ライフサイエンスコーパス: CCI

1 CCI (at hospital discharge and after 6 months) was the r

2 CCI data were prospectively collected over a 1-year peri

3 CCI induced up-regulation of MyD88 and chemokine C-C mot

4 CCI injury strongly induced Runx1 expression in activate

5 CCI patients were older, with greater comorbidities, and

6 CCI ranged from 53 to 88 and correlated with the proport

7 CCI significantly up-regulated GFAP, V1aR and AQP4 prote

8 CCI was associated with increased overall mortality in t

9 CCI was not accurate in calculating the severity of a co

10 CCI, registered during 90 days after pouch construction,

11 CCI-006 inhibited mitochondrial respiration and induced

12 CCI-induced mechanical hyperalgesia was reduced in IL-33

13 CCI-ION caused orofacial hypersensitivity that correlate

14 igh 90-day morbidity (odds ratio 3.96 per 10 CCI points, P < 0.001).

15 with higher CCI category and MELD >=18 (12% (CCI = 0), 22% (CCI = 1-2) and 33% (CCI > 2), (p = 0.002)

16 category and MELD >=18 (12% (CCI = 0), 22% (CCI = 1-2) and 33% (CCI > 2), (p = 0.002)) but not MELD-

17 =18 (12% (CCI = 0), 22% (CCI = 1-2) and 33% (CCI > 2), (p = 0.002)) but not MELD-Na <=17.

18 CCI scores were as follows: CCI 2, n = 589; CCI 3 or 4, n = 599; CCI 5 or 6, n = 229; and CCI >/= 7,

19 ollows: CCI 2, n = 589; CCI 3 or 4, n = 599; CCI 5 or 6, n = 229; and CCI >/= 7, n = 102.

20 subhazard ratio [SHR] 1.4; 95% CI, 1.1-1.9), CCI score higher than 3 (SHR 2.8; 95% CI, 2.1-3.7), a ce

21 y, among patients with pT1Nx-0 disease and a CCI </= 1, risk of non-RCC death exceeded that of abdomi

22 For patients with pT1Nx-0 disease but a CCI >/= 2, the risk of non-RCC death exceeded that of ab

23 200-12.767; P = 0.024) as risk factors for a CCI >60.

24 survival was independently associated with a CCI >=3 (HR 1.62 IC 1.09-2.41 p<0.02) and the use of CNI

25 survival was independently associated with a CCI of >=3 (hazard ratio 1.62; confidence interval 1.09-

26 Among women with a CCI score of >=3, 15 additional deaths per 100 patients

27 d by 39% after 6 years among patients with a CCI score of >=3, while among women with no comorbidity,

28 16,007) of super-utilizers presented with a CCI score of >=3.

29 Age-adjusted CCI (hazard ratio [HR] = 1.36, P < .001), L5HU (HR = 2.8

30 oncancer death versus 0.718 for age-adjusted CCI alone.

31 ng, androgen deprivation, race, age-adjusted CCI, L5HU, and PsoasL4-5 were included in a multivariabl

32 of YAP and TAZ was on day 14 and day 1 after CCI, respectively; (3) there were also unique topographi

33 to chronic Alzheimer-like alterations after CCI in Tg/htau mice.

34 brain resident microglia prior to and after CCI, in order to confirm that modulations of HP [1-(13)C

35 transient impairment in motor function after CCI in rats and mice.

36 ing the CA1 and CA3 of the hippocampus after CCI.

37 tment was delivered for the first hour after CCI.

38 we found that neuronal edema 48 hours after CCI was associated with reduced cellular and network exc

39 gulated, with a 305-fold peak 12 hours after CCI, which effectively counteracted the 2- to 3-fold inc

40 at 2 g/kg, i.p.) initiated immediately after CCI was found to significantly attenuate a TBI-induced d

41 Immediately after CCI, rats received either a hemi-craniectomy (TBI Open S

42 expression was significantly increased after CCI, indicating translocation of TAZ from the cytoplasma

43 l hippocampus 6 weeks but not 7 months after CCI.

44 ollowed two distinct temporal patterns after CCI, such that the highest expression of YAP and TAZ was

45 ne-synthesizing enzyme serine racemase after CCI injury improved synaptic plasticity, brain oscillati

46 Tregs are essential for pain recovery after CCI.

47 sed susceptibility to SDs and seizures after CCI, showing that neuronal volume reduction, regardless

48 en neuronal edema normalized by 1 week after CCI.

49 Among CCI patients, independent risk factors for death by 12 m

50 cin) pathway using rapamycin or its analogue CCI-779 can improve the cellular and behavioural phenoty

51 In multivariate analysis, CCI was the most powerful predictor of OS, which was sti

52 In-hospital mortality was 1%, and CCI was 21 +/- 19.

53 CI 3 or 4, n = 599; CCI 5 or 6, n = 229; and CCI >/= 7, n = 102.

54 All complications graded with the CDC and CCI and related to the initial admission, or until disch

55 ed patients (P=0.020 and P=0.025 for CDC and CCI, respectively).At a linear regression model, age (be

56 8.2L (15.6-20.6), P=0.009, respectively] and CCI>=40, or not [20.3L (18.5-22.7) vs. 18.3L (15.6-20.6)

57 nduced cold allodynia (at 10-30 mug sc), and CCI-induced thermal hyperalgesia (at 11.5 mg/kg ip) mice

58 In CCI-vehicle, sham and CCI-SR49059 groups, fluorescence intensity of GFAP was 3

59 In CCI-vehicle, sham and CCI-SR49059 groups, GFAP was 1.58+/-0.04, 0.47+/-0.02, a

60 atched with CSS alone in six, CSS as well as CCI in one, and neither CSS or CCI in two scenarios.

61 %; 9.5+/-0.9 microm(2)), and SR49059 blunted CCI-induced increases in brain edema (79.0+/-0.2%; 9.4+/

62 oth tissue and neurological function in both CCI and CHI TBI models in mice.

63 Morris water maze test showed that both CCI and S-CCI produced persisting memory deficits.

64 a randomized trial (effect size detected by CCI vs conventional standardized morbidity outcomes).

65 e YAP expression were selectively induced by CCI but not CFA-induced hindpaw inflammation; and (5) th

66 val after resection of CLM was stratified by CCI (high, >/=26.2; low, <26.2).

67 In the multivariate analysis, CDC, CCI, age, and duration of surgery were all associated wi

68 ewer patients with morbidity, but comparable CCI when morbidity is present.

69 ociated with a complex postoperative course (CCI at 6 months >60).

70 ting poor outcome as defined by a cumulative CCI >=37.1 at 90-days.

71 Lower HRR scores and higher D15 CCI (both indicating worse color vision) were associated

72 and Lanthony D15 color confusion index (D15 CCI).

73 6.7%% vs 63.7%, P = 0.029) and median 90-day CCI {21 [interquartile range (IQR) 0-36] vs 29 [IQR 0-40

74 Despite CCI, the HP [1-(13)C] lactate-to-pyruvate ratio at the i

75 comorbidity burden and patients that develop CCI.

76 d recovery (RAP), whereas 99 (33%) developed CCI.

77 The recently developed CCI for measuring complications is a step forward in thi

78 e observed between patients in the different CCI groups.

79 IL-33-mediated hyperalgesia during CCI was dependent on a reciprocal relationship with TNF-

80 ons, intrathecal injection of IL-33 enhanced CCI hyperalgesia and induced hyperalgesia in naive mice.

81 Following CCI injury, hippocampal neurons downregulated d-serine l

82 t edema was predominantly cellular following CCI and documented that V1aR inhibition with SR49059 sup

83 sions and increased motor deficits following CCI injury.

84 Resulting CCI scores were as follows: CCI 2, n = 589; CCI 3 or 4, n = 599; CCI 5 or 6, n = 229

85 However, T cells from CCI patients exhibited no suppressed TCR response at the

86 We found that T cells from CCI patients featured higher basal levels of activation

87 strate an augmented response in T cells from CCI patients in response to TCR/coreceptor (CD3/CD28) ch

88 sity was reduced in high-threshold CSNs from CCI mice compared with sham animals, with no differences

89 ociceptive-like phenotype among neurons from CCI animals compared with sham mice.

90 Control and Prevention has set itself a goal CCI of 90 as being easy to understand.

91 220 (35%) were age >/=65 years, and 92% had CCI > 0, indicating >/=1 comorbid conditions.

92 controls), among whom 520 (52%) patients had CCI on imaging.

93 High CCI (odds ratio 3.99, P <0.001) was associated with high

94 High CCI is a potent predictor of worse RFS and CSS after res

95 c resection were worse in patients with high CCI than in patients with low CCI (RFS at 3 yrs 26% vs.

96 ort, LCT-EOS cutoff best discriminating high-CCI, 90-day-mortality and severe-morbidity were 3, 3 and

97 nd 17.7% the accuracy of the models for high-CCI, 90-day-mortality and severe-morbidity, respectively

98 Higher CCI was significantly associated with lower OS probabili

99 th no differences based on gender but higher CCI in patients with fatty and cryptogenic liver disease

100 ality was specifically increased with higher CCI category and MELD >=18 (12% (CCI = 0), 22% (CCI = 1-

101 Median in-hospital CCI was comparable for both groups (DCD 38.2; DBD 36.7;

102 However, CCI was not associated with the percentage of low EA in

103 ctive for MLL-rearranged leukemia identified CCI-006 as a novel inhibitor of MLL-rearranged and CALM-

104 ss into a state of chronic critical illness (CCI) and their post-discharge outcomes are unclear.

105 clinical study of chronic critical illness (CCI) patients aimed at assessing the long-term consequen

106 In the controlled cortical impact (CCI) animal model of pediatric TBI (postnatal day 16-17)

107 mild-to-moderate controlled cortical impact (CCI) in 5-7-month-old Tg/htau mice, which express all si

108 s produced using controlled cortical impact (CCI) in a rat model, and TNS treatment was delivered for

109 veral days after controlled cortical impact (CCI) in mice.

110 citability after controlled cortical impact (CCI) in mice.

111 damage caused by controlled cortical impact (CCI) injury in mice results in a switch from neuronal to

112 to TBI using the controlled cortical impact (CCI) injury model.

113 1(-/-) mice in a controlled cortical impact (CCI) injury murine model of traumatic brain injury (TBI)

114 lly prepared for controlled cortical impact (CCI) injury or sham surgery.

115 ed adult mice to controlled cortical impact (CCI) injury, and isolated RNA from the SVZ and DG at dif

116 el of unilateral controlled cortical impact (CCI) injury.

117 The controlled cortical impact (CCI) model is one of the most commonly used models of co

118 s study, using a controlled cortical impact (CCI) model of head injury, we show a large increase in t

119 arget in a mouse controlled cortical impact (CCI) model of traumatic brain injury.

120 injury (CHI) and controlled cortical impact (CCI) models, we developed a bilateral head injury model

121 rats received a controlled cortical impact (CCI) over the caudal forelimb area (CFA) of the motor co

122 Using a controlled cortical impact (CCI) procedure in rats, we show that traumatic brain inj

123 odel of moderate controlled cortical impact (CCI) while considering different time points (1 day, 3 d

124 xperimental TBI, controlled cortical impact (CCI), and closed head injury (CHI).

125 at 6 weeks after controlled cortical impact (CCI).

126 t models of TBI (controlled cortical impact [CCI] and fluid percussion injury [FPI]).

127 In CCI-vehicle, sham and CCI-SR49059 groups, fluorescence i

128 In CCI-vehicle, sham and CCI-SR49059 groups, GFAP was 1.58+

129 ded are data from 2862 participants (1337 in CCI's, 1425 in HH's, and 100 street youth).

130 n in HH reported an adequate diet vs. 95% in CCI's and 99% among street youth.

131 ent, also diminishes mechanical allodynia in CCI in female mice.

132 on, MrgprD is essential in cold allodynia in CCI-induced neuropathic pain through the PKA-TRP-A1 path

133 ed the beta-alanine-induced pain behavior in CCI models.

134 y low height-for-age compared to children in CCI's, suggesting chronic malnutrition among them.

135 ave an adequate diet compared to children in CCI's.

136 ive outcomes yielded a resultant decrease in CCI in the most current era.

137 neuropathic painful conditions evaluated in CCI and STZ murine model.

138 rea (n=3/group) were significantly higher in CCI-vehicle (80.5+/-0.3%; 18.0+/-1.4 microm(2)) versus s

139 For every 1-point improvement in CCI, low EA patients increase by 0.2% (P < 0.05), transl

140 Globally, national level increases in CCI were 17.5% faster than they would have been without

141 LPB neurons in CCI-Pain animals showed a reduction in inhibitory, GABAe

142 ignaling and adhesion, were found reduced in CCI-injured juvenile compared to CCI-injured adult immun

143 analgesia was associated with reductions in CCI-related GAD65 and GAT-1 serine dephosphorylation as

144 o have an adequate diet compared to those in CCI's (AOR 0.4, 95% CI 0.2-1.0).

145 hereas the itching behavior was unchanged in CCI models compared with sham-injured animals.

146 urvival (OS) and crude cumulative incidence (CCI) of local recurrence (LR) and distant metastasis (DM

147 02) were independent predictors of increased CCI.

148 ssessed using the Clear Communication Index (CCI).

149 any comorbidity [Charlson Comorbidity Index (CCI) = 0] and 49.8% (n = 16,007) of super-utilizers pres

150 plication of the Charlson comorbidity index (CCI) and other uremia-related comorbidities, not include

151 ith age-adjusted Charlson Comorbidity Index (CCI) by using the Harrell c statistic.

152 The Charlson comorbidity index (CCI) score was calculated for each patient at inclusion

153 ts, depending on Charlson Comorbidity Index (CCI) score, was observed 1 year after hip fracture.

154 The Charlson Comorbidity Index (CCI) was developed in 1987 and is the most used comorbid

155 sorders; and the Charlson Comorbidity Index (CCI), which includes major chronic disorders predictive

156 ailty score, and Charlson comorbidity index (CCI).

157 asured using the Charlson Comorbidity Index (CCI).

158 gnosis using the Charlson Comorbidity Index (CCI); 511 indexed comorbidities were reported in 1519 CM

159 = 80 years), and Charlson comorbidity index (CCI; </= 1 and >/= 2).

160 ell as the Comprehensive Complication Index (CCI) (Ann Surg 258(1):1-7, 2013).

161 ints (high comprehensive complication index (CCI) scores, 90-day-mortality and severe-morbidity), pro

162 lue of the comprehensive complication index (CCI) to standard assessment of postoperative morbidity,

163 (CSS) with comprehensive complication index (CCI) using a questionnaire-based survey of experienced g

164 Mean comprehensive complication index (CCI) was 26.0 (IQR, 8.7-36.2).

165 d with the comprehensive complication index (CCI), and the neutrophil-to-lymphocyte ratio (NLR) was u

166 The Comprehensive Complication Index (CCI), covering the first 7 postoperative days, was calcu

167 luding the comprehensive complication index (CCI), were compared between patients who underwent hepat

168 the novel Comprehensive Complication Index (CCI).

169 using the comprehensive complication index (CCI).

170 ), and the Comprehensive Complication Index (CCI).

171 on and the Comprehensive Complication Index (CCI).

172 including comprehensive complications index (CCI), Clavien-Dindo complication (CDC), and pulmonary co

173 leading to a "chlorophyll/carotenoid index" (CCI) that tracks evergreen photosynthesis at multiple sp

174 ed trends in a composite coverage indicator (CCI) based on eight reproductive, maternal, newborn, and

175 al root ganglion (DRG) neurons and inhibited CCI-evoked neuroinflammation in DRGs and spinal cord tis

176 weeks in murine chronic constriction injury (CCI) and spared nerve injury models.

177 l nerve injury: chronic constriction injury (CCI) and spinal nerve ligation (SNL).

178 yperalgesia and chronic constriction injury (CCI) induced cold allodynia and models of inflammatory a

179 but not in the chronic constriction injury (CCI) model of the sciatic nerve.

180 pain using the chronic constriction injury (CCI) model.

181 ynia induced by chronic constriction injury (CCI) of the sciatic nerve in mice, was related to both a

182 Chronic constriction injury (CCI) of the sciatic nerve induced IL-33 production in th

183 pain following chronic constriction injury (CCI), were reduced in CKO mice.

184 d rat models of chronic constriction injury (CCI)-induced neuropathic pain.

185 le of MrgprD in chronic constriction injury (CCI)-induced neuropathic pain.

186 ving pain after chronic constriction injury (CCI).

187 brain edema after cortical contusion injury (CCI) in rat 5h post-injury.

188 bolic changes in controlled cortical injury (CCI) mice (n = 57).

189 y chronic constriction sciatic nerve injury (CCI).

190 (HH), 19 Charitable Children's Institutions (CCIs), and 100 street-involved children.

191 ulation with confirmed cortical involvement (CCI) and was analysed using the Hochberg multi-step proc

192 Eighty-eight patients had high and 487 low CCI.

193 ents with high CCI than in patients with low CCI (RFS at 3 yrs 26% vs. 41%, P = 0.003; CSS at 5 yrs 4

194 Overall, ta-IPAA led to lower CCI scores.

195 Blood was drawn from 12 male CCI patients (median age 67 y, range 48-79 y) receiving

196 In patients with morbidity, mean CCI of the transanal approach was 2.23 points lower than

197 Six-month postoperative median CCI was significantly higher for DCD grafts (53.4 vs 47.

198 The median CCI was 24 (IQR 0.0-24.2), and 24 patients (9.6%) had a

199 ffect of a controlled cortical impact model (CCI) of traumatic brain injury (TBI) on their distributi

200 nstriction injury to the infraorbital nerve (CCI-ION) to study whether CCI-ION caused calcium channel

201 nstriction injury to the infraorbital nerve (CCI-ION).

202 nstriction injury of the infraorbital nerve (CCI-Pain) displayed higher spontaneous and evoked activi

203 Healthy non-CCI rats (n = 5), were also employed.

204 Genome-wide comparison of CCI-injured peripheral whole blood showed a significant

205 015 was associated with a lower incidence of CCI >=26.2 (odds ratio 0.7, 95% confidence interval 0.6-

206 lization (7, 7, 6 days, P < 0.001), rates of CCI >=26.2 (20%, 22%, 16%, P < 0.001) and 90-day mortali

207 own study providing insight into the role of CCI in Alzheimer-like brain alterations in young adult m

208 Mice were subjected to S-CCI or CCI using an electromagnetic impactor (Impactor One, MyN

209 SS as well as CCI in one, and neither CSS or CCI in two scenarios.

210 Multivariate analyses for OS, CCI of LR, and DM were performed.

211 ical and behavioral outcome in the pediatric CCI model.

212 ations (2 g/kg, i.p.) at 0, 1, 3 and 6h post-CCI.

213 urons in cortex and hippocampus at 24 h post-CCI.

214 assessed on a skilled reaching task on post-CCI weeks 1-4, 8, 12, and 16.

215 erficial dorsal horn (lamina I) 3 weeks post-CCI-ION.

216 e, MyNeuroLab; semicircular tip: 3mm radius; CCI tip diameter: 3mm).

217 o specific allosteric inhibitors (rapamycin, CCI-779, and RAD001) of the pivotal cell growth regulato

218 Rat CCI and FPI displayed distinct serum miRNA profiles.

219 Moreover, i.t. BMSCs reduced CCI-induced spontaneous pain and axonal injury of dorsal

220 ptor (IL-33 decoy receptor) markedly reduced CCI-induced hyperalgesia.

221 Resulting CCI scores were as follows: CCI 2, n = 589; CCI 3 or 4,

222 ver operating characteristic curves revealed CCI to be a more sensitive, specific, and accurate predi

223 s water maze test showed that both CCI and S-CCI produced persisting memory deficits.

224 Here we report a new semicircular CCI (S-CCI) model by increasing the impact tip area to cover bo

225 We showed that S-CCI, at two injury severities, significantly decreased t

226 matosensory and motor deficits only in the S-CCI groups.

227 ages after the injury, suggesting that the S-CCI model produces long-lasting motor deficits.

228 otor cortex, and hippocampal damage in the S-CCI.

229 Mice were subjected to S-CCI or CCI using an electromagnetic impactor (Impactor O

230 Here we report a new semicircular CCI (S-CCI) model by increasing the impact tip area to c

231 ator and rapidly (within minutes) suppressed CCI-evoked spinal synaptic plasticity and DRG neuronal h

232 DA-approved rapamycin analogue temsirolimus (CCI-779) blocks ANDV protein expression and virion relea

233 particular the mTOR inhibitor temsirolimus (CCI-779), induce autophagy, which can promote tumor surv

234 Thus, the present findings reveal that CCI sepsis patients feature signs of immune suppression

235 The CCI adds information on postoperative morbidity in almos

236 The CCI at postoperative day 7 strongly predicted high 90-da

237 The CCI in the RCT on colon resections confirmed the absence

238 The CCI is calculated as the sum of all complications that a

239 The CCI may serve as an appealing endpoint for future RCTs a

240 The CCI summarizes all postoperative complications and is mo

241 The CCI summarizes all the postoperative complications grade

242 The CCI used was unadjusted for recipient age.

243 The CCI was 0 (no comorbidities) in 44%, 1-2 in 44% and > 2

244 The CCI was highly sensitive in detecting treatment effect d

245 The CCI was introduced about 3 years ago as a novel metric o

246 The CCI was tested in 3 published RCTs from European centers

247 The CCI, integrating all complications including their sever

248 From 1994 to 2014, the CCI increased by 0.82 percent points a year across all c

249 Three weeks after the CCI injury, the TBI Closed Skull Group demonstrated impr

250 postoperative events were assessed, and the CCI calculated.

251 obtained were compared with the CSS and the CCI for these patients.

252 The CDC and the CCI were moderately to strongly correlated with overall

253 d to separate comorbidity covariates and the CCI.

254 ex hospital stay for DCD and DBD LT, but the CCI increases significantly for DCD recipients in 6 mont

255 Information gained by the CCI increased with the complexity of surgery and observa

256 using any or most severe complications, the CCI revealed significant differences between treatment g

257 In contrast, the CCI induced motor deficits only at early stages after th

258 In our environment, the CCI presented associations with OPC.

259 es in trials are up to 9 times lower for the CCI than for traditional morbidity endpoints.

260 inter-connection, should be included in the CCI calculation to best mirror the patients' postoperati

261 n IOF rate experienced a 43% increase in the CCI compared with patients who received less than the me

262 In the CCI population, the proportion was 50% (121/244) in the

263 ion intensity and the primary outcome in the CCI population: the proportion with favourable outcome i

264 a-related comorbidities, not included in the CCI, were associated with mortality in these patients.

265 hils and on infiltrating immune cells in the CCI-injured juvenile cortex.

266 Of note at 12 months, the CCI cohort had persistent severely impaired performance

267 Beyond MELD-Na, the CCI was independently associated with 90-day mortality (

268 pain behavior in the oxaliplatin but not the CCI model.

269 sed to determine the additional value of the CCI compared to the Clavien-Dindo classification.

270 This study demonstrates superiority of the CCI to traditional endpoints.

271 To compare the sensitivity of the CCI with traditional morbidity endpoints, for example, p

272 suggest solutions for consistent use of the CCI.

273 It remains unclear, how often the CCI adds to standard reporting of complications and how

274 nd 51 also showed significant effects on the CCI-induced neuropathic pain model.

275 ging Spectroradiometer satellite sensor, the CCI closely follows the seasonal patterns of daily gross

276 lly in hippocampal tissue ipsilateral to the CCI injury.

277 loped, and its influence was compared to the CCI.

278 le size calculations were compared using the CCI and traditional endpoints.

279 Using the CCI, the corresponding prevalences were 73.1% (all prete

280 Besides, we wondered whether the CCI was best to study the influence of comorbidity in ki

281 ex that incorporated these measures with the CCI was associated with improved accuracy for prediction

282 cation by the time of discharge, and thereby CCI added information to the standard grading system of

283 Thus, CCI-ION-induced Cavalpha2delta1 up-regulation may contri

284 unresponsive MLL-rearranged leukemia cell to CCI-006, indicating that this pathway plays a role in de

285 reduced in CCI-injured juvenile compared to CCI-injured adult immune cells.

286 ger increases observed after SNL relative to CCI.

287 s, if all centers improved their websites to CCI of 90.

288 tomoses less than 10 cm from the anal verge, CCI of 3 or more, high inferior mesenteric artery ligati

289 nfraorbital nerve (CCI-ION) to study whether CCI-ION caused calcium channel alpha2delta1 (Cavalpha2de

290 preoperative sarcopenia was associated with CCI (P = 0.043), and CDC >/=IIIb (P = 0.003).

291 tients (9.6%) had a complication burden with CCI>=40.

292 r calculating morbidity and compared it with CCI.

293 281 matched with CSS while 143 matched with CCI (P = 0.0001, odds ratio: 3.7; 95% CI 2.8-4.8).

294 The mice with CCI also exhibited cognitive and locomotor impairment.

295 at 5 years was 37% higher for patients with CCI >= 3, and 46% higher in those with CCI < 3, compared

296 at 5 years was 37% higher for patients with CCI >=3, and 46% higher in those with CCI <3, compared w

297 %, 89.4%, 77.6%, and 46.4% for patients with CCI 2, 3 to 4, 5 to 6, and >/=7, respectively.

298 with CCI >= 3, and 46% higher in those with CCI < 3, compared with patients remaining on the WL.

299 s with CCI >=3, and 46% higher in those with CCI <3, compared with patients remaining on the WL.

300 Combination treatment with CCI-779 and HCQ suppressed melanoma growth and induced c

301 The 5, 8, and 10-year CCI of LR and DM were 25.9 (95% CI, 23.1, 29.1), 31.3 (9