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1 ion site on the virus binding surface of the CD4 receptor.
2 d it block the interaction of gp120 with the CD4 receptor.
3 characteristic or atypical expression of the CD4 receptor.
4 n and antagonized the normal function of the CD4 receptor.
5 een the viral gp120 protein and the cellular CD4 receptor.
6 s HIV-1 at the level of interaction with the CD4 receptor.
7 p120 protein not recognized by the host cell CD4 receptor.
8 120 recognition that includes mimicry of the CD4 receptor.
9 gp120, which binds with high affinity to the CD4 receptor.
10  efficiently mediate entry using the macaque CD4 receptor.
11 esus and pig-tailed macaque versus the human CD4 receptor.
12 p120 monomer similar to those induced by the CD4 receptor.
13 minants controlling raft localization of the CD4 receptor.
14 ut not in cells expressing low levels of the CD4 receptor.
15  on the gp120-induced internalization of the CD4 receptor.
16 ole in the HIV-induced downmodulation of the CD4 receptor.
17 s transfer requires the engagement of T-cell CD4 receptors.
18 f gp120 is essential for HIV binding to host CD4 receptors.
19 he initial binding of HIV virions to surface CD4 receptors.
20 ns of the HIV-1 envelope protein to cellular CD4 receptors.
21 t of the gp120 glycoprotein upon binding the CD4 receptor, allow it to evade antibody-mediated neutra
22                      Because ligation of the CD4 receptor alone or the CXCR4 receptor alone causes p3
23  the four modular ectodomains (D1-D4) of the CD4 receptor, an important receptor in immune signaling.
24 the high affinity of R3A Env for binding the CD4 receptor and (ii) Nef activity, which is involved in
25 the high affinity of R3A Env for binding the CD4 receptor and (ii) Nef activity, which is involved in
26                           HIV-1 requires the CD4 receptor and a coreceptor (CCR5 [R5 phenotype] or CX
27 elope glycoproteins (Envs) interact with the CD4 receptor and CCR5/CXCR4 coreceptor expressed on targ
28 earrangement of Env upon binding to the host CD4 receptor and chemokine coreceptor drives membrane fu
29 it enhanced exposure after attachment to the CD4 receptor and comprise some of the most conserved and
30 w that sFN-mediated enhancement requires the CD4 receptor and does not alter the specificity of gp120
31 rises from the interaction of gp120 with the CD4 receptor and enables interactions with specific core
32 irus type 1 (HIV-1) Vpu protein binds to the CD4 receptor and induces its degradation by cytosolic pr
33 3) is a protein with a high affinity for the CD4 receptor and is expressed mainly by regulatory T cel
34 ain microglia that express low levels of the CD4 receptor and is the cause of HIV-associated dementia
35 d has important roles in down-regulating the CD4 receptor and modulating T-cell signaling pathways.
36  the viral envelope glycoprotein to both the CD4 receptor and one of several chemokine receptors and
37       HIV-1 infection of DCs via its primary CD4 receptor and secondary chemokine receptors leads to
38 in the trimer is capable of attaching to the CD4 receptor and the coreceptor, and each of the three g
39  envelope glycoprotein gp120 to the cellular CD4 receptor and the coreceptor, usually CCR5 or CXCR4.
40                             The roles of the CD4 receptor and the src kinase p56lck were examined in
41 text of an HIV-1 gp120 core complexed to the CD4 receptor and to the X5 antibody at 3.5 angstrom reso
42  of cells expressing low levels of the human CD4 receptor and with soluble CD4 sensitivity.
43 ral envelope glycoprotein (Env) and cellular CD4 receptors and coreceptors.
44 f this signaling pathway requires functional CD4 receptors and is independent of binding to CXCR4.
45 the virus invades host cells by attaching to CD4 receptors and thereafter one of two major chemokine
46 ts within a given trimer have to bind to the CD4 receptors and to the coreceptors, and how many gp41
47 at two envelope proteins have to engage with CD4-receptors and coreceptors and that two fusion protei
48 es of isolated viral envelope antigens, host CD4 receptors, and cognate antibodies.
49 n, mediates degradation of the primary viral CD4 receptors, and inhibits activation of the transcript
50 enal tubular epithelial cells do not express CD4 receptors, and it is unclear how these cells become
51  envelope glycoprotein gp120 to the cellular CD4 receptor, are largely unknown.
52 oluble CD4) or on the T-cell surface (native CD4 receptor) as determined by a competitive gp120 captu
53 pends on membrane expression of the critical CD4 receptor, as well as certain chemokine coreceptors.
54 e show that the spatial orientation of gp120-CD4 receptor binding relative to the site of TCR engagem
55  in VC20013 and an epitope that overlaps the CD4 receptor binding site in VC10014.
56 C01 class of antibodies blocks the conserved CD4 receptor binding site interaction that is necessary
57  of VRC01-class bnAbs, which bind within the CD4 receptor binding site of Env.
58      These bnAb precursors, which target the CD4 receptor binding site, had undergone somatic hypermu
59 rved in "open" state structures formed after CD4 receptor binding.
60 r the structurally conserved site of initial CD4 receptor binding.
61 egions of the protein surface to antibody or CD4 receptor binding; the number of glycans that can pot
62  of the viral envelope glycoprotein with the CD4 receptor, binding of the envelope-CD4 complex to che
63   The epitope recognized by b12 overlaps the CD4 receptor-binding site (CD4bs) on gp120 and has been
64 tely mimics native Env spikes, including the CD4 receptor-binding site and the epitope for the VRC PG
65 The latter is different from the fully open, CD4 receptor-bound conformation and may represent an int
66 irus (HIV) entry is mediated not only by the CD4 receptor, but also by interaction with closely relat
67                              Ligation of the CD4 receptor by HIV envelope glycoprotein gp120 inhibits
68  Functionally, the observed shape changes in CD4 receptor causes dissociation of lymphocyte kinase fr
69 dependence on the formation of a gp120-human CD4 receptor complex.
70 ti-CD4 mAb to the OKT4A/Leu3a epitope of the CD4 receptor, compound 24 being the most active in this
71                                          The CD4 receptor contributes to T-cell activation by coligat
72 ce in their ability to infect cells with low CD4 receptor densities, in their sensitivity to soluble
73 ry-based quantitative method to quantify the CD4 receptor density in units of copy number per cell on
74 n the cells of New World monkeys because the CD4 receptor does not efficiently support HIV-1 entry.
75 some isolates of HIV-1 subtype C can use the CD4 receptor encoded by permissive Spix's owl monkey all
76                            We found that the CD4 receptors encoded by two other species of owl monkey
77 , including functional differences with host CD4 receptor engagement and possible changes in the CD4
78  local thresholds for signaling propagation, CD4 receptor engagement by gp120-containing ICs all arou
79 gp120 and undergo conformational change upon CD4 receptor engagement by the HIV-1 envelope spike.
80 ion structures emerging on trimeric Env post CD4 receptor engagement.
81  entry into cells by down-modulating surface CD4 receptor expression through binding to the CD4 signa
82 V-1 infection relating to down-regulation of CD4 receptor expression.
83 in (gp120) and cluster of differentiation 4 (CD4) receptor extends beyond residue phenylalanine 43 of
84  do not use nonhuman primate versions of the CD4 receptor for cellular entry, or they do so poorly.
85 in formed syncytia with cells expressing the CD4 receptor for HIV.
86       A key function of Nef is to remove the CD4 receptor from the cell surface by hijacking clathrin
87          Although autoantibodies against the CD4 receptor have previously been identified in people w
88 ptide containing residues 36-59 of the human CD4 receptor includes most of the residues thought to be
89 man immunodeficiency virus type 1 (HIV-1) to CD4 receptors induces multiple cellular signaling pathwa
90 t binding of HIV-1 envelope glycoproteins to CD4 receptor initiates a signaling pathway(s) independen
91 s massive virus internalization requires Env-CD4 receptor interactions but is resistant to inhibition
92 caspase-3 and caspase-6 depended on envelope-CD4 receptor interactions; CCR5-utilizing as well as CXC
93 the HIV-1 gp120 envelope glycoprotein to the CD4 receptor involves exceptional changes in enthalpy an
94                       HIV attachment via the CD4 receptor is an important target for developing novel
95 eficiency virus type 1 (HIV-1) gp120 and the CD4 receptor is highly specific and involves relatively
96 iating unilineage precursors showed that the CD4 receptor is present on approximately 15% of the star
97  the HIV-1 gp120 glycoprotein that binds the CD4 receptor is recognized by broadly reactive antibodie
98 ings suggest that HIV-1 gp120 binding to the CD4 receptor is required for m(6)A up-regulation in cell
99                                          The CD4 receptor is required for the entry of human immunode
100    The site on HIV-1 gp120 that binds to the CD4 receptor is vulnerable to antibodies.
101 murine mAb that recognizes an epitope on the CD4 receptor, is a potent immunosuppressive agent in vit
102 ry into HeLa/CD4 cells containing a tailless CD4 receptor, located outside lipid rafts, was fully per
103                    Additionally the disabled CD4 receptor may be less able to signal the cell to allo
104 imulated by the binding of HIV-1 or gp120 to CD4 receptors, may play an essential role in the transcr
105 ontain gp120, and suggest that IC binding to CD4 receptors might contribute to the progressive declin
106 a conformation in which it is bound to three CD4 receptor molecules (state 3)(8-10).
107         Preincubation of Jurkat cells with a CD4 receptor-neutralizing antibody blocked HIV-1-induced
108 to inhibit HIV-1 infections at low levels of CD4 receptor occupancy, showing that GSK3732394 can work
109 es for their ability to infect cells via the CD4 receptor of 15 different primate species.
110            HOC with NH2-terminal fused HIV-I CD4 receptor of 183 amino acids can be detected on the T
111  it loses the ability to enter cells via the CD4 receptor of many primate species as the binding affi
112 ay, we demonstrate that the stoichiometry of CD4 receptor-oligomeric envelope interaction is 1:1.
113                   The HIV envelope binds the CD4 receptor on T cells as soluble shed antigen or as an
114                            Engagement of the CD4 receptor on T cells from HIV-uninfected donors befor
115   We hypothesized that Env engagement of the CD4 receptor on T-helper cells results in anergic effect
116 t attaching with their surface spikes to the CD4 receptor on target cells.
117   Viral entry is initiated by binding to the CD4 receptor on the cell surface, which induces large co
118 lowed the virus to infect cells by utilizing CD4 receptors on their surface.
119 lective and enter cells through some primate CD4 receptor orthologs but not others.
120                Initial signaling through the CD4 receptor played a major role in the sensitization of
121 s or recombinant HIV-1 glycoprotein gp120 to CD4 receptors resulted in association and tyrosine phosp
122                        A soluble form of the CD4 receptor (sCD4) can either enhance or inhibit the in
123 and Raf-1 was mediated by stimulation of the CD4 receptors, since it was abolished by preincubation o
124 nodeficiency virus type 1 (HIV-1) virions to CD4 receptors stimulates association of Lck with Raf-1 a
125  We identify six primate species that encode CD4 receptors that fully support the entry of early HIV-
126                    When interacting with the CD4 receptor, the HIV gp120 envelope glycoprotein underg
127 lating HIV-1 variants cannot use the macaque CD4 receptor to enter cells and have to be adapted to th
128 use chemokine coreceptors in addition to the CD4 receptor to initiate virus infection.
129 ifferences in the functional capacity of the CD4 receptor to mediate entry mapped to a single amino a
130                                    HIV-1 use CD4 receptors to infect their primary targets, CD4+ cell
131                                Expression of CD4 receptor together with CXCR4 and/or CCR5 coreceptor
132                               Binding to the CD4 receptor triggers a cascade of conformational change
133 the HIV-1 envelope gp120 protein to cellular CD4 receptors via a specific and competitive mechanism.
134 ted single-site mutant (F43V) version of the CD4 receptor, was captured onto the sensor surface using
135 rilla CD4 variants into the permissive human CD4 receptor, we demonstrate that acquired substitutions
136                  Differentially glycosylated CD4 receptors were biochemically purified and used in ne
137  compounds that mimic the interaction of the CD4 receptor with HIV-1 envelope glycoproteins (Env).
138 d similar infectivity with macaque and human CD4 receptors (within approximately 2-fold).

 
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