ライフサイエンスコーパス: CD8 T-cell

1 genetic alteration of Ag-experienced memory CD8 T cells.

2 ted to the activation of IFN-gamma-producing CD8 T cells.

3 cing plasma cells, and activation of CD4 and CD8 T cells.

4 of the ECM and an increased infiltration of CD8+ T cells.

5 ectively mediated by virus-specific CD4+ and CD8+ T cells.

6 n injected GBMs and an increase in IFNgamma+ CD8+ T cells.

7 e regulatory mechanisms mediated by CD4+ and CD8+ T cells.

8 companied by increased tumor infiltration of CD8(+) T cells.

9 antigen presentation and recruit innate-like CD8(+) T cells.

10 because of dampened activation of cytotoxic CD8(+) T cells.

11 supports residence of hypertension-specific CD8(+) T cells.

12 ated with the abundance of effector HLA-DR(+)CD8(+) T cells.

13 tes, with a particular focus on NK cells and CD8(+) T cells.

14 CR signaling in senescent-like CD27(-)CD28(-)CD8(+) T cells.

15 cytokine production in allogeneic CD4(+) and CD8(+) T cells.

16 apoptosis in Fcgr2b(+), but not Fcgr2b(-/-), CD8(+) T cells.

17 ect tumors in high proportions, dependent on CD8(+) T cells.

18 o CD4(+) T cells, whilst Granzyme B/TIA-1 to CD8(+) T cells.

19 inase domain to mediate mTORC1 activation in CD8(+) T cells.

20 cells, which improves anti-tumor efficacy of CD8(+) T cells.

21 mitochondrial-biogenesis in activated mouse CD8(+) T cells.

22 -restricted peptides targeted by circulating CD8(+) T cells.

23 abeta repertoire diversity of virus-specific CD8(+) T cells.

24 st cancer patients, also increases cytotoxic CD8(+) T cells.

25 agnitude of NFAT1 activation in single mouse CD8(+) T cells.

26 presenting cells relate to the activation of CD8(+) T-cells.

27 lesions suggests this may be informative for CD8+ T-cell accumulation within tumors.

28 merging as a central player in physiology of CD8(+) T cells, acting as a barrier to prevent premature

29 ame effect on memory responses by CD4(+) and CD8(+) T cells activated after transplantation has not b

30 neural and adipose cells and how it promotes CD8 T cell activation, as well as epithelial repair.

31 Neutrophilia and higher levels of CD4 and CD8 T-cell activation were found in CDC patients as well

32 n type I and III responses, early CD4(+) and CD8(+) T cell activation, and counterregulation by the c

33 learance and immunopathology associated with CD8 T cell activity in the CNS.

34 lear cells revealed an increase in activated CD8+ T cells after CYD-TDV vaccination, a phenomenon tha

35 threshold and a conceptually simple model of CD8(+) T cell Ag recognition, in which Ag dose and affin

36 1c(+) APCs are critical for early priming of CD8 T cells against the immunodominant TMEV peptide VP2(

37 d bladder tumor elimination requires CD4 and CD8 T cells, although augmentation or inhibition of bact

38 reveals prominent interactions of exhausted CD8 + T-cells and PD-L1 + macrophages and PD-L1 + tumor

39 d Akt-dependent nuclear trafficking in mouse CD8 T cells and augmented the expression of canonical Fo

40 o1) was largely excluded from the nucleus of CD8 T cells and failed to transactivate these genes.

41 eatment markedly reduced the infiltration of CD8(+) T cells and brain pathology.

42 ted in an increased number of central memory CD8(+) T cells and diabetes protection by central memory

43 n processing and priming for both CD4(+) and CD8(+) T cells and of the direct orchestration of their

44 al unique molecular signatures of protective CD8(+) T cells and pave the way for T-cell-based immunot

45 ablation of Dot1L resulted in loss of naive CD8(+) T cells and premature differentiation toward a me

46 Inhibition of NOX4 increased CD8(+) T cells and restored responsiveness to immune the

47 , led to exhaustion of anti-male tetramer(+) CD8(+) T cells and subsequently the acceptance of skin g

48 e therapy, CRTH2-expressing ILC2, CD4(+) and CD8(+) T cells and Treg cells showed attenuated response

49 an anergic T-bet(-)IFN-gamma(-) phenotype in CD8(+) T cells and was equally suppressive compared to P

50 acteristics comparable to influenza-specific CD8(+) T cells and were detectable in SARS-CoV-2 convale

51 adverse outcome was correlated with elevated CD8+ T cell and reduced granulocytic cell proportions.

52 sed 5-hydroxymethylcytosine (5hmC) levels of CD8+ T cells and enhanced their cytotoxic activity in a

53 icantly increase the population of cytotoxic CD8+ T cells and simultaneously decrease the population

54 planation is that coordinated CD4(+) T cell, CD8(+) T cell, and antibody responses are protective, bu

55 d to license the cytotoxic activity of tumor CD8(+) T cells, and in their absence, T cells did not ly

56 in tumor cells, increased IFNgamma-producing CD8(+) T cells, and reduced Treg frequency in vivo.

57 We find that low oxygen level diminishes CD8(+) T cell anti-viral response in vivo.

58 Respiratory mucosal antibodies and CD8+ T cells appear to contribute to preventing infectio

59 Memory CD4 and cytotoxic CD8 T cells appeared early in islets, accompanied by reg

60 pre-existing and induced SARS-CoV-2-specific CD8(+) T cells, applying peptide-loaded major histocompa

61 Effector CD8(+) T cells are important mediators of adaptive immun

62 epletion studies revealed that both cDC1 and CD8(+) T cells are required for tumor regression followi

63 text optimal for generating antigen-specific CD8 T cells, as they have natural tropism for dendritic

64 In contrast, increased frequency of EM CD8(+) T cells associated with reduced risk of graft fai

65 r rationale for renewed efforts to develop a CD8(+) T cell-based HIV vaccine in conjunction with B ce

66 reductionist system, in which primary human CD8(+) T cell blasts are stimulated by recombinant pepti

67 still developed in the absence of NOD-PerIg CD8(+) T cells but required CD4(+) T cells.

68 Activation of cytotoxic CD8(+) T cells by cross-priming DC contributes to exacer

69 restore cancer- and virus-induced exhausted CD8(+) T cells, by enhancing the quality and survival of

70 Cytotoxic CD8(+) T cells can effectively kill target cells by prod

71 evidence that cellular immunity mediated by CD8(+) T cells can sustain long-term disease-free and tr

72 imilar rapid, early response in EM and TEMRA CD8(+) T cells, CD16 engagement resulted in selective ac

73 ets of gamma-delta T cells (CD3(+)TCRgd(+)), CD8(+) T cells (CD3(+)CD8(+)CD161(+)PD1(+)), and memory

74 Senescent CD8 + T cells, CD56 + T cells, CD56(dim) natural killer

75 substantial population of 'memory-phenotype' CD8(+) T cells (CD8-MP cells) that exhibit hallmarks of

76 In an HIV-1 latency model using autologous CD8(+) T cell clones as biosensors of antigen presentati

77 n from abacavir/abacavir analogue-responsive CD8(+) T-cell clones was measured using IFN-gamma ELIspo

78 High-avidity CD8+ T cell clones isolated from healthy donors killed C

79 in of these cells and their kinship to other CD8+ T cell compartments.

80 indings demonstrate that STAT1 signaling and CD8 T cells concomitantly act to mitigate MuPyV-encephal

81 that CD8(+) T cells express all 19 Wnts and CD8(+) T cell-conditioned medium (CM) induced canonical

82 ific T cell receptors (TCRs) transduced into CD8+ T cells conferred antileukemic activity in vitro.

83 of memory CD4(+) T cells were reduced, while CD8(+) T cells consisted predominately of expanded diffe

84 36 or M36, exhibit greater susceptibility to CD8 T cell control than mutants lacking the set of immun

85 d from several mumps cases, and MuV-specific CD8+ T cells could be identified by peptide/dextramer st

86 HCV-specific CD8(+) T cells cross-reacted with allogeneic class-I HLA

87 A class I autoantigen epitopes implicated in CD8 T cell (CTL)-mediated beta-cell destruction in type

88 that the histone deacetylase HDAC3 inhibits CD8 T cell cytotoxicity early during activation and is r

89 NOD-LNSC significantly reduced G9Calpha(-/-)CD8(+) T-cell cytotoxicity and dendritic cell-induced pr

90 These findings imply that CD8+ T cell cytotoxicity against both tumor and viral an

91 ased, naive B cells increased, and senescent CD8 T cells decreased (human cells); effects were genera

92 ith patients with low SDom and low CD3(+) or CD8(+) T-cell density (P = 0.002 and P = 0.03, respectiv

93 ients with both high SDom and high CD3(+) or CD8(+) T-cell density had markedly improved disease-spec

94 FTY720 and BAF312 caused a profound CD4+ and CD8+ T cell depletion in blood and lungs but only treatm

95 ng chronic infection generated new antiviral CD8 T cells, despite sustained virus replication in the

96 oxic marker expression by mucosal CD4(+) and CD8(+) T cells differed according to the mucosal compart

97 More CD8(+) T cells differentiate to memory cells following G

98 While the transcriptional control of CD8 T cell differentiation and effector function followi

99 CD8 T cell differentiation is orchestrated by dynamic me

100 Here, we discuss recent insights into memory CD8(+) T cell differentiation and exhaustion and the ass

101 ique and early role for NR4A3 in programming CD8(+) T cell differentiation and function.

102 rleukin (IL)-2 and IL-21 dichotomously shape CD8(+) T cell differentiation.

103 inal intraepithelial CD8(+) T-cell lines, or CD8(+) T cells directly isolated from intestinal biopsie

104 We find that tumor and CD8(+) T cells display distinct metabolic adaptations to

105 findings in experimental models suggest that CD8+ T cells drive disease pathogenesis.

106 ng that P2RX7 signaling drives induction and CD8(+) T cell durability in barrier sites.

107 ly expressed on highly functional ganglionic CD8(+) T cells during acute and latent HSV-1 infection.

108 es towards tolerant phenotypes that promoted CD8(+) T cell dysfunction.

109 lly, TCR signal strength is able to regulate CD8(+) T cell effector cytokine R production independent

110 athway in which exhausted or "dysfunctional" CD8+ T cells enhance cellular adhesiveness to maintain t

111 RV infection but, surprisingly, HRV-specific CD8 T cell epitopes remain yet to be identified.

112 We identified 12 CD8-positive (CD8(+)) T cell epitopes, including epitopes common to bo

113 ors and increases numbers of memory CD4+ and CD8+ T cells, eradicating all detectable tumor.

114 e interaction of HLA-mediated protection and CD8 T-cell exhaustion is less well characterized.

115 These findings confirm antiviral CD8(+) T cell exhaustion during SYMP herpes infection an

116 SARS-CoV-2-specific memory CD8(+) T cells exhibited functional characteristics comp

117 We show that CD8(+) T cells express all 19 Wnts and CD8(+) T cell-con

118 e terminally differentiated dysfunctional UC CD8(+) T cells expressing IL-26, which attenuate acute c

119 There was no increase in tumor infiltrating CD8+ T cells expressing "exhaustion" markers, yet oHSV i

120 vels return to near baseline, LSD1-deficient CD8 T cells failed to remethylate the Pdcd1 locus to the

121 ver, by mapping the long-term development of CD8(+) T cell families derived from single naive precurs

122 and is required for persistence of activated CD8 T cells following resolution of an acute infection.

123 Zr-IAB22M2C, a radiolabeled minibody against CD8+ T cells, for targeted imaging of CD8+ T cells in pa

124 Total CD4(+) and CD8(+) T cell frequencies were markedly lower in the pre

125 ailable transcriptomes and DNA methylomes of CD8(+) T cells from 3 adult patient cohorts with and wit

126 how restricted growth of B16-F10 tumors, and CD8(+) T cells from these mice express less PD-1 and TOX

127 by directly or indirectly excluding effector CD8+ T cells from the tumor microenvironment.

128 lood and LN compared to NCs, but had similar CD8 T cell function.

129 Therefore, restoration of CD8 T-cell function is critical in cure strategies.

130 , we found that Tim-3 (often associated with CD8(+) T cell functional exhaustion) is not upregulated

131 We found that ME/CFS CD8+ T cells had reduced mitochondrial membrane potentia

132 ceptor 2 (TGFBR2) in CD4(+) T cells, but not CD8(+) T cells, halts cancer progression as a result of

133 HBsAg levels and impairment of intrahepatic CD8+ T cells has not been established.

134 ve transfer of ex vivo expanded CMV-specific CD8+ T cells has provided proof-of-concept that immunoth

135 Metformin-educated CD8(+) T cells have increased (i) mitochondrial mass, ox

136 RNA sequencing on the intratumoral CD8(+) T cells identified the presence of T cell exhaust

137 Abacavir and ten analogues stimulated CD8(+) T-cell IFN-gamma release.

138 hus, immunomodulatory therapies that improve CD8(+) T cell immune surveillance and clearance of CHIKV

139 Optimal CD8 T cell immunity is orchestrated by signaling events

140 for dendritic cells, preeminent inducers of CD8 T cell immunity; elicit Th1-promoting inflammation;

141 bitory function of FcgammaRIIB in regulating CD8(+) T cell immunity.

142 CD8(+) T cell immunological memory of past antigen expos

143 s a surrogate of interferon-primed exhausted CD8 + T-cells in the tumor microenvironment.

144 ilico-designed mock neoantigens also induced CD8 T cells in nonhuman primates.

145 tion of highly differentiated virus-specific CD8(+) T cells in an Ag-dependent manner, a phenomenon k

146 here is a protective role for central memory CD8(+) T cells in autoimmune diabetes and that this prot

147 compiled an unbiased atlas of human colonic CD8(+) T cells in health and ulcerative colitis (UC) usi

148 ectin-9 (Gal-9) and VISTA on both CD4(+) and CD8(+) T cells in HIV-infected human patients.

149 Peanut-specific CD8(+) T cells in nonallergic individuals are not delete

150 , we have uncovered the diverse landscape of CD8(+) T cells in psoriatic and healthy skin, including

151 Remarkably, CD8(+) T cells in recurrent tumors overexpressed KLRB1 (

152 ntly expands the proportion of proliferating CD8(+) T cells in the tumor with enhanced cytolytic pote

153 ls and diabetes protection by central memory CD8(+) T cells in vivo.

154 of susceptibility/severity; (2) RSV-specific CD8+ T cells in bronchoalveolar lavage fluid preinfectio

155 e from patients with MS points to a role for CD8+ T cells in disease pathogenesis.

156 induced in vaccine-induced antigen-specific CD8+ T cells in healthy human volunteers.

157 nally expanded, but phenotypically exhausted CD8+ T cells in human melanoma.

158 t oHSV infection led to a reduction in PD-1+ CD8+ T cells in injected GBMs and an increase in IFNgamm

159 gainst CD8+ T cells, for targeted imaging of CD8+ T cells in patients with cancer.

160 CD8+ T cells in patients with severe disease express hig

161 igen, R848, and PUUC increased percentage of CD8+ T-cells in the lungs, percentage of antigen-specifi

162 rete lineages of intestinal antigen-specific CD8(+) T cells, including a Blimp1(hi)Id3(lo) tissue-res

163 Immunohistochemistry confirmed enhanced CD8(+) T cell infiltration and accumulation by R848-TSLs

164 urden and neoantigen load) and the degree of CD8(+) T cell infiltration were not associated with clin

165 aused enhanced disease mediated by pulmonary CD8(+) T cell infiltration.

166 uiescent phenotype and promoted intratumoral CD8(+) T-cell infiltration, overcoming the exclusion eff

167 cinoma, even in tumors that were classically CD8(+) T cell inflamed.

168 r the phenotype and function of autoreactive CD8+ T cells influence disease progression.

169 Cross-recognition of viral epitopes by CD8 T cells is associated with viral control during HIV-

170 the functional consequence of LEC priming of CD8(+) T cells is unknown.

171 e PD-1/PD-L1 pathway reinvigorates exhausted CD8(+) T cells, it fails to restore T cell repertoire di

172 CD8 T cells lacking LSD1 expressed higher levels of Pdcd

173 ne the kinetic selection model of CD4(+) and CD8(+) T cell lineage commitment.

174 timulated primary intestinal intraepithelial CD8(+) T-cell lines, or CD8(+) T cells directly isolated

175 a, and other cytokines and severe CD4(+) and CD8(+) T-cell lymphopenia and coagulopathy.

176 nd invariant NK (iNK) T cell development and CD8+ T cell maintenance.

177 Treatment-induced changes in intratumoral CD8(+) T cells may represent a biomarker to identify pat

178 In addition, CD4+ T cells and CD8+ T cells may be vital for altering host immune funct

179 Noninvasive imaging of CD8+ T cells may provide new insights into the mechanism

180 Tissue-resident memory (Trm) CD8(+) T cells mediate protective immunity in barrier ti

181 Tumor-infiltrating CD8+ T cells mediate antitumor immune responses.

182 hat are essential for cross-presentation and CD8 T cell-mediated immunity against intracellular patho

183 rmed MDSCs into myeloid cells that activated CD8(+) T cell-mediated immunity against cancer.

184 ) T-cell-mediated immune tolerance and lower CD8(+) T-cell-mediated cytotoxicity.

185 In addition, CD8+ T cell-mediated cytotoxicity has not been linked to

186 e localization are important determinants of CD8+ T cell-mediated efficacy against SIV.

187 a cell-intrinsic role of Batf3 in regulating CD8 T cell memory development.

188 cination directly correlates with downstream CD8(+) T cell memory and protective immunity against inf

189 us, aberrant activation and dysregulation of CD8+ T cells occur in patients with severe COVID-19 dise

190 CD8(+) T cells, of monofunctional, polyfunctional and cy

191 these pDCexos primed naive antigen-specific CD8 T cells only in the presence of bystander cDCs, simi

192 adoptive transfer of virus-specific effector CD8(+) T cells or immunization with a vaccine that induc

193 themselves, but not through their action on CD8+ T cells or APC.

194 s dual system of peptide generation enhances CD8(+) T cell participation in diversifying both antigen

195 Regenerative stem cell-like memory (T(SCM)) CD8(+) T cells persist longer and produce stronger effec

196 sure created an environment that altered the CD8+ T cell phenotype, for example expression of regulat

197 Thus, we identify colonic CD8(+) T-cell phenotypes in health and UC, define their

198 CD8(+) T cells play a critical role in adaptive immunity

199 Additionally, vaccine-induced CD8 T cells poorly cross-recognized variant epitopes enc

200 lungs, with a depleted and exhausted CD4 and CD8 T-cell population that resides within a heavily hype

201 early effects on the phenotype of the total CD8 T-cell population were apparent only in HLA-B*57-neg

202 uction in mean tumor volume, increase in the CD8 T-cell population, and immune activated gene signali

203 thus possible to visualize antigen-specific CD8(+) T-cell populations in vivo, which may serve progn

204 show accumulation of activated ZIKV-specific CD8(+) T cells primed by recombinant L. monocytogenes is

205 vaccine that induces virus-specific effector CD8(+) T cells prior to infection enhanced the clearance

206 at all antileishmanial drugs inhibit CD4 and CD8 T cell proliferation at the doses that are not relat

207 Increases in TILs and CD8+ T cell proportions in response to NAC are independe

208 Memory CD8 T cells provide durable protection against diverse i

209 t their multifaceted impact on the exhausted CD8(+) T cell receptor (TCR) repertoire.

210 currently understood to focus on deflecting CD8 T cell recognition of infected cells by disrupting a

211 , we investigated whether naive MBP-specific CD8+ T cells recruited to the CNS during CD4+ T cell-ini

212 Congruently, gene editing of LAYN in human CD8+ T cells reduced direct tumor cell killing ex vivo.

213 role of cDC1s in expansion of tumor-specific CD8(+) T cells remains unclear.

214 ar TCRs were identified in EBV(RPP)-specific CD8(+) T cell repertoires across multiple HLA-B7(+) indi

215 In conclusion, we show that MEKi leads to CD8(+) T cell reprogramming into T(SCM) that acts as a r

216 Antigen-specific CD8+ T cells respond early during acute influenza infect

217 When using primary human memory CD8(+) T cells responding to autologous APCs, equivalent

218 n of the CNS is cleared in C57BL/6 mice by a CD8 T cell response restricted by the MHC class I molecu

219 ss of H-2D(b) on CD11c(+) APCs mitigates the CD8 T cell response, preventing early viral clearance an

220 vast sequence diversity, the ability of the CD8 T-cell response to recognize several variants of a s

221 CD8+ T cell response to vaccination is impaired as a res

222 c versus acute viral infections and identify CD8 T cell responses and downstream anorexia as driver m

223 vaccination had higher baseline MA-specific CD8 T cell responses but no evidence for improved functi

224 CD8 T cell responses likely play an important role in th

225 ut microbiome shifts and enhanced intestinal CD8 T cell responses.

226 uence of HLA-B*57:01 on the deterioration of CD8 T-cell responses during HIV infection in the absence

227 HIV-1-specific CD4 and CD8 T-cell responses have remained absent at 27 months.

228 HLA-B*57:01-restricted, HIV epitope-specific CD8 T-cell responses showed beneficial functional patter

229 compared HLA-B*57:01-restricted HIV-specific CD8 T-cell responses to responses restricted by other HL

230 When CD8(+) T cell responses are inhibited, HSV-1 can reactiv

231 oss-reactive and induced SARS-CoV-2-specific CD8(+) T cell responses as potentially important determi

232 pre-existing and induced SARS-CoV-2-specific CD8(+) T cell responses during the natural course of SAR

233 ore, we demonstrated that SYIPSAEKI-specific CD8(+) T cell responses elicited by viral-vectored CSP-e

234 ibitors are effective in restoring exhausted CD8(+) T cell responses in persistent viral infections o

235 arge but transient boost of the SIV-specific CD8(+) T cell responses occurred in IL-2-DT-treated RMs.

236 De novo neoantigen-specific CD4(+) and CD8(+) T cell responses were observed post-vaccination i

237 n the light of 'protective' or 'detrimental' CD8(+) T cell responses which are restricted by the host

238 4) and D614G mutant(2) SARS-CoV-2 as well as CD8(+) T cell responses, and protects against SARS-CoV-2

239 hown to elicit broadly protective CD4(+) and CD8(+) T cell responses.

240 dritic cells and the induction of protective CD8(+) T cell responses.

241 with delayed kinetics and induce suboptimal CD8(+) T cell responses.

242 thereby inducing potent cytotoxic CD4(+) and CD8(+) T cell responses.

243 ction-elicited influenza-specific CD4(+) and CD8(+) T-cell responses were measured using flow cytomet

244 Here we demonstrate that contraction of lung CD8+ T cell responses after influenza infection is conte

245 CD8+ T cell responses are necessary for immune control o

246 Current immunotherapies involving CD8+ T cell responses show remarkable promise, but their

247 which can be attributed to defective Th1 and CD8+ T cell responses.

248 ) model, Tregs are known to inhibit effector CD8+ T-cell responses and contribute to virus persistenc

249 For 6 epitopes, CD8+ T-cell responses were confirmed in T cells derived

250 ce of STAT1 signaling, however, depletion of CD8 T cells resulted in lytic infection of the choroid p

251 in vitro activation of both mouse and human CD8(+) T cells resulted in an increased number of centra

252 ession of microbiota-dependent activation of CD8(+) T cells, resulting in colitis.

253 teomics analysis on cytokine-producing fixed CD8(+) T cells revealed that IL-2(+) cells produce helpe

254 CD4/CD8 T-cell selection of the apheresis product improved C

255 scriptome, phenotype, and function of memory CD8(+) T cells, sharing the same HSV-1 epitope-specifici

256 Using G9Calpha(-/-)CD8(+) T cells specific for proinsulin, we studied the m

257 A distinct TEMRA CD8(+) T cell subpopulation was identified that was char

258 ddition, treatment expanded a CXCR3+PD1-/low CD8 T-cell subset with the ability to secrete cytokines.

259 nd their association with antiviral effector CD8+ T cell subsets were also characterized in lung infi

260 rging data indicate that SARS-CoV-2-specific CD8(+) T cells targeting different viral proteins are de

261 s, NKT, MAIT, TCR-gammadelta, Monocytes, and CD8 + T-cells that are related to both gene activation a

262 ganglia (TG) is influenced by virus-specific CD8(+) T cells that infiltrate the ganglia at the onset

263 rus-specific T cells comprised both CD4+ and CD8+ T cells that expressed markers for central memory a

264 Contrary to the established role of CD69 on CD8 T cells, the functions of CD103 and CD49a on this po

265 umour cells disrupt methionine metabolism in CD8(+) T cells, thereby lowering intracellular levels of

266 onferred this compromised metabolic state to CD8(+) T cells, thereby paralyzing their effector functi

267 s, particularly viruses, making the study of CD8(+) T cells timely.

268 c potential is restored, thereby sensitizing CD8 T cells to DEX-induced apoptosis in vitro and signif

269 ore antigen-specific multifunctional CD4 and CD8 T cells to the lung parenchyma prior to challenge an

270 adapts the CRISPR/Cas9 technology for memory CD8 T cells to undertake gene editing in vivo, for the f

271 Cs induced proliferation of naive CD4(+) and CD8(+) T cells to a larger extent than B. burgdorferi.

272 emonstrates the potential of tumour-specific CD8(+) T cells to prevent and treat cancer.

273 is contemporized with egress of CD69+/CD103+ CD8+ T cells to the draining mediastinal LN via the lymp

274 antigen-specific progeny of individual naive CD8+ T cells to the T effector (TEFF), T circulating mem

275 , B, and NK cells and exhibited a skewing of CD8+ T cells toward a terminally differentiated/senescen

276 ces an influx of stem-like Tcf1(+) Slamf6(+) CD8(+) T cells, triggers regression not only of primary,

277 Tissue resident memory CD8(+) T cells (Trm) are poised for immediate reactivati

278 fic minibody ((89)Zr-Df-IAB22M2C) to monitor CD8(+) T-cell tumor infiltrates by PET.

279 ors expressing HBV Ags engender HBV-specific CD8(+) T cells unconventionally restricted by MHC class

280 ffect on the expansion of HBV-specific naive CD8+ T cells undergoing intrahepatic priming.

281 up has demonstrated that CNS myelin-specific CD8 T cells unexpectedly harbor immune regulatory capaci

282 nstrate this by functionally altering memory CD8 T cells using CRISPR/Cas9-mediated targeted gene dis

283 geted mutations can be introduced into naive CD8(+) T cells using CRISPR-based homology-directed repa

284 We identified islet-specific CD8+ T cells using high-content, single-cell mass cytome

285 lthough some Ags were detected by CD4(+) and CD8(+) T cells, VME1 was mainly recognized by CD4(+) T c

286 cells were reduced, while the proportion of CD8(+) T cells was significantly increased in both tumor

287 The number of intravascular CD3+CD8+ T cells was influenced by CM status (CM+ > CM-, P =

288 interventional study, BKPyV-specific CD4 and CD8 T cells were measured in 32 of 36 viremic pediatric

289 Resting CMV-specific CD8 T cells were terminally differentiated and expressed

290 acy of adoptively transferred tumor-specific CD8(+) T cells were abrogated in Batf3(-/-) mice.

291 had fewer neutrophils, while their cytotoxic CD8(+) T cells were activated, reflected as higher HLA-D

292 pecific poly-functional/cytotoxic CD4(+) and CD8(+) T cells were detected with the IL-4R antagonist a

293 en, and bone marrow, as well as expansion of CD8 T cells, which has been observed in CD4-depleted hum

294 nt resulted in selective activation of TEMRA CD8(+) T cells, which mediated antibody-dependent cytoto

295 arget cell killing by freshly isolated human CD8(+) T cells, which represent a challenging but valuab

296 iated with cerebrovascular engagement of CD3+CD8+ T cells, which is exacerbated by HIV coinfection.

297 XCR3 is upregulated in the expanded synovial CD8 T cells, while two CXCR3 ligands, CXCL9 and CXCL10,

298 However, infection-induced memory CD8 T cells with defined history of repeated Ag encounte

299 We observed a striking accumulation of CD8 T cells with highly cytotoxic and proliferative stat

300 Thus, local lung infection induces CD8+ T cells with a TRM phenotype that nevertheless unde

301 , IL-17, and IL-22 cytokine levels in CD4(+)/CD8(+) T cells, with inducible costimulator molecule and

302 ate tumor antigen- and oHSV antigen-specific CD8+ T cells within 7 days after oHSV injection.