ライフサイエンスコーパス: CD40L

1 CD40L and CpG significantly increased the level of IL-10

2 CD40L has been shown to potentiate platelet activation a

3 CD40L is a key stimulator of dendritic cells and B cells

4 CD40L mutants defective in integrins have potential as a

5 CD40L plays a major role in immune response and is a maj

6 CD40L plays an important role in malignant B cell biolog

7 CD40L transiently enhanced axon growth from embryonic mo

8 CD40L was synthesized in early DRG targets and was co-ex

9 CD40L(+) SE retain the capacity to induce dendritic cell

10 When culturing such IL-21(+)CD40L(-) Th cells with B cells, the former directly indu

11 D-L1-expressing functional itBreg cells in a CD40L- and B cell-activating factor receptor-dependent m

12 ry disseminated mycobacterial infection in a CD40L-deficient patient by recombinant human IFN-gamma (

13 ependently of neurotrophins, disruption of a CD40L/CD40 autocrine loop impaired early neurotrophin-pr

14 ppression and TE can be uncoupled and that a CD40L dAb with an inert Fc tail is expected to be effica

15 Here, we show that a CD40L-adjuvanted DNA/modified vaccinia virus Ankara (MVA

16 IL-15-activated CD40L(+) ILC3s helped B-cell survival, proliferation, an

17 These results suggest that CD40-activated CD40L reverse signalling has striking and opposite effec

18 M-CSF, HGF), T-cell development/activation (CD40L, IL-7, CCL25, IL-2RB, IL-15RA, CD6) and angiogenes

19 hout IFN-alpha, and compared with activators CD40L plus IL-21, to identify differentially responsive

20 To be active, CD40L must cluster CD40 receptors on responding cells.

21 Additionally, CD40L-induced naive B cell genes were also significantly

22 cell help for IgG production in an IL-21 and CD40L dependent manner.

23 lated with increased expression of IL-21 and CD40L in Tfh cells from Sfpi1(lck-/-) mice compared with

24 demonstrated reduced chemokine ligand-3 and CD40L expression that resulted in compromised CD8+ T cel

25 id follicles and ability to express IL-4 and CD40L.

26 in D (SPD), HIV-1 Gag as a test antigen, and CD40L, where SPD serves as a scaffold for the multitrime

27 olos and Ikaros protein levels and BAFF- and CD40L-induced proliferation, plasmablast differentiation

28 sion of the costimulatory molecules CD27 and CD40L.

29 hich expressed CD45RA, CCR7, CD27, CD28, and CD40L-suggestive of a naive T cell (TN).

30 ate expressed high levels of CD69, CD28, and CD40L; differentially expressed IL-27 and IL-10 anti-inf

31 Blockade of the interaction between CD40 and CD40L induces long-term cardiac allograft survival in ra

32 es indicate that the interaction of CD40 and CD40L is critical for IL-12 production and resistance to

33 We show that although CD40 and CD40L knockout (KO) mice are highly susceptible to L. ma

34 Leishmania major infection in both CD40- and CD40L-deficient mice after treatment with rIL-12.

35 esults show that dual stimulation by CpG and CD40L for 48 h is optimal for IL-10 induction, and this

36 CTLA-4 blockade increased IFN-gamma and CD40L production, while PD-1 blockade strongly augmented

37 Stimulation of DC with IFN-gamma and CD40L resulted in rapid induction of IDO1 and IDO2 trans

38 rsistent autoimmune disease in an IFN-I- and CD40L-dependent manner when transferred to wild-type mic

39 T-cell costimulator (ICOS)/ICOS ligand, and CD40L/CD40 hindered GC formation and cGVHD.

40 ocyte-derived and primary DCs in an MR1- and CD40L-dependent manner.

41 functions and hypothesized that DST and anti-CD40L mAb-modulated FRC interactions with CD4(+) T cells

42 nor-specific splenocyte transfusion and anti-CD40L monoclonal antibody were used as tolerogen.

43 essions by FRC, which were inhibited by anti-CD40L mAb.

44 rategy combining donor apoptotic cells, anti-CD40L, and rapamycin effectively inhibits proinflammator

45 Conversely, anti-CD40L mAb inhibited FRC inflammatory responses.

46 affect GCB cells in Sfpi1(lck-/-) mice, anti-CD40L treatment of immunized Sfpi1(lck-/-) mice decrease

47 n of a combination of CTLA-4Ig and MR1 (anti-CD40L mAb) for blockade of these interactions induces to

48 tory blockade through multiple-doses of anti-CD40L antibody.

49 fibrosis and strengthened the effect of anti-CD40L in prolonging heart allograft survival.

50 munized or tolerized by DST or DST plus anti-CD40L mAb.

51 Blockade of CD40L by Abs, such as the anti-CD40L Ab 5c8, demonstrated positive clinical effects in

52 Furthermore, the anti-CD40L dAb-Fc exhibited a notable efficacy comparable to

53 cific BALB/c splenocyte transfusion -/+ anti-CD40L monoclonal antibody), or made tolerant and receive

54 nor apoptotic cells in combination with anti-CD40L and rapamycin, and this treatment leads to signifi

55 Costimulatory blockade with anti-CD40L monoclonal antibody (mAb) plus donor-specific sple

56 1 effector functions on CD4(+) TILs, such as CD40L and IFNgamma expression.

57 ules that control T-helper function, such as CD40L and SAP.

58 wer expression of activation markers such as CD40L, CD69, and CD137.

59 enes relevant for T cell activation, such as CD40L, IRAK1, IRAK2, STAT1, and c-Myb in the list of val

60 s, providing critical helper signals such as CD40L.

61 lls through interaction of virion-associated CD40L with CD40 on B cells.

62 In this study, we tested whether augmenting CD40L expression by coexpressing it with the ALVAC vecto

63 used for the assay contributed to background CD40L (CD154) expression in the CD154-enriched CD4 cells

64 which plays a vital role downstream of BAFF, CD40L, lymphotoxin, and other inflammatory mediators.

65 To date, the consequences of membrane-bound CD40L (mCD40L) on its immune-stimulatory function are un

66 results demonstrate that VLP-membrane-bound CD40L serves as a novel adjuvant for an HIV vaccine.

67 was shown to inhibit production of IL-12 by CD40L-activated DCs.

68 ad regulation of axon and dendrite growth by CD40L reverse signalling later in development, CD40-Fc,

69 ss TCRalpha, TCRbeta, CD152 (CTLA-4), CD154 (CD40L), T-bet, GATA-3, and STAT-1.

70 However, CD154 (CD40L) expression on cytokine-positive memory CD4(+) T c

71 We introduce CD154 (CD40L) upregulation as a fast, unbiased, and quantitativ

72 ination required T cell expression of CD154 (CD40L) and target cell expression of CD40.

73 Furthermore, old CD154 (CD40L)-deficient mice did not accrue ABCs, confirming th

74 requencies and functions of Ag-specific CD4 (CD40L(+)) and CD8 (CD69(+)) T cells were evaluated by in

75 e ligand of the costimulatory receptor CD40 (CD40L) and the Notch ligand Delta-like 1 (DLL1).

76 CD40-CD40L interactions play a critical role in regulating im

77 We show that CD28-CD80/86 and CD40-CD40L costimulatory interactions, which mediate negative

78 cooperativity between CD28-CD80/86 and CD40-CD40L pathways is required for normal medullary epitheli

79 Combined absence of CD28-CD80/86 and CD40-CD40L results in profound deficiency in mTEC development

80 rmation, but involves GPIbalpha-vWF and CD40-CD40L-dependent platelet interactions.

81 Blocking CD40-CD40L costimulatory signals induces transplantation tole

82 gn agonists, and is further enhanced by CD40-CD40L interactions between DC1 and CD4(+) T lymphocytes.

83 C-T-cell interface (eg, CD80/CD86-CD28, CD40-CD40L, OX40L-OX40, CD155/CD112-DNAM-1) and subsequent co

84 tural requirements needed for efficient CD40-CD40L inhibition, and serve to guide the search for such

85 The inflammatory CD40-CD40L pathway is implicated in various autoimmune diseas

86 Because blockade of CD40-CD40L interactions results in tolerance in mice, identif

87 Loss of CD4(+) T cells or CD40-CD40L interaction leads to reduced B cell homeostatic pr

88 novel small-molecule inhibitors of the CD40-CD40L interaction designed starting from the chemical sp

89 ng endogenous host CD103(+) DCs and the CD40-CD40L pathway can similarly induce rapid accumulation of

90 Tumor elimination via NOS2 required the CD40-CD40L pathway.

91 sion, our data suggest that therapeutic CD40-CD40L blocking agents may prove efficacious not only in

92 interaction with CD4(+) T cells through CD40-CD40L, and activated FRC interacted directly with CD4(+)

93 tion between FRC and CD4(+) T cells via CD40-CD40L, thereby altering FRC gene expression of immune re

94 he HLA-DRB1*04:02 allele and leads, via CD40-CD40L-dependent T cell-B cell interaction, to the produc

95 l secretion of IL-21 and IFN-gamma in a CD40/CD40L-dependent manner.

96 Blocking of costimulatory CD28/B7 and CD40/CD40L interactions is an experimental approach to immune

97 eir emergence required MHC class II and CD40/CD40L interactions.

98 f alpha5beta1 and CD40 work together in CD40/CD40L signaling or how alpha5beta1 binds to CD40L.

99 D40L, and this plays a critical role in CD40/CD40L signaling.

100 egrins have potential as antagonists of CD40/CD40L signaling.

101 The CD40/CD40L-assisted crosstalk between mesenchymal stromal cel

102 immune escape via antigen loss through CD40/CD40L-mediated cytotoxicity and induction of a sustained

103 re provided early in infection, whereas CD40/CD40L help was provided late in infection.

104 We engineered an ALVAC-SIV coexpressing CD40L with SIV(mac251) (ALVAC-SIV/CD40L) gag, pol, and e

105 due to viral-promoter-dependent constitutive CD40L expression.

106 more, proliferation in response to high-dose CD40L was altered and immunoglobulin production was elev

107 1beta receptors on CD4(+) T cells, eliciting CD40L, proliferation, and up-regulation of CD45RO(+) mem

108 ) cells, including Il21 and Tnfsf5 (encoding CD40L).

109 the transgene paralleled that of endogenous CD40L in unedited T cells, both at rest and in response

110 a Nef-dependent manner, they barely express CD40L.

111 Platelets express CD40L and are a major source of soluble CD40L.

112 ific for this lipid simultaneously expressed CD40L, IFN-gamma, IL-2, and TNF-alpha.

113 40L at relatively lower levels, we expressed CD40L in a membrane-bound form, along with SIV antigens,

114 PP4 Tg+ mice with a single dose of rAd5-S1/F/CD40L elicited as robust and significant specific immuno

115 g CD40-targeted S1 fusion protein (rAd5-S1/F/CD40L), untargeted S1 (rAd5-S1), and Green Fluorescent P

116 However, rAd5-S1- but not rAd5-S1/F/CD40L-immunized mice exhibited marked pulmonary perivasc

117 with the CD4(+) T helper cell-derived factor CD40L.

118 ivation of CLL cells with CXCL12, fibroblast CD40L(+), BCR cross-linking, or autologous nurse-like ce

119 -related changes, with key contributions for CD40L and IFNgamma signaling in the antitumor responses

120 data on 130 patients who underwent HSCT for CD40L deficiency between 1993-2015.

121 ptor signaling pathway and the receptors for CD40L, BAFF and TLR ligands.

122 f IgHV and IgHJ usage, clustering apart from CD40L/IL-21 and control conditions.

123 y, we investigated macrophage functions from CD40L-deficient patients.

124 Macrophages from CD40L-deficient patients exhibited defective fungicidal

125 ells to bind HEp-2 cells, whereas those from CD40L/IL-21-stimulated cells did not.

126 Because of its immunomodulatory function, CD40L has been used to enhance immune responses to vacci

127 pGag), DNA vaccination of mice with pSPD-Gag-CD40L induced an increased number of Gag-specific CD8(+)

128 This plasmid, pTrimer-Gag-CD40L, was only weakly active on CD40-bearing cells and

129 This SPD-Gag-CD40L protein activated CD40-bearing cells and bone marr

130 ovirus 5 (Ad5) vaccine incorporating SPD-Gag-CD40L was much stronger than Ad5 expressing Gag alone (A

131 e CCR3-PI3K-AKT signaling modulates the GLI2-CD40L axis, and GLI2 is required for CCR3-PI3K-AKT-media

132 These HIGM1 CD40L mutants were defective in binding to alpha5beta1 a

133 Human CD40L(+) ILC3s provide innate B-cell help and are involv

134 t B cells with cells stably expressing human CD40L results in increased Erk phosphorylation and incre

135 ribe that the integrin-binding site of human CD40L is predicted to be located in the trimeric interfa

136 y of bone marrow malignancies, we identified CD40L as a novel GLI2 target gene in stromal cells.

137 nment associated with a relative increase in CD40L and IFNgamma expression on intratumoral CD4(+) TIL

138 Several missense mutations in CD40L that induce immunodeficiency with hyper-IgM syndro

139 Disease reactivation in CD40L KO mice was associated with impaired IL-12 and IFN

140 It has been shown that TRAF2 plays a role in CD40L-mediated platelet activation.

141 d that GLI2 overexpression induced increased CD40L expression, and, conversely, GLI2 knockdown reduce

142 Moreover, rfhSP-D inhibited CD40L/IL-4- and IL-21-mediated IgE production (77.12%; P

143 ace of monomeric CD40L and generate integrin-CD40L-CD40 ternary complex.

144 frequently expressed OX40 and intracellular CD40L.

145 B cells in limiting dilution upon irradiated CD40L-expressing EL4.B5 cells and testing the culture su

146 ression of IL-1ra, P-Selectin, IL-4, RANK-L, CD40L and C3a.

147 the immune-stimulatory molecule CD40 ligand (CD40L) and explored efficacy in different mouse leukemia

148 0 weeks old) were cultured with CD40 ligand (CD40L) and the Toll-like receptor 9 (TLR9) agonist cytid

149 CD40 ligand (CD40L) deficiency predisposes to opportunistic infection

150 CD40 ligand (CD40L) deficiency, an X-linked primary immunodeficiency,

151 rowth factor for ILC3s, induced CD40 ligand (CD40L) expression on circulating and tonsillar ILC3s.

152 Loss of CD40 ligand (CD40L) expression or function results in X-linked hyper-

153 ection from HIV.IMPORTANCE CD40-CD40 ligand (CD40L) interaction is crucial for inducing effective cyt

154 ntact that is dependent on CD40-CD40 ligand (CD40L) interactions; and (iv) fully activated CD4(+) alp

155 CD40 ligand (CD40L), a member of the tumor necrosis factor (TNF) supe

156 ch involves the contribution of CD40 ligand (CD40L)-expressing bystander mast cells infiltrating SMZL

157 CD40 ligand (CD40L, CD154) is a membrane protein that is important fo

158 Accordingly, CD40 and its ligand, CD40L, have long been considered targets for the treatme

159 weeks ex vivo with stromal or lymphoid-like (CD40L) cells to determine which interactions could suppo

160 lation of IL-21(+) IFN-gamma(high) PD-1(low) CD40L(high) CXCR5(-) Bcl-6(-) T cells specifically expan

161 in vitro and highlight the importance of MC CD40L signaling in the colon.

162 factors (TRAFs) plays key roles in mediating CD40L-CD40 signaling.

163 ous expression of the costimulatory molecule CD40L (CD154) by the ALVAC-HIV vector could increase bot

164 st expression of the co-stimulatory molecule CD40L, and promoted the development of antibody-secretin

165 reased expression of costimulatory molecules CD40L, CD28, and ICOS on the T cells.

166 site in the trimeric interface of monomeric CD40L and generate integrin-CD40L-CD40 ternary complex.

167 that integrin alpha5beta1 binds to monomeric CD40L through the binding site in the trimeric interface

168 , termed a "domain Ab" (dAb), against murine CD40L was identified and fused to a murine IgG1 Fc domai

169 g retroviral gene transfer to correct murine CD40L expression restored immune function; however, trea

170 manner, suggesting that alphavbeta3 is a new CD40L receptor.

171 TLR activators, but not CD40L/IL-21, similarly promoted increased sharing of CDR

172 The absence of CD40L dysregulated the macrophage transcriptome, which w

173 Absence of CD40L impairs macrophage development and function.

174 cell surface, which enhances accumulation of CD40L and chromogranin B granules at the human TFH cell

175 ontrolling the transcriptional activation of CD40L in bone marrow-derived stromal cells.

176 wnregulates NFAT-driven promoter activity of CD40L and IL-17.

177 ively, our results highlight the benefits of CD40L adjuvant for enhancing antiviral humoral and cellu

178 Here, we utilized the benefits of CD40L, a costimulatory molecule that can stimulate both

179 Blockade of CD40L by Abs, such as the anti-CD40L Ab 5c8, demonstrate

180 Blockade of CD40L during Ag-specific interactions with CD4 SP, but n

181 Blockade of CD40L-Mac-1 interaction with anti-Mac-1 mAb led to spont

182 Although coexpression of CD40L did increase humoral responses, it blunted type 1

183 However, the consequences of CD40L deficiency on macrophage function remain to be inv

184 We sought to determine the effect of CD40L absence on monocyte-derived macrophage responses.

185 In addition, the effect of CD40L absence on the macrophage transcriptome before and

186 s thus demonstrate the stimulatory effect of CD40L-overexpressing CAR T cells on innate and adaptive

187 We demonstrate selective enrichment of CD40L and ICOS in SE in response to addition of CD40 and

188 VRs demonstrated expansion of CD40L+ and CD69+ Ag.pTfh, with induction of intracellula

189 atient T cells restored normal expression of CD40L and CD40-murine IgG Fc fusion protein (CD40-muIg)

190 action, primarily due to their expression of CD40L and secretion of IL-4.

191 In order to modulate local expression of CD40L at relatively lower levels, we expressed CD40L in

192 after CD40 ligation and higher expression of CD40L on activated T cells compared with healthy control

193 tions, as evidenced by reduced expression of CD40L on Tfh cells and reduced B cell proliferation in t

194 ent Tc2 cytokines and elevated expression of CD40L.

195 To produce a soluble form of CD40L that clusters CD40 receptors necessitates the use

196 that expresses a multitrimer soluble form of CD40L, leading to strongly protective CD8(+) T cell resp

197 lation represents a novel helper function of CD40L and a superior mechanism of intercellular communic

198 Incorporation of CD40L into rAd5-based MERS-CoV S1 vaccine targeting mole

199 irmed in cell assays including inhibition of CD40L-induced activation in NF-kappaB sensor cells, THP-

200 olars on day 0, followed by the injection of CD40L and CpG into the palatal gingiva on days 3, 6, and

201 cantly increased after gingival injection of CD40L and CpG.

202 cantly decreased after gingival injection of CD40L and CpG.

203 he binding site in the trimeric interface of CD40L, and this plays a critical role in CD40/CD40L sign

204 orts to characterize downstream mediators of CD40L signaling, we have identified GPR120 and KDM6B as

205 nderlines the importance and practicality of CD40L as an adjuvant for vaccines against infectious dis

206 ck-/-)) demonstrated increased production of CD40L and IL-21 in vitro.

207 a novel molecular mechanism of regulation of CD40L by the transcription factor GLI2 in the tumor micr

208 o CD8+ T cells due to aberrant regulation of CD40L expression.

209 ficient patients reveal the critical role of CD40L-CD40 interaction for the function of T, B, and den

210 ollectively, our data reveal a novel role of CD40L-Mac-1 interaction in IL-12 production, development

211 In this study, we used gene signatures of CD40L stimulation derived from human immature dendritic

212 Studies of CD40L-deficient patients reveal the critical role of CD4

213 mice and provide a rationale for the use of CD40L(+) CAR T cells in cancer treatment.

214 g IL-21, anti-BCR, CpG oligodeoxynucleotide, CD40L, and IL-2, we were able to obtain more than 90% GZ

215 This enhancement was dependent on CD40L, indicating that Myd88 and FcRgamma, presumably on

216 ased CD86 expression, which was dependent on CD40L, suggesting that T cells interact with B cells in

217 Furthermore, blockade of CD40 or CD40L accessory molecules largely neutralized the EV aug

218 K expression is especially induced by CpG or CD40L in combination with IL-21, but not BCR stimulation

219 ost vaccine regimens that included GM-CSF or CD40L adjuvants and conferred significant but incomplete

220 ns in which a soluble form of TRAIL, FasL or CD40L is genetically fused to a high-affinity anti-fluor

221 oding sequence (green fluorescent protein or CD40L) upstream of the translation start site within exo

222 Further, HIF promoted CD40L expression while restraining the FoxP3-positive CD

223 ion, and, conversely, GLI2 knockdown reduced CD40L expression.

224 ene repair to restore endogenously regulated CD40L, and the potential for its use in T-cell therapy f

225 gene signatures with CD4(+) Tfh, and require CD40L/CD40 and TCR/MHCI interactions to deliver help to

226 -DNA responses in Dnase1l3(-/-) mice require CD40L-mediated T cell help, but proceed independently of

227 Several CD40L mutants defective in integrin binding were defecti

228 ttern of DC responsiveness to the Th signal, CD40L.

229 We then tested the potential of DNA/SIV-CD40L vaccine to adjuvant the DNA prime of a DNA/modifie

230 Unexpectedly, the ALVAC-SIV/CD40L vector had a blunting effect on CD4(+) Th1 helper

231 The ALVAC-SIV/CD40L was superior to the ALVAC-SIV regimen in inducing

232 expressing CD40L with SIV(mac251) (ALVAC-SIV/CD40L) gag, pol, and env genes.

233 In contrast, soluble CD40L in combination with IL-2 and IL-21 induces these a

234 evels of a key circulating cytokine, soluble CD40L.

235 d decreased plasma concentrations of soluble CD40L (376 pg/ml vs. 505 pg/ml, P = 0.001) compared with

236 The use of soluble CD40L multimers may help to improve vaccination response

237 In contrast, the addition of soluble CD40L multimers to T cell/B cell cultures redirects B ce

238 ress CD40L and are a major source of soluble CD40L.

239 or blood cultured in the presence of soluble CD40L.

240 examined the impact of mCD40L versus soluble CD40L (sCD40L) on T24 bladder carcinoma gene expression

241 of Cd40(+/+) mice by treatment with soluble CD40L and were dependent on PKC-beta and PKC-gamma, resp

242 Strikingly, CD40L or IFNgamma blockade compromised the ability of PL

243 ivation and B cell activation and suppressed CD40L signaling induced by wild-type CD40L; however, the

244 uper-resolution microscopy demonstrated that CD40L is present in microclusters within CD81 defined SE

245 We further find that CD40L-overexpressing CAR T cells stimulate tumor-residen

246 -12 from infected macrophages and found that CD40L engagement of CD40 amplified the IL-12 response in

247 tiation toward plasma cells, indicating that CD40L determines the direction of IL-21-dependent B cell

248 sed malignant B cell growth, indicating that CD40L in the tumor microenvironment promotes malignant B

249 We observed that CD40L(+) CAR T cells circumvent tumor immune escape via

250 portant for antigen cross-presentation, that CD40L-overexpressing CAR T cells elicit an impaired anti

251 Gene set variation analysis revealed that CD40L-responsive genes in immature dendritic cells and n

252 Our previous results show that CD40L-overexpressing CAR T cells mobilize endogenous imm

253 The CD40L-adjuvanted vaccine enhanced the functional quality

254 Costimulatory cascades such as the CD40L-CD40 dyad enhance immune cell activation and infla

255 We coexpressed the CD40L with our DNA/SIV vaccine such that the CD40L is an

256 Early spinal nerves of embryos lacking the CD40L receptor (Cd40 (-/-) mice) were significantly shor

257 Notably, the CD40L adjuvant enhanced the control of viral replication

258 expression of the membrane-bound form of the CD40L by CD4(+) T cells in lymph nodes.

259 for CCR3-PI3K-AKT-mediated regulation of the CD40L promoter.

260 ctly binds and regulates the activity of the CD40L promoter.

261 ested the immunogenicity and efficacy of the CD40L-adjuvanted vaccine in macaques using a heterologou

262 Our results demonstrated that the CD40L adjuvant enhanced the functional quality of anti-E

263 CD40L with our DNA/SIV vaccine such that the CD40L is anchored on the membrane of SIV virus-like part

264 Noteworthy, our findings reveal that the CD40L/CD40 axis plays a significant role in MC-driven ex

265 After adoptive cell transfer, the CD40L(+) CAR T cells displayed superior antitumor effica

266 These CD40L containing SIV VLPs showed enhanced activation of

267 a direct contact with myeloid cells through CD40L-CD40 interaction and IFN-gamma release.

268 CB-derived Bregs can be potentiated through CD40L signaling, suggesting that inflammatory environmen

269 rized membrane-bound isoleucine zipper (TMZ) CD40L.

270 Gene transfer of murine TMZ-CD40L prolonged survival in an animal model.

271 llate cells and myeloid suppressors with TMZ-CD40L and IL-6R blockade.

272 rkedly reduced the binding of alpha5beta1 to CD40L.

273 alpha5beta1 and CD40 simultaneously bind to CD40L.

274 activation while maintaining full binding to CD40L.

275 /CD40L signaling or how alpha5beta1 binds to CD40L.

276 dely distributed vascular integrin, bound to CD40L in a KGD-independent manner, suggesting that alpha

277 ation but does not prompt cell death, due to CD40L-induced cFLIP expression and limited RIP1 cleavage

278 ling nanotube-like structures in response to CD40L-expressing Th cells or rCD40L.

279 ant to secondary L. major challenge, treated CD40L KO reactivated their lesion after cessation of rIL

280 pressed CD40L signaling induced by wild-type CD40L; however, they still bound to CD40.

281 ations, and favored secretion of IgM, unlike CD40L/IL-21, which drove IgM and IgG more evenly.

282 bition of FOXP3/NFAT interaction upregulated CD40L expression on effector T cells and enhanced T cell

283 une cells, and provide a rationale for using CD40L-overexpressing CAR T cells to improve immunotherap

284 ction by dendritic cells and macrophages via CD40L-macrophage Ag 1 (Mac-1) interaction is responsible

285 oduction and IgM autoantibody formation were CD40L independent.

286 Whereas CD40L enhanced early axon growth independently of neurot

287 In particular, stimulation of CLL cells with CD40L results in substantial resistance mediated by indu

288 Stimulation of healthy donor B cells with CD40L, anti-IgM, IL-21, CpG, IFN-alpha, IL-6 or BAFF ind

289 growth in malignant B cells cocultured with CD40L-expressing stromal cells.

290 is factor alpha alone or in combination with CD40L or interleukin-17.

291 Crosses with CD40L-deficient mice revealed that increased IL-6 produc

292 ns of proliferation similarly differed, with CD40L/IL-21 inducing proliferation of most memory and na

293 CD40 interacts with CD40L and plays an essential role in immune regulation a

294 HSCT is curative in patients with CD40L deficiency, with improved outcome if performed bef

295 tential therapeutic option for patients with CD40L deficiency.

296 administered sequentially after priming with CD40L-adjuvanted DNA/simian-human immunodeficiency virus

297 not in those stimulated to proliferate with CD40L/IL-4, despite their similarities in the cell pathw

298 E production by B cells when stimulated with CD40L, IL-4, and IL-21 was also determined.

299 miRNA expression in B cells stimulated with CD40L/IL-4, and those infected with EBNA-2- and LMP-1-de

300 ation of naive B cells upon stimulation with CD40L and IL-4 was similar in patients and controls, whi