 d the Rab Ypt7, bound to membranes by either C-terminal prenyl groups (Ypt7-pr) or a recombinant tran

188 Rabs are anchored to membranes by C-terminal prenyl groups, but can also function when anc

189 Structural modeling suggested that C-terminal processing increases the upper substrate size

190 C-terminal processing releases the mature peptide from i

191 our different N-terminal and three different C-terminal products (type I-III).

192 begins with the oxidative folding of ~30-kDa C-terminal propeptide (C-Pro) domains.

193 etic and nonphotosynthetic bacteria lack the C-terminal prosequence, suggesting it is a recent functi

194 eed these proteins' sequences lack conserved C-terminal rare codons.

195 Because the C-terminal Ras association (RA2) domain of PLCepsilon wa

196 tablished receptors, an extended loop in the C-terminal receptor-binding domain (HC) of BoNT/B (HC/B)

197 to produce a bicyclic peptide to target the C-terminal region (residues 31-42) of the 42-residue for

198 (VK210, VK247 and P. vivax-like) and of the C-terminal region (shared by all PvCSP variants) in natu

199 aryotic replisome, Timeless, harbours in its C-terminal region a previously unappreciated DNA-binding

200 proteins from chromatin, bound to the Stat3 C-terminal region and antagonized its transcriptional an

201 re-function analyses of SKIP reveal that the C-terminal region comprising three pleckstrin homology (

202 acterize a minor conformational state of the C-terminal region of DHFR.

203 Finally, we demonstrate that the C-terminal region of FOXN1 is required for high-affinity

204 ce catalytic activity, and suggests that the C-terminal region of NEIL3 is involved in both DNA damag

205 llelic variants, antibodies elicited against C-terminal region of protein did not correlate with epid

206 Furthermore, the C-terminal region of SSX confers preferential affinity t

207 01 is based on the major NPNA repeat and the C-terminal region of the circumsporozoite protein (CSP).

208 ve healthy donors responded similarly to the C-terminal region of the spike proteins of the human end

209 two individuals with de novo variants in the C-terminal region of TOMM70.

210 t the ligand prevents optimal folding of the C-terminal region of VDR.

211 ed structure revealed a unique alpha-helical C-terminal region which we demonstrated to be essential

212 Kindlin-2, through its C-terminal region, binds to and stabilizes MafA, which a

213 pore-forming alpha1 subunit and, through its C-terminal region, scaffolds the beta subunit of VGCC an

214 Da peptide, designated NC1-peptide, from the C-terminal region, via the action of MMP-9 (matrix metal

215 ing oligomerization involving binding to the C-terminal region.

216 NA topological stress require distinct N and C terminal regions of the protein, whereas the other fun

217 on of UPF1 occurs in its unstructured N- and C-terminal regions at Serine/Threonine-Glutamine (SQ) mo

218 ly protective subdominant responses to PfCSP C-terminal regions expanded with subsequent boosts.

219 airpin peptides derived from the central and C-terminal regions of Abeta, which bear "tails" derived

220 idate RTS,S/AS01 is based on the central and C-terminal regions of the circumsporozoite protein (CSP)

221 x, such as the zinc-binding motif and N- and C-terminal regions of the protein.

222 ly in nine amino acid residues in their very C-terminal regions, play distinct roles in neurogenesis.

223 packing of the residues from the central and C-terminal regions, with the N-terminus of Abeta accommo

224 crystallin domain flanked by variable N- and C-terminal regions.

225 of an N-terminal effector domain (NTD) and a C-terminal regulatory domain (CTD); a carotenoid spans t

226 nslocation domain (L188P and G383D), and the C-terminal regulatory domain (E547*, R568Q, and W570*) o

227 the N-terminal histone fold, as well as the C-terminal REM (rat sarcoma exchange motif), CDC25 (cell

228 with FXR family members are mediated by the C-terminal repeating peptide of HVD.

229 (32) in the trypsin S1 pocket, the inhibitor C-terminal residue Ser(33) cleavage, and the cyclization

230 he N and C termini, and deletion of up to 11 C-terminal residues had little impact on the agonist-ind

231 By replacing the N- and C-terminal residues of homooligomers of trans-2-aminocyc

232 us prions and provides evidence that the 113 C-terminal residues of PrP are sufficient for a self-pro

233 le the core interactions between SUN and the C-terminal residues of the KASH peptide are similar in a

234 further report that a Nup1 mutant lacking 36 C-terminal residues recapitulates the phenotypes of the

235 evidence for correction of mis-annotated 28 C-terminal residues within the NADH dehydrogenase subuni

236 olipin membrane domains via a patch of basic C-terminal residues, and this membrane sequestration is

237 functional domains: a catalytic domain and a C-terminal ricin-like lectin domain comprised of three p

238 RNF4 is a ssE3 ligase with a C-terminal RING domain and disordered N-terminal region

239 ypeptidase D is responsible for removal of a C-terminal RKRR motif(2) from the alpha-chain of the ins

240 that CDR3beta reaches the peptide's featured C-terminal segment for pMHC sampling, establishing the s

241 Conserved residues in the C-terminal segment interact with the phospho-sugar backb

242 The C-terminal segment is found broadly in N4/N6-adenine DNA

243 sident calmodulin bound to the intracellular C-terminal segment of the GluN1 subunit of the receptor.

244 The N-to-C terminal self-interaction of BRCA2 is sensitive to DSS

245 Furthermore, a small peptide comprising the C-terminal sequence of peptide ephrinB2/CTF2 rescues ang

246 reduced form of the protein that exposes the C-terminal sequence, but not its disulfide-oxidized coun

247 consists of an SH2 domain flanked by N- and C-terminal SH3 domains (nSH3/cSH3).

248 g the central channel of Rho from the distal C-terminal side of the ring.

249 a-1,3-diazol-4-yl [NBD]) at different N- and C-terminal sites.

250 has been difficult, leading to focus on the C-terminal six cysteine domain (6C) with the use of fusi

251 CB1 C-terminal alpha-helix and the SMARCA4/2 C-terminal SnAc/post-SnAc regions, with disease-associat

252 tein containing an N-terminal cutinase and a C-terminal SnapTag domain react with an ethyl p-nitrophe

253 plex with syntaxin-1 and SNAP-25 through its C-terminal SNARE motif and competes with synaptobrevin-2

254 al bacterium, Myxococcus xanthus, a putative C-terminal sorting tag (MYXO-CTERM) is predicted to help

255 binding protein-C) fragment and an insoluble C'-terminal SpyTag-C8-C10 fragment that remains associat

256 rotein kinase A (PKA) complex that activates C-terminal Src kinase (CSK) and thereby down-regulates k

257 d by additional experimentation leaving CSK (C-terminal Src kinase) as the strongest candidate for ib

258 can be combined with two different types of C-terminal ssDNA binding domains to form diverse bacteri

259 ICP22 contains an N-terminal J domain and a C-terminal substrate binding domain, similar to type II

260 (2020) discover that the C-terminal substrate-binding domain of FBXL5 contains a

261 initiate signaling, serine 365 (S365) in the C-terminal tail (CTT) of STING is phosphorylated, leadin

262 Most SecA proteins contain a long C-terminal tail (CTT).

263 During apoptosis, the C-terminal tail is cleaved by caspase, allowing the rele

264 The C-terminal tail of CENH3 is confirmed to be responsible

265 Finally, we provided evidence that the C-terminal tail of DHHC5 can be palmitoylated in respons

266 acteria known to interact with the conserved C-terminal tail of FtsZ.

267 Our structure also implicates a unique C-terminal tail of MlaF in self-dimerization.

268 tionally relevant interactions with both the C-terminal tail of Na(v)1.6 and FGF14.

269 There is also evidence that the C-terminal tail of PC2 is also cleaved in ELVs.

270 required for RV-A16 replication, nor was the C-terminal tail of STING that mediates IRF3 signaling.

271 taarr1 in complex with only a phosphorylated C-terminal tail of the vasopressin 2 receptor activates

272 Our data supports a model in which a single C-terminal tail tethers XLF to Ku, while allowing XLF to

273 regulated by a conformational change in the C-terminal tail that leads to creation of an enlarged bi

274 t and second UBL domains (UBL1-2) within the C-terminal tail.

275 -stranded RNA-binding domains (dsRBDs) and a C-terminal tail.

276 elices interlinked by three loops and a long C-terminal tail.

277 Thus, our data suggest that C-terminal tails harbor crucial signals for both the ins

278 atively simple architecture, synthesize such C-terminal tails in the absence of a small ribosomal sub

279 e direct interaction is mediated through the C-terminal tails of both Dyn2 and alpha-actinin 4, and t

280 We show that the flexible C-terminal tails of Mtf1 and TFB2M play a crucial role i

281 intrinsically disordered, negatively charged C-terminal tails that interact with microtubule-binding

282 to modify aberrant translation products with C-terminal tails which assist with RQC-mediated protein

283 nal domain containing TDP-43 variants, while C-terminal TDP-43 was not essential for Abeta interactio

284 The troponin core domain, the C-terminal third of TnI, and tropomyosin under the influ

285 tion analysis has further shown that domains C-terminal to its catalytic Dbl homology (DH) domain con

286 Substrate sequences C-terminal to the dephosphorylation site make intimate c

287 ted into an N-terminal ABC ATPase fold and a C-terminal Toprim domain.

288 es contain an N-terminal ATPase domain and a C-terminal Toprim domain.

289 ptional activity mediated through its unique C-terminal transcriptional activation domain (TAD).

290 at engages a substrate docking exosite and a C-terminal transition-state analog moiety targeted to th

291 rface of the N-domain to the interior of the C-terminal transmembrane beta-barrel (inter-N-C).

292 They are characterized by a single C-terminal transmembrane domain that mediates posttransl

293 disease-linked and experimentally generated C-terminal truncated KCNQ3 mutants retain the ability to

294 HCC cell lines expressed C-terminal-truncated AR-SV; 28 primary HCC samples abund

295 tient-derived xenografts and cell lines with C-terminal truncations showed increased cell surface Fri

296 ibit their activity by phosphorylating their C-terminal tyrosine residues.

297 microscopy analysis, here we studied two BAX C-terminal variants, T182I and G179P.

298 Here, we truncated the C-terminal winged-helix-domain (WHD) of Mcm6 to slow dow

299 The N-terminal SNAG domain and C-terminal ZF domains of Gfi1, but not its transcription

300 found that arsenic interacts with the N- and C-terminal zinc finger motifs of GATA-1, causing zinc lo