ライフサイエンスコーパス: C. jejuni

1 C. jejuni 81-176 naturally lacks the fuc locus and is un

2 C. jejuni also activated the NLRP3 inflammasome in human

3 C. jejuni also transitioned to coccoid within epithelial

4 C. jejuni belongs to the commensal microbiota of a numbe

5 C. jejuni DNA was less prevalent (42% of samples positiv

6 C. jejuni helical shape and corresponding peptidoglycan

7 C. jejuni IA3902 (representative of the sheep abortion c

8 C. jejuni is capable of systemic invasion in the rabbit,

9 C. jejuni is known to produce capsular polysaccharide (C

10 C. jejuni lineages vary in host range and prevalence in

11 C. jejuni lipooligosaccharide (LOS) is a potent activato

12 C. jejuni NCTC11168 forms less biofilms in the presence

13 C. jejuni possesses an unusual phospholipidome that is h

14 C. jejuni regulates gene expression under various enviro

15 C. jejuni typically colonizes the gut, but a hypervirule

16 C. jejuni-induced bactericidal NO production was reduced

17 genomic variation associated with AMR in 168 C. jejuni and 92 C. coli strains isolated from humans, l

18 cteriosis isolates, comprising 2,207 (89.3%) C. jejuni isolates and 265 (10.7%) C. coli isolates.

19 ed the antimicrobial susceptibilities of 320 C. jejuni and 115 C. coli isolates obtained from feedlot

20 erent time periods and compared them with 42 C. jejuni isolates associated with sheep abortion during

21 Here, we analyzed 54 C. jejuni isolates collected from U.S. sheep abortions a

22 LST-characterised isolates, we sequenced 600 C. jejuni and C. coli isolates from various stages of po

23 The first outbreak involved 1,644 C. jejuni infections at 11 state correctional facilities

24 is study, we examined stress tolerance in 70 C. jejuni strains isolated from retail chicken under sev

25 A C. jejuni addAB mutant demonstrated enhanced sensitivity

26 A C. jejuni transposon (Tn) mutant library was screened fo

27 tients, who previously developed GBS after a C. jejuni infection (n = 27) and controls (n = 26).

28 To address this, we generated a C. jejuni transposon mutant library that is amenable to

29 Furthermore, incubation of CTB or LTB with a C. jejuni isolate capable of altering its lipooligosacch

30 vailable mouse monoclonal antibodies against C. jejuni were investigated to construct direct, sandwic

31 s in understanding the mechanisms that allow C. jejuni to colonize the chicken gastrointestinal tract

32 Although C. jejuni can be transformed by C. jejuni-derived DNA, i

33 Altogether, C. jejuni was isolated from 7 of 15 (46.7%) bovine fecal

34 hese loci had alleles that were shared among C. jejuni and C. coli consistent with horizontal transfe

35 es and time of isolation, while the analyzed C. jejuni isolates were genetically diverse, suggesting

36 roglodytis (33%), C. upsaliensis (7.7%), and C. jejuni/C. coli (2.6%).

37 est that in the gut of warm-blooded animals, C. jejuni depends on at least formate or hydrogen as don

38 As C. jejuni transformed from helical to coccoid, peptidogl

39 -10 expression, an intriguing observation as C. jejuni FlaA is not a TLR5 agonist.

40 sistant profile of these outbreak-associated C. jejuni isolates.

41 In contrast to NLRP3 activation by ATP, C. jejuni activation did not require priming of these ma

42 Furthermore, neutrophil depletion attenuated C. jejuni-induced crypt abscesses and intestinal inflamm

43 Importantly, sodium nitroprusside attenuated C. jejuni-induced colitis in Il10(-/-); Nod2(-/-) mice.

44 flagella-TLR5 driven pro-inflammatory axis, C. jejuni flagella instead promote an anti-inflammatory

45 we studied LOS structural variation between C. jejuni strains associated with different ecological s

46 to effectively control infections caused by C. jejuni.

47 critical for normal chicken colonization by C. jejuni.

48 consumption of meat that was contaminated by C. jejuni during harvest.

49 se leads to secretion of an alpha-dextran by C. jejuni and that a secreted protease, Cj0511, is requi

50 Lipo-oligosaccharides (LOS), expressed by C. jejuni induce antibodies that cross-react with self-g

51 e use of enterobactin hydrolysis products by C. jejuni, Vibrio cholerae, and other bacteria with homo

52 Although C. jejuni can be transformed by C. jejuni-derived DNA, it is poorly transformed by the s

53 ght into the molecular mechanism utilized by C. jejuni, and possibly other intestinal pathogens, to s

54 Decreased contamination of drinking water by C. jejuni and S. enterica was also observed, suggesting

55 educe colonization of natural and challenged C. jejuni and natural Salmonella enterica.

56 nd shows antibody is ineffective in clearing C. jejuni from the ceca within the production lifetime o

57 comparison of our isolates with 249 clinical C. jejuni from other states showed frequent phylogenetic

58 We conclude that the diversity of clinical C. jejuni in New Hampshire in 2017 was driven mainly by

59 ility of the immune system to detect coccoid C. jejuni may be significant in its pathogenesis.

60 ifferences in pathogenic properties; coccoid C. jejuni were non-motile and non-infectious, with minim

61 In contrast, C. jejuni isolates from Great Britain were genetically d

62 the effectiveness of LC(+mcra) in decreasing C. jejuni colonization by means of kanamycin resistant s

63 ulturing (plating) method was able to detect C. jejuni in the real chicken sample at less than 500 CF

64 ion in both the OS and LA among 15 different C. jejuni isolates.

65 blockade of PI3K-gamma signaling diminished C. jejuni-induced intestinal inflammation, neutrophil ac

66 gating genetic markers that can discriminate C. jejuni source were used with STRUCTURE software to pr

67 obe sequences from 1,713 genetically diverse C. jejuni and C. coli genomes, supported by RT-PCR testi

68 lack of insight into the mechanisms driving C. jejuni growth and survival within hosts and the envir

69 Genes preferentially expressed during C. jejuni infection were screened, and acs, cj1385, cj02

70 ystem was found to be required for efficient C. jejuni colonization of the chicken intestine.

71 ridization and culture assay showed enhanced C. jejuni invasion into the colon and mesenteric lymph n

72 haped laboratory, clinical and environmental C. jejuni and Campylobacter coli contained genetic chang

73 ficity of the protein N-glycosylation enzyme C. jejuni PglB was tested using a logical, synthetic arr

74 ped severe intestinal inflammation following C. jejuni infection, compared with Nod2(-/-) and Il10(-/

75 For C. jejuni, strains with the fuc locus possess a competit

76 100% for Shigella spp., 97.5% and 99.0% for C. jejuni and C. coli, and 100% and 99.7% for Shiga toxi

77 99.7% for Shigella spp., 97.2% and 98.4% for C. jejuni and C. coli, and 97.4% and 99.3% for Shiga tox

78 , 8 x 10(-6), and 3 x 10(-7) [corrected] for C. jejuni, Salmonella spp., and enteroviruses, respectiv

79 We compared culture for C. jejuni/C. coli, EIA (ProSpecT), and duplex PCR to dis

80 ative Microbial Risk Assessment was done for C. jejuni, Salmonella spp., and enteroviruses to estimat

81 CFU mL(-1), the minimum infectious dose for C. jejuni while a commercial ELISA kit was unable to det

82 Instead, secretion of CiaI was essential for C. jejuni to facilitate commensal colonization of the na

83 ce in dairy manure, while risk estimates for C. jejuni were not sensitive to any single variable.

84 The DL-carboxypeptidase Pgp1 important for C. jejuni helical morphology and putative N-acetylmuramo

85 f a rapid and sensitive detection method for C. jejuni.

86 e a rapid and sensitive detection method for C. jejuni.

87 orrelated with possession of the pathway for C. jejuni RM1221 (fuc+) and 81116 (fuc-).

88 IA-positive samples were positive by PCR for C. jejuni/C. coli, but 27.6% were positive for non-jejun

89 tively, compared with the results of PCR for C. jejuni/C. coli.

90 DNA synthesis via RNR which is required for C. jejuni's growth.

91 s, cj1385, cj0259 seem to be responsible for C. jejuni invasion.

92 r, these results support a critical role for C. jejuni's helical morphology in enabling it to travers

93 -SPR method showed excellent sensitivity for C. jejuni with a limit of detection (LOD) of 131 +/- 4 C

94 ents that define the morphological shape for C. jejuni as an intestinal pathogen.

95 ), whereas pigs were a negligible source for C. jejuni infections.

96 Formate, a primary energy source for C. jejuni, inhibits oxidase activity in other bacteria.

97 ing (WGS) has emerged as a powerful tool for C. jejuni outbreak detection.

98 butyrate sensing by this system is vital for C. jejuni colonization of multiple hosts.

99 We found C. jejuni to be a potent inducer of human and murine DC

100 e identical structure purified directly from C. jejuni.

101 pCJDM202 (119 kb) and pCJDM67L (116 kb) from C. jejuni strains WP2-202 and OD2-67, respectively, were

102 When the megaplasmid pCJDM202 from C. jejuni WP2-202 was transferred via conjugation to C.

103 aseline diversity of the wider New Hampshire C. jejuni population during the outbreak.

104 The mean probability of human C. jejuni isolates to originate from chickens was highes

105 evelopment of vaccines against hypervirulent C. jejuni.

106 ed limited resolution to adequately identify C. jejuni outbreaks and separate out sporadic isolates d

107 In C. jejuni, TsdA Heme 2 has His/Met ligation and an E(m)

108 uoroquinolone resistance reached to 35.4% in C. jejuni and 74.4% in C. coli, which are significantly

109 g the differential level of aerotolerance in C. jejuni and that AT and HAT strains of C. jejuni are m

110 ts and phase-variants, the cj0031c allele in C. jejuni strain NCTC11168 was demonstrated to specifica

111 407 cells in vitro The importance of Ape1 in C. jejuni biology makes it a good candidate as an antimi

112 Additionally, overexpression of arsB in C. jejuni 11168 resulted in a 16-fold increase in the MI

113 Inactivation of arsB in C. jejuni resulted in 8- and 4-fold reduction in the MIC

114 protein while CtsP is membrane associated in C. jejuni.

115 In certain environments, changes in C. jejuni morphology due to genetic heterogeneity may pr

116 Here, oxygen-dependent changes in C. jejuni physiology were studied at constant growth rat

117 high-level resistance to chloramphenicol in C. jejuni, using integrated genomic and proteomic analys

118 ique Ent trilactone esterase Cee (Cj1376) in C. jejuni.

119 ide sensitivity, and chicken colonization in C. jejuni Inactivation of the CjNC110 ncRNA led to a sta

120 st abundant periplasmic c-type cytochrome in C. jejuni, as a novel and unexpected protein required fo

121 pendent manner but a significant decrease in C. jejuni colonization in the spleen and liver of chicke

122 This mechanism of DNA discrimination in C. jejuni is distinct from the DNA discrimination descri

123 that Cee is the sole trilactone esterase in C. jejuni.

124 aspecies conservation of the target genes in C. jejuni and C. coli Rare instances of a lack of specif

125 plain the essential role of glycosylation in C. jejuni motility, and show how the outer domains have

126 A genome-wide association study (GWAS) in C. jejuni ST-21 and ST-45 complexes identified genetic e

127 rulence plasmid named pVir was identified in C. jejuni 81-176 and IA3902, but determining the role of

128 enella resulted in a significant increase in C. jejuni colonization in the cecum in a parasite dose-d

129 onization, and host-pathogen interactions in C. jejuni Therefore, changes in PG greatly impact the ph

130 s and other arsenic resistance mechanisms in C. jejuni have not been characterized.

131 are major contributors to microaerophily in C. jejuni; hemerythrins help prevent enzyme damage micro

132 orA mRNA and immunoblot detection of MOMP in C. jejuni showed that disruption of T (porA) significant

133 CjNC110 is a conserved ncRNA in C. jejuni, located downstream of the luxS gene, which is

134 not required to regulate flagellar number in C. jejuni.

135 Despite the importance of porA in C. jejuni pathogenesis, mechanisms modulating its expres

136 ernative mechanism for arsenic resistance in C. jejuni and provide new insights into the adaptive mec

137 assage on calcofluor white (CFW) resulted in C. jejuni 81-176 isolates with morphology changes: eithe

138 ergy metabolism and microaerobic survival in C. jejuni.

139 nes required for efficient transformation in C. jejuni include those similar to components of type II

140 re gene with the highest p-distance value in C. jejuni was annotated in the reference genome as a put

141 Recent work in C. jejuni identified a gene encoding a novel phosphoetha

142 Formate also significantly increased C. jejuni's growth, motility, and biofilm formation unde

143 ggesting that chicken transmission increased C. jejuni virulence.

144 t the toxin B-subunits (CTB and LTB) inhibit C. jejuni growth by binding to GM1-mimicking lipooligosa

145 tinal inflammation in response to intestinal C. jejuni infection.

146 oration of the carbohydrate sialic acid into C. jejuni lipooligosaccharides (LOS) is associated with

147 Herein, we aimed to investigate C. jejuni-mediated effects on dendritic cell (DC) immuni

148 oxygen-sensitive (OS) strains of C. jejuni, C. jejuni strains with increased aerotolerance, such as

149 WGS analysis linked C. jejuni isolates in humans and pet store puppies even

150 populations and provides evidence that major C. jejuni lineages have distinct genotypes associated wi

151 In this model, C. jejuni successfully established infection and piglets

152 At the cellular level, Cj-P1 induced more C. jejuni invasion and neutrophil infiltration into the

153 Most C. jejuni capsules are known to be decorated nonstoichio

154 We also demonstrate that the native C. jejuni flagellum filament is 11-stranded, contrary to

155 -positive bacteria but also in Gram-negative C. jejuni, advancing our knowledge of the methods of sur

156 mutant studies reveal are needed for normal C. jejuni motility at low oxygen conditions.

157 ed in dissemination of FQ(R) C. coli but not C. jejuni.

158 We report novel C. jejuni factors essential throughout its life cycle.

159 D) of 150 colony forming unit (CFU)mL(-1) of C. jejuni in solution.

160 Here, we report a detailed analysis of C. jejuni fitness across models reflecting stages in its

161 PCR analysis of C. jejuni isolates from different animals hosts indicate

162 Furthermore, analysis of C. jejuni localization within the ceca of infected mice

163 Analysis of a vast array of C. jejuni mutants with defects in capsule formation, LPS

164 The capsule of C. jejuni 81-176 has been shown to be required for serum

165 hypervirulent and rapidly expanding clone of C. jejuni recently emerged, which is able to translocate

166 ners of CjNC110 in a sheep abortion clone of C. jejuni These data were then utilized to focus further

167 ainable approach to decrease colonization of C. jejuni and S. enterica in poultry gut along with othe

168 Control of C. jejuni is a priority for the poultry industry but no

169 of the phosphoramidate moiety in the CPS of C. jejuni is unknown.

170 with a couple of exceptions, the ecology of C. jejuni and C. coli differed, with the latter forming

171 it is important to control the elevation of C. jejuni virulence during chicken transmission process.

172 Exposure of C. jejuni to pancreatic amylase promotes biofilm formati

173 nhydrases (CAs) are encoded in the genome of C. jejuni strain NCTC 11168 (Cj0229 and Cj0237).

174 logy models of the N-linked glycoproteome of C. jejuni This evaluation highlights the potential diver

175 eacts with superoxide, rescued the growth of C. jejuni cultured in the presence of deoxycholate.

176 More specifically, continuous growth of C. jejuni in deoxycholate was found to: 1) induce the pr

177 We recently found that growth of C. jejuni in medium with deoxycholate, a component of bi

178 essity of the pmf for motility and growth of C. jejuni.

179 y poor understanding of the immunobiology of C. jejuni infection.

180 s of infection, the adhesion and invasion of C. jejuni to eukaryotic cells.

181 t associated with the aerotolerance level of C. jejuni.

182 des composed of the inner-core of the LOS of C. jejuni extended by various ganglioside mimics.

183 ypeptidase Pgp1 essential for maintenance of C. jejuni helical shape was recently identified.

184 ives a unique insight into the mechanisms of C. jejuni disease in terms of host physiology and contri

185 Specifically, we show that modification of C. jejuni lipid A with pEtN results in increased recogni

186 e valuable insights into the pathobiology of C. jejuni sheep abortion clone and strongly suggest that

187 el to study determinants of pathogenicity of C. jejuni.

188 butor to the capnophilic growth phenotype of C. jejuni.

189 a suggest that the capsule polysaccharide of C. jejuni and the MeOPN modification modulate the host i

190 e related to the capsular polysaccharides of C. jejuni HS:4 is very remarkable, owing to the unique,

191 y to accurately assess how the population of C. jejuni changes over the long term.

192 Presence of C. jejuni was solely associated with poultry (OR: 4.7 (9

193 l shape and extended this to a wide range of C. jejuni and C. coli isolates.

194 mprovement was accompanied by a reduction of C. jejuni translocation into the colon and extraintestin

195 Instead, two regions of C. jejuni FlhG that are absent or significantly altered

196 is required for the chemotactic response of C. jejuni to galactose, as shown using wild type, alleli

197 aluable tools for investigating the roles of C. jejuni cell surface glycoconjugates in host pathogen

198 n the reannotation of the genome sequence of C. jejuni isolate NCTC 11168, chosen as being present in

199 Following deep sequencing of C. jejuni mutants in the cecal outputs, several novel fa

200 Utilizing a series of C. jejuni isogenic mutants we found the major flagellin

201 , these results indicate that sialylation of C. jejuni LOS increases DC activation and promotes subse

202 was caused by a single, persistent strain of C. jejuni belonging to clonal complex ST-45, with eviden

203 and in vivo of a highly pathogenic strain of C. jejuni.

204 s on the survivability of several strains of C. jejuni and C. coli, which were previously isolated fr

205 in C. jejuni and that AT and HAT strains of C. jejuni are more tolerant to oxidants and low temperat

206 The HAT and AT strains of C. jejuni exhibited significantly increased activities o

207 Compared to oxygen-sensitive (OS) strains of C. jejuni, C. jejuni strains with increased aerotoleranc

208 We report the 2.1-A crystal structure of C. jejuni MOMP expressed in E. coli and a lower resoluti

209 hicken liver juices enhanced the survival of C. jejuni and C. coli strains at low temperatures, which

210 for CeuE within the Fe(III) uptake system of C. jejuni, provide a molecular-level understanding of th

211 Here we report the complete transcriptome of C. jejuni during colonization of the chicken cecum and i

212 tial for their function in transformation of C. jejuni.

213 these analyses enhance our understanding of C. jejuni PG maturation and help to clarify how PG struc

214 ing its mRNA and influences the virulence of C. jejuni.

215 , which has two major porins, OmpC and OmpF, C. jejuni has one, termed major outer membrane protein (

216 the impact that E. tenella infection had on C. jejuni colonization of chickens, including the influe

217 eltapatA and DeltapatB had minimal impact on C. jejuni growth and fitness under the conditions tested

218 C. coli, one additional E. faecium, and one C. jejuni also developed resistance when exposed to 0.25

219 her, formate might play a role in optimizing C. jejuni's adaptation to the oxygen-limited gastrointes

220 Like many competent organisms, C. jejuni restricts the DNA that can be used for transfo

221 are essential for DNA replication) in other C. jejuni genomes.

222 Overall, C. jejuni strains showed greater survival in retail live

223 cells of the microaerophilic human pathogen C. jejuni using RNA-seq revealed differential expression

224 Like many bacterial pathogens, C. jejuni assembles complex surface structures that inte

225 e development of novel strategies to prevent C. jejuni colonization of food-producing animals or to t

226 ogy due to genetic heterogeneity may promote C. jejuni survival.

227 that exposure to pancreatic amylase protects C. jejuni from stress conditions in vitro, suggesting th

228 he single Thr-86-Ile mutation in GyrA, FQ(R) C. jejuni isolates had other mutations in GyrA in additi

229 Kinetic studies with purified recombinant C. jejuni TsdA showed it to be a bifunctional tetrathion

230 LC(+mcra) was found to reduce C. jejuni colonization in cecum, ileum and jejunum, by m

231 8 multistate outbreak of multidrug-resistant C. jejuni Here, we aimed to elucidate the baseline diver

232 a highly pathogenic, tetracycline-resistant C. jejuni clone (named SA) has become the predominant ca

233 Mainly isolated from stool samples, C. jejuni can also become invasive.

234 We have searched C. jejuni genome for homologues and found one candidate

235 straight morphology, representing the second C. jejuni gene affecting cell shape.

236 All rod-shaped C. jejuni Tn mutants and all rod-shaped laboratory, clin

237 in the increased pathogenicity of sialylated C. jejuni and may be key to the initiation of B cell-med

238 the amplified response of DCs to sialylated C. jejuni LOS is CD14 dependent.

239 gs reveal the emergence of cattle specialist C. jejuni lineages from a background of host generalist

240 Here we used an infant rabbit to study C. jejuni infection, which enables us to define several

241 In this study, C. jejuni arsP was expressed in Escherichia coli and sho

242 tent Escherichia coli and the native system, C. jejuni, revealed that efficient glycosylation of glyc

243 In response to a low oxygen tension, C. jejuni increases the transcription and activity of th

244 nalyzed for Campylobacter species other than C. jejuni and C. coli using a filtration method and micr

245 We previously discovered that C. jejuni has the capacity to spatially discern differen

246 tion cryoelectron microscopy (cryo-EM), that C. jejuni accommodated these mutations by forming filame

247 Additionally, we found that C. jejuni FlhG influences FlhF GTPase activity, which ma

248 We hypothesized that C. jejuni must repair DNA damage caused by reactive oxyg

249 Our findings indicate that C. jejuni-induced PI3K-gamma signaling mediates neutroph

250 In this study, we report that C. jejuni infection of mouse macrophages induces upregul

251 Subsequently, we showed that C. jejuni 81-176 (wildtype) exhibited enhanced chemoattr

252 The C. jejuni invasion-related activation of the NLRP3 infla

253 etween peptide and glycan substrates and the C. jejuni PglB offer new experimental information on sub

254 Further, we assessed the C. jejuni genes required for infection of the porcine ga

255 We explored how the C. jejuni flagellum is a versatile secretory organelle b

256 In this study, we identified the C. jejuni butyrate-modulated regulon and discovered that

257 The residues in the C. jejuni TLR5 epitope have reduced contacts with the ad

258 In the guinea pig model, the C. jejuni construct with an interrupted T (porA) was sig

259 e now determined the atomic structure of the C. jejuni G508A flagellar filament from a 3.5- angstrom-

260 A comparison of the C. jejuni requirements to colonize the mouse intestine w

261 activation libraries were generated in three C. jejuni strains and the impact on fitness during chick

262 for fitness during in vitro growth in three C. jejuni strains, revealing that a large part of its ge

263 i WP2-202 was transferred via conjugation to C. jejuni NCTC11168 Nal(+), transconconjugants acquired

264 mmasome activation and likely contributes to C. jejuni-induced intestinal inflammation.

265 his is first study of functional immunity to C. jejuni in chicken and shows antibody is ineffective i

266 ologic development of protective immunity to C. jejuni, we assessed the ability of an initial infecti

267 strain differences in protective immunity to C. jejuni.

268 retreated with anti-IL-10R were resistant to C. jejuni-induced intestinal inflammation compared with

269 ctional role of B lymphocytes in response to C. jejuni in the chicken through depletion of the B lymp

270 gh intrinsic dendritic cell (DC) response to C. jejuni LOS through Toll-like receptor 4 (TLR4) activa

271 The DC response to C. jejuni LOS was highly variable between, but not withi

272 igger intestinal inflammation in response to C. jejuni.

273 High responsiveness to C. jejuni LOS by former GBS patients was evidenced by in

274 Intrinsic DC responsiveness to C. jejuni LOS was investigated first in 20 healthy contr

275 ep abortion clone) is genetically similar to C. jejuni W7 (representative of strain type NCTC 11168);

276 bbit polyclonal antibody with specificity to C. jejuni was first mixed with C. jejuni cells and unbou

277 ility to highly regulate gene transcription, C. jejuni encodes few transcription factors and its geno

278 nd PCR-derived DNA can efficiently transform C. jejuni when only a subset of the CtsM sites are methy

279 ous recombination is sufficient to transform C. jejuni, whereas otherwise identical unmethylated DNA

280 DNA derived from a ctsM mutant transforms C. jejuni significantly less well than DNA derived from

281 It remains unknown how chicken-transmitted C. jejuni and microbiota impact on human campylobacterio

282 those elicited by the helix-shaped wild-type C. jejuni and complemented strains.

283 ired for in vitro competition with wild-type C. jejuni but is dispensable for growth in monoculture.

284 ne operon) are widely distributed in various C. jejuni strains, suggesting that Campylobacter require

285 rends within this Tn library, and in various C. jejuni wild type strains, were compared and correlate

286 We identified the ability of both viable C. jejuni and purified flagellum to bind to Siglec-10, a

287 e ceca, the main site of colonisation, where C. jejuni persist to beyond commercial slaughter age, bu

288 this mouse model was used to define whether C. jejuni's characteristic helical shape plays a role in

289 While C. jejuni PglB (CjPglB) can transfer many diverse glycan

290 e blue with E. coli K12 and rose bengal with C. jejuni showed an enhancing effect.

291 C. jejuni received an initial challenge with C. jejuni CG8421 with rechallenge 3 months later.

292 Compared with C. jejuni NCTC 11168 and 81-176, a clone SA isolate (IA3

293 Il10(-/-);Rag2(-/-) mice were infected with C. jejuni (10(9) CFU/mouse).

294 Il10(-/-); Nod2(-/-) mice were infected with C. jejuni (10(9) colony-forming units/mouse) 24 hours af

295 Less than 1 in 1,000 persons infected with C. jejuni develop GBS, and the factors that determine GB

296 subjects underwent a primary infection with C. jejuni CG8421; 14 (93.3%) experienced campylobacterio

297 immunologic evidence of prior infection with C. jejuni received an initial challenge with C. jejuni C

298 e development of GBS after an infection with C. jejuni.

299 pecificity to C. jejuni was first mixed with C. jejuni cells and unbound antibody was subsequently se

300 ur findings provide further evidence that WW C. jejuni subtypes show niche adaptation and may be impo