ライフサイエンスコーパス: CCCTC-binding factor

1 h bind the transcriptional insulator protein CCCTC-binding factor.

2 (LTR) that has high-affinity binding to the CCCTC-binding factor.

3 hose Xi allele extensively binds the protein CCCTC-binding factor.

4 tocyte nuclear factor 1, Forkhead box A1 and CCCTC-binding factor.

5 Cocaine exposure reduces binding of CCCTC-binding factor, a chromosomal scaffolding protein,

6 protein 1) and its interaction partner CTCF (CCCTC-binding factor) act as transcription regulators of

7 eats contain an insulator element that binds CCCTC-binding factor and reduces its insertional genotox

8 se Igkappa gene V-J intervening region binds CCCTC-binding factor and specifies locus contraction and

9 sappears on stimulation; it is stabilized by CCCTC-binding factor and TFIIB and poises the gene for a

10 ent manner, cohesin subunits interacted with CCCTC-binding factor and the MHC-II-specific transcripti

11 remains unclear why acute depletion of CTCF (CCCTC-binding factor) and cohesin only marginally affect

12 of two chromatin structural proteins, Ctcf (CCCTC-binding factor) and Hmgb2 (high mobility group pro

13 Interestingly, the insulator protein CTCF (CCCTC-binding factor) and the Cohesin complex occupy the

14 bound the transcriptional insulator protein CCCTC-binding factor, and interacted with each other, cr

15 Cohesin and CTCF (CCCTC-binding factor) are key regulators; perturbing the

16 h sequences that bound the insulator protein CCCTC-binding factor as determined by chromatin immunopr

17 hat ATRX loss leads to a global depletion in CCCTC-binding factor association with DNA, gene dysregul

18 hicken hypersensitive site 4, which contains CCCTC binding factor binding sites.

19 ylation, splice sites, RNA stem-loops, CTCF (CCCTC-binding factor) binding sites, and several histone

20 a proposed insulator region containing CTCF (CCCTC-binding factor) binding sites, i.e. hs5/6/7 and th

21 T(CM) cells also acquire de novo CTCF (CCCTC-binding factor) binding sites, which are not only

22 romoted BMPR2 expression by decreasing CTCF (CCCTC-binding factor) binding to the BMPR2 promoter.

23 Here, we show that deletion of CTCF (CCCTC-binding factor)-binding sites at TAD and sub-TAD t

24 (TSP50) and the testis-specific paralogue of CCCTC-binding factor, BORIS (brother of the regulator of

25 In addition, our results suggest that the CCCTC-binding factor CTCF plays a key role in recruiting

26 (within an inter-chromosomal Sox-2 enhancer/CCCTC-binding factor CTCF/cohesin loop) to an active (wi

27 EGF-induced CCCTC binding factor (CTCF) activation subsequently inhi

28 The flanking HSs bind CCCTC binding factor (CTCF) and are thought to interact

29 D1 loci are packaged in chromatin-containing CCCTC binding factor (CTCF) and nucleophosmin (NPM) at t

30 onal regulator, often in colocalization with CCCTC binding factor (CTCF) and RNA Polymerase II Subuni

31 tained in part by the architectural proteins CCCTC binding factor (CTCF) and the cohesin complex, whi

32 CCCTC binding factor (CTCF) controls DNA imprinting, ins

33 CCCTC binding factor (CTCF) is an important factor in th

34 EGF-induced activation of the epigenetic CCCTC binding factor (CTCF) plays an important role in c

35 Epigenetic factor CCCTC binding factor (CTCF) plays important roles in the

36 CCCTC binding factor (CTCF) regulates gene expression th

37 Chromatin looping mediated by the CCCTC binding factor (CTCF) regulates V(D)J recombinatio

38 th RNA polymerase III (Pol III) elements and CCCTC binding factor (CTCF) sites.

39 Expression of insulator CCCTC binding factor (CTCF) was found to be required for

40 The transcriptional insulator CCCTC binding factor (CTCF) was shown previously to be c

41 CCCTC binding factor (CTCF), a transcriptional regulator

42 ution data of H3K4 di-methylation (H3K4me2), CCCTC binding factor (CTCF), AR and FoxA1 cistrome data

43 pectrum of insulator elements which bind the CCCTC binding factor (CTCF), is relatively poorly charac

44 binding of the vertebrate insulator protein, CCCTC binding factor (CTCF), to the maternally hypomethy

45 Knockdown of the insulator factor CCCTC binding factor (CTCF), which binds XL9, an interge

46 regulated by long noncoding RNAs (lncRNAs), CCCTC binding factor (CTCF)-mediated boundaries, and DNA

47 notype that could be rescued by deleting the CCCTC-binding factor (CTCF) anchor of the stripe.

48 ith the former binding the insulator protein CCCTC-binding factor (CTCF) and acting to block access o

49 anisotropic "tension globule." In the other, CCCTC-binding factor (CTCF) and cohesin act together to

50 y conserved chromosome loop anchors bound by CCCTC-binding factor (CTCF) and cohesin are vulnerable t

51 CCCTC-binding factor (CTCF) and cohesin play critical ro

52 sing reciprocal binding of epigenetic factor CCCTC-binding factor (CTCF) and its paralog BORIS.

53 e sequence specificity in vitro and in vivo, CCCTC-binding factor (CTCF) and its paralog brother of t

54 ooping of chromatin anchored by host-encoded CCCTC-binding factor (CTCF) and other factors, which con

55 a subset of DNA-binding proteins, including CCCTC-binding factor (CTCF) and pluripotency factors.

56 oding germline transcripts, and proximity to CCCTC-binding factor (CTCF) and Rad21 sites were compare

57 specific chromatin interactions mediated by CCCTC-binding factor (CTCF) and RNA polymerase II (RNAPI

58 We link pairing to allelic partitioning of CCCTC-binding factor (CTCF) and show that tethering DCP1

59 pression of transcription factors, including CCCTC-binding factor (CTCF) and specific KRAB zinc finge

60 Two of these targets, the CCCTC-binding factor (CTCF) and the epidermal growth fac

61 Sequence variants in CCCTC-binding factor (CTCF) and transcription factor bin

62 dent on interaction of the insulator protein CCCTC-binding factor (CTCF) and was required for enhance

63 omic binding sites for the insulator protein CCCTC-binding factor (CTCF) are constitutively occupied,

64 Cohesin and CCCTC-binding factor (CTCF) are key regulatory proteins

65 entified the DNA-binding zinc-finger protein CCCTC-binding factor (CTCF) as a crucial regulator of lo

66 chromatin fiber and the proteins cohesin and CCCTC-binding factor (CTCF) as key players anchoring suc

67 tions at sites containing binding motifs for CCCTC-binding factor (CTCF) at two cis-regulatory elemen

68 gnificant interactions that are enriched for CCCTC-binding factor (CTCF) bidirectional motifs and int

69 s-expression QTLs, histone modifications and CCCTC-binding factor (CTCF) binding data in the region.

70 the human IL26 gene, compromised of a single CCCTC-binding factor (CTCF) binding site and retained in

71 We employed CRISPR/Cas9 to disrupt the CCCTC-Binding Factor (CTCF) binding site on an insulator

72 CCCTC-binding factor (CTCF) binding sites are hotspots o

73 lapping transcription start sites (TSSs) and CCCTC-binding factor (CTCF) binding sites, and uncovered

74 latory elements, many of which coincide with CCCTC-binding factor (Ctcf) binding sites, for example,

75 1q42 break sites and NID1 promoter revealed CCCTC-binding factor (CTCF) binding sites.

76 ially methylated regions to be enriched with CCCTC-binding factor (CTCF) binding sites.

77 a binding but decreased transcription factor CCCTC-binding factor (CTCF) binding.

78 We found that the CCCTC-binding factor (CTCF) binds to E(alpha) and to man

79 We then discovered a critical CCCTC-binding factor (CTCF) boundary that reinforces CRE

80 the mechanism through which HOTTIP accesses CCCTC-binding factor (CTCF) chromatin boundaries and reg

81 E STATEMENT This work provides evidence that CCCTC-binding factor (CTCF) controls an early fate decis

82 impact promoter-enhancer interactions, with CCCTC-binding factor (CTCF) defining TAD borders and loo

83 The host cell CCCTC-binding factor (CTCF) functions in genome-wide chr

84 Here we demonstrate that the CCCTC-binding factor (CTCF) functions to insulate these

85 zes with the architectural/insulator protein CCCTC-binding factor (CTCF) genome-wide.

86 As a key regulator of genome organization, CCCTC-binding factor (CTCF) has been characterized as a

87 Because CCCTC-binding factor (CTCF) has been demonstrated to be

88 Insulators also gain H3K27ac and CCCTC-binding factor (CTCF) in anaphase/telophase.

89 77% of TAD boundaries bound by the insulator CCCTC-binding factor (CTCF) in mammals.

90 The function of the CCCTC-binding factor (CTCF) in the organization of the g

91 MIR insulators appear to be CCCTC-binding factor (CTCF) independent and show a disti

92 omains (TADs) and boundaries enforced by the CCCTC-binding factor (CTCF) insulator, but the underlyin

93 Here, we show that the CCCTC-binding factor (CTCF) is a barrier for 2C-like rep

94 The CCCTC-binding factor (CTCF) is a central regulator of ch

95 CCCTC-binding factor (CTCF) is a central regulator of hi

96 CCCTC-binding factor (CTCF) is a DNA-binding protein tha

97 icroglial dysfunction.SIGNIFICANCE STATEMENT CCCTC-binding factor (CTCF) is a DNA-binding protein tha

98 CCCTC-binding factor (CTCF) is a key regulator of nuclea

99 CCCTC-binding factor (CTCF) is a multi-functional chroma

100 CCCTC-binding factor (CTCF) is a transcription factor th

101 CCCTC-binding factor (CTCF) is a versatile zinc finger p

102 The CCCTC-binding factor (CTCF) is a zinc finger DNA binding

103 CCCTC-binding factor (CTCF) is an 11 zinc finger DNA-bin

104 CCCTC-binding factor (CTCF) is critical to three-dimensi

105 CCCTC-binding factor (CTCF) is essential for chromatin o

106 The insulator protein CCCTC-binding factor (CTCF) is involved in creating boun

107 CCCTC-binding factor (CTCF) is known to anchor loops and

108 The evolutionarily conserved CCCTC-binding factor (CTCF) is required for insulator fu

109 further determined that chromatin insulator CCCTC-binding factor (CTCF) is TGF-beta inducible and fa

110 al class of architectural proteins, of which CCCTC-binding factor (CTCF) is the best characterized.

111 rates, the versatile transcription regulator CCCTC-binding factor (CTCF) is the only identified trans

112 o euchromatin bound by the insulator protein CCCTC-binding factor (CTCF) on the inactive X chromosome

113 Four repeats in the DMD bind CCCTC-binding factor (CTCF) on the maternal allele and h

114 Omission of CCCTC-binding factor (CTCF) or deletion of the maternal

115 The CCCTC-binding factor (CTCF) organises the genome in 3D t

116 mouse embryonic stem cells (mESC), and mESC CCCTC-binding factor (CTCF) PLAC-seq data.

117 s paired box 5 (PAX5), Yin Yang 1 (YY1), and CCCTC-binding factor (CTCF) play a role in regulating th

118 CCCTC-binding factor (CTCF) plays a key role in the form

119 CCCTC-binding factor (CTCF) plays an essential role in r

120 DNA demethylation facilitated CCCTC-binding factor (CTCF) recruitment to the maternall

121 The highly conserved zinc finger CCCTC-binding factor (CTCF) regulates genomic imprinting

122 borders of which are enriched in cohesin and CCCTC-binding factor (CTCF) required for long-range inte

123 one H3 lysine 4 trimethylation (H3K4me3) and CCCTC-binding factor (CTCF) signals.

124 H19/Igf2 ICR [Delta2,3] removing two of four CCCTC-binding factor (CTCF) sites and the intervening se

125 tacts occur between enhancers, promoters and CCCTC-binding factor (CTCF) sites and we show that trans

126 CCCTC-binding factor (CTCF) sites were predicted in sili

127 sociated TAD borders reveals the presence of CCCTC-binding factor (CTCF) sites with diverging orienta

128 disrupts the binding of extrusive cohesin at CCCTC-binding factor (CTCF) sites, thereby promoting the

129 n part mediated by the architectural protein CCCTC-binding factor (CTCF) that binds to the boundaries

130 s both independently and in cooperation with CCCTC-binding factor (CTCF) to set up the chromatin land

131 Binding of CCCTC-binding factor (CTCF) to the first exon of the hTE

132 Recruitment of the transcriptional repressor CCCTC-binding factor (CTCF) to the MSMP enhancer region

133 together with mediator complexes, while the CCCTC-binding factor (CTCF) was relatively depleted from

134 One distal enhancer region was occupied by CCCTC-binding factor (CTCF) whose binding site was disru

135 Element) database identified association of CCCTC-binding factor (CTCF) with Ahr promoter in mouse l

136 mbines a recent map of the insulator protein CCCTC-binding factor (CTCF) with previous ER location st

137 tabolic changes regulated the association of CCCTC-binding factor (CTCF) with select genomic sites.

138 the binding of the enhancer-blocking element CCCTC-binding factor (CTCF) within the intergenic IGF2-H

139 In this report, we demonstrate that the CCCTC-binding factor (CTCF), a crucial chromatin organiz

140 lysis indicate that LINC00346 interacts with CCCTC-binding factor (CTCF), a known transcriptional rep

141 tor's function requires association with the CCCTC-binding factor (CTCF), a protein that recognizes l

142 CCCTC-binding factor (CTCF), a sequence-specific transcr

143 contains a high density of binding sites for CCCTC-binding factor (CTCF), a zinc finger protein assoc

144 Analysis of two well-studied TFs, NRSF and CCCTC-binding factor (CTCF), also suggests that HHMM yie

145 D9 interacts with androgen receptor (AR) and CCCTC-binding factor (CTCF), and modulates AR-dependent

146 ce of chromosomes (SMC1) cohesin complex and CCCTC-binding factor (CTCF), and the KSHV transactivator

147 e first evidence that a DNA-binding protein, CCCTC-binding factor (CTCF), can promote inclusion of we

148 The multidomain CCCTC-binding factor (CTCF), containing a tandem array o

149 he chromatin occupancy of the key insulator, CCCTC-binding factor (CTCF), is unchanged at the develop

150 Distinct combinations of CCCTC-binding factor (CTCF), Mediator, and cohesin show

151 The CCCTC-binding factor (CTCF), which anchors DNA loops tha

152 y of BDNF chromatin by DNA insulator protein CCCTC-binding factor (CTCF), which is associated with su

153 r (GR), with two C4 zinc finger domains, and CCCTC-binding factor (CTCF), with eleven C2H2 zinc finge

154 neutralized by simultaneous mutation of two CCCTC-binding factor (CTCF)-binding elements (CBE1 and C

155 We found weak CCCTC-binding factor (CTCF)-binding sites and reduced CT

156 While constitutive CCCTC-binding factor (CTCF)-binding sites are needed to

157 anking gene desert form a 1 Mbp loop between CCCTC-binding factor (CTCF)-binding sites that is separa

158 omas exhibit hypermethylation at cohesin and CCCTC-binding factor (CTCF)-binding sites, compromising

159 nt chromatin hyperaccessibility resolves: at CCCTC-binding factor (CTCF)-binding sites, CTCF and nucl

160 characterized by clusters of hypomethylated CCCTC-binding factor (CTCF)-bound elements, which were p

161 ription start sites (TSS), and the number of CCCTC-binding factor (CTCF)-cohesin complexes between th

162 0-NAP1-H1 interactions, is propagated over a CCCTC-binding factor (CTCF)-demarcated region through a

163 Strikingly, this interaction is CCCTC-binding factor (CTCF)-dependent and strictly allel

164 r and activates HPIP gene transcription in a CCCTC-binding factor (CTCF)-dependent manner.

165 ongation, long noncoding RNAs (lncRNAs), and CCCTC-binding factor (CTCF)-RNA interactions, but system

166 or I (NFI), while DPF2-L sites were bound by CCCTC-binding factor (CTCF).

167 iating domain (TAD) boundaries, enriched for CCCTC-binding factor (CTCF).

168 its movement by transcription and DNA-bound CCCTC-binding factor (CTCF).

169 ite motifs for the enhancer blocking protein CCCTC-binding factor (CTCF).

170 tylation, transcription factor [Abeta(42) or CCCTC-binding factor (CTCF)] binding, and Txnip promoter

171 The CCCTC-binding factor, CTCF, binds to the insulator eleme

172 CCCTC-binding factor, CTCF, has received much attention

173 ditional deletion of the chromatin remodeler CCCTC-binding factor impaired nerve regeneration, implic

174 ociated with reduced occupancy of Ikaros and CCCTC-binding factor in the Vkappa-Jkappa intervening se

175 (rs17736312 [ROBO2]) and rs113230990 (near a CCCTC-binding factor insulator [< 750 base pair]) passed

176 CTCF (CCCTC-binding factor) is a highly conserved multifunctio

177 CTCF (CCCTC-binding factor) is a key architectural protein tha

178 CTCF (CCCTC-binding factor) is the only known major insulator-

179 Loss of STAG2 inhibited CCCTC-binding-factor-mediated expression of dual specifi

180 of the HSV-1 genome contain clustered CTCF (CCCTC-binding factor) motifs, (ii) CTCF motif clusters s

181 acterized human transcription factors: CTCF (CCCTC-binding factor), NRSF (neuron-restrictive silencer

182 ng regions for the transcriptional regulator CCCTC-binding factor of ESR1 and ESR2, consistent with s

183 e that the vertebrate genome organizer CTCF (CCCTC-binding factor) played an important role for the e

184 DMD that bind the insulator-associated CTCF (CCCTC-binding factor) protein and are implicated in medi

185 A previous study demonstrated that CTCF (CCCTC binding factor) regulates homeobox Pax6 gene expre

186 control sequences due to stalled cohesin at CCCTC-binding factor sites.

187 boundary protein and transcription repressor CCCTC-binding factor was enriched at the EBNA2 transcrip

188 n domains defined by constitutive binding of CCCTC binding factor, which appears to restrict the regu

189 1-CTCF (a catalytically dead Cpf1 fused with CCCTC-binding factor) with target CRISPR RNA enhanced ME