ライフサイエンスコーパス: C-terminal region

1 ing oligomerization involving binding to the C-terminal region.

2 a function for other amino acids within this C-terminal region.

3 in-binding sequence (CBS) located within its C-terminal region.

4 o conserved cysteine residues located in the C-terminal region.

5 gh mediating the local unfolding of the Mad2 C-terminal region.

6 d state, with structure apparent only in the C-terminal region.

7 he reported functional regulation of the p53 C-terminal region.

8 region and residues 30-36 (AIIGLMV) from the C-terminal region.

9 regions of Abeta: the central region and the C-terminal region.

10 uggesting enhanced local cleavage of the CgA C-terminal region.

11 t ion-permeation properties are conferred by C-terminal region.

12 y of the amino acid changes occurring in the C-terminal region.

13 ptor, CdiA delivers a toxin derived from its C-terminal region.

14 ion range, and are partly conferred by WRN's C-terminal region.

15 nding site to the conformationally malleable C-terminal region.

16 ontains a tryptophan-rich (TR) domain in the C-terminal region.

17 ng at the N terminus propagates to the ATP7B C-terminal region.

18 bohydrate binding module (CBM) followed by a C-terminal region.

19 E activation within the switch regions and a C-terminal region.

20 to force owing to the high stability of the C-terminal region.

21 as a large N-terminal domain and a catalytic C-terminal region.

22 an N-terminal disease-related surface, and a C-terminal region.

23 ERM domain with a more flexible and extended C-terminal region.

24 stabilize the alpha-helical character of the C-terminal region.

25 nsmembrane protein beta-dystroglycan via its C-terminal region.

26 on was likely affected by its N-terminal and C-terminal regions.

27 rent dynamic interactions involving loop and C-terminal regions.

28 rming a catalytic domain and extended N- and C-terminal regions.

29 with Titin truncations in the N-terminal and C-terminal regions.

30 are involved in RAD51 interaction via their C-terminal regions.

31 BC-ATPase fold embedded between novel N- and C-terminal regions.

32 ger composite NC domain formed by the N- and C-terminal regions.

33 erwise highly divergent nature of the N- and C-terminal regions.

34 rminal lysine residues but not at central or C-terminal regions.

35 crystallin domain flanked by variable N- and C-terminal regions.

36 Among the basic amino acids in the PA-X C-terminal region, 3 residues, 195K, 198K, and 199R, wer

37 aryotic replisome, Timeless, harbours in its C-terminal region a previously unappreciated DNA-binding

38 ays a previously unrecognized element in its C-terminal region, a 'gatekeeper' helix, which extends o

39 In the Ca(2+)/NCS-1.D2R peptide complex, the C-terminal region adopts a 310 helix-turn-310 helix, whe

40 e present study, we identified a NiV-G stalk C-terminal region (amino acids 159 to 163) that is impor

41 sensor that detects RNA viruses through its C-terminal region and activates the production of antivi

42 proteins from chromatin, bound to the Stat3 C-terminal region and antagonized its transcriptional an

43 This alpha-helix was located in the C-terminal region and included residues 101-106.

44 sary for +TIP activity whereas the conserved C-terminal region and its PGGG motif are not.

45 Rather, EGCG immobilizes the C-terminal region and moderately reduces the degree of b

46 hen constructed two deletion mutants lacking C-terminal regions and mutants with point mutations of t

47 of PINK1, including the architecture of the C-terminal region, and reveals how the N lobe of PINK1 b

48 ch to ECL2 established the importance of its C-terminal region, and site-directed mutagenesis of each

49 AF2 binds to multiple motifs within the TAF8 C-terminal region, and these interactions dictate TAF2 i

50 sing truncated MeCP2 lacking both the N- and C-terminal regions (approximately half of the native pro

51 ed type-III effector AvrRps4; however, their C-terminal regions are dissimilar, indicating that they

52 idues within the core LIR motif and adjacent C-terminal region as well as ATG8 subfamily-specific res

53 r report the crystal structure of the MMADHC C-terminal region at 2.2 A resolution, revealing a modif

54 ates of Cdk5, which phosphorylates it in its C-terminal region at Ser(549) (site 6) and Ser(551) (sit

55 on of UPF1 occurs in its unstructured N- and C-terminal regions at Serine/Threonine-Glutamine (SQ) mo

56 Kindlin-2, through its C-terminal region, binds to and stabilizes MafA, which a

57 The USP7 C-terminal region (C-USP7) contains five ubiquitin-like

58 epsin B cleaved chemokines especially in the C-terminal region, cathepsins K, L, and S cleaved chemok

59 CdiA effector proteins, which carry a toxic C-terminal region (CdiA-CT) that is cleaved from the eff

60 cteria and delivers a toxin derived from its C-terminal region (CdiA-CT).

61 ealing a pilin-like protein with an extended C-terminal region composed of two discrete domains conne

62 re-function analyses of SKIP reveal that the C-terminal region comprising three pleckstrin homology (

63 enhancement of fragmentation near the N- and C-terminal regions consistent with slight fraying.

64 We find that the N- and C-terminal regions constitute two independent domains of

65 n angiosperms and possess a highly conserved C-terminal region containing linear motifs (CKII-acidic,

66 This analysis also revealed that the C-terminal region contains a previously unrecognized WRD

67 Further, the Rgd3 C-terminal region contains several phosphorylatable resi

68 The C-terminal region contains the catalytic glucosyltransfe

69 CC MBS (localized within and adjacent to the C-terminal region) contributing to the dimer-dimer inter

70 uced splice-site mutation that truncates the C-terminal region (CTR) domain of RELN protein and displ

71 A new Reln mutant with a truncation of the C-terminal region (CTR) domain shows that Reln mutation

72 es 326-380 of p62 directly interact with the C-terminal region (CTR) of FIP200.

73 g inhibits the RNA chaperone activity of the C-terminal region (CTR) of Gag-p45.

74 exhibits shifts in cytoplasmic loops and the C-terminal region (CTR) to occlude the cytoplasmic exit

75 reover, deletions at both ends of the N- and C-terminal regions disrupt their ability to interact wit

76 We further show that the N- and C-terminal regions, either separated or when fused in ta

77 By contrast, a mutation in the whirlin C-terminal region eliminated all normal whirlin isoforms

78 hifting that often results in synthesis of a C-terminal region encoded by a new frame.

79 We recently proposed that the C-terminal region encompassing the C(1), C(2)B, MUN and

80 In contrast, TIR2, located at the C-terminal region encompassing the PH domain, decreases

81 ly protective subdominant responses to PfCSP C-terminal regions expanded with subsequent boosts.

82 odel of 13 transmembrane helices and a large C-terminal region exposed to the periplasm.

83 However, the realization that the N- and C- terminal regions flanking the repeats play essential

84 ities are indirectly regulated by the N- and C-terminal regions flanking the FH1-FH2 domains.

85 We demonstrate here that a yeast-specific C-terminal region from Pat1 interacts with several short

86 sent the crystal structures of the catalytic C-terminal regions from the Burkholderia pseudomallei an

87 lar dichroism of the isolated CBM, and a CBM-C-terminal region fusion revealed folded domains dominat

88 nuclear localization of PA-X mediated by its C-terminal region has a significant impact on shutoff ac

89 ressive C-terminal deletions showed that the C-terminal region has higher affinity for ssDNA than the

90 erase and methyltransferase (MTase), and the C-terminal region has the polymerase (POL), all of which

91 with deletion of residues 338 to 347 in the C-terminal region, has been an enigma, because the basis

92 scopy assays indicated that the Rec10 N- and C-terminal regions have complex interactions with Rec25.

93 nking and mass spectrometry, we identified a C-terminal region in Hel2/Rqt1 as an RNA binding domain.

94 that both mutations lead to unfolding of the C-terminal region in the t-SNARE complex.

95 To ensure helical C-terminal regions in the truncated peptides, we produce

96 (Btl) proteins bind DNA but lack the N- and C-terminal regions, in which TAL effectors harbor their

97 ot the interaction between AP2M and the TRKB C-terminal region, indicating that the fluoxetine-bindin

98 hereas phosphorylation in the N-terminal and C-terminal regions inhibited but did not prevent fibrill

99 Both the N- and C-terminal regions inhibited viral RNA replication.

100 with peptides corresponding to the conserved C-terminal region inhibits the extracellular assembly of

101 Cross-dimer domain-swapping of the C-terminal region is a determinant of alphaA-crystallin

102 The largely disordered/dynamic C-terminal region is conjectured to mediate the promiscu

103 d N-terminal transmembrane domain, while the C-terminal region is cytosolic.

104 ical to what is observed when the entire LIC C-terminal region is deleted.

105 We propose that the flexible nature of the C-terminal region is essential to allow it to modulate i

106 h kinase-mediated phosphorylation within the C-terminal region is inhibitory and regulates catalytic

107 lization, it has also been reported that the C-terminal region is involved in p130Cas FA targeting.

108 The C-terminal region is required for CofB to initiate pilus

109 complex is CcmM, a multidomain protein whose C-terminal region is required for RubisCO recruitment.

110 sential for its biological function, and its C-terminal region is sufficient for LLG binding.

111 bacterial orthologs because of an additional C-terminal region, known as domain B.

112 odimers linked to DNA-PKcs via flexible Ku80 C-terminal regions (Ku80CTR) in a complex stabilized thr

113 on and demonstrate that perturbations of the C-terminal region lead to developmental defects in both

114 n against hydrogen/deuterium exchange in the C-terminal region near the N-glycan sites, suggesting th

115 NA topological stress require distinct N and C terminal regions of the protein, whereas the other fun

116 The C-terminal region of a truncated LcrG (residues 52-73) s

117 Abeta and residues 30-36 (AIIGLMV) from the C-terminal region of Abeta assemble to form homotetramer

118 ively inhibited by antibodies binding to the C-terminal region of Abeta42.

119 In yeast and humans, the unstructured C-terminal region of alpha7 contains an acidic patch wit

120 igate the interaction between the disordered C-terminal region of Artemis and the DNA binding domain

121 motif (proteolytic signal) is located at the C-terminal region of AtWRI1(IDR) (3).

122 ious studies suggested the importance of the C-terminal region of B-chain in this pathway.

123 he structural pocket proximal to S184 in the C-terminal region of Bax, directly activating its proapo

124 Replacing the C-terminal region of beta-arrestin-1 with its counterpar

125 Cross-linking between the C-terminal region of both E1a and G729R E1a with the E2o

126 dies identified phosphorylation sites in the C-terminal region of BRM at SnRK2 target sites that are

127 The very C-terminal region of Bruchpilot (Brp), a key component o

128 l DQ2- or DQ8-restricted epitopes within the C-terminal region of C-peptide that partially overlap wi

129 nding question concerns the structure of the C-terminal region of CA and the peptide SP1 (CA-SP1), wh

130 The C-terminal region of capsid (CA) and the p2 region of Pr

131 The C-terminal region of cardiac troponin T (TnT), a tropomy

132 -binding homeodomain) we discovered that the C-terminal region of Caudal contributes to the preferent

133 tural and biochemical analysis show that the C-terminal region of Chz1 (Chz1-C) harbors a conserved D

134 vator CBP by masking its binding site in the C-terminal region of Ci.

135 fied and conserved Sufu-binding motif in the C-terminal region of Ci/Gli and provides mechanistic ins

136 biologically active peptide derived from the C-terminal region of collagen alpha3(IV) chain, a struct

137 CDI(+) bacteria deliver the toxic C-terminal region of contact-dependent inhibition A prot

138 th CsMAF1 for CsC34 interaction, whereas the C-terminal region of CsMAF1 is essential for PthA4 bindi

139 dies showed the existence of epitopes in the C-terminal region of DENV nonstructural protein 1 (NS1)

140 ne mAb designated 2E8 does not recognize the C-terminal region of DENV NS1 in which host-cross-reacti

141 potentially harmful events, we replaced the C-terminal region of DENV NS1 with the corresponding reg

142 acterize a minor conformational state of the C-terminal region of DHFR.

143 The C-terminal region of DP2 contains two conserved cysteine

144 and structural approaches, we find that the C-terminal region of DRC2 is critical for the coassembly

145 Pol II subunit RPB12 and the phosphorylated C-terminal region of DSIF subunit SPT5.

146 Tau and EBs form a complex via the C-terminal region of EBs and the microtubule-binding sit

147 The 6 aa at C-terminal region of ESAT-6 are essential for ESAT6:beta

148 In an earlier study, we have shown that the C-terminal region of ESAT-6 is crucial for its interacti

149 In contrast, the C-terminal region of Ets-1, including its Pointed (PNT)

150 Finally, we demonstrate that the C-terminal region of FOXN1 is required for high-affinity

151 which efficiently competes with ZipA for the C-terminal region of FtsZ, a central hub for multiple in

152 2' sugar modifications and revealed that the C-terminal region of FUS is sufficient to retain ASOs in

153 art of an amphipathic alpha-helix within the C-terminal region of GobX.

154 The C-terminal region of HELLP, HELLP(215-278), encompassing

155 truncating or missense variants in the same C-terminal region of hnRNPR and who have multisystem dev

156 an E3 ubiquitin ligase, interacted with the C-terminal region of HSPA5 and mediated HSPA5 ubiquitina

157 nance (NMR) analysis to demonstrate that the C-terminal region of human dynein light intermediate cha

158 primarily at the dimer interface and at the C-terminal region of IFN-gamma.

159 Mutagenesis defined the C-terminal region of JP2 as the predominant calpain clea

160 We show that the C-terminal region of KDM4D mediates its rapid recruitmen

161 ap the RNA chaperone domain (RCD) within the C-terminal region of La in close proximity to a novel AK

162 cal assays and mutagenesis indicate that the C-terminal region of LcrG (residues 52-73) is important

163 The C-terminal region of LRRK2 is a Trp-Asp-40 (WD40) domain

164 f Ly49B, demonstrating unexpectedly that the C-terminal region of Ly49s can play a significant role i

165 itulated in a strain lacking only the unique C-terminal region of MceG, suggesting an important funct

166 n, and to a 25-residue-long peptide from the C-terminal region of MG491 by surface plasmon resonance

167 cytoplasmic loop is adjacent to the proximal C-terminal region of mouse melanopsin in the inactive co

168 inds via its substrate-binding domain to the C-terminal region of MRTF-A and that CCTepsilon is able

169 We have identified a C-terminal region of MTBP (the CTM domain) that binds ef

170 cture of MtTOP1 by first predicting that the C-terminal region of MtTOP1 contains four repeated domai

171 Two of these mutations are located in the C-terminal region of mu1, which has not previously been

172 region of MUC5B (D1-D2-D'-D3 domains, NT5B), C-terminal region of MUC5B (D4-B-C-CK domains, CT5B) and

173 with different degrees of truncation in the C-terminal region of NBD2 reveal the importance of the l

174 ce catalytic activity, and suggests that the C-terminal region of NEIL3 is involved in both DNA damag

175 proteolytic product p22-FLIP all require the C-terminal region of NEMO/IKKgamma (amino acids 272-419)

176 Consistent with a role for the C-terminal region of NKAP in embryogenesis, nkap mutant

177 These mutations are clustered in the C-terminal region of NKAP where NKAP interacts with HDAC

178 indicates that dramatic rearrangement of the C-terminal region of Nop15 in the pre-ribosome exposes t

179 Substitutions in the conserved C-terminal region of Oma1 impair its ability to form a l

180 ociation required B domain in OsRBR1 and the C-terminal region of OsPP2A B''.

181 The C-terminal region of p130Cas or Cas family homology doma

182 full-length p17 demonstrating that the final C-terminal region of p17 is irrelevant for the protein's

183 Using the cytosolic C-terminal region of p22phox as bait to screen a human s

184 Moreover, the largely dispensable C-terminal region of pp150 is critical for pp150-pUL96 i

185 ha-helix binds to other alpha-helices in the C-terminal region of predominantly one of the beta-subun

186 n its binding to specific regions within the C-terminal region of PRG-2.

187 llelic variants, antibodies elicited against C-terminal region of protein did not correlate with epid

188 ever, the N-terminal region of pp150 and the C-terminal region of pUL96, which are critical for these

189 In addition, the C-terminal region of Redbeta corresponding to residues 1

190 the central part of M-Tha, and the specific C-terminal region of RelAp43 are required for this inter

191 The interaction occurred through the C-terminal region of RING1B (C-RING1B), with an affinity

192 tingly, the Walker A motif is located in the C-terminal region of RNase R, whereas the Walker B motif

193 nd identify an 18 amino acid sequence in the C-terminal region of S2 -SLF1 (SLF1 of S2 haplotype) tha

194 Moreover, the C-terminal region of SNX3 recruits galectin-9, a lectin

195 We found that the C-terminal region of Spt16 binds specifically to the his

196 Expression of the C-terminal region of SS4 alone increased granule initiat

197 Furthermore, the C-terminal region of SSX confers preferential affinity t

198 ture-function analysis demonstrates that the C-terminal region of TACC2 is both necessary and suffici

199 The C-terminal region of TDP-43 was required for this functi

200 he MORF-MORF protein connections require the C-terminal region of the central conserved MORF box.

201 01 is based on the major NPNA repeat and the C-terminal region of the circumsporozoite protein (CSP).

202 Additionally, we show that the C-terminal region of the citrus TFIIIB component BRF1 co

203 is proposed to be its active state, but the C-terminal region of the enzyme adopts a distinct confor

204 ibrinogen induced a structural change in the C-terminal region of the fibrinogen beta-chain (beta384-

205 lasia (mes) mice harbour a truncation in the C-terminal region of the Hh-ligand receptor, Patched-1 (

206 Here we show that the C-terminal region of the HSV-1 pUL25 protein is required

207 The IP6 binding site is located within the C-terminal region of the Ino80 subunit.

208 ecently, an allosteric binding pocket in the C-terminal region of the ligand-binding domain (LBD) of

209 Additionally, the C-terminal region of the linker forms previously unrepor

210 WY domain of ATR1, partially specified by a C-terminal region of the LRR domain.

211 ring the parasite's hepatic replication, the C-terminal region of the parasitic PV membrane protein e

212 atory mechanism does not require the diverse C-terminal region of the PilA pilins but specifically in

213 identified a highly conserved motif near the C-terminal region of the PP2C.D catalytic domain that is

214 The C-terminal region of the protein contains a predicted Do

215 y the presence of distinct insertions at the C-terminal region of the protein responsible for a struc

216 static interaction of the positively charged C-terminal region of the protein with a negatively charg

217 We focus on the C-terminal region of the protein, which comprises a memb

218 sociation of antimicrobial activity with the C-terminal region of the protein.

219 phosphorylation of an array of sites in the C-terminal region of the protein.

220 These new structures reveal the C-terminal region of the small coat protein subunit, whi

221 S889 lies within a C-terminal region of the SMARCAL1 protein.

222 ve healthy donors responded similarly to the C-terminal region of the spike proteins of the human end

223 IgG that targets amino acid residues in the C-terminal region of the V3 loop crown, suggesting the i

224 g the potentially protective response in the C-terminal region of the V3 loop crown.

225 rtant regulator of insulin fibrillation, the C-terminal region of this peptide is also crucial for th

226 ng interface of LvgA also interacts with the C-terminal region of three additional effectors, SidH, S

227 plex activity, likely through binding to the C-terminal region of Tim44.

228 eractions of the central part of Tm with the C-terminal region of TnI.

229 two individuals with de novo variants in the C-terminal region of TOMM70.

230 The C-terminal region of TOPBP1 interacts with TOP2A, and TO

231 Our results show that the C-terminal region of TPX2 regulates Kif15 in vitro, cont

232 nserved catalytic site was identified in the C-terminal region of TRP120, and TRP120 autoubiquitinati

233 t the ligand prevents optimal folding of the C-terminal region of VDR.

234 a cyclin F-specific amino acid motif in the C-terminal region of Vif indicated rescue of the protein

235 Mutagenesis of the C-terminal region of Vpu from two clade C viruses led to

236 that synthetic peptides corresponding to the C-terminal region of wt-MoaA rescue the GTP 3',8-cyclase

237 ucine-rich motifs (HLMs), spread in the long C-terminal region of yeast Dcp2 decapping enzyme.

238 ion/translocation region, kinase domain, and C-terminal region of YpkA.

239 These studies show that the central and C-terminal regions of Abeta can preferentially segregate

240 airpin peptides derived from the central and C-terminal regions of Abeta, which bear "tails" derived

241 bilized trimers derived from the central and C-terminal regions of Abeta.

242 termolecular interactions between the N- and C-terminal regions of alpha-syn play critical roles in m

243 tramolecular interactions between the N- and C-terminal regions of alpha-Syn, resulting in the protei

244 millisecond-timescale dynamics of the N- and C-terminal regions of C2alpha.

245 Cleavage of the N- and C-terminal regions of circulating chromogranin A (CgA, C

246 the FG/GLFG region of Nup98 binds to N- and C-terminal regions of DHX9 in an RNA facilitated manner.

247 hat are localized within and adjacent to the C-terminal regions of each homodimer.

248 fragmentation that allows mapping of N- and C-terminal regions of large proteins without the need fo

249 The N- and C-terminal regions of MlcC make critical contacts that c

250 We find that both the N- and C-terminal regions of Sca2 interact with actin monomers

251 nvestigated the specific roles of the N- and C-terminal regions of SS4 by expressing truncated versio

252 Both N-terminal and C-terminal regions of tamalin played critical roles in m

253 bly of peptides derived from the central and C-terminal regions of the beta-amyloid peptide (Abeta).

254 study the insertion capacity of hydrophobic C-terminal regions of the BH3-only proteins Bik, Bim, No

255 idate RTS,S/AS01 is based on the central and C-terminal regions of the circumsporozoite protein (CSP)

256 Differential localization of N- and C-terminal regions of the collagen VI alpha3 chain revea

257 ns of DLD-4-1.4E and U3-bind the central and C-terminal regions of the delivery domain of TcdB.

258 in electrophoretic mobility originate in the C-terminal regions of the gamma-tubulins.

259 sue of the JCI, Xu et al. show that specific C-terminal regions of the MOR can modulate side effects

260 lping it contact the N-terminal, middle, and C-terminal regions of the peptide.

261 x, such as the zinc-binding motif and N- and C-terminal regions of the protein.

262 fluences interactions between N-terminal and C-terminal regions of the subdomain that are important i

263 Through manipulation of the C-terminal regions of these proteins we show the SPKTG m

264 ted peptides with sequences derived from the C-terminal regions of two LsbB-related bacteriocins inhi

265 o of 1:2, unsaturated binding of YoeB to the C-terminal regions of YefM dimer forms an optimal hetero

266 NuMA localization to minus-ends involves a C-terminal region outside NuMA's canonical microtubule-b

267 Three basic residues at the C-terminal region play a critical role in nuclear locali

268 hat the first 15 residues of the PA-X unique C-terminal region play a critical role in shutoff activi

269 2 and HO1 and indicate that their dissimilar C-terminal regions play a major role in controlling the

270 ly in nine amino acid residues in their very C-terminal regions, play distinct roles in neurogenesis.

271 e novo non-synonymous variants involving the C-terminal region presented a more severe phenotype with

272 at formed a dimer, indicating that the NCS-1 C-terminal region prevents NCS-1 oligomerization.

273 to produce a bicyclic peptide to target the C-terminal region (residues 31-42) of the 42-residue for

274 ue because it did not seem to contain a RecQ C-terminal region (RQC) found in the other RecQ paralogu

275 pore-forming alpha1 subunit and, through its C-terminal region, scaffolds the beta subunit of VGCC an

276 (VK210, VK247 and P. vivax-like) and of the C-terminal region (shared by all PvCSP variants) in natu

277 but not isoform3 (i3) which shares a common C-terminal region, suppresses these malignant properties

278 erminus, a hydrophobic core and a more polar C-terminal region that contains the cleavage site for th

279 s a stretch of hydrophobic residues from the C-terminal region that form a hydrophobic cleft, an adja

280 in the RNase III domain, and two were in the C-terminal region that has no homology to known motifs.

281 HCMV fusion factor has a Cys residue in the C-terminal region that is palmitoylated and mediates met

282 In particular, it includes an extra C-terminal region that is part of the acceptor binding s

283 g a role of membrane anchor, an unstructured C-terminal region that is weakly associated with the mem

284 s experiments we identified a portion of the C-terminal region that mediates toxin binding to mammali

285 pP2 has non-canonical features in its N- and C-terminal regions that explain its poor interaction wit

286 soluble protein (Delta-JDBD) with the N- and C-terminal regions tightly associated together in a well

287 Here, we first show that the RIG-I C-terminal region undergoes deacetylation to regulate it

288 Da peptide, designated NC1-peptide, from the C-terminal region, via the action of MMP-9 (matrix metal

289 pke in vivo and in vitro, whereas a separate C-terminal region was required for Sstn localization to

290 s CROPS [combined repetitive oligopeptides]) C-terminal region, was shown to elicit protective immuni

291 last two beta-strands in NBD2 and the whole C-terminal region, we further characterized truncation m

292 Non-amyloid component and C-terminal regions were consistently found to contain be

293 ged N-terminal and positively charged middle/C-terminal regions, whereas hydrophobic interactions pla

294 ed structure revealed a unique alpha-helical C-terminal region which we demonstrated to be essential

295 In contrast, the C-terminal region, which contains a putative DNA-binding

296 ths detected using mAbs against the head and C-terminal regions, which are widely separated in the te

297 The coiled-coil comprises N- and C-terminal regions with distinct registers accommodated

298 packing of the residues from the central and C-terminal regions, with the N-terminus of Abeta accommo

299 amide shifts are localized mostly to N- and C-terminal regions within the rigid beta structure in th

300 eta42, only differ by two amino acids in the C-terminal region, yet they display markedly different a