ライフサイエンスコーパス: C2H2

1 C2H2 zinc finger bearing proteins are a large superfamil

2 C2H2 zinc finger protein genes encode nucleic acid-bindi

3 C2H2 zinc finger proteins that do not bind arsenic were

4 C2H2 zinc fingers are found in several key transcription

5 C2H2 zinc fingers define the largest transcription facto

6 C2H2 zinc-finger family members are key targets of DE mi

7 C2H2 zinc-finger proteins play important roles in plant

8 KS1 contains 10 C2H2 zinc fingers, a KRAB-A/B motif, and an ID sequence

9 st three protein isoforms that contain 12-18 C2H2 zinc fingers.

10 ula, a member of the Cysteine-2/Histidine-2 (C2H2) family of plant TFs that is required for normal sy

11 dt =1,3-propanedithiolate and dppv = cis-1,2-C2H2(PPh2)2), was generated by reduction of the differou

12 A domain and a SCAN domain, but lacks the 22 C2H2-type zinc fingers present in ZnF197.

13 brid screen, encoded a protein containing 29 C2H2 zinc fingers of the TFIIIA type.

14 transcription factors that share a common 3 C2H2 zinc finger DNA binding domain and have broad activ

15 ription factors and is found in more than 60 C2H2 zinc finger genes in the human genome, including th

16 OVOL2 encodes ovo-like zinc finger 2, a C2H2 zinc-finger transcription factor that regulates mes

17 Our previous studies showed that UNC-98, a C2H2 Zn finger protein, acts as a linkage between UNC-97

18 usly reported structures, Sgf73 ZnF adopts a C2H2 coordination with unusual tautomeric forms for the

19 he Drosophila Doublefault (Dbf) protein as a C2H2 zinc-finger protein, primarily expressed in testes,

20 We cloned grauzone and identified it as a C2H2-type zinc finger transcription factor.

21 gle DNA binding homeodomain but lacks both a C2H2 zinc finger DNA binding domain and an apparent Dig1

22 ee different protein isoforms that contain a C2H2 zinc-finger domain.

23 Peg3 encodes a C2H2 type zinc finger protein that is implicated in a no

24 The die-1 gene encodes a C2H2 zinc finger protein containing four fingers, which

25 sible for awn inhibition in wheat, encodes a C2H2 zinc finger protein with EAR motifs which putativel

26 RABBIT EARS (RBE) encodes a C2H2 zinc finger transcriptional repressor and is requir

27 tlp-1 encodes a C2H2 zinc-finger protein that is a member of the Sp fami

28 him-8 encodes a C2H2 zinc-finger protein that is expressed during meiosi

29 We show that lin-48 encodes a C2H2 zinc-finger protein that is similar to the product

30 Mutants of pita, which encodes a C2H2 zinc-finger protein, are homozygous lethal and show

31 We cloned ehn-3, and found that it encodes a C2H2 zinc-finger protein.

32 development, POPOVICH (POP), which encodes a C2H2 zinc-finger transcription factor.

33 The SUPERMAN (SUP) gene encodes a C2H2 zinc-finger transcriptional repressor that regulate

34 Sh1 encodes a C2H2-like zinc finger transcription factor that promotes

35 oned pag-3 and found that the gene encodes a C2H2-type zinc finger protein related to the mammalian G

36 UP, also called FLO10) gene, which encodes a C2H2-type zinc finger protein, is involved in maintenanc

37 cribe a POINTED TIP (PT) gene that encodes a C2H2-type zinc finger transcription factor.

38 The grauzone gene encodes a C2H2-type zinc-finger transcription factor that binds to

39 forty leaflets, we show that MPL1 encoding a C2H2-zinc finger protein sculpts a morphogenetic gradien

40 ene, No Transmitting Tract (NTT), encoding a C2H2/C2HC zinc finger transcription factor specifically

41 Here we provide evidence for a C2H2 zinc finger gene family with similarity to Ikaros a

42 identified SUF4 (SUPPRESSOR OF FRIGIDA4), a C2H2 transcription factor, as a direct regulator of the

43 e that was in turn ultimately derived from a C2H2 Zn-finger domain.

44 odes several functional domains, including a C2H2 zinc finger, a leucine zipper, and a winged-helix/f

45 Located on chromosome 5A, B1 is a C2H2 zinc finger encoding gene with ethylene-responsive

46 nine aminopeptidases (MetAPs), and Rei1 is a C2H2 zinc finger protein whose function in ribosome biog

47 ction of two conserved DNA-binding motifs, a C2H2 zinc finger (ZF) and a Myb motif, located within th

48 eotide primer, for the facile isolation of a C2H2 zinc finger protein cDNA (Pszf1) from pea petals.

49 the identification of a natural allele of a C2H2-type transcription factor in rice that confers non-

50 Cocultures of Pelobacter SFB93, a C2H2-fermenting bacterium, with D. mccartyi strain 195 o

51 Here we discovered that a C2H2 zinc finger protein, ZNF827, is strongly induced du

52 , changing a C2C2 type Zn-binding motif to a C2H2 motif.

53 nit in the C terminus of the HYB domain to a C2H2-like zinc finger in HYB(DeltaC).

54 shown for PRMT3, we found that ZNF277 uses a C2H2-type zinc finger domain to recognize uS5.

55 P gene encodes a transcription factor with a C2H2-type zinc finger motif, a serine/proline-rich domai

56 scription factor-binding motif for ZNF263, a C2H2 zinc finger protein.

57 performed genome-wide ChIP-seq for ZNF263, a C2H2 ZNF that contains 9 finger domains, a KRAB repressi

58 ive to high-temperature hydrogen-abstraction-C2H2-addition (HACA) sequences to form polycyclic aromat

59 Acetylene (C2H2) can be generated in contaminated groundwater sites

60 rs or so), whereas methane (CH4), acetylene (C2H2), ethylene (C2H4), and ethane (C2H6) are abundant m

61 ith simple prototype hydrocarbons acetylene (C2H2) and ethylene (C2H4).

62 protocol we measured intrabreath acetylene (C2H2) and carbon monoxide (CO) transfer, pulmonary funct

63 tunneling spectra for an isolated acetylene (C2H2) molecule adsorbed on the copper (100) surface show

64 ing of the molecular structure of acetylene (C2H2) 9 femtoseconds after ionization.

65 acids form by one-pot reaction of acetylene (C2H2) and carbon monoxide (CO) in contact with nickel su

66 Here we report the detection of acetylene (C2H2) in the infrared spectrum of comet C/1996 B2 (Hyaku

67 to the selective hydrogenation of acetylene (C2H2) to ethylene (C2H4).

68 th the nonphysiological substrate acetylene (C2H2) to generate deuterated ethylenes (C2H3D and C2H2D2

69 pper sheet at 850 degrees C using acetylene (C2H2) as carbon source in an argon (Ar) and nitrogen (N2

70 AMO activity was inactivated with acetylene (C2H2) after mRNA depletion.

71 ron monosulfide radical (BS) with acetylene (C2H2) under single collision conditions in the gas phase

72 an extensive and largely unstudied adaptive C2H2-ZF regulatory network that targets a diverse range

73 analog 1-N6-ethenoadenosine diphosphate (ADP[C2H2]) from the active site of Cys707-modified (by N-eth

74 ked (by N,N'-p-phenylene dimaleimide) S1.ADP[C2H2].AlF4- and S1.ADP[C2H2].BeFx.

75 e dimaleimide) S1.ADP[C2H2].AlF4- and S1.ADP[C2H2].BeFx.

76 However, missense variants affecting C2H2-ZnFs, DNA binding, and "specificity residues" impai

77 sts, and evidence is presented that C2H4 and C2H2 formation occur via C2H6 and C2H4 dehydrogenation,

78 h small hydrocarbons, namely C2H6, C2H4, and C2H2, are investigated by experiment and density functio

79 tion is inhibited noncompetitively by CO and C2H2 with Ki values of ca. 0.0008 and 0.006 atm, respect

80 on factor that contains a BTB/POZ domain and C2H2 zinc finger motifs.

81 ichloroethene (TCE) by in situ minerals, and C2H2 is known to inhibit bacterial dechlorination.

82 nscription factors (AP2-EREBP, WRKY, NAC and C2H2), osmoprotectants, ion transporters and heat shock

83 of the structure of randomly oriented O2 and C2H2 molecules, with pig and piu symmetries, respectivel

84 motifs for the nuclear hormone receptor and C2H2 zinc finger families and reveal unexpected diversit

85 t contaminated sites containing both TCE and C2H2.

86 C4 is packed against N-terminal GRF-type and C2H2 zinc finger domains and a C-terminal CCHC domain, c

87 tobacco has a higher proportion of ERF/AP2, C2H2 zinc finger, homeodomain, GRF, TCP, zinc finger hom

88 e showed that two genes encoding Arabidopsis C2H2 ZINC FINGER PROTEIN (ZFP) transcription factors, ZP

89 ption of 5S rRNA genes and is the archetypal C2H2 zinc finger protein.

90 itated by repeats of sequence motifs such as C2H2 zinc fingers.

91 he temperature changes for molecules such as C2H2, O2, H2O, and NH3.

92 LA (SAP) genes and novel subfamilies of BES, C2H2 zinc finger, SAP, and NAC genes.

93 the potential energy surface (PES) between (C2H2)n(+) isomers and provide evaporative cooling to dis

94 ynthetic protein libraries to select binding C2H2-ZF domains for each possible three base pair target

95 In survivors of BPD C2H2 transfer with exercise did increase, but not as muc

96 rinciple of recognition of methylated CpG by C2H2 ZnF proteins, which involves a spatially conserved

97 tal biological processes: DNA recognition by C2H2 zinc-finger proteins and homology-directed repair o

98 Predictions for the CH4 = CH3 + H and C2H3 = C2H2 + H reaction systems are in excellent agreement wit

99 ription factor families including bHLH, C3H, C2H2, MYB, MYB-related, AP2/ ERF, NAC, bZIP, and WRKY su

100 hat one of these zinc fingers is a canonical C2H2 DNA binding domain.

101 e contains binding sites for a non-canonical C2H2 zinc finger protein.

102 actor family containing three characteristic C2H2-type zinc finger motifs.

103 v)Ni(mu-pdt)Fe(CO)(dppv) ([1](0); dppv = cis-C2H2(PPh2)2) and its hydride derivatives have yielded to

104 he invariant 12 amino acids in the classical C2H2 motif.

105 eceptors and proteins with three consecutive C2H2 zinc fingers.

106 a DNA binding domain with three consecutive C2H2 zinc fingers.

107 was localized to an evolutionarily conserved C2H2 zinc finger and leucine zipper motif.

108 ferentiation via an evolutionarily conserved C2H2 zinc finger motif.

109 , that encode proteins with highly conserved C2H2 zinc fingers.

110 nd primarily functions through its conserved C2H2 Kruppel type zinc finger and BTB/POZ domains.

111 e identification of a SCAN domain-containing C2H2 zinc finger protein, ZNF24, that represses the tran

112 de direct evidence that most KRAB-containing C2H2-ZF proteins bind specific endogenous retroelements

113 and DAZ2, which encode EAR motif-containing C2H2-type zinc finger proteins.

114 Proteins containing C2H2 type zinc finger motifs represent one of the larges

115 , a class of zinc finger proteins containing C2H2 zinc fingers in tandem arrays of two or three is pr

116 In contrast, C2H2 zinc finger (ZF) proteins recognize CpG and CpA, wh

117 In contrast, C2H2-ZF DNA binding in fungi, plants, and other lineages

118 yeast fbp1 gene, binding of Rst2 (a critical C2H2 zinc-finger TF) is mediated by a local loop structu

119 ain from the Zif268 protein, using different C2H2 ZF domains as structural templates.

120 BTB/POZ-domain C2H2 zinc(Zn)-finger proteins are encoded by a subfamily

121 1 is a 55-kDa protein that contains a double C2H2-type zinc finger domain.

122 d Hym hydrogenase were down-regulated during C2H2 inhibition, consistent with the physiological obser

123 aa, each having a DNA-binding domain (eight C2H2 zinc fingers) and a proline-rich transcription acti

124 Sequence analysis reveals eight C2H2 zinc finger motifs at the C-terminus of ZNF210 and

125 nding profiles for a benchmark set of eleven C2H2 zinc finger transcription factors, five of known an

126 rescence organs, ZFP8 and GIS2, which encode C2H2 transcription factors related to GLABROUS INFLORESC

127 re, that combines two functionally essential C2H2 zinc-finger domains, which are probably involved in

128 cardiac output at rest and during exercise (C2H2 rebreathing) were measured at the same time periods

129 Both at rest and during exercise, C2H2 transfer corrected for body surface area was lower

130 enitor of placental mammals, but that extant C2H2-ZF domains typically bind different sequences from

131 pe, Cytochrome P450 superfamily, Zinc finger C2H2-type, RING/FYVE/PHD-type, etc.) were identified.

132 The C2H2 zinc finger (C2H2-ZF) is the most numerous protein domain in many met

133 Cys2-His2 zinc finger (C2H2-ZF) proteins represent the largest class of putativ

134 BCL11B is a Cys2-His2 zinc-finger (C2H2-ZnF) domain-containing, DNA-binding, transcription

135 Cys2His2 zinc fingers (C2H2-ZFs) comprise the largest class of metazoan DNA-bin

136 (TFs) with multiple Cys2-His2 zinc fingers (C2H2-ZFs) remain poorly studied.

137 ing specificities for Cys2His2 zinc fingers (C2H2-ZFs), the largest family of DNA-binding proteins in

138 This screen identified the Zinc fingers, C2H2 and BTB domain containing (ZBTB) family members ZBT

139 milar DNA binding structure of four and five C2H2 zinc finger motifs (ZF), respectively.

140 an 83.8 kDa nuclear protein containing five C2H2-type Kruppel-like zinc finger motifs that exhibit 9

141 the C-terminal 174 amino acids contains five C2H2 zinc finger domains, and the N terminus (residues 1

142 a per-finger basis and merge predictions for C2H2-ZF domains that are arrayed within sequences.

143 ) representing DNA-binding specificities for C2H2-ZF proteins.

144 ith UNC-98, a 37-kD protein, containing four C2H2 Zn fingers, that localizes to M-lines.

145 l 310-residue polypeptide consisting of four C2H2 Zn fingers and several possible nuclear localizatio

146 n of 1920 amino acids that contains fourteen C2H2-type zinc fingers, and glutamine-rich and proline-r

147 ypes of zinc fingers separated from a fourth C2H2 finger by a long spacer; ID1 is distinct from other

148 ted Rox7, is shown here to be Mot3, a global C2H2 zinc finger regulator.

149 d, isomerization of acetylene (nomega+C2H2-->C2H2(2+)-->CH2++C+) is controlled via a barrier-suppress

150 volatiles (H2O, C2H6, HCN, CO, CH3OH, H2CO, C2H2, and CH4) in the Jupiter-family comet Tempel 1 usin

151 abundance of simple organic molecules (HCN, C2H2, and CO2), water vapor, and OH.

152 In this study, we show that while high C2H2 (1.3 mM) concentrations reversibly inhibit reductiv

153 roteins that contain two atypical Cys2/His2 (C2H2) zinc finger-like domains that are evolutionarily w

154 ents Zfp335 as a model for understanding how C2H2-ZF TFs may use multiple recognition motifs to contr

155 on a family of ubiquitously expressed human C2H2 zinc finger proteins comprised of ZFX, ZFY and ZNF7

156 his study, LoZAT12, a Lilium oriental hybrid C2H2 zinc finger protein, was found to be a key regulato

157 ization in the series of simple hydrocarbons C2H2, C2H4, and C2H6, we show that double-slit interfere

158 Eu(II)DTPA, displaying a strong activity in C2H2 reduction while demonstrating an ability to reduce

159 Further, CN- did not induce cooperativity in C2H2 reduction and, therefore, CO and CN- are unlikely t

160 ther, largely due to extensive divergence in C2H2 zinc finger proteins.

161 form holodinitrogenase 2, which functions in C2H2, H+, and N2 reduction.

162 Members of one group include C2H2 zinc finger motifs.

163 Examples explored in this study include C2H2 zinc finger, homeodomain and bHLH DNA-binding motif

164 ntaining only two predicted genes, including C2H2 zinc finger transcriptional repressor TraesCS5A02G5

165 N2 also inhibits C2H2 reduction catalyzed by the alpha-195(Gln) nitrogena

166 ated by products whose empirical formula is (C2H2) n(+), just like ionized acetylene clusters.

167 hrough sequence-specific DNA binding via its C2H2 zinc finger (ZF) tandem array, which is highly poly

168 ve been identified: lanthanacyclopropene [La(C2H2)], La(cyclobut-1-en-3-yne) [La(C4H2)], and La(benzy

169 criptomic profiling of three mutants lacking C2H2 zinc finger proteins, ypr013cDelta,ypr015cDelta and

170 We now find that the hunchback/Ikaros-like C2H2 zinc-finger factor ztf-16 is also required.

171 ent cultures containing D. mccartyi sp., low C2H2 (0.4 mM) concentrations do not inhibit growth or me

172 unsaturated substrates (e.g., CS2, Me3SiCCH, C2H2, and CH3CN).

173 However, for most C2H2-ZF proteins it is unknown whether they even bind DN

174 e transcripts were found to contain multiple C2H2-type zinc finger motifs in tandem arrays, indicatin

175 dsRNA binding domain consisting of multiple C2H2 zinc fingers.

176 ters (V(m)O(n)) with C2H2 molecules, V(m)O(n)C2H2 are assigned as the major products of the associati

177 mprise the majority of zinc fingers, namely, C2H2-like finger, treble clef finger and the zinc ribbon

178 ng DNA-binding data for thousands of natural C2H2-ZF domains.

179 est our approach on a diverse set of natural C2H2-ZF proteins with known binding specificities and de

180 precipitation analyses, we show that natural C2H2-ZFs encoded in the human genome bind DNA both in vi

181 ption factors characterized by seven to nine C2H2 zinc finger motifs.

182 form of apodinitrogenase 2 that exhibits no C2H2, H+, or N2 reduction activities in the in vitro FeV

183 ances the binding of H, C, N, O, O2, CO, NO, C2H2, and C2H4 on the Ag(111) surface.

184 Second, isomerization of acetylene (nomega+C2H2-->C2H2(2+)-->CH2++C+) is controlled via a barrier-s

185 A novel C2H2 zinc finger gene, ZNF277, has been localized to hum

186 Here, we describe lsy-2, a novel C2H2 zinc finger transcription factor that is required f

187 thought to occur only in eukaryotes, a novel C2H2 zinc finger transcription factor, Ros, which regula

188 Here, we report that ZFP3, a nuclear C2H2 zinc finger protein, acts as a negative regulator o

189 lso shows impressive selective adsorption of C2H2, C2H4, and C2H6 over CH4 at room temperature, indic

190 onal analyses uncovered important aspects of C2H2-ZF domain-DNA interactions, including the roles of

191 n the adsorption energy and configuration of C2H2, while the influence of the ensemble structure is w

192 Our results suggest that the evolution of C2H2-ZFs in metazoans was expedited by the interaction o

193 rs of the large, but under-studied family of C2H2 zinc finger proteins.

194 rotein 1) is one member of a small family of C2H2 zinc finger-encoding sequences previously character

195 is the founding member of a small family of C2H2 zinc-finger DNA-binding proteins that carry out cri

196 a nematode-specific, fast-evolving family of C2H2 zinc-finger transcription factors, lsy-27, is mutat

197 t integrates crystallographic information of C2H2 zinc finger-DNA complexes with binding data from 11

198 uce N2 and insensitivity to CO inhibition of C2H2 reduction.

199 rise the most comprehensive investigation of C2H2-ZF DNA-binding interactions to date.

200 p elucidate the complex binding landscape of C2H2-ZF domains and provide a foundation for efforts to

201 The majority of C2H2-ZF proteins, including KRAB proteins, also show wid

202 Characteristic motifs of C2H2 zinc fingers and leucine heptad repeats are present

203 omain, SANT domains and a variable number of C2H2 type zinc fingers (3-14).

204 alternative splicing to one of four pairs of C2H2 zinc-finger domains (Z1, Z2, Z3, and Z4).

205 Among a large pool of C2H2-zinc finger targets, PBK is essential for evicting

206 d to the successful design and prediction of C2H2-ZF DNA-binding specificities.

207 a-277His MoFe-protein-catalyzed reduction of C2H2 showed sigmoidal kinetics, which is consistent with

208 , KRIP-1 interacts with the KRAB-A region of C2H2 zinc finger proteins and may mediate or modulate KR

209 demonstrates highly selective separation of C2H2/CO2 at ambient temperature and pressure.

210 ans conformational change in the S1 state of C2H2 and the bond-breaking HCN-HNC isomerization.

211 found near the N-terminus of a subfamily of C2H2 zinc finger proteins.

212 ion factors (KLFs) constitute a subfamily of C2H2-type zinc finger proteins with distinct cell-type e

213 ino acid sequence identified a novel type of C2H2 zinc finger.

214 rogram, and the results of PCOAT analysis on C2H2 alignment and ACT domain alignment.

215 y DNA triplet was recognized by at least one C2H2-ZF domain in the common progenitor of placental mam

216 hydrocarbon ice such as CH4, C2H6, C2H4, or C2H2 on 1993SC.

217 No substrate reduction (H+ or C2H2) was detected when wild-type MoFe protein was compl

218 at of the catalyzed reduction of H+, HCN, or C2H2, the extent of azide reduction to either N2 or N2H4

219 h stroke volume derived from cardiac output (C2H2 rebreathing) and heart rate.

220 he effects of these regulators, particularly C2H2 ZFs, in inducing HbF expression for treating beta-h

221 t of the isolation of a three-fingered plant C2H2 ZFP gene and we discuss its possible evolutionary o

222 JAGGED (JAG), a gene that encodes a putative C2H2 zinc-finger transcription factor, as a key regulato

223 Roaz, a rat C2H2 zinc finger protein, plays a role in the regulation

224 reductase component of nitrogenase to reduce C2H2 in an ATP-dependent reaction.

225 BCL11 proteins are related C2H2 zinc-finger transcription factors that act as trans

226 Here, we show that a family of four related C2H2 zinc-finger proteins plays a central role in these

227 expansion and diversification of repressive C2H2 zinc finger proteins.

228 c-binding motifs in the form of two separate C2H2 zinc finger sequences.

229 t splice isoforms, which contain up to seven C2H2 Zn-finger domains, and is localized to the nucleus,

230 ists of a basic N-terminal region with seven C2H2 zinc finger motifs and an acidic C-terminal region

231 These data show that single C2H2 zinc fingers can bind RNA specifically and suggest

232 ogene encodes a zinc finger protein with six C2H2-type, C-terminal zinc finger motifs and is activate

233 Another web interface for our software, C2H2-enoLOGOS, generates logos for the DNA-binding prefe

234 xidase protein, AtSWP1, and a plant-specific C2H2 zinc finger-SET domain protein, AtCZS, interact wit

235 ferase bi-domain module with a RET1-specific C2H2 zinc finger and RNA recognition (RRM) domains.

236 1C protein has a zinc finger-like structure (C2H2 motif) at its N terminus, which is conserved from y

237 the reduction of the alternative substrates, C2H2, HCN, HN3, and protons.

238 large and highly variable numbers of tandem C2H2 zinc finger (tandem ZF) transcription factor protei

239 We show that the conserved N-terminal C2H2 zinc finger domain is essential for direct DNA bind

240 ar domain structure, including an N-terminal C2H2 zinc finger domain, a central putative core transpo

241 with our recognition code and indicate that C2H2-ZF proteins recognize more motifs than all other hu

242 The C2H2 TFIIIA/Kruppel class of zinc finger proteins are an

243 The C2H2 zinc finger (C2H2-ZF) is the most numerous protein

244 The C2H2 zinc finger is one of the most abundant protein dom

245 The C2H2 zinc finger is the most commonly utilized framework

246 The C2H2 zinc finger is the most prevalent protein motif in

247 The C2H2 zinc-finger protein Pita binds to several BX-C boun

248 The C2H2 zinc-finger-containing transcription factors encode

249 The C2H2-type zinc finger protein ZNF764 acts as an enhancer

250 which regulate neuronal development, and the C2H2 superfamily of zinc-finger transcription factors.

251 BEL1-like homeodomain protein PINNA1 and the C2H2 zinc finger protein PALMATE-LIKE PENTAFOLIATA1 (PAL

252 a physical interaction between UNC-3 and the C2H2 zinc finger transcription factor PAG-3, the mammali

253 g protein HYPONASTIC LEAVES1 (HYL1), and the C2H2 Zn-finger protein SERRATE (SE), are required for th

254 es (e.g., tceA) were not affected during the C2H2-inhibition, while genes encoding for ATP synthase,

255 that the ASE motif is a binding site for the C2H2 zinc finger TF CHE-1, which is essential for the co

256 logenetically conserved binding site for the C2H2 zinc-finger transcription factor CHE-1, a previousl

257 ntrotus purpuratus genome, we identified the C2H2 zinc finger genes indicated in the sequence, and ex

258 ge a histidine (H) to an arginine (R) in the C2H2 domain of PT and the two alleles are referred to as

259 We find that mutations in the C2H2 motif have no perceptible effect on UV sensitivity

260 Ub-PCNA was not affected by mutations in the C2H2 motif or the D570 residue.

261 ave examined the effects of mutations in the C2H2 zinc binding motif and in the conserved D570 residu

262 eviously reported a mutation (R1092W) in the C2H2-ZF TF Zfp335 that led to selective loss of binding

263 n containing seven zinc finger motifs of the C2H2 class, four of which are arranged in two pairs wide

264 n factor with four zinc-finger motifs of the C2H2 class.

265 d three carboxy-terminal zinc fingers of the C2H2 DNA-binding type.

266 s a global mechanism for inactivation of the C2H2 family.

267 621) contain seven zinc finger motifs of the C2H2 type as well as proline and glutamine rich areas.

268 ame contains seven zinc-finger motifs of the C2H2 type, as well as proline-, glutamine-, and glutamic

269 ar protein with 11 zinc-finger motifs of the C2H2 type.

270 ers indicates that ZBP-89 is a member of the C2H2 zinc finger family subclass typified by the Drosoph

271 riments indicated that the activation of the C2H2 zinc finger transcription factor, AT5G06070/RABBIT

272 We demonstrate that mutations of the C2H2 zinc fingers encoded by the him-8 (high incidence o

273 logos for the DNA-binding preferences of the C2H2 zinc-finger transcription factor family members.

274 In animal systems the C2H2 zinc finger protein (ZFP) gene family is the larges

275 These results demonstrate that the C2H2 motif provides a versatile platform for both sequen

276 Here, we show that the C2H2 zinc finger transcriptional repressor encoded by RA

277 Here, we show that the C2H2-ZF expansion in metazoans is facilitated by contrib

278 An ortholog of one of these, the C2H2 zinc finger protein DEFECTIVELY ORGANIZED TRIBUTARI

279 obtained snapshots as a proton departs the [C2H2](2+) ion.

280 strains generally correlated well with their C2H2- and proton-reduction activities, which range from

281 ied transcription factor that contains three C2H2 Kruppel-type zinc fingers.

282 The predicted Tef protein contains three C2H2 zinc-finger motifs, one at the amino terminus and t

283 Two C2H2 fingers in Ikaros are dedicated to homotypic intera

284 e observed upon postembryonic removal of two C2H2 zinc finger transcription factors, die-1 and che-1,

285 AD2 is located within two C2H2 ZFs, ZF1 and ZF2.

286 We have isolated Kruppel-type (C2H2) zinc-finger genes, ZIM3 (zinc-finger gene 3 from i

287 ists of 11 exons and encodes a Kruppel-type (C2H2) zinc-finger protein with a conserved Kruppel-assoc

288 er gene 1), encoding a typical Kruppel-type (C2H2) zinc-finger protein, located within 30 kb of a kno

289 Half of all human transcription factors use C2H2 zinc finger domains to specify site-specific DNA bi

290 ditionally, a dehydration reaction for VO3 + C2H2 to produce VO2C2 is also identified.

291 reactions VO3+C2H4 --> VO2CH2 + H2CO and VO3+C2H2 --> VO2C2 + H2O are thermodynamically favorable and

292 lations of the pathways for VO3+C2H4 and VO3+C2H2 reaction systems indicate that the reactions VO3+C2

293 des a large protein containing 12 widespread C2H2 zinc fingers and 3 motifs containing periodic proli

294 om exercise, but this did not correlate with C2H2 transfer or DL(CO)/VA.

295 hannel leading to the production of H2S with C2H2 also has been observed.

296 s of vanadium oxide clusters (V(m)O(n)) with C2H2 molecules, V(m)O(n)C2H2 are assigned as the major p

297 differentiation, her encodes a protein with C2H2-type zinc fingers.

298 unlikely to share common binding sites with C2H2.

299 Missense variants within C2H2-ZnF DNA-contacting alpha helices cause highly varia

300 , we performed detailed comparisons of yeast C2H2 ZF proteins with identical canonical recognition re