ライフサイエンスコーパス: CD40 ligand

1 teract with CD4 T cells (the major source of CD40 ligand).

2 ies, such as those that target CD4 or CD154 (CD40 ligand).

3 onocyte-derived dendritic cells matured with CD40 ligand.

4 itic cells, in part through up-regulation of CD40 ligand.

5 costimulation can be achieved by addition of CD40 ligand.

6 lls at a site that differs from that used by CD40 ligand.

7 e-forming enzyme perforin, and expression of CD40 ligand.

8 ed signaling platforms that serve to cluster CD40 ligand.

9 s using guanylic acid-grade soluble trimeric CD40 ligand.

10 ure to interferon-alpha, interferon-gamma or CD40 ligand.

11 actor, Toll-like receptor (TLR) ligands, and CD40 ligand.

12 cy disorder caused by genetic alterations in CD40 ligand.

13 0.005), IL-1beta (0.615, p<0.05) and soluble CD40 ligand (0.868, p<0.005), and CSF levels of IL-10 (0

14 IFN-gamma but released it when stimulated by CD40 ligand, a cytokine found in atheroma.

15 ic cell transfusion in combination with anti-CD40 ligand Ab (DST/anti-CD40L).

16 g properties of rATG on CD27- naive B cells, CD40 ligand-activated B cells, and plasma cells in vitro

17 st, naive CD8 T cells primed with allogeneic CD40 ligand-activated monocyte-derived DCs (DC1) differe

18 , and such transmission is also augmented by CD40 ligand activation.

19 ed apoptosis of B cell targets stimulated by CD40 ligand alone was increased in the absence of Btk.

20 ng costimulation blockade (CTLA4-Ig and anti-CD40 ligand) alone or in combination with donor cells en

21 In this study we show that soluble CD40 ligand also promotes the formation of complexes bet

22 ed by stimulation with interleukin 4/soluble CD40 ligand and by stroma cell contact.

23 xP3 Tg mice display reduced up-regulation of CD40 ligand and fewer IFN-gamma-producing cells.

24 tion to plasmablasts in vitro in response to CD40 ligand and IL-21 was abolished.

25 s is elicited by external stimuli, including CD40 ligand and IL-4, provided by bystander immune cells

26 everal different isotypes after culture with CD40 ligand and IL-4.

27 scripts in vitro unless exposed to exogenous CD40 ligand and IL-4.

28 e IgG, IgA, or IgE upon in vitro exposure to CD40 ligand and IL-4.

29 naive B cells ex vivo with a combination of CD40 ligand and interleukin 4.

30 Gene induction by TNF, CD40 ligand and interleukin-1beta was attenuated in cpdm

31 Stimulation of B cells with CD40 ligand and interleukin-4 promoted their ability to

32 ressing T cells depends on clustering of the CD40 ligand and is abrogated by inhibition of CD40 ligan

33 have introduced two new biomarkers, soluble CD40 ligand and ischemia-modified albumin, which may aid

34 y B cells, helper T cells act on B cells via CD40 ligand and secreted cytokines that guide Ig class s

35 sma levels of soluble P-selectin and soluble CD40 ligand and serum TxB2 were significantly higher in

36 ranscription as well as its targets, such as CD40 ligand and Th1/Th2 cytokines.

37 ckade of CXCL13 as well as inhibition of the CD40 ligand and the ICOS ligand suppressed DSA productio

38 nse to signals from activated T cells and to CD40-ligand and soluble T cell-derived signals.

39 excess RGD proteins, including vitronectin, CD40-ligand and thrombospondin-1.

40 activation of B cells by T cells via CD154 (CD40 ligand) and cytokines.

41 natriuretic peptide, interleukin-6, soluble CD40 ligand, and insulin-like growth factor binding prot

42 natriuretic peptide, interleukin-6, soluble CD40 ligand, and insulin-like growth factor binding prot

43 , hemostasis (von Willebrand factor, soluble CD40 ligand, and P-selectin), pulmonary inflammation and

44 y C-reactive protein, interleukin-6, soluble CD40 ligand, and peripheral blood leukocyte subsets in p

45 s such as plasma soluble P-selectin, soluble CD40 ligand, and serum thromboxane B2 (TxB2) were measur

46 CD40 ligand- and Toll-like receptor 9-mediated signaling

47 icient (apoE(-/-)) mice but only slightly in CD40 ligand(-/-)apoE(-/-) mice, compared with apoE(-/-)

48 we show that patient B cells stimulated with CD40 ligand are impaired in both p65 and c-Rel activatio

49 CD40 and CD154 (CD40 ligand) are surface molecules that are central to t

50 growth factor (EGF), HER2, osteoactivin, and CD40-ligand, are increased in the medium of BT474 breast

51 ombomodulin, soluble P-selectin, and soluble CD40 ligand, as well as coagulation factors, endogenous

52 went blood draw the next morning for soluble CD40 ligand, asymmetric dimethylarginine (ADMA), and nit

53 In vivo blockade of CD40 ligand attenuated B-cell abnormalities in a mouse m

54 ; inhibition of tyrosine-protein kinase BTK; CD40 ligand blockade; interfering with the presentation

55 interferon gamma (IFN-gamma), TNF-alpha, or CD40 ligand but did depend on cell-to-cell contact.

56 B cell receptor triggering was reversed with CD40 ligand, but not B cell activation factor.

57 NFalpha, interferon-gamma, IL-1alpha, and/or CD40 ligand, but not by IL-18.

58 lin M syndrome due to impaired expression of CD40 ligand by CD4(+) T cells.

59 etry and the expression of activation marker CD40 ligand by CD4(+)T cells.

60 The expression of CD154 (CD40 ligand) by activated T lymphocytes plays a central

61 ains that contain a Glu or Gln residue (Tnf5/CD40 ligand, C79a/Ig-alpha, C79b/Ig-beta, and Fut3/alpha

62 me-complexed HIV-1 proteins and matured with CD40 ligand can prime CD8(+) T cells to HIV-1 in vitro.

63 We previously showed that a stromal cell/CD40 ligand (CD154) culture system reproduced this switc

64 CD40 ligand (CD154) expression has been shown to be regu

65 Abnormalities in B-lymphocyte CD40 ligand (CD154) expression have been described for a

66 Platelets are an abundant source of CD40 ligand (CD154), an immunomodulatory and proinflamma

67 in producers of interleukin (IL)-21, express CD40 ligand (CD154), and are located within the germinal

68 During cognate interaction with CD40 ligand (CD154)-expressing T cells, Ag-presenting ac

69 cells transduced with an adenovirus encoding CD40-ligand (CD154) caused rapid reductions in leukemia-

70 vidence supports a role of the CD40 receptor-CD40 ligand (CD40-CD40L) interaction in the pathogenesis

71 etry was used to assess SEB-induced CD69 and CD40 ligand (CD40-L) expression and IFN-gamma production

72 Hyper-IgM syndromes result from mutations in CD40 ligand, CD40, AID, or UNG in 70-80% of affected pat

73 CD28-B7 and CD40 ligand-CD40 (CD40L-CD40) costimulatory pathways aff

74 CD4+ T cells and platelets express CD40 ligand (CD40L) and are reported to mediate proinfla

75 infection, we asked whether blockade of the CD40 ligand (CD40L) and CD28 costimulatory pathways impa

76 Interactions between CD40 ligand (CD40L) and CD40 have been shown to have plu

77 vely express the immune-stimulatory molecule CD40 ligand (CD40L) and explored efficacy in different m

78 luding mutations of the genes coding for the CD40 ligand (CD40L) and IKK-gamma (NEMO) genes, both X-l

79 ophage colony-stimulating factor (GM-CSF) or CD40 ligand (CD40L) and investigated their biological ac

80 mice (8 to 10 weeks old) were cultured with CD40 ligand (CD40L) and the Toll-like receptor 9 (TLR9)

81 proinflammatory and proatherogenic mediators CD40 ligand (CD40L) and thromboxanes (TXs).

82 age-mediated repression and identify soluble CD40 ligand (CD40L) as a second repressive factor secret

83 Strong evidence supports a role for CD40 ligand (CD40L) as marker and mediator of inflammato

84 sCD40-immunoglobulin (Ig), blocking the CD40-CD40 ligand (CD40L) costimulatory pathway, from genetica

85 CD40 ligand (CD40L) deficiency causes recurrent sinopulm

86 CD40 ligand (CD40L) deficiency predisposes to opportunis

87 CD40 ligand (CD40L) deficiency, an X-linked primary immu

88 It is known that CD40 ligand (CD40L) exists in platelets, that a soluble

89 iple functions, such as cytokine production, CD40 ligand (CD40L) expression (associated with the cost

90 IL-12 production and up-regulation of CD40 ligand (CD40L) expression are impaired in the PBMC

91 Deficiency in CD40 ligand (CD40L) expression is associated with impair

92 5, a potent growth factor for ILC3s, induced CD40 ligand (CD40L) expression on circulating and tonsil

93 Loss of CD40 ligand (CD40L) expression or function results in X-

94 nventional T cells differ in their 4-1BB and CD40 ligand (CD40L) expression signatures, allowing a cl

95 CD40 ligand (CD40L) expression was enhanced on unpolariz

96 ence implicates the proinflammatory cytokine CD40 ligand (CD40L) in atherosclerosis and accumulating

97 eviously, we detected high levels of soluble CD40 ligand (CD40L) in CSF and plasma of HIV-infected pa

98 studies demonstrated a requirement for CD40-CD40 ligand (CD40L) interaction in the development of re

99 To explore the role of CD40/CD40 ligand (CD40L) interaction in this model, Wt mice g

100 ralization of IL-12 and blockade of the CD40/CD40 ligand (CD40L) interaction in vivo did not alter th

101 ffording protection from HIV.IMPORTANCE CD40-CD40 ligand (CD40L) interaction is crucial for inducing

102 CD40-CD40 ligand (CD40L) interactions appear to play pathogen

103 CD40-CD40 ligand (CD40L) interactions play a critical role in

104 CD40-CD40 ligand (CD40L) interactions play a significant role

105 ent induction of IL-12 is regulated via CD40/CD40 ligand (CD40L) interactions, we examined the effect

106 ll-to-cell contact that is dependent on CD40-CD40 ligand (CD40L) interactions; and (iv) fully activat

107 rove vaccine immunogenicity, we incorporated CD40 ligand (CD40L) into the dSIV envelope.

108 CD40 ligand (CD40L) is an essential effector cytokine fo

109 The blockade of CD40 ligand (CD40L) is effective in autoimmune disease p

110 show that the T-cell costimulatory molecule CD40 ligand (CD40L) is required for ovx to expand SCs; p

111 CD40 ligand (CD40L) is upregulated on activated CD4 T ce

112 X-linked hyper-IgM syndrome (X-HIGM) due to CD40 ligand (CD40L) mutations are susceptible to fungal

113 Binding of CD40 by CD40 ligand (CD40L) on activated CD4+ T cells provides a

114 Costimulation through the CD40-CD40 ligand (CD40L) pathway is critical to allograft rej

115 ss-talk of cluster of differentiation (CD)40/CD40 ligand (CD40L) plays a key role in CD4(+) T-cell pr

116 the control of the cell activation-dependent CD40 ligand (CD40L) promoter.

117 CD40/CD40 ligand (CD40L) signaling contributes to proinflamma

118 CD40/CD40 ligand (CD40L) signaling is a potent activator of e

119 Although the CD40-CD40 ligand (CD40L) signaling pathway has been implicate

120 Activation of B-CLL cells through CD40 ligand (CD40L) stimulation decreases expression of

121 the type 1 or type 2 pathways, respectively, CD40 ligand (CD40L) strongly activates both.

122 The CD40-CD40 ligand (CD40L) system (CD154) is a central means of

123 vestigated the capacity of IFN-gamma and the CD40 ligand (CD40L) to affect the expression and functio

124 Furthermore, T cells, through CD40 ligand (CD40L) to CD40 costimulation, promote OPG p

125 t an approach to arm an oncolytic virus with CD40 ligand (CD40L) to stimulate beneficial immunologic

126 CD40 ligand (CD40L) transduction of antigen-pulsed dendr

127 ey capsule can synergize with transient anti-CD40 ligand (CD40L) treatment to induce robust donor-spe

128 We have previously shown that combining CD40 ligand (CD40L) with Leishmania antigen preferential

129 CD40 ligand (CD40L), a member of the tumor necrosis fact

130 CD40 ligand (CD40L), a member of the tumor necrosis fact

131 ) and a second cassette encoding full-length CD40 ligand (CD40L), a molecule expressed on activated C

132 CD4+ T cells that express CD40 ligand (CD40L), along with other accessory immune a

133 mutations in forkhead box protein 3 (FOXP3), CD40 ligand (CD40L), and IL-10 receptor alpha(IL10RA), a

134 pid raft fraction of PMN membranes expressed CD40 ligand (CD40L), CD28, and leukocyte function-associ

135 bution of the major costimulatory molecules, CD40 ligand (CD40L), CD80, and CD86, in the priming of C

136 s in peripheral blood mononuclear cells [ie, CD40 ligand (CD40L), IL-23alpha subunit p19 (IL23A), adr

137 were characterized by the activation markers CD40 ligand (CD40L), interleukin-2 (IL-2), tumor necrosi

138 stimuli, such as the B-cell receptor (BCR), CD40 ligand (CD40L), or interleukin-4 (IL-4).

139 ype switching, is caused by mutations of the CD40 ligand (CD40L), which is normally expressed on acti

140 s, which were matured by addition of LPS and CD40 ligand (CD40L), with or without ESAT-6.

141 CD40 ligand (CD40L)-deficient C57BL/6 mice failed to con

142 CD40 ligand (CD40L)-deficient mice have been shown to ha

143 ealed that protective immunity requires CD40/CD40 ligand (CD40L)-dependent, interleukin-12 (IL-12)-dr

144 al cells, which involves the contribution of CD40 ligand (CD40L)-expressing bystander mast cells infi

145 Likewise, there was strong inhibition of CD40 ligand (CD40L)-induced activation of MAPKs in TWEAK

146 CD40 ligand (CD40L)-induced cell survival was associated

147 We compared the roles of CD28- and CD40 ligand (CD40L)-mediated costimulation in C. muridar

148 ascular endothelial cells (HIMEC) induced by CD40 ligand (CD40L)-positive T cells and soluble CD40L a

149 lets express CD40 led us to hypothesize that CD40 ligand (CD40L)-positive T cells could bind to plate

150 sed on costimulation blockade, in particular CD40 ligand (CD40L)-specific antibodies, have been highl

151 clearance in a manner partially dependent on CD40 ligand (CD40L).

152 tumor necrosis factor alpha (TNF-alpha), and CD40 ligand (CD40L).

153 der caused by mutations in the gene encoding CD40 ligand (CD40L).

154 mor-associated antigen fragment fused to the CD40 ligand (CD40L).

155 pe 5 fiber, phage T4 fibritin, and the human CD40 ligand (CD40L).

156 al role of the T-cell costimulatory molecule CD40 ligand (CD40L).

157 The interaction between CD40 ligand (CD40L, CD154) and its receptor CD40 on anti

158 B cells are exposed to high levels of CD40 ligand (CD40L, CD154) in chronic inflammatory disea

159 CD40 ligand (CD40L, CD154) induces apoptosis of tumor ce

160 CD40 ligand (CD40L, CD154) is a membrane protein that is

161 ding CD28/B7 molecules (CD80 and CD86), CD40/CD40 ligand (CD40L, CD154), and LFA-1 (CD18)/ICAM-1 (CD5

162 sogenic population induced to proliferate by CD40-ligand (CD40L) and IL4 has revealed that EBV can ov

163 atase 4 (DUSP4) that shortened expression of CD40-ligand (CD40L) and inducible T-cell costimulator (I

164 HIGM patients who carry mutations in the CD40-ligand (CD40L) gene expressed by CD4(+) T cells suf

165 LL) treated with adenovirus CD154 (Ad-CD154, CD40 ligand [CD40L]) gene therapy experienced rapid redu

166 te chemoattractant protein 1, nitrotyrosine, CD40 ligand [CD40L], and monocyte function).

167 e sites in the promoter of the gene encoding CD40 ligand (Cd40lg), and maximum Cd40lg promoter activi

168 The functional significance of CD40 ligand clustering is indicated by the finding that

169 D40 ligand and is abrogated by inhibition of CD40 ligand clustering.

170 n, syndecan-1), platelet activation (soluble CD40 ligand), coagulation activation/inhibition (prothro

171 together with TriMix, a mix of mRNA encoding CD40 ligand, constitutive active Toll-like receptor 4 an

172 s have shown that iNKT-produced IFNgamma and CD40 ligand contribute to this dendritic cell maturation

173 hat CD28 but not ICOS, OX40, 4-1BB, CD27, or CD40 ligand costimulation maintained high levels of Foxp

174 idenced by increased serum levels of soluble CD40 ligand costimulatory molecules.

175 srupting either the CD80/86-CD28 or the CD40-CD40 ligand costimulatory pathway abrogates T-dependent

176 The CD80/86-CD28 and CD40-CD40 ligand costimulatory pathways are essential for Th

177 ma(IL2RG) gene as well as IL-10 receptor and CD40 ligand deficiencies had normal or near-normal mitog

178 immunodepression favoring cryptosporidiosis (CD40 ligand deficiency [n = 1], human immunodeficiency v

179 IgE-expressing B cells in control subjects, CD40 ligand-deficient patients, and patients with atopic

180 ed proliferation and SHM and were present in CD40 ligand-deficient patients, indicating a GC-independ

181 pression of P-selectin, glycoprotein 53, and CD40 ligand, demonstrating tonic inhibition of platelet

182 ding constitutively active TLR4 (caTLR4) and CD40 ligand (DiMix-DCs), or these factors together with

183 emarkably, both B cell-activating factor and CD40 ligand do not significantly induce expression of NI

184 in priming these cells for their response to CD40 ligand during airway inflammation.

185 The CD40/CD40 ligand dyad in endothelial cells (EC) has a central

186 Thus, we find no evidence that CD40 ligand-expressing CD4 T cells are required to activ

187 antitumor efficacy and induced TT-specific, CD40 ligand-expressing CD4(+) T helper cells and maturat

188 D40 on B lymphocytes upon co-incubation with CD40 ligand-expressing T cells depends on clustering of

189 IFN-gamma production was correlated with CD40 ligand expression on the tumor and inversely with i

190 D28-induced IL-2 production, and TCR-induced CD40 ligand expression, both key functions of activated

191 CD154 (CD40 ligand) expression on CD4 T cells is normally tight

192 lso had reduced CMV-specific IL-2 and CD154 (CD40 ligand) expression, suggesting an early blockade in

193 terestingly, platelet-derived excess soluble CD40 ligand found in the plasma and cerebrospinal fluid

194 yper-IgM) syndrome who, due to a mutation in CD40 ligand gene, do not have a classical, class-switche

195 3, 4, 5, and 9) and other factors, including CD40 ligand, GM-CSF, and IL-4 as well as the neuropeptid

196 ulated serum concentrations of CD40 antigen, CD40 ligand, IL-16, monocyte chemotactic protein-1, and

197 In this study, we show that CD40 ligand, IL-2, and IL-10 together drive this transit

198 ts of B-cell function after stimulation with CD40 ligand, IL-21, or both; and differential gene expre

199 IL-35 inhibited CD40 ligand-, IL-4-, and IL-21-mediated IgE production b

200 We aimed to study in detail the kinetics of CD40 ligand/IL-21-induced B-cell differentiation to defi

201 that CD86 and/or beta(2)AR stimulation on a CD40 ligand/IL-4-activated B cell increases the level of

202 ease the level of IgG1 protein produced by a CD40 ligand/IL-4-activated B cell.

203 el of mature IgG1 transcription increases in CD40 ligand/IL-4-activated B cells following stimulation

204 study, we report that, in comparison with a CD40 ligand/IL-4-primed murine B cell alone, beta2AR eng

205 hibited IL-23 production induced by TSLP and CD40 ligand in a signal transducer and activator of tran

206 restimulated by the activated T-cell signal CD40 ligand in the absence of cmvIL-10.

207 hey responded to Ag in vivo and up-regulated CD40 ligand in vitro.

208 HeLa) epithelial cells upon stimulation with CD40 ligand, indicating that Act1 is involved in this si

209 to IL-4 priming, DCs activated with TSLP and CD40 ligand induce the differentiation of naive CD4(+) T

210 ous, apoptotic CD8(-) cells and matured with CD40 ligand induced gamma interferon production in autol

211 Lipopolysaccharide- and CD40 ligand-induced maturation of iLC derived from laten

212 depleting Abs targeting CD4, CD8, and CD154 (CD40 ligand) induces dominant transplantation tolerance

213 ound no evidence of any requirement for CD40-CD40 ligand interaction at this level.

214 CD40-CD154 (CD40 ligand) interaction in the co-stimulatory pathway i

215 l help, B7-dependent costimulation, and CD40/CD40 ligand interactions.

216 7.1/B7.2 interactions, but not CTLA4 or CD40-CD40 ligand interactions.

217 cells, B7-dependent costimulation, and CD40-CD40-ligand interactions.

218 8/B7 and with anti-CD154 mAb to inhibit CD40/CD40-ligand interactions.

219 2) and/or the beta2-adrenergic receptor on a CD40 ligand/interleukin-4-activated B cell increased the

220 Clustering of the CD40 ligand is mediated by an association of the ligand

221 cells by exposure to lipopolysaccharide and CD40 ligand is not sufficient to trigger virus reactivat

222 CD154 (CD40 ligand) is a type II transmembrane protein that bel

223 enovirus encoding a chimeric, membrane-bound CD40 ligand (ISF35).

224 ation of donor dendritic cells (DC) and anti-CD40 Ligand (L) (CD154) monoclonal antibody (mAb) marked

225 8 T cell response by activating APC via CD40-CD40 ligand (L) interactions.

226 monstration that activated platelets express CD40 ligand (L) provides a mechanism of interaction with

227 nd thrombin-antithrombin complex and soluble CD40 ligand levels were elevated compared with wild-type

228 n OSA and control children; however, soluble CD40 ligand levels were higher in OSA children and were

229 ADMA was found in children with OSA, soluble CD40 ligand levels were increased in OSA and reflected t

230 geneic intact active bone and transient anti-CD40 ligand mAb therapy.

231 nce induced with intact active bone and anti-CD40 ligand mAbs.

232 tosis is only achieved by membrane-presented CD40 ligand (mCD40L), as soluble receptor agonists are b

233 cell receptor (TCR) signaling and preformed CD40 ligand mobilization to the immunological synapse, t

234 =5) or treatment with MR1 (hamster antimouse CD40 ligand monoclonal antibody) 500 microg intraperiton

235 treated with a tolerogenic protocol of anti-CD40 Ligand MR1 mAb and CTLA4Ig.

236 nd MMF, a monoclonal antibody against murine CD40 ligand (MR1), recombinant murine Ctla4Ig, and a com

237 Prior treatment with CD40 ligand normalized subsequent responses of xid B cel

238 ivities were maintained due to expression of CD40 ligand on a subset of CD4(+) Foxp3+ T cells.

239 ly requires engagement of CD40 on B cells by CD40 ligand on Ag-activated CD4(+) T cells.

240 cells undergo CSR upon engagement of CD40 by CD40 ligand on CD4+ T cells.

241 Constitutive expression of CD40 ligand on HMC-1 surface was not altered by NECA.

242 tes and depended on interactions between the CD40 ligand on NK cells and CD40 on infected monocytes.

243 r and lung, while the IL-4 response required CD40 ligand only in the spleen.

244 Treatment of CLL or normal B cells with CD40-ligand or B-cell-activating factor upregulated miR-

245 onse to stimulation with lipopolysaccharide, CD40 ligand, or anti-IgD plus appropriate cytokines.

246 )-1alpha, -4, -10, -13, -17, and -18; and/or CD40 ligand, or combinations thereof), with FKN mRNA bei

247 te BAFF and APRIL upon stimulation by T cell CD40 ligand, our findings indicate that NHL B cells dere

248 ic regression analysis showed plasma soluble CD40 ligand (p < 0.001) and soluble P-selectin (p < 0.00

249 se to all the toll-like receptor ligands and CD40 ligands, pDCs rapidly make large amounts of IFN-alp

250 F [epidermal growth factor], sCD40L [soluble CD40 ligand], PDGF [platelet-derived growth factor], RAN

251 cleotides containing certain CpG motifs plus CD40 ligand plus GM-CSF led to increased MHC class II, C

252 pically similar population of CD4(+) Foxp3+, CD40 ligand-positive T cells was found in diseased liver

253 ecretion coincident with diminished IL-6 and CD40 ligand production.

254 igate the safety and efficacy of recombinant CD40 ligand (rCD40L) in the treatment of the disease.

255 for cancer treatment: CD30/CD30 ligand, CD40/CD40 ligand, receptor activator of nuclear factor-kappaB

256 In Model 2, only soluble CD40 ligand remained strongly associated with death/MI w

257 ressing interferon-gamma, interleukin-2, and CD40 ligand) responses were evaluated at month 6.5 for a

258 transfection, ligation of CD40 with soluble CD40 ligand resulted in a significant increase in VEGF t

259 a under the curve (AUC) for IL-6 and soluble CD40 ligand (sCD40L) and chronic viremia was observed on

260 High levels of circulating soluble CD40 ligand (sCD40L) are frequently found in patients wi

261 Soluble CD40 ligand (sCD40L) has been implicated in the developm

262 High levels of the soluble fragment of CD40 ligand (sCD40L) have previously been associated wit

263 Elevated plasma concentrations of soluble CD40 ligand (sCD40L) indicate increased risk for future

264 Soluble CD40 ligand (sCD40L) is a platelet-derived proinflammato

265 in vitro effects of rhIFN-gamma and soluble CD40 ligand (sCD40L) treatment on macrophages.

266 relation between AF and preoperative soluble CD40 ligand (sCD40L), a proinflammatory marker released

267 wn to cause the release of a soluble form of CD40 ligand (sCD40L), a prothrombotic and proinflammator

268 arlier reported that the soluble form of the CD40 ligand (sCD40L), is involved in thrombosis by stabi

269 , fibrinogen, von Willebrand factor, soluble CD40 ligand (sCD40L), soluble P-selectin (sCD62P) concen

270 the proinflammatory, prothrombotic cytokine CD40 ligand (sCD40L).

271 LR4 activation by releasing IL-6 and soluble CD40 ligand (sCD40L).

272 tivator inhibitor type 1 [PAI-1] and soluble CD40 ligand [sCD40L]) in recently vaccinated individuals

273 , and platelet-derived inflammation (soluble CD40 ligand [sCD40L]) were measured using enzyme-linked

274 of a membrane-bound ligand of CD40 (soluble CD40 ligand; sCD40L) was significantly elevated in the s

275 mycophenolic acid was accompanied by reduced CD40 ligand serum levels and the prevention of IgM-to-Ig

276 subclinical atherosclerosis, serum levels of CD40 ligand, serum amyloid A and monocyte chemoattractan

277 In carcinomas, the nature of CD40 ligand shapes the outcome of CD40 ligation.

278 llograft rejection associated with both CD40-CD40 ligand signaling as well as VEGF expression and fun

279 These B cells probably require CD40/CD40 ligand signaling for their generation and have a un

280 ility complex (MHC) class II and CD40-CD154 (CD40 ligand) signaling.

281 ion using either a soluble recombinant human CD40 ligand (srhCD40L) or anti-CD40 monoclonal antibody

282 can be up-regulated by chemokine CXCL13 and CD40 ligand stimulation in wild-type B cells, elevation

283 DCs to produce large amounts of IL-12 after CD40 ligand stimulation, similar to IL-4 priming of DCs.

284 ability to produce IL-12p70 after subsequent CD40 ligand stimulation.

285 macrophage migration inhibitory factor, and CD40 ligand, that promote atherosclerotic lesion formati

286 ression of forkhead box P3 and expression of CD40 ligand; that loss of CD4 expression protects these

287 timulate microbe-specific T cells to express CD40 ligand, thereby licensing APCs that bear both micro

288 as essential for this process in response to CD40 ligand, TNFalpha, and IL-1.

289 We found that TSLP synergized with CD40 ligand to promote DC activation and pathogenic IL-2

290 mmunized T cells use IL-4 and IL-10 (but not CD40 ligand) to 'educate' dendritic cells, which in turn

291 endent Bcl-2 family members by anti-Ig after CD40 ligand treatment.

292 izing factor IL-12p70 in response to LPS and CD40 ligand triggering.

293 We investigated the effect of recombinant CD40 ligand trimer (CD40LT) on the functional capacity o

294 ed with a defined cocktail of cytokines or a CD40 ligand trimer matured fully, as measured by the ind

295 adily induced by B cell-activating factor or CD40 ligand, two major physiological inducers of p100 pr

296 effects on platelet biomarkers (P-selectin, CD40 ligand, urinary 11-dehydrothromboxane B(2)).

297 Finally, CD40 ligand was essential for induction of IFN-gamma in

298 [IQR, 1.5-2.21] at BL; P=0.002), and soluble CD40 ligand was significantly decreased at 60 minutes (8

299 e chemotactic protein-1 (MCP-1), and soluble CD40 ligand were also observed in the experimental group

300 tivated LDM expressing high levels of CD154 (CD40 ligand) with human cholangiocytes resulted in (1) C