ライフサイエンスコーパス: C-terminally truncated

1 wed that both full-length 27 kDa 7B2 and the C-terminally truncated 21 kDa form lack appreciable seco

2 codon, which resulted in the expression of a C-terminally truncated 45-kDa protein.

3 The prcA-prtP mutant produced only a C-terminally-truncated 62-kDa PrcA protein.

4 es of varying length ranging from the N- and C- terminally truncated 90-228 up to the full-length mat

5 ave also produced transgenic mice in which a C-terminally truncated (aa384-715) glycosylated HCV E2 p

6 Notably, all MMP-generated C-terminally truncated Abeta fragments were highly solub

7 tB effectively cleaved Abeta1-42, generating C-terminally truncated Abeta peptides that are less amyl

8 at the protective variant of CARD9, which is C-terminally truncated, acted in a dominant-negative man

9 approaches, we generated null and additional C-terminally truncated alleles in sut-6 and found that l

10 These new C-terminally truncated alpha- and beta-tubulin variants,

11 Herein, we demonstrate that C-terminally truncated alpha-Syn (alpha-SynDeltaC), enri

12 To investigate the presence of C-terminally truncated alpha-syn in DLBD, AD, and LBV, w

13 promoted conversion of both full-length and C-terminally truncated alpha-synuclein species into inso

14 and alphaB-crystallins on the degradation of C-terminally truncated alphaA-crystallin (alphaA(1-162))

15 damaged or abnormal lens proteins, including C-terminally truncated alphaA-crystallin.

16 AML1-ETO9a encodes a C-terminally truncated AML1-ETO protein of 575 amino aci

17 The tryptophan-substituted, B-chain C-terminally truncated analogs [TrpB25-alpha-carboxamide

18 c V(2)R agonists, we synthesized a series of C-terminally truncated analogues of [Val(4)]dDAVP, 2, mo

19 The mutant had both C-terminally truncated and full-length A17L open reading

20 rity of tau released from healthy neurons is C-terminally truncated and lacks the microtubule-binding

21 mutant class is made up of proteins that are C-terminally truncated and that cause a cold-sensitive g

22 reS2 deletions, preS2 start codon mutations, C-terminally truncated and/or "a" determinant mutated S

23 ugmented (1.5-4-fold) the binding of various C-terminally truncated apoB peptides to MTP.

24 mpts were made to study interactions between C-terminally truncated apoB polypeptides and MTP.

25 y and promotes receptor endocytosis, whereas C-terminally truncated ARR-1 does not.

26 of wild-type ARR-1, whereas expression of a C-terminally truncated ARR-1 effectively rescues only th

27 ombination and in vitro nuclease assays with C-terminally truncated ARTEMIS showing DNA-PKcs-independ

28 i, we determined x-ray crystal structures of C-terminally truncated Aspergillus nidulans and Coccidio

29 ly modified to improve J domain affinity and C-terminally truncated at position 14, 20, or 34 to stim

30 II-induced Src activation was abolished in a C-terminally truncated AT1a-(1--309), where Ang II-induc

31 We generated full-length and C-terminally truncated ATGL variants fused with various

32 Here, we solve the structure of a C-terminally truncated B. subtilis Noc bound to NBS DNA

33 ptor that is kinase-inactive (B82L-K721M) or C-terminally truncated (B82L-c'973) exhibit little PDGF-

34 nt effectively blocks apoptosis induced by a C-terminally truncated Bax molecule, but does not block

35 This screen identified a series of C-terminally truncated Bax molecules that contain comple

36 C-terminally truncated Bcl-xL(Delta21) interacts with pu

37 This mutation leads to reduced expression of C-terminally truncated BCOR (BCOR(DeltaE9-10)).

38 By using N- and C-terminally truncated beta- and gamma-subunits, we dete

39 In Xenopus, however, overexpression of C-terminally truncated beta-catenin activates Wnt signal

40 HCC-1937 breast cancer cells, which express C-terminally truncated BRCA1, was not affected by either

41 lypeptide from S. mutans Ingbritt, which was C-terminally truncated by approximately 400 aa residues,

42 ivo, we generated knock-in mice expressing a C-terminally truncated CBFbeta-SMMHC (CBFbeta-SMMHCDelta

43 Analysis of a series of C-terminally truncated Cbl mutants revealed that the N-t

44 CXCR4 and a C-terminally truncated CCR5 mutant (CCR5-KRFX) lacking t

45 a minimal PCNA-binding motif (aa 352-372) to C-terminally truncated Cdc27 derivatives restored proces

46 CHMP2B gene lead to the generation of mutant C-terminally truncated CHMP2B.

47 Deltatau314, the C-terminally-truncated cleavage products, are soluble an

48 C-terminally truncated Clk1(Delta487-610) was growth-inh

49 verexpression of Far1 restores inhibition of C-terminally truncated Cln3-1-associated kinase activity

50 Inhibition of the C-terminally truncated Cln3-1-associated kinase is not o

51 ed no increase in intrinsic Tnk1 activity in C-terminally truncated constructs, suggesting that the t

52 sing the full-length progranulin but not the C-terminally truncated constructs.

53 Analysis of a panel of C-terminally truncated Delta6-27p88 VacA proteins indica

54 s, hallmarks of Parkinson's disease, contain C-terminally truncated (DeltaC) alpha-synuclein (alpha-s

55 f secA, which results in the production of a C-terminally truncated derivative of SecA.

56 We also show that a C-terminally truncated DMyb protein, which is similar to

57 We found here that C-terminally truncated Drosophila TnT (TpnT-CD70) retain

58 1p active centers upon assembly with E2p and C-terminally truncated E2p proteins by hydrogen/deuteriu

59 crosomes containing the expressed ECaSt/PDI, C-terminally truncated ECaSt/PDI, calreticulin, or calse

60 Using C-terminally truncated EcoSSB mutant proteins, human mit

61 However, neither the C-terminally truncated EGF receptor (Delta1022-1186) nor

62 ected with (a) wild type EGF receptor, (b) a C-terminally truncated EGF receptor at residue 1022, (c)

63 runcated EGF receptor at residue 1022, (c) a C-terminally truncated EGF receptor at residue 973, or (

64 growth phenotype of yeast strains expressing C-terminally truncated eIF5B.

65 A nonsense mutation that resulted in a C-terminally truncated Ena protein lacking the EVH2 doma

66 microscopy studies have been performed with C-terminally truncated Env of the HIV-1(JR-FL) strain in

67 The resulting C-terminally truncated enzyme (ending at Ala(716)) is ac

68 atalytic activity was examined by studies on C-terminally truncated enzymes and on human/rat chimeric

69 g EGF receptors that are kinase-inactive, or C-terminally truncated, exhibit little migration toward

70 phage display libraries of N-terminally and C-terminally truncated FGF-BP1 fragments that were then

71 Importantly, the resulting C-terminally truncated fibrils acted as superior seeds i

72 Labeling of C-terminally truncated FN constructs revealed efficient

73 A C terminally-truncated form of NF-kappaB p100 (p85), pro

74 sion and localization of Tdrd6, identified a C-terminally truncated form as predominant after meiosis

75 NS2Aalpha, a C-terminally truncated form of 190 amino acids, results

76 constructs required the C terminus of Abl; a C-terminally truncated form of Abl was not activated, al

77 Using knockin (KI) mice expressing a C-terminally truncated form of ASXL1-mutant (ASXL1-MT),

78 The KaiBC sample was formed with a C-terminally truncated form of KaiC, KaiC-Delta489, whic

79 en probability of Kir6.2/SUR1 channels, or a C-terminally truncated form of Kir6.2 expressed in the a

80 ta are consistent with the hypothesis that a C-terminally truncated form of Ku80 is localized in mamm

81 REST4, a C-terminally truncated form of NRSF/REST, contains the f

82 e putative 75-kDa polypeptide of dCAF-1 is a C-terminally truncated form of p105 that does not coexis

83 onstituted system, as observed in cells, the C-terminally truncated form of p105, p97, was processed

84 roduce the largest increases in the Ki for a C-terminally truncated form of stromelysin 1, MMP-3(Delt

85 replication, we expressed a full-length or a C-terminally truncated form of SYNCRIP in mammalian cell

86 A recombinant, C-terminally truncated form of the beta subunit was empl

87 The enzymatic activity of a C-terminally truncated form of the RNA-dependent RNA pol

88 Surprisingly, the C-terminally truncated form of v-Abl (p90) transforms pr

89 A C-terminally truncated form of yapsin 1 (yeast aspartic

90 omplexes prepared with full-length beta or a C-terminally truncated form, supporting interesting para

91 RC-B contain the bZIP domain, and CRC-D is a C-terminally truncated form.

92 cent ciliary membrane, where it appears as a C-terminally truncated form.

93 Moreover, full-length Gli3 and all C-terminally truncated forms act antagonistically wherea

94 C-terminally truncated forms of alpha-syn enhance the ag

95 Truncations of QSR1 predicted to encode C-terminally truncated forms of Qsr1p do not substitute

96 reconstituted human P-protein complexes and C-terminally truncated forms with ricin A chain (RTA), w

97 interactions between MTP and apoB100 or its C-terminally truncated forms.

98 ccurs much more efficiently with a few N- or C-terminally truncated forms.

99 orting process and its fidelity, the fate of C-terminally truncated fragments of influenza hemaggluti

100 eceptor appears to enhance the production of C-terminally truncated fragments of the protein.

101 of wild-type or nitrated alpha-syn generate C-terminally truncated fragments that retain their fibri

102 expression pattern, however, with prominent C-terminally truncated fragments.

103 minant-negative mutant constructs encoding a C-terminally truncated FZD7 protein decreased wild-type

104 The mutations result in the expression of C-terminally truncated G-CSFRs that promote strong cell

105 We now show that GPIT complexes containing C-terminally truncated Gaa1 possess a full complement of

106 nding and assembly properties of a series of C-terminally truncated Gag mutants.

107 The minimal region in a series of C-terminally truncated Gag proteins conferring plasma me

108 syndromes, but it is not clear whether these C-terminally truncated Gli proteins fulfil the same func

109 Mutations in you-too (yot) encode C-terminally truncated Gli2.

110 , derived from the deregulated production of C-terminally truncated GLI3 proteins.

111 orm of the human H2A.Z-2 gene that encodes a C-terminally truncated H2A.Z protein that is similar to

112 Drosophila models, we provide evidence that C-terminally truncated Hay/XPB alleles enhance overgrowt

113 However, C-terminally-truncated HJURP, that does not bind CENP-A,

114 Finally, a C-terminally truncated HMW2 derivative was partly Triton

115 ic properties, and chaperone function of the C-terminally truncated human alphaA-crystallin mutants w

116 ably transfected with wild type (wt-CFTR) or C-terminally truncated human CFTR (CFTR-DeltaTRL).

117 Mice expressing C-terminally truncated human NK(1)R, corresponding to a

118 ), which mimics a naturally occurring N- and C-terminally truncated human p53 isoform, and by p53AS,

119 e have determined the crystal structure of a C-terminally truncated human Rab9 (residues 1-177) to 1.

120 The C-terminally-truncated human prion protein variant Y145S

121 ing domain for human VDR (hVDR), a series of C-terminally truncated hVDR mutants (Delta134, Delta113,

122 Expression of full-length and C-terminally truncated I-1 in HEK293T cells established

123 Cells that expressed a C-terminally truncated IL-13Ralpha2 chain (Delta335) did

124 The C-terminally truncated IN (residues 1-269) produced an i

125 he trapped synaptic complex using either the C-terminally truncated IN or wild type IN (1-286 residue

126 integrase-LexA DNA-binding domain, or N- or C-terminally truncated integrase-LexA proteins were fuse

127 a full-length isoform (CalDAG-GEF Ia) and a C-terminally truncated isoform (CalDAG-GEF Ib).

128 rom the 5' end of intron 4, which produces a C-terminally truncated isoform in lung and stomach.

129 n to transduce IL-4 signals through a unique C-terminally truncated isoform of STAT6.

130 We show that in contrast to C-terminally truncated isoforms, which do not co-fibrill

131 es of cysteine-to-serine substitutions and a C-terminally truncated ITF were made by PCR site-directe

132 n of the full-length Kv11.1a isoform and the C-terminally truncated Kv11.1a-USO isoform plays an impo

133 sting of full-length catalytic subunit and a C-terminally truncated large subunit.

134 by expression of full-length Lte1p but not a C-terminally truncated Lte1p lacking its GEF homology do

135 MCMV mutants lacking M45 or expressing C-terminally truncated M45 proteins induced neither NF-k

136 More importantly, we identify a new C-terminally truncated Matr3 isoform that is likely to b

137 Furthermore, by analysis of C-terminally truncated MeCP2 proteins, we found that bin

138 Further, a C-terminally truncated, membrane-anchorless hTPO(848) is

139 ys, the degree of association of a series of C-terminally truncated minireceptors with WT-M showed a

140 ut rather is the result of dominantly acting C-terminally truncated MN1 protein.

141 A severely C-terminally truncated molecule (lacking the last 207 am

142 re appearance of a stop-codon resulting in a C-terminally truncated molecule that is PEG-3.

143 Functional analyses of N- and C-terminally truncated molecules identify Msx2 residues

144 successfully identified the full length and C-terminally truncated monomeric Abeta species 1-35 to 1

145 C-terminally truncated MR-GEF, lacking the GEF catalytic

146 gulation is posttranslational and identify a C-terminally truncated MRE11, which is formed after HDAC

147 C-terminally truncated MT1-MMP lacking its transmembrane

148 Furthermore, the C-terminally truncated mtrII protein TTL49, but not trun

149 truncated human p53 isoform, and by p53AS, a C-terminally truncated murine p53 isoform generated thro

150 We found that C-terminally truncated mutant Armadillo has a deficit in

151 ansgenic mice expressing either wild-type or C-terminally truncated mutant CHMP2B.

152 d transforms 3T3 fibroblasts; in contrast, a C-terminally truncated mutant form of EWS-Fli1 that cann

153 C-terminally truncated mutant GLI3 proteins are also ass

154 ocalizations in transfected cells, whereas a C-terminally truncated mutant is essentially confined to

155 A C-terminally truncated mutant of bZIP28 eliminating most

156 immunoprecipitated Tpl-2 and Tpl-2deltaC (a C-terminally truncated mutant) phosphorylated and activa

157 the tight junction-associated protein ZO-1, C-terminally truncated mutants and a deletion mutant of

158 In this work, C-terminally truncated mutants which terminate at or nea

159 anical fingerprinting studies of a series of C-terminally truncated mutants, along with an analysis o

160 Six N- and/or C-terminally truncated mutants, delta(1-41), delta(1-59)

161 howing an elevated tumorigenic potential for C-terminally truncated mutants, our data suggest that th

162 2 mutants, the point mutation D511V, and the C-terminally truncated mutation R742X did not alter the

163 ficient (mdx; N=3) mice, and mice expressing C-terminally truncated Na(v)1.5 (DeltaSIV; N=3).

164 ANAP was incorporated in full-length and C-terminally truncated Na(v)1.5 channels using mammalian

165 A newly discovered C-terminally truncated native isoform, HRES-1/Rab4(1-121

166 rmined a 1.95 A X-ray crystal structure of a C-terminally truncated Neurospora crassa mitochondrial t

167 embryogenesis, nkap mutant zebrafish with a C-terminally truncated NKAP demonstrate severe developme

168 g enzyme (ADE), cleaves Abeta to produce the C-terminally truncated non-toxic Abeta fragment Abeta34

169 se, to create functional fusions from N- and C-terminally truncated, non-functional genes.

170 rated which possessed a full-length NS1 or a C-terminally truncated NS1 protein of 73, 99, or 126 ami

171 ength NTAP-UL28 fusion protein (vFH476) or a C-terminally truncated NTAP-UL28 fusion protein (vFH499)

172 e receptor was investigated by examining the C-terminally truncated or point-mutated mu opioid recept

173 A mutant with a C-terminally truncated ORF3 is noninfectious in pigs, in

174 ethal OXA2b T-DNA insertional mutants with a C-terminally truncated OXA2b lacking the TPR domain.

175 Ectopic expression of a C-terminally truncated P13 in B. burgdorferi indicated t

176 effector of the apoptosis induced by N- and C-terminally truncated p53, such that knockdown of IGFBP

177 lly rescues the cell death induced by N- and C-terminally truncated p53.

178 3 inhibit the induction of IGFBP3, such that C-terminally truncated p63 and p73 isoforms induce the e

179 termined the abilities of both wild-type and C-terminally truncated (p90) forms of v-Abl to transform

180 tely 60% decreased levels of piccolo that is C-terminally truncated (partial knockout), or <5% levels

181 The crystal structure of Pep2-8 bound to C-terminally truncated PCSK9 at 1.85 A resolution showed

182 R171) is activated by BigLEN, but not by the C terminally truncated peptide LittleLEN.

183 exon 2 and thus would be predicted to encode C-terminally truncated peptides of 153 and 509 aa long,

184 l determination revealed that MMP3 generated C-terminally truncated peptides of amino acids 1-78, 1-9

185 C-terminally truncated peptides with sequences ranging f

186 C-terminally truncated peripherin/rds (Xper38)-GFP chime

187 In transgenic Xenopus, a C-terminally truncated peripherin/rds-GFP fusion predomi

188 allele, pex14-3, accumulated low levels of a C-terminally truncated PEX14 product that retained parti

189 Whereas both N- and C-terminally truncated PG deletion mutants restored adhe

190 Detailed analyses of the C-terminally truncated PGD2-1 protein showed that peroxi

191 development, a progressive accumulation of a C-terminally truncated polypeptide of approximately 51 k

192 Recombinant C-terminally truncated prion protein PrP23-144 (which co

193 ically inactive SpoIVFB was coexpressed with C-terminally truncated Pro-sigma(K)(1-126) (which can be

194 rsions of catalytically inactive SpoIVFB and C-terminally truncated Pro-sigma(K)(1-126) (which can be

195 trate for RIP were investigated by producing C-terminally truncated pro-sigmaK fused at different poi

196 press full-length progranulin, two different C-terminally truncated progranulin proteins, lacking eit

197 The susceptibility allele encodes a C-terminally truncated protein (Oas1b-tr).

198 aled that the Cvi-1 FtsZ2-2 allele encodes a C-terminally truncated protein lacking a region required

199 ional disruption of RPM2, which produces the C-terminally truncated protein Rpm2-DeltaCp, supports gr

200 ated decay (NMD), and most likely generate a C-terminally truncated protein with a distinct -1 readin

201 s predicted to produce a 199-amino acid-long C-terminally truncated protein, likely to be inactive.

202 Several additional alleles that encode C-terminally truncated proteins or proteins containing i

203 Our observations that such C-terminally truncated proteins promote efficient TLS op

204 CH/CMML-associated ASXL1 mutations encode C-terminally truncated proteins that enhance the deubiqu

205 9d--three of which could potentially produce C-terminally truncated proteins that lack the RPGR-inter

206 always degraded efficiently and can generate C-terminally truncated proteins which might have residua

207 ns by proteases results in the generation of C-terminally truncated proteins, called STATgamma, which

208 C-terminally truncated proyapsin 1 was also expressed in

209 The C-terminally truncated receptor and mutant receptor T394

210 to 5 microM of DAMGO, phosphorylation of the C-terminally truncated receptor and the mutant receptor

211 ls expressing either the wild-type human IR, C-terminally truncated receptors, or mutant receptors wi

212 (q/11) coupling, we constructed chimeric and C-terminally truncated receptors.

213 also displayed activities similar to that of C-terminally truncated receptors.

214 of 41-year-old lenses were: alphaA-fragment (C-terminally truncated, residues 1-157), alphaB-fragment

215 rm a tight 1:1 binary complex where XptC1 is C-terminally truncated, resulting in a 77-kDa protein.

216 The defect is suppressed by expression of C-terminally truncated Rim101-405p, as expected for muta

217 growth phenotype caused by overexpression of C-terminally truncated Rpl10p and found that these Rpl10

218 Cells transduced with a C-terminally truncated Runx1 (Runx1.d190), which lacks i

219 The intracellular form of the C-terminally truncated S protein (but not the secreted f

220 By contrast, C-terminally truncated septin mutants form 4-nm thin mon

221 vel polyclonal antibody (SYN105) against the c-terminally truncated sequence (amino acids 121 to 123)

222 Experiments using a series of N- and C-terminally truncated SH2-Bbeta constructs indicate tha

223 Furthermore, three C-terminally truncated SloR variants were generated usin

224 fusion proteins indicate that both SMAD4 and C-terminally truncated SMAD3, but not SMAD2, can bind th

225 A C-terminally truncated SNAP-47 was impaired in interacti

226 addition, similar quantities of the soluble, C-terminally truncated somatic isozyme of ACE (ACEP) wer

227 he importance of full-length CaV1.3L and two C-terminally truncated splice variants (CaV1.342A and Ca

228 have solved the X-ray crystal structure of a C-terminally truncated Spo0J (amino acids 1-222) from Th

229 ining the role of this subunit, we find that C-terminally truncated SPT7 resulted in derepressed HIS3

230 1-derived NLS-GFP fusion protein and several C-terminally truncated Ssd1 proteins, which presumably l

231 red plasma levels of full-length and several C-terminally truncated subfractions of RBP4 among 468 wo

232 between gp3 rings containing full-length and C-terminally truncated subunits are consistent with loca

233 s of a Sup35 point mutation as well as N and C-terminally truncated Sup35 fragments is further demons

234 exes containing a series of N-terminally and C-terminally truncated Swr1 subunits reveal further deta

235 tau, 3R and 4R tau isoforms, ubiquitin, and C-terminally truncated tau.

236 Mutant viruses with a C-terminally truncated TFP (19, 32, or 50 residues) had

237 x metalloproteinase inhibitory activity, was C-terminally truncated to remove its toxic vasopressive

238 Intriguingly, native C-terminally truncated Toutatis isoforms do not associat

239 In RVCL, an aberrant, C-terminally truncated TREX1 mislocalizes to the nucleus

240 A C terminally truncated variant of HjLPMO9A containing 21

241 study, we present a model system in which a C-terminally truncated variant of androgen receptor (TC-

242 Two C-terminally truncated variants (NK1 and NK2) of this gr

243 des domains responsible for the binding, two C-terminally truncated variants of recombinant fimbrilli

244 creased ATPase and chaperone activity of the C-terminally truncated variants.

245 notypic effects, whereas overexpression of a C-terminally truncated version disturbed tube growth, su

246 A full-length and C-terminally truncated version of human endogenous retro

247 n of Gag that is missing the MA domain and a C-terminally truncated version that is missing the NC do

248 by heterologously expressed full-length and C-terminally truncated versions of Anabaena sensory rhod

249 C-terminally truncated versions of Rta bind DNA efficien

250 Furthermore, a C-terminally truncated Vpr mutant and point mutants R80A

251 exon 6 of PPM1D that result in expression of C-terminally truncated Wip1.

252 A C-terminally truncated Y145Stop variant of the human pri