ライフサイエンスコーパス: C-terminal domain

1 proteins that lack the characteristic nexin C terminal domain.

2 d ability to interact with Mhf1-Mhf2 via its C-terminal domain.

3 , c-di-AMP-dependent regulation requires the C-terminal domain.

4 horylation of either Ser396 or Ser404 in the C-terminal domain.

5 p53, which leads to the demethylation of its C-terminal domain.

6 f transient interactions with the structured C-terminal domain.

7 action with mitochondria is mediated via its C-terminal domain.

8 n domain, a microtubule-binding domain and a C-terminal domain.

9 steric effect exerted by the kinesin-binding C-terminal domain.

10 ansporter-functioning selenocysteines in its C-terminal domain.

11 epeat region and a well-defined cleft of the C-terminal domain.

12 geting signals along with the NES-containing C-terminal domain.

13 ognition particle pathway through a Lys-rich C-terminal domain.

14 icing isoform (LIG3beta) that differs in the C-terminal domain.

15 an N-terminal domain, a middle domain, and a C-terminal domain.

16 urrents when expressed in the absence of the C-terminal domain.

17 P orthologues share an extended, cytoplasmic C-terminal domain.

18 D zinc finger domain, as well as an extended C-terminal domain.

19 ract with positively charged residues in the C-terminal domain.

20 -unopened dsDNA portion will bind to another C-terminal domain.

21 omoted interaction between the PrP(C) N- and C-terminal domains.

22 the protein's toxic N-terminal and globular C-terminal domains.

23 ential phosphorylation in the N-terminal and C-terminal domains.

24 sive interactions between its N-terminal and C-terminal domains.

25 ains a large basic patch spanning its N- and C-terminal domains.

26 mains to the ATPase, Rubisco recognition and C-terminal domains.

27 ong RNA, which is held in place by auxiliary C-terminal domains.

28 D7s bind ligands either within the N- or the C-terminal domains.

29 nts bound in opposite polarity to the N- and C-terminal domains.

30 ure of the effects of phosphorylation of the C-terminal domain(7-12).

31 A polymerase family A, exhibits a polymerase C-terminal domain, a central domain, and an N-terminal h

32 contractile tail phages, such as T4, and its C-terminal domain adopt an Ig-like fold of unknown funct

33 ntration and avidity to CSP (NANP-repeat and C-terminal domains) after a 3-dose vaccination against t

34 erplay between a folded but highly dynamical C-terminal domain and a disordered N-terminal domain tha

35 frameshift mutations, including those in the C-terminal domain and a large number of patient-associat

36 n (PrP(C)) comprises two domains: a globular C-terminal domain and an unstructured N-terminal domain.

37 d two decavanadate-binding sites, one in the C-terminal domain and another in the intersubunit MHR in

38 Sixteen Ca ions are present in the LH1 C-terminal domain and are coordinated by residues from t

39 or PCF11, which directly binds to the Pol II C-terminal domain and dismantles elongating Pol II from

40 We have structurally characterized this C-terminal domain and have discovered that it adopts the

41 r-bound PP2A dephosphorylates the RNA Pol II C-terminal domain and Spt5, preventing the transition to

42 We also show that the IMC3 C-terminal domain and the IMC6 N-terminal domain are nec

43 dered N-terminal domain (NTD) and structured C-terminal domain are essential for silencing.

44 Conserved aromatic residues within the CCS1 C-terminal domain are integral in these processes.

45 endows an additional function for the GSDMD C-terminal domain as a caspase-recruitment module beside

46 ntified two motifs in the distal part of the C-terminal domain as being important for this specific l

47 a potential oligomerization interface in the C-terminal domain as well as a conserved oligomerization

48 RapZ at 3.40 A and 3.25 A, and its isolated C-terminal domain at 1.17 A resolution.

49 minal extension that positions the conserved C-terminal domain at the ribosomal tunnel exit for an ef

50 ess kinetically stable than their respective C-terminal domains at denaturant concentrations predicte

51 of RapZ possesses a kinase fold, whereas the C-terminal domain bears closest homology to a subdomain

52 natures of helical elements that dock on the C-terminal domain beta-sheet in the dark and unfold in t

53 which assembles membrane pores, whereas its C-terminal domain binds the N-terminal domain to inhibit

54 In the absence of coiled-coil formation, the C-terminal domain bound liposomes and ProP concentrated

55 onal activation activity, due to a divergent C-terminal domain, but retains the ability to interact w

56 We demonstrate that the CX3CL1 C-terminal domain can upregulate neurogenesis, which may

57 n lipoxygenases, the topologically conserved C-terminal domain catalyzes the oxidation of polyunsatur

58 Nascent C-terminal domain clusters at primed genomic loci lower

59 und structures: the full-length Nup84-Nup133 C-terminal domain complex and the Nup133 N-terminal doma

60 ondrial Cbp3 homologs and a highly conserved C-terminal domain comprising a ubiquinol-cytochrome c ch

61 Furthermore, we identified a C-terminal domain conserved in all tonoplast-localized A

62 0-amino acid-long N-terminal extension and a C-terminal domain containing two heme regulatory motifs

63 The Pol3 C-terminal domain contains a 4Fe-4S cluster and emerges

64 The C-terminal domain (CT) of GluD1 has a classic PDZ-bindin

65 a catalytically active, weakly ssDNA binding C-terminal domain (CTD) and a catalytically inactive, st

66 1 phosphorylates serine-2 (S2) in the RNAPII C-terminal domain (CTD) and promotes transcript elongati

67 ranslational modifications on the RNA pol II C-terminal domain (CTD) and the chromatin template.

68 dynamic phosphorylation patterns of the Rpb1 C-terminal domain (CTD) and the factors that recognize t

69 d the inner vestibule of the channel-and the C-terminal domain (CTD) as well as hydrophobic interacti

70 ytic N-terminal domain (NTD) and a catalytic C-terminal domain (CTD) connected by a short linker.

71 ional modifications of the RNA polymerase II C-terminal domain (CTD) coordinate the transcription cyc

72 ion and negative imprinting, a region in the C-terminal domain (CTD) exhibits a differential behavior

73 RfaH exists in two states, with its C-terminal domain (CTD) folded either as alpha-helical h

74 The H1 C-terminal domain (CTD) localizes primarily to a single

75 Many of these proteins bind the C-terminal domain (CTD) of FtsZ, which serves as a hub f

76 Although it is now established that the long C-terminal domain (CTD) of H1 remains disordered upon nu

77 The methyltransferase (MTase) domain and the C-terminal domain (CTD) of L adopt a unique conformation

78 viously, we found that an excess of the free C-terminal domain (CTD) of ParB impeded DNA condensation

79 rase (Pol) II elongation, phosphorylates the C-terminal domain (CTD) of Pol II and negative elongatio

80 Here, we tested the importance of the C-terminal domain (CTD) of Pol IV's largest subunit give

81 s to the conserved elongation factor binding C-terminal domain (CTD) of ribosomal P stalk proteins to

82 The C-terminal domain (CTD) of RNA polymerase II (Pol II) is

83 gulates transcription by phosphorylating the C-terminal domain (CTD) of RNA polymerase II (RNAPII).

84 The C-terminal domain (CTD) of RNA polymerase II contains a

85 tad repeat array structurally related to the C-terminal domain (CTD) of RNA polymerase II.

86 ibits the phosphorylation of serine-2 in the C-terminal domain (CTD) of RNA-polymerase II (Pol II), a

87 In this work, we tested the function of the C-terminal domain (CTD) of Rpf2 during these anchoring s

88 We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is re

89 lves the catalytic core domain (CCD) and the C-terminal domain (CTD) of the integrase.

90 (P-TEFb) phosphorylates Ser2 residues of the C-terminal domain (CTD) of the largest subunit (RPB1) of

91 Interest in the C-terminal domain (CTD) of the RPB1 subunit of the RNA p

92 ent RIS induced by the Y320A mutation in the C-terminal domain (CTD) of the S1 subunit, indicating th

93 esidue mutations in the putative coiled-coil C-terminal domain (CTD) of the SMARCB1 (BAF47) subunit,

94 ge enabled measurement of RDCs in the mobile C-terminal domain (CTD) of the stalk protein bL12.

95 topo II-targeted drugs is influenced by the C-terminal domain (CTD) of the topo II isoforms and by a

96 The Ska1 C-terminal domain (CTD) recruits protein phosphatase 1 (

97 Hfq possesses an intrinsically disordered C-terminal domain (CTD) that may tune the function of th

98 bstrate; an interfacial site between TMD and C-terminal domain (CTD) that modulates the Zn(2+) transp

99 an arginine residue in the RNA polymerase II C-terminal domain (CTD) to citrulline, uncovering a pote

100 OMPASS associates with the RNA polymerase II C-terminal domain (CTD) to establish proper levels and d

101 merase II (RNA Pol II) contains a disordered C-terminal domain (CTD) whose length enigmatically corre

102 ckpoint, leads to SUMOylation of the Topo II C-terminal domain (CTD).

103 trimer bound to three copies of the Redbeta C-terminal domain (CTD).

104 polymerase II by hyperphosphorylation of its C-terminal domain (CTD).

105 4 but was defective for association with its C-terminal domain (CTD).

106 conserved core of the protein and the entire C-terminal domain (CTD).

107 ported through, and a regulatory cytoplasmic C-terminal domain (CTD).

108 residues for DNAJB6b oligomerization in its C-terminal domain (CTD).

109 N-terminal ankyrin repeat domains (ARD) and C-terminal domains (CTD).

110 important differences in how the Rb and p107 C-terminal domains (CTDs) associate with the coiled-coil

111 recognize different DNA motifs, via diverged C-terminal domains (CTDs).

112 ator complex subunit 9 (IntS9) through their C-terminal domains (CTDs).

113 Its C-terminal domain displays strong affinity for double-st

114 bound a hydrophobic pocket within the GSDMD C-terminal domain distal to its N-terminal domain.

115 s suggest that phosphorylation of the Pol II C-terminal domain drives an exchange from condensates th

116 The C-terminal domain facilitates ER export of proSP-B.

117 ase A (PKA), which phosphorylates SK2 in its C-terminal domain, facilitating its endocytosis.

118 arrying a TRPV1 construct lacking the distal C-terminal domain features an enhanced response to capsa

119 scription start site and phosphorylating the C-terminal domain for RNA polymerase II (RNAPII) for act

120 tastatic mediator, which is dependent on its C-terminal domain for this function.

121 o central domains synapse the ends while two C-terminal domains form a separate dimer that contacts o

122 ifies the site of LC3 lipidation, includes a C-terminal domain formed by 7 WD40-type repeats (WD40 do

123 e C-terminal fragments of TDP-43 CTD (TDP-43 C-terminal domain), formed upon proteolytic cleavage of

124 rated using the known interactions between a C-terminal domain fragment of human galectin-3 (hGal-3C)

125 ere, we solved the crystal structure of this C-terminal domain from a bacterial homolog at 1.4 angstr

126 nthase when ATP binding prevents the epsilon C-terminal domain from entering the inhibitory 'up' stat

127 ring (SAXS) data revealed that the protein's C-terminal domain has a PG-binding-competent conformatio

128 In GNIP1Aa the accompanying C-terminal domain has a unique fold composed of three ps

129 k7/Kin28 blocked phosphorylation of the Rpb1 C-terminal domain heptad repeats at serines 5 and 7, the

130 scence microscopy to demonstrate that both a C-terminal domain histidine residue and the 2-amino grou

131 AcrIIA1 binds and inhibits Cas9 with its C-terminal domain; however, the function of its highly c

132 lexity of the RNA polymerase II unstructured C-terminal domain in animal viability, development, and

133 HIV-1 particles, and we identify a distinct C-terminal domain in CLASP2 that promotes both MT stabil

134 P catalytic domain, but the role of the TIMP C-terminal domain in MMP inhibition is poorly understood

135 t an N-terminal domain that wraps around the C-terminal domain in the oligomer.

136 icted membrane protein with an extracellular C-terminal domain in which point mutation of residues th

137 confirmed that phosphorylation of SK2 in the C-terminal domain increases its ubiquitination and endoc

138 VP40 dimers assemble extended chains via C-terminal domain interactions.

139 We find that the PRPH2 C-terminal domain interacts with STX3 as well as other p

140 Pol II-like conformation, in which the A12.2 C-terminal domain is bound in a previously unobserved po

141 10, indicating that the activity of the BcsG C-terminal domain is essential for integrity of the pell

142 rate liposomes, the overall structure of the C-terminal domain is in good agreement with crystallogra

143 oinositide lipid content is reduced, and the C-terminal domain is key to determining agonist response

144 ed on the face of the beta-helix whereas the C-terminal domain is likely involved in carbohydrates bi

145 We also find that the hyperphosphorylated C-terminal domain is preferentially incorporated into co

146 The C-terminal domain is relatively unstructured in the mono

147 The C-terminal domain is smaller in overall size than in the

148 A from S. aureus strain RN6390 indicates its C-terminal domain is toxic when targeted to the Escheric

149 The C-terminal domain is typically a nuclease that inhibits

150 The RNA polymerase II (RNAPII) C-terminal domain kinase, CDK12, regulates genome stabil

151 GPIHBP1's LU domain binds to LPL's C-terminal domain, largely by hydrophobic interactions.

152 e transport function by removing a conserved C-terminal domain, leading to low fruit acidity in apple

153 family of proteins, homologs to the CTD, the C-terminal domain-like carotenoid proteins (CCPs).

154 cessed by CO2 in a manner dependent on a key C-terminal domain located in its transactivation domain.

155 nerated a mutant p53(KQ) mouse where all the C-terminal domain lysine residues were mutated to glutam

156 monstrates that two basic loops in the mVP40 C-terminal domain make important contributions to anioni

157 The tertiary structural interactions of the C-terminal domain mimic the quaternary structural intera

158 ng multimerization and explained why several C-terminal domain mutations are remarkably resistant to

159 The other is the NP C-terminal domain (NP-Ct), whose function has not previo

160 he MAD2-interaction motif (MIM), both N- and C-terminal domains (NTD and CTD) of MAD1 also contribute

161 Cooperation between the DBD and C-terminal domain occurs in response to heat shock (HS),

162 of Ltp2 with a DUF35 domain derived from the C-terminal domain of a hydratase (ChsH2(DUF35)) that cat

163 atalyzes isomerization of proline 128 in the C-terminal domain of alpha-synuclein.

164 sibly contribute to the higher levels of the C-terminal domain of Astn1 detected on neuronal membrane

165 rogeneity in determining the activity of the C-terminal domain of bacterial Enzyme I (EIC).

166 Here we present evidence that the C-terminal domain of BcsG from E. coli (EcBcsG(DeltaN))

167 athway-driven hemolysis, suggesting that the C-terminal domain of C3b has an important function in cl

168 ified arrhythmogenic mutations reside in the C-terminal domain of CaM and mostly affect Ca(2+)-coordi

169 n alpha-helix and develops contacts with the C-terminal domain of CaM in about 2 ms.

170 This p.Tyr715Cys variant, located in the C-terminal domain of ClC-7, resulted in increased outwar

171 a conserved valine-proline (VP) motif in the C-terminal domain of CRY2 (CCT2), which resembles the co

172 t a highly conserved arginine residue in the C-terminal domain of diverse HPV E7 mediates the interac

173 te for the substrate eEF-2 is located in the C-terminal domain of eEF-2K, a region predicted to harbo

174 induce a conformational rearrangement in the C-terminal domain of ExoU.

175 in metastatic prostate cancers, truncate the C-terminal domain of FOXA1, enable dominant chromatin bi

176 ependent conformational rearrangement of the C-terminal domain of heme binding protein (PhuS) is requ

177 , a deletion of either the N-terminal or the C-terminal domain of HflX abrogates ribosome splitting a

178 observed that NB and KU-32 both bind to the C-terminal domain of Hsp90, but surprisingly, KU-32 stim

179 port a cryo-EM structure of the Vif-targeted C-terminal domain of human A3F in complex with HIV-1 Vif

180 IL-33 from stromal cells and binding of the C-terminal domain of IL-33 to its receptor ST2 on target

181 AURKB/AURKC) are activated by binding to the C-terminal domain of INCENP.

182 econdary-structure rearrangements within the C-terminal domain of L99A.

183 lication and the potential for targeting the C-terminal domain of LANA to block viral persistence.IMP

184 The C-terminal domain of LiaX plays a role in inhibiting the

185 Domain swapping in the alpha-helical C-terminal domain of M(pro) (M(pro)C) locks M(pro) into

186 We find that the C-terminal domain of M1 is disordered in solution but ca

187 ta-sandwich formed by 2 beta-sheets from the C-terminal domain of MTPalpha.

188 ined and solved the crystal structure of the C-terminal domain of NP (NP-Ct), but its role in virus r

189 f four conserved cysteine-rich motifs in the C-terminal domain of ORF66.

190 o sustain transcription takes place when the C-terminal domain of PARP-1 binds to chromatin by intera

191 A polymerase (RNAP), also interacts with the C-terminal domain of PigR, thus anchoring the (MglA-SspA

192 We find that the hypophosphorylated C-terminal domain of Pol II is incorporated into mediato

193 that two highly conserved histidines in the C-terminal domain of PrP(C) are essential for the protei

194 this inhibitory effect required the globular C-terminal domain of PrP(C), which has not been previous

195 The C-terminal domain of RecA binds to dsDNA and directs it

196 Upon recruitment, the C-terminal domain of RfaH refolds from an alpha-hairpin,

197 rease in serine-2 phosphorylation within the C-terminal domain of RNA polymerase II (RNAP II) and in

198 lational modification of key residues at the C-terminal domain of RNA polymerase II (RNAP2-CTD) coord

199 t kinases (CDKs) 12 and 13 phosphorylate the C-terminal domain of RNA polymerase II, regulating trans

200 ion and termination by dephosphorylating the C-terminal domain of RNA polymerase II.

201 bers that enhances its interactions with the C-terminal domain of RNA polymerase II.

202 SSUP-72 would normally remodel the C-terminal domain of RNA polymerase in anticipation of t

203 Whereas expression of the NES-containing C-terminal domain of RPW8.2 in the cytoplasm is sufficie

204 and the biochemical characterization of the C-terminal domain of S. aureus OatA.

205 the remodeling of PriA requires a functional C-terminal domain of SSB.

206 o V(o) is the conformation of the inhibitory C-terminal domain of subunit H (H(CT)).

207 ngation; however, molecular details like the C-terminal domain of the alpha-chain, the heparin-bindin

208 Moreover, C5, the short and most C-terminal domain of the alpha3 chain, recently has been

209 t structural and biophysical analyses of the C-terminal domain of the bacteriophage phi29 ATPase (CTD

210 e catalytic sites by the DELSEED loop in the C-terminal domain of the beta subunits.

211 o one of the three PCNA monomers through the C-terminal domain of the catalytic subunit.

212 nse variants identified in the intracellular C-terminal domain of the GluN2B NMDAR subunit.

213 Here, we demonstrate for the C-terminal domain of the human immunodeficiency virus ty

214 The C-terminal domain of the human Ino80 subunit (Ino80CTD)

215 (alpha-MoRE) of the intrinsically disordered C-terminal domain of the measles virus nucleoprotein (N(

216 A) forms dimers of heterotrimers through the C-terminal domain of the PA subunit, the thumb subdomain

217 e stability and folding cooperativity of the C-terminal domain of the ribosomal protein L9 in the pre

218 ce, and catalyzes methyl transfer, while the C-terminal domain of the second molecule binds the non-t

219 ster-bound (holo-) WhiB1 in complex with the C-terminal domain of the sigma70-family primary sigma fa

220 W) in the catalytic domain or truncating the C-terminal domain of TPS1 severely compromised growth.

221 ember of the superfamily, owing to its extra C-terminal domain of unknown function and the absence of

222 The N- and C-terminal domains of all gasdermins possess lipid-bindi

223 ifferent lipid-dependent roles to the N- and C-terminal domains of alpha-syn accounting for both elec

224 The cytosolic C-terminal domains of both NMDA receptors (NMDARs) and A

225 Our results indicated that the C-terminal domains of both proteins determine their spec

226 The N-terminal and C-terminal domains of CA (NTD and CTD, respectively) eng

227 nique to this group of proteins, whereas the C-terminal domains of DivIVA and GpsB are radically diff

228 on determinants located in the noncatalytic C-terminal domains of GBF1.

229 inclusion or exclusion of 1 N-terminal and 2 C-terminal domains of GluN1 results in 8 splicing varian

230 ure-sensitive interaction between the N- and C-terminal domains of mV1 but not pV1 drives a conformat

231 The dynamic interaction of the N- and C-terminal domains of mycobacterial F-ATP synthase subun

232 iously shown that one likely function of the C-terminal domains of OPG is to bind cell surface hepara

233 the exact biological functions of the three C-terminal domains of OPG remain uncertain.

234 ses, our results show the function of N- and C-terminal domains of RdRp: the former opens the genome

235 es that are encoded in the structured N- and C-terminal domains of the complex.

236 ck the hydrolysis (HD) domain and regulatory C-terminal domains of the long RSHs such as Rel, RelA, a

237 interaction that occurs between ORC and the C-terminal domains of the MCM helicases.

238 specifically interacts with both the N- and C-terminal domains of the RNA polymerase alpha-subunit.

239 nt to trigger MeV phase separation, with the C-terminal domains of the viral N and P proteins playing

240 We find that both the N- and C-terminal domains of TTP are involved in an interaction

241 ing site is located in a crevice between the C-terminal domains of two subunits where they stack via

242 We identified N- and C-terminal domains on TRPV1 responsible for TRPA1-TRPV1

243 with the oligomerization domain (P(OD)) and C-terminal domain (P(CTD)) of a tetramer of P.

244 ur earlier studies, the presence of the p261 C-terminal domain (p261C) and the three small subunits i

245 of the CER11 gene revealed that it encodes a C-TERMINAL DOMAIN PHOSPHATASE-LIKE2 (CPL2) protein.

246 ed by nutritional stress, affect the RNAP II C-terminal domain phosphorylation at Ser2, and control r

247 r SEC components and impairs P-TEFb-mediated C-terminal domain phosphorylation of RNA polymerase II b

248 Young and coworkers now establish that C-terminal domain phosphorylation regulates Pol II parti

249 sitic, and antiinvasive activities, with the C-terminal domain potentiating the 2 latter activities.

250 t bound to the two alpha-helices forming its C-terminal domain, probably because they are shorter tha

251 not equally effective; the trimerization and C-terminal domains promoted regeneration, while the THBS

252 sphorylation of threonine in the cytoplasmic C-terminal domain, providing the first direct evidence o

253 n is the active part of the protein, and the C-terminal domain regulates the activity.

254 te whether the phosphorylation of the Pol II C-terminal domain regulates the incorporation of Pol II

255 ther, the crystal structures of the Na(V)1.4 C-terminal domain relevant complexes and thermodynamic b

256 thermodynamic stability measurements on the C-terminal domains (residues 90-231) of two PrP variants

257 rylated at Ser2 in heptad repeats within the C-terminal domain (RNAP2 Ser2ph), and miR-430 transcript

258 The C-terminal domain showed strong PPIase activity, no role

259 e bioactive LN-511-E8 fragment carrying only C-terminal domains showed similar efficacy as full-lengt

260 so showed that deletion of the 1B domain and C-terminal domain significantly reduced the helicase act

261 was more remarkable and appeared to bind two C-terminal domains simultaneously via nonoverlapping epi

262 fused to a degenerate polymerase fold and a C-terminal domain structurally similar to Cas11.

263 Moreover, we report a unique C-terminal domain structure that participates in stabili

264 0 adopts a novel open state and has a unique C-terminal domain structure, which plays a crucial role

265 ing domain for membrane association fused to C-terminal domains supporting oligomerization.

266 s revealed that SpSbnI forms a dimer through C-terminal domain swapping and a dimer of dimers through

267 in vivo Only hAChE-S contains an amphiphilic C-terminal domain (T40, AChE(575-614)), with AChE(586-59

268 GPR158 displays three VCPWE motifs in its C-terminal domain that are putatively involved in G-prot

269 ins (TULPs) are characterized by a conserved C-terminal domain that binds phosphoinositides.

270 ly disordered regions followed by a globular C-terminal domain that binds the template.

271 s and almost all arise in the low complexity C-terminal domain that does not affect RNA binding and p

272 Trl1-LIG has a distinctive C-terminal domain that instates fungal Trl1 as the found

273 Pol II contains an intrinsically disordered C-terminal domain that is phosphorylated by cyclin-depen

274 ges in secondary structure within the TIMP-1 C-terminal domain that stabilize interdomain interaction

275 functional cooperativity between its N- and C-terminal domains that are crucial for actin nucleation

276 coil surfaces in the AtEDS1-AtSAG101 partner C-terminal domains that are necessary for reconstituted

277 Additionally, optimal activity requires C-terminal domains that enhance the avidity of the molec

278 Additionally, like the C-terminal domain, the N-terminal domain when overexpres

279 a mouse model deleting the final two unique C-terminal domains, the serine-rich region (SRR) and the

280 the catalytic core to the flexibly attached C-terminal domains, thereby fixing a conformation that i

281 d directly interacts with Nup98-Rae1 via its C-terminal domain to impair docking of cargo-receptor (k

282 onfiguration with close apposition of N- and C-terminal domains to an extended state that is required

283 This allows the C-terminal domains to capture one strand of underwound n

284 the propensity of the intrinsically unfolded C-terminal domains to drive pathological aggregation.

285 of TRADD (TRADD-N), which interacts with the C-terminal domain (TRADD-C) and TRAF2 to modulate the ub

286 g conformation substantially and the epsilon C-terminal domain transitioning via an intermediate 'hal

287 In contrast, we found two residues in the C-terminal domain, tyrosine 351 and glutamate 355, that

288 amer bound to promoter DNA reveals that YefM C-terminal domain undergoes disorder to order transition

289 n which the N-terminal domain I (DI) and the C-terminal domain V (DV) are exposed to the solvent.

290 A novel conserved C-terminal domain was identified in diatoms and other st

291 lining a contiguous adjacent surface on the C-terminal domain were critical for 16S rRNA modificatio

292 ts inclusion in the complex depends upon its C-terminal domain, which contains highly conserved cyste

293 rs, the automodification domain (A), and the C-terminal domain, which includes the protein interactin

294 agment functions to provide stability to the C-terminal domain, which is necessary for lethal toxicit

295 th WT CLASP2 and a CLASP2 mutant lacking its C-terminal domain, which mediates its interaction with s

296 rtions of the M1 sequence, especially in the C-terminal domain, whose structure is undetermined, were

297 In full-length enzymes, a C-terminal domain with a previously unknown fold has no

298 ion, thus influencing the interaction of the C-terminal domain with different components of the initi

299 anslation termination via interaction of its C-terminal domain with eukaryotic polypeptide chain rele

300 nd quaternary arrangement of the capsid (CA) C-terminal domain within the assembled capsid that is co