ライフサイエンスコーパス: CC chemokine

1 s so by facilitating removal of inflammatory CC chemokines.

2 inactivating CXC chemokines and inactivating CC chemokines.

3 se of infectious viral particles and CXC and CC chemokines.

4 s and destroys many of these proinflammatory CC chemokines.

5 in the zebrafish genome that encode putative CC chemokines.

6 served synteny between teleost and mammalian CC chemokines.

7 at sequestering and scavenging inflammatory CC chemokines.

8 ding conventional receptors for inflammatory CC chemokines.

9 e binding affinity between vCCI and multiple CC chemokines.

10 umably causing greater steric hindrance with CC-chemokines.

11 ternalizes and degrades most proinflammatory CC-chemokines.

12 argeting CCL2 and CCL13 in addition to other CC-chemokines.

13 ine milieu and caused significant release of CC-chemokines.

14 racting with up to 14 different inflammatory CC-chemokines.

15 g, internalizing, and degrading inflammatory CC-chemokines.

16 A subset of CC chemokines, acting through CC chemokine receptors (CC

17 dothelia venules, and production of IL-6 and CC chemokines, all characteristics of mucosal lymphoid t

18 rat cytomegalovirus (RCMV) encodes multiple CC chemokine-analogous proteins, including r129 (HCMV UL

19 d considerably less TNF-alpha, IL-6, and CXC/CC chemokine and soluble ICAM-1 proteins in bronchoalveo

20 ox infection and is able to selectively bind CC chemokines and inhibit their interactions with host r

21 ophage populations in response to a range of CC chemokines and other chemoattractant signalling molec

22 and scavenger receptor for most inflammatory CC chemokines and prevents the development of exacerbate

23 ceptor that binds and scavenges inflammatory CC chemokines and reduces local leukocyte accumulation.

24 cine induced the significant upregulation of CC chemokines and the downmodulation of CCR5 expression

25 We therefore investigated the role of CC chemokines and their receptors in hepatic fibrogenesi

26 CC chemokines and their receptors play a fundamental rol

27 onocyte chemoattractant protein-1 (MCP-1), a CC chemokine, and interleukin-8 (IL-8), a CXC chemokine,

28 hatic endothelium, internalizes and degrades CC chemokines, and D6(-/-) mice demonstrated increased c

29 y secretory IgA antibodies, up-regulation of CC chemokines, and the first demonstration of protective

30 ncept that an innate mechanism consisting of CC chemokines, APOBEC3G, and adaptive immunity by CD4 an

31 The zebrafish CC chemokines are highly clustered on several chromosome

32 CXC and CC chemokines are involved in numerous biological proces

33 The N termini of CC chemokines are shown to be involved in receptor bindi

34 blood group Ag (dfy) binds selective CXC and CC chemokines at high affinity and is expressed on eryth

35 nificant time-related decrease in IL-17A and CC chemokine attractant ligand-20 in CD25KO LGs.

36 R, transforming growth factor-beta1, IL-17A, CC chemokine attractant ligand-20) and Th-1-associated c

37 , and use it to identify 10 novel polyvalent CC-chemokine binding evasin-like peptides from salivary

38 Dog tick saliva contains polyvalent CC-chemokine binding peptides termed evasins 1 and 4, th

39 nt negative Toll/IL-1 signaling adapter, and CC-chemokine binding protein (MVADelta4-HIV); (ii) harbo

40 against HIV-1, but more potent in inhibiting CC-chemokine binding, occupied the upper region of the b

41 elucidate the ligand-binding surface of the CC chemokine-binding proteins Evasin-1 and Evasin-4, pro

42 Each of these CC chemokines binds EVM1 with 1:1 stoichiometry and equi

43 to the inserted domain, producing a typical CC chemokine "body" containing even further-increased CC

44 ACKR2 binds many inflammatory CC chemokines but cannot stimulate cell migration or act

45 Neutralization of CC chemokines by the broad-spectrum CC chemokine inhibit

46 and it remains controversial whether dimeric CC chemokines can bind and activate their receptors.

47 ression of metalloproteases (MMP-9, ADAM-8), CC chemokines (CCL-20), CXC chemokines (IL-8, CXCL-10, C

48 7) (Cys + 4), are crucial for binding of the CC chemokines CCL1 (agonist) and MC148 (antagonist), res

49 Although recent studies have suggested that CC chemokine CCL2 may directly affect the angiogenesis,

50 IFN-beta and the peripheral induction of the CC chemokine CCL2.

51 y of the CXCL1 dimer is novel: dimers of the CC chemokines CCL2 and CCL4 are inactive, and the dimer

52 icated that macrophages and the inflammatory CC-chemokine CCL2, which is scavenged by ACKR2, are asso

53 n-8) were found to be the most abundant, but CC chemokines (CCL2/monocyte chemotactic protein 1 and C

54 nd biological properties of the prototypical CC chemokine, CCL2.

55 ial cells, cause excessive production of the CC chemokine CCL3 (also known as MIP-1alpha), which recr

56 -4), Th1 cytokines (IL-2 and IL-21), and the CC chemokine CCL3 (MIP-1).

57 Hypoxia promoted secretion of CC chemokines Ccl3/4/5 and macrophage migration inhibito

58 Recent studies showed that the CC chemokine CCL6 enhanced antimicrobial immunity during

59 show that syndecan-1 ectodomains bind to the CC chemokines (CCL7, CCL11, and CCL17) implicated in all

60 s cancer-related inflammation genes (CXC and CC chemokines, chemokine receptors, cytokines and Cox-2)

61 onflicting results and indicate that dimeric CC chemokines do not bind to their receptors with affini

62 an atypical viral chemokine consisting of a CC chemokine domain and a unique non-chemokine domain, b

63 CC chemokines exist in equilibrium between monomeric and

64 CCL11/eotaxin-1 is a potent eosinophilic CC chemokine expressed by primary human fibroblasts.

65 Human CC chemokine expression was assessed by means of quantit

66 ecreted (RANTES, or CCL5) is a member of the CC chemokine family of proteins, strongly chemoattractan

67 essed and secreted; CCL5) is a member of the CC chemokine family of proteins, which is strongly chemo

68 Results are discussed in terms of CXC and CC chemokine function and have significant biological im

69 cate, physiologically relevant regulation of CC chemokine functions.

70 d the genomic sequences and structures of 23 CC chemokine genes.

71 n can be protumorigenic, and proinflammatory CC chemokines have been linked with various aspects of c

72 ver, the interactions between vCCI and other CC chemokines have not yet been fully explored.

73 Ltn-CC1) or third disulfide (Ltn-CC3) in the CC chemokine, HCC-2.

74 genin (ANG), growth factors, and the CXC and CC chemokines IFN-gamma inducible protein (IP)-10, growt

75 nd KMplotter, we examined the association of CC chemokines in BrCa outcomes and disparity.

76 laboratory was first to show involvement of CC chemokines in BrCa.

77 without the availability of similar sets of CC chemokines in closely related species or a sequenced

78 emonstrate the importance of proinflammatory CC chemokines in de novo tumorigenesis and reveal chemok

79 analysis suggests significant association of CC-chemokines in BrCa progression, OS and disparate dise

80 HHV-6A U51 has been reported to bind to CC chemokines including RANTES, but the biological funct

81 upffer cells displayed strong suppression of CC chemokine-induced migration.

82 lysis provides insight into the mechanism of CC-chemokine inhibition employed by the poxvirus family

83 The poxvirus-encoded viral CC chemokine inhibitor (vCCI) binds to many CC chemokine

84 The soluble poxvirus-encoded protein viral CC chemokine inhibitor (vCCI), a CC chemokine inhibitor,

85 ation of CC chemokines by the broad-spectrum CC chemokine inhibitor 35k efficiently reduced hepatic f

86 otein viral CC chemokine inhibitor (vCCI), a CC chemokine inhibitor, can bind to human CC chemokines

87 In turn, this NKp30-induced secretion of cc-chemokines is able to significantly suppress the repl

88 receptor ACKR2, which scavenges inflammatory CC-chemokines, is differentially expressed during mammar

89 -alpha) markedly increased the expression of CC chemokine ligand (CCL) 20, a CC chemokine receptor (C

90 N-formyl methionyl leucyl phenylalanine and CC chemokine ligand (CCL) 3 (neutrophils), or upon stimu

91 ar cells (FRCs), through their expression of CC chemokine ligand (CCL)19 and CCL21, attract and retai

92 Levels of the CC chemokine ligand (CCL)2, CCL3, CCL5, CCL19, CCL20, an

93 ve in chemotactic responses to the chemokine CC chemokine ligand (CCL)20, which is up-regulated durin

94 e show that a latency-associated increase in CC chemokine ligand (CCL)8 results in the recruitment of

95 tor 9 (CCR9), which is a unique receptor for CC chemokine ligand (CCL25), is mainly expressed on lymp

96 be activated to secrete when stimulated with CC chemokine ligand 11 (eotaxin-1).

97 endothelial growth factor receptor 2, CCR3, CC chemokine ligand 11/eotaxin-1, and CC chemokine ligan

98 CC chemokine ligand 14, CCL14, is a human CC chemokine t

99 C5aR-targeted mice produced large amounts of CC chemokine ligand 17 (CCL17) and CCL22 ex vivo, sugges

100 e thymus- and activation-regulated chemokine/CC chemokine ligand 17 (TARC/CCL17) and macrophage-deriv

101 The CC chemokine ligand 18 (CCL18) is one of the most highly

102 CC chemokine ligand 18 (CCL18), acting through CC chemok

103 CC chemokine ligand 18 (CCL18)/pulmonary and activation-

104 rete immunosuppressive (interleukin [IL] 10, CC chemokine ligand 18) and tumor-promoting (IL-6, IL-8)

105 The CC chemokine ligand 2 (CCL2) and CC chemokine receptor 2

106 kine ligand 9 (CXCL9) and CXCL10, as well as CC chemokine ligand 2 (CCL2) and CCL5, were prominently

107 evels of monocyte chemoattractant protein 1 [CC chemokine ligand 2 (CCL2) in the systematic nomenclat

108 The CC chemokine ligand 2 (CCL2) may contribute to the tumor

109 CC chemokine ligand 2 (CCL2), a ligand of CC chemokine r

110 by its cognate chemokine ligands, including CC chemokine ligand 2 (CCL2), plays a central role in re

111 chemokine (C-X-C motif) ligand 1 (CXCL1) and CC chemokine ligand 2 (CCL2), the chemotactic cytokines

112 hat is activated primarily by the endogenous CC chemokine ligand 2 (CCL2).

113 e overexpression of APOE, interleukin-6, and CC chemokine ligand 2 (CCL2).

114 of murine PD, several chemokines, including CC chemokine ligand 2 (CCL2, Monocyte Chemoattractant Pr

115 Obese adipose tissue exhibits increases in CC chemokine ligand 2 (CCL2, or monocyte chemoattractant

116 ession of monocyte chemoattractant protein-1/CC chemokine ligand 2 (MCP-1/CCL2), a chemokine required

117 the production of proinflammatory molecules CC chemokine ligand 2 and interleukin 6 in diseased ging

118 d with wild type, Ackr2 deficiency increases CC chemokine ligand 2 levels in tumor necrosis factor-st

119 k inflammatory cytokines TNF-alpha, IL-6, or CC chemokine ligand 2 succumb to infection with A/Vietna

120 cyte chemoattractant protein-1 (MCP-1)/CCL2 (CC chemokine ligand 2).

121 NF) alpha, interleukin (IL) 1beta, IL-6, and CC chemokine ligand 2.

122 leukin 8, and monocyte chemotactic protein-1/CC chemokine ligand 2.

123 x with C chemokine ligand 1/lymphotactin and CC chemokine ligand 2/monocyte chemoattractant protein 1

124 d the macrophage inflammatory protein 3alpha/CC chemokine ligand 20 (CCL20) produced by epithelial ce

125 d Piasy inhibits, keratinocyte production of CC chemokine ligand 20 (CCL20), a psoriatic chemokine es

126 C-X-C motif) ligand 1 (CXCL1), CXCL8 and the CC chemokine ligand 20 (CCL20).

127 CC chemokine ligand 20 induction by tumor necrosis facto

128 downstream effector molecules (IL-17, IL-22, CC chemokine ligand 20, and beta-defensin 4).

129 Ectopic expression of CC chemokine ligand 21 (CCL21) in the thyroid leads to d

130 to secondary lymphoid tissue chemokine (SLC)/CC chemokine ligand 21 (CCL21) were significantly lower

131 CXC chemokine ligand 13 (CXCL13), CC chemokine ligand 21 (CCL21), and CCL19 are constituti

132 emokine ligand 12 (CXCL12) but not CXCL13 or CC chemokine ligand 21.

133 CCR3, CC chemokine ligand 11/eotaxin-1, and CC chemokine ligand 24/eotaxin-2 all reduced CNV area an

134 toxin-sensitive chemoattractant signaling by CC chemokine ligand 25 through CC chemokine receptor 9,

135 We previously found CC chemokine ligand 3 (CCL3) to be a potent effector of

136 Both CC chemokine ligand 3 and vascular endothelial growth fa

137 CC chemokine ligand 5 (CCL5) and CCL3 are critical for i

138 Pretreatment of control mice with CC chemokine ligand 5 [CCL5 (RANTES)] enabled naloxone t

139 Interestingly, plasma levels of chemokines CC chemokine ligand 5 and CXC-chemokine ligand 4 were in

140 d in Trim32-deficient keratinocytes, whereas CC chemokine ligand 5 induction by tumor necrosis factor

141 apy on antigen-stimulated secretion of IL-4, CC chemokine ligand 5, and IFN-alpha.

142 ndritic cells and chemokine mRNA expression (CC chemokine ligand [CCL]5, CCL2, and CC chemokine recep

143 n a significant up-regulation of E-selectin, CC chemokine ligand-2, and interleukin-6 promoter activi

144 acrophage colony-stimulating factor (GM-CSF)-CC-chemokine ligand 17 (CCL17) chemokine axis, offer the

145 nflammatory monocytes (IMs) recruited by the CC-chemokine ligand 2 (CCL2).

146 ugh induction of expression of the chemokine CC-chemokine ligand 28 (CCL28), which, in turn, promotes

147 ssive PMN (PMN-II) with abilities to produce cc-chemokine ligand-2 and IL-10.

148 and can be recruited to the TME through the CC chemokine ligands CCL17 and CCL22.

149 mediates their migration towards endogenous CC chemokine ligands such as CCL2.

150 and control cell migration toward endogenous CC chemokine ligands, named for the adjacent cysteine mo

151 predominant in solution and forms a specific CC chemokine-like dimer.

152 We have produced a covalent dimer of the CC chemokine macrophage inflammatory protein-1beta (MIP-

153 ng enzyme catalytic polypeptide 3 G/F/H) and CC chemokines (macrophage inflammatory protein 1-alpha,

154 esses by demonstrating that IL-13 stimulates CC chemokines, matrix metalloproteinases, mucin genes, a

155 The CC chemokine MCK-2 encoded by mouse CMV (MCMV) has an at

156 port that the murine cytomegalovirus-encoded CC chemokine, MCK2, enhanced CCR2-dependent recruitment

157 by the murine cytomegalovirus (MCMV)-encoded CC chemokine, MCK2, which promotes recruitment of CX3CR1

158 ng affinity between vCCI and other wild type CC chemokines, MCP-1 (monocyte chemoattractant protein-1

159 study, we describe the interactions of three CC chemokines, MCP-1/CCL2, MCP-2/CCL8, and MCP-3/CCL7, w

160 17) implicated in allergic diseases, inhibit CC chemokine-mediated T cell migration, and suppress all

161 llergic lung inflammation via suppression of CC chemokine-mediated Th2 cell recruitment to the lung.

162 vides the first definitive evidence that the CC chemokine MIP-1beta dimer is not able to bind or acti

163 The CC chemokines MIP-1alpha, MIP-1beta, and RANTES and thei

164 CD8(+) T cells produced abundant amounts of CC chemokines (MIP-1beta, MIP-1alpha, and RANTES) but no

165 n orthopoxvirus vCCI in complex with a human CC chemokine, MIP-1beta (macrophage inflammatory protein

166 nverse correlation between the proportion of CC chemokine-modulated CCR5-expressing CD4(+) T cells an

167 The CC chemokine Monocyte Chemoattractant Protein (MCP)-1/CC

168 ded by marked and selective induction of the CC chemokine monocyte chemoattractant protein-1 (MCP-1).

169 or activate its receptor and implicates the CC chemokine monomer as the sole receptor-interacting un

170 Bronchial epithelial cells (BECs) produce CC chemokines, notably CCL26 (eotaxin-3), which recruits

171 Mouse CCL8 is a CC chemokine of the monocyte chemoattractant protein (MC

172 ly on two dimerization motifs represented by CC-chemokine or CXC-chemokine dimer interfaces.

173 homology among monomer folds of all CXC and CC chemokines permits heterodimer assembly, our calculat

174 K11 is a rainbow trout (Oncorhynchus mykiss) CC chemokine phylogenetically related to both mammalian

175 ization of late memory CD8(+) T cells toward CC chemokine production and away from IL-2 production su

176 icular, the content of T lymphocytes bearing CC chemokine receptor (CCR) 1, CCR3, and CCR5 receptors

177 Also, CXCR4 forms heteromers with CC chemokine receptor (CCR) 2, CCR5, the Na(+)/H(+) exch

178 nophil signaling molecules [eg, eotaxins and CC chemokine receptor (CCR) 3] in IL-13-mediated airway

179 CC chemokine receptor (CCR) 4 was dispensable for donor

180 points to cross-talk between FcepsilonRI and CC chemokine receptor (CCR)-mediated signaling pathways

181 sted naloxone-induced down-regulation of the CC chemokine receptor (CCR)5 in NY1DD mice but not in co

182 xpression of CC chemokine ligand (CCL) 20, a CC chemokine receptor (CCR)6 ligand, in human keratinocy

183 led altered expression of the CCL20 receptor CC chemokine receptor (CCR)6, suggesting that Fpr2/3 reg

184 The mechanisms by which CC chemokine receptor (CCR)7 ligands are selectively pre

185 Among 11 surveyed chemokine receptors, only CC chemokine receptor (CCR5), CXC chemokine receptor (CX

186 CC chemokine receptor 1 (CCR1) is found on a variety of

187 CC chemokine receptor 10 and its ligand, CCL27, are impo

188 m of vitamin D3, signaled T cells to express CC chemokine receptor 10, which enabled them to migrate

189 CC Chemokine Receptor 2 (CCR2) and its endogenous ligand

190 ing restrictions to a linear aminobutyramide CC chemokine receptor 2 (CCR2) antagonist lead (2) led t

191 The CC chemokine ligand 2 (CCL2) and CC chemokine receptor 2 (CCR2) are expressed in the hear

192 Activation of CC chemokine receptor 2 (CCR2) by its cognate chemokine

193 CC chemokine receptor 2 (CCR2) is a part of the chemokin

194 CC chemokine receptor 2 (CCR2) is essential to acute ske

195 Here we report that CC chemokine receptor 2 (CCR2) is highly expressed on a

196 CC chemokine receptor 2 (CCR2) is one of 19 members of t

197 with relatively high numbers of parasites in CC chemokine receptor 2 (CCR2) KO mice, indicating that

198 dels that the expression of the inflammatory CC chemokine receptor 2 (CCR2) on donor-derived CD8+ T c

199 We show that inhibition of CC chemokine receptor 2 (CCR2) receptor signaling with p

200 huGFAP-CCL2hi tg+ mice lacking CC chemokine receptor 2 (CCR2) were normal, showing that

201 Signaling between the CC chemokine receptor 2 (CCR2) with its ligand, monocyte

202 CC chemokine ligand 2 (CCL2), a ligand of CC chemokine receptor 2 (CCR2), is essential to mount an

203 CC chemokine receptor 2 (CCR2)-/-embryos display an iden

204 egeneration was examined in mice lacking the CC chemokine receptor 2 (CCR2).

205 ssion (CC chemokine ligand [CCL]5, CCL2, and CC chemokine receptor 2 [CCR2]) remained unchanged.

206 ice was reduced by 67%, but was unaltered in CC chemokine receptor 2(-/-) (CCR2(-/-)), CCR3(-/-), or

207 ory chemokine/receptor and cytokines (MCP-1, CC chemokine receptor 2, and interleukins 1beta and 6),

208 This study demonstrates that expression of CC chemokine receptor 4 (CCR4) by DCs is required for EA

209 ive of this study was to examine the role of CC chemokine receptor 4 (CCR4) in macrophage polarizatio

210 CC chemokine receptor 4 (CCR4) is expressed by Th2 and r

211 One candidate, CC chemokine receptor 4 (CCR4), is expressed by innate a

212 amulizumab, a defucosylated, humanized, anti-CC chemokine receptor 4 monoclonal antibody, in 41 pretr

213 However, this is not related to CC chemokine receptor 4, cutaneous lymphocyte-associated

214 ecurrent somatic mutations in CCR4, encoding CC chemokine receptor 4.

215 T-cell expression levels of CC chemokine receptor 5 (CCR5) are a critical determinan

216 iency virus-HIV chimera (SHIV) that uses the CC chemokine receptor 5 (CCR5) co-receptor.

217 CC chemokine receptor 5 (CCR5) is a receptor for chemoki

218 CC Chemokine Receptor 5 (CCR5) is an important mediator

219 CC chemokine receptor 5 (CCR5) is prominently expressed

220 CC chemokine receptor 5 (CCR5) is the receptor for sever

221 The CC chemokine receptor 5 (CCR5) is used by the human immu

222 eptor, CD4, and through a coreceptor, either CC chemokine receptor 5 (CCR5) or CXC chemokine receptor

223 We demonstrate that signaling through the CC chemokine receptor 5 (CCR5) prevents uncontrolled pos

224 globulin (Ig) G4 monoclonal antibody against CC chemokine receptor 5 (CCR5) with robust in vitro acti

225 a32, a complete loss-of-function mutation in CC chemokine receptor 5 (CCR5), has been previously asso

226 deficiency virus type-1 (HIV-1) co-receptor, CC chemokine receptor 5 (CCR5).

227 These cells expressed high levels of CC chemokine receptor 5 and were commonly double negativ

228 CC chemokine receptor 5 antagonists are a new class of a

229 SIV hosts from AIDS and the discovery of low CC chemokine receptor 5 expression on CD4+ T cells as a

230 Because CC chemokine receptor 6 (CCR6) deficiency affects the ge

231 r gut homing, as indicated by high levels of CC chemokine receptor 6 and integrin beta7 expression.

232 that, even when LN retention signals such as CC chemokine receptor 7 (CCR7) are down-regulated, T cel

233 CC chemokine receptor 7 (CCR7) is expressed in IIP biops

234 s T helper 1 (Th1) effector memory cells and CC chemokine receptor 7 (CCR7)(+) cells resembling centr

235 that migration to lymph nodes occurred in a CC chemokine receptor 7-independent manner but, overall,

236 Although the CC chemokine receptor 7-positive (CCR7+) population of b

237 chemokine ligand 18 (CCL18), acting through CC chemokine receptor 8 (CCR8) on mononuclear cells, was

238 svirus (KSHV) that selectively activates the CC chemokine receptor 8 (CCR8), for which the endogenous

239 sm depended on alpha(4) beta(7) integrin and CC chemokine receptor 9 (CCR9) expression by LSEC-primed

240 CC chemokine receptor 9 (CCR9), which is a unique recept

241 re a gut-homing phenotype (alpha 4 beta 7(+) CC chemokine receptor 9(+)) and the capacity to home to

242 signaling by CC chemokine ligand 25 through CC chemokine receptor 9, and binding of the integrins al

243 ors cyclo-oxygenase-2 and 5-lipoxygenase and CC chemokine receptor antagonist Met-RANTES.

244 When EGFP-NPs from CC chemokine receptor CCR2 knock-out mice were transplan

245 rmore that DARC hetero-oligomerizes with the CC chemokine receptor CCR5.

246 zin-1-yl]ethoxy}ethanol (ZK 756326), for the CC chemokine receptor CCR8.

247 did translational studies to examine CXC and CC chemokine receptor expression by flow cytometry on ne

248 etic ablation or pharmacologic inhibition of CC chemokine receptor type 2 (CCR2) reduced macrophage (

249 in rectal tissue (both P < .001), and plasma CC chemokine receptor type 5 (CCR5) ligand (macrophage-i

250 reted), the ligands for HIV entry coreceptor CC chemokine receptor type 5.

251 CC chemokine receptor type 9 (CCR9) activation by CCL25

252 dial smooth muscle cells, express functional CC chemokine receptor-1 (CCR1) and respond to RANTES by

253 uctures of PXR LBD with Adnectin-1 and CCR1 (CC chemokine receptor-1) antagonist Compound-1 were dete

254 g with our previously described(20) class of CC chemokine receptor-3 (CCR3) antagonist, we improved t

255 A subset of CC chemokine receptor-6(+) (CCR6(+)), gammadelta-low (GD

256 This study investigates whether cytokine and CC-chemokine receptor (CCR) production by DCs stimulated

257 Mice with genetic deficiency of CC-chemokine receptor (CCR) type 5, the common receptor

258 are rapidly mobilized upon inflammation in a CC-chemokine receptor 2-dependent manner, and the noncla

259 6- and 2.4-fold increases in Ly6-C(high) and CC-chemokine receptor 2-positive cells in lesions of apo

260 e in the airways of allergic mice upregulate CC-chemokine receptor 4 (CCR4) expression.

261 nce assay (HTRF) to quantify properly folded CC-chemokine receptor 5 (CCR5).

262 mentation of LXA(4) identified modulation of CC-chemokine receptor 7 (CCR7) and sphingosine 1- phosph

263 CC-chemokine receptor 7 (CCR7) is expressed on the surfa

264 ix (ECM) organization, mast cell activation, CC-chemokine receptor binding, circulating immunoglobuli

265 Here, we analyzed the role of the CC-chemokine receptor CCR8 for the biological functions

266 Here, we find inflammatory-related CC-chemokine-receptor 2 (Ccr2) expression in non-hematop

267 A subset of CC chemokines, acting through CC chemokine receptors (CCRs) 1 to 5, is instrumental in

268 CC chemokine receptors 2 (CCR2) and 5 (CCR5) are involve

269 r appears to be present in a large number of CC chemokine receptors and thereby could play a more gen

270 uitment upon exposure to DEPs and that these CC chemokine receptors are important in the DEP-induced

271 We hypothesized that CC chemokine receptors CCR2, CCR5, and CCR6 critically m

272 ng assays, we determined that r129 binds rat CC chemokine receptors CCR3, CCR4, CCR5, and CCR7.

273 ration was associated with downregulation of CC chemokine receptors in renal macrophages.

274 (ACKR2) binds and scavenges proinflammatory CC-chemokines, regulates cutaneous T-cell positioning, a

275 CC chemokines represent the largest subfamily of chemoki

276 f MMP processing of all 14 monocyte-directed CC chemokines revealed that each is precisely cleaved by

277 crease in the expression of the nonsignaling CC chemokine scavenging receptor D6 in whole lung sample

278 s in models of inflammation, suggesting that CC-chemokine scavenging by D6 is an important component

279 MT6-MMP processes seven each of the CXC and CC chemokine subfamilies.

280 emokines while retaining selectivity for the CC chemokine subfamily.

281 Our data therefore support a role for the CC chemokine system in hepatic fibrogenesis and suggest

282 atic cirrhosis, confirming activation of the CC chemokine system in human fibrogenesis.

283 action between vCCI and eotaxin-1 (CCL11), a CC chemokine that is an important factor in the asthma r

284 CC chemokine ligand 14, CCL14, is a human CC chemokine that is of recent interest because of its n

285 D6 is a scavenging-receptor for inflammatory CC chemokines that are essential for resolution of infla

286 recorded with IL-15 receptors, APOBEC3G and CC chemokines, the latter downmodulating CCR5 molecules.

287 ession, IFN-lambda induced the expression of CC chemokines, the ligands for CCR5.

288 Expression of a CC chemokine thymus-expressed chemokine (TECK) has previ

289 a CC chemokine inhibitor, can bind to human CC chemokines tightly to impair the host immune defense.

290 charged BBXB motif is key for the binding of CC chemokines to GAG.

291 a "silent" receptor, as it can bind CXC and CC chemokines to undergo ligand-induced receptor interna

292 talurus punctatus, we identified 26 distinct CC chemokine transcripts and obtained the genomic sequen

293 13Phe) caused vMIP-II to form a pH-dependent CC chemokine-type dimer as determined by analytical ultr

294 CCL-2, a CC chemokine, was released by the liver in response to a

295 BEC3G was significantly upregulated, as were CC chemokines which induce downregulation of CCR5 in CD4

296 l activity of inflammatory mediators such as CC chemokines, which have been implicated in a wide rang

297 gland expresses high levels of inflammatory CC-chemokines, which are essential in vivo regulators of

298 owed a significant decrease in the levels of CC chemokines, while exposure to R5-subtype HIV gp120 ha

299 CC chemokine inhibitor (vCCI) binds to many CC chemokines with high affinity, acting as a potent inh

300 and -4 use different pharmacophores to bind CC chemokines, with the principal binding occurring thro