ライフサイエンスコーパス: CDP choline

1 CDP-choline also elevated hypothalamic extracellular tot

2 CDP-choline also provided significant protection for hip

3 CDP-choline caused a dose- and time-dependent increase i

4 CDP-choline liposomes deliver the agent intact to the br

5 CDP-choline restored cardiolipin levels, arachidonic aci

6 CDP-choline treatment significantly attenuated PLA2 acti

7 CDP-choline treatment significantly attenuated the infar

8 ndicate that Sec14p functions to alleviate a CDP-choline pathway-mediated toxicity to yeast Golgi sec

9 DHODH in regulating immune evasion through a CDP-choline dependent mechanism and implicate DHODH as a

10 this raises the possibility that they use a CDP-choline pathway for the biosynthesis of phosphatidyl

11 One of the enzymes was a CDP-choline pyrophosphatase, the first Nudix hydrolase a

12 closure opens to the cytosolic side, where a CDP-choline and two Mg(2+) are coordinated.

13 that this transition was driven by an active CDP-choline pathway that synthesized PC enriched in spec

14 Brain UTP, CTP, and CDP-choline were all elevated 15 min after UMP (from 254

15 line, uridine (a precursor for UTP, CTP, and CDP-choline), and a PUFA (e.g., docosahexaenoic acid); m

16 h catalyzes the synthesis of PC from DAG and CDP-choline.

17 T/EPT) that use 1,2-diacylglycerol (DAG) and CDP-choline or CDP-ethanolamine to produce phosphatidylc

18 the phosphatidylethanolamine methylation and CDP-choline pathways are not responsible for generating

19 r in P. falciparum, thus making the SDPM and CDP-choline pathways the only routes for phosphatidylcho

20 significant elevations in UTP, CT, USAP and CDP-choline levels in PC12 cells.

21 e identify other possible substrates such as CDP-choline, ATP, and ADP.

22 UMP dose that significantly increased brain CDP-choline was 0.05 mmol/kg.

23 nal step of PtdCho synthesis is catalyzed by CDP-choline:1,2-diacylglycerol cholinephosphotransferase

24 n the suppression of the sec14(ts) defect by CDP-choline pathway mutations, indicating a role for pho

25 PtdCho, which was significantly restored by CDP-choline treatment.

26 ha protein, which were partially restored by CDP-choline.

27 f CCT activity, the accumulation of cellular CDP-choline, and enhanced radiolabeling of phosphatidylc

28 present in cytidine 5'-diphosphate choline (CDP-choline), are major precursors of the phosphatidylch

29 wo substrates, cytidine diphosphate-choline (CDP-choline) and diacylglycerol (DAG), to produce PC, an

30 oline into the cytidine diphosphate-choline (CDP-choline) PC biosynthetic pathway relative to betaine

31 nthesis of phosphatidylcholine from choline (CDP-choline pathway), the parasite synthesizes this majo

32 T. denticola does contain a licCA-dependent CDP-choline pathway for phosphatidylcholine biosynthesis

33 hosphatidylcholine through a licCA-dependent CDP-choline pathway identified only in the genus Trepone

34 m radiolabeled cytidine 5'-diphosphocholine (CDP-choline) in HCCs.

35 rdic effect of cytidine 5'-diphosphocholine (CDP-choline).

36 Cytidine-5'-diphosphocholine (CDP-choline, Citicoline, Somazina) is in clinical use (i

37 Activities of the cytidine diphosphocholine (CDP-choline) and phosphatidylethanolamine-N-methyltransf

38 se enzymes in the cytidine diphosphocholine (CDP-choline) pathway of PtdCho biosynthesis.

39 onents of the liposomes and the encapsulated CDP-choline.

40 kely to inhibit the conversion of endogenous CDP-choline to PC.

41 ; this enhances the production of endogenous CDP-choline which then combines with fatty acids (as dia

42 cell survival questions whether endonuclear, CDP-choline pathway phosphatidylcholine synthesis may oc

43 ance PC synthesis, we developed an assay for CDP-choline, an immediate and rate-limiting precursor in

44 phosphate from CTP to phosphocholine to form CDP-choline.

45 62%) compared to the equivalent dose of free CDP-choline (by 26%) after 1 h focal cerebral ischemia a

46 in vitro phosphatidylcholine formation from CDP-choline and diacylglycerol, and full activity requir

47 ne caused concentration-related increases in CDP-choline levels, and that this effect was mediated by

48 ransferase (lyso-PAF-AT) and DTT-insensitive CDP-choline 1-alkyl-2-acetyl-sn-glycerol cholinephosphot

49 The structures of apo-LicC and the LicC-CDP-choline-Mg(2+) ternary complex were determined, and

50 line cytidylyltransferase (CCT), which makes CDP-choline.

51 Administration of CDP-choline to rats increases blood and brain cytidine a

52 Oral administration of CDP-choline to rats raises plasma and brain cytidine lev

53 erebroventricular (i.c.v.) administration of CDP-choline was made and blood pressure and heart rate w

54 However, the mechanism of conversion of CDP-choline to phosphatidylcholine remained unclear.

55 ould contribute to the beneficial effects of CDP-choline in treating stroke or other brain damage.

56 Beneficial effects of CDP-choline liposomes in stroke may derive from a synerg

57 rase (CPCT) which catalyzes the formation of CDP-choline, a key intermediate in the choline branch of

58 Bacillus cereus catalyzes the hydrolysis of CDP-choline to produce CMP and phosphocholine.

59 s inhibitor] 5 min prior to the injection of CDP-choline to determine the effects of these inhibitors

60 CCT1 exhibited a V max of 23904 nmol of CDP-choline min (-1) mg (-1) and apparent K m values for

61 a uridine source, enhances the synthesis of CDP-choline, the immediate precursor of PC, in gerbil br

62 In contrast, in humans oral CDP-choline increases plasma levels of uridine.

63 The two branches of the Kennedy pathways (CDP-choline and CDP-ethanolamine) are the predominant pa

64 n of [methyl-3H]choline into phosphocholine, CDP-choline, and phosphatidylcholine in cells carrying t

65 nalyses reveal that DHODH inhibition reduces CDP-choline level and attenuates the synthesis of phosph

66 ly that includes the enzymes that synthesize CDP-choline and CDP-ethanolamine for phosphatidylcholine

67 Finally, we determine that CDP-choline pathway activity contributes to the inositol

68 Our data show that CDP-choline liposomes significantly (P < 0.01) decreased

69 Immunohistochemical studies showed that CDP-choline increased COX-1 and -2 immunoreactivities in

70 Others showed that CDP-choline liposomes significantly increased brain upta

71 The results suggest that CDP-choline may stimulate prostaglandin synthesis throug

72 These data suggest that CDP-choline prevented the activation of phospholipase A(

73 Taken together, these results suggest that CDP-choline significantly restores Ptd-Cho levels by dif

74 The CDP-choline then condenses with diacylglycerol (DAG) to

75 found distinction in PC profiles between the CDP-choline pathway and the PE methylation pathway.

76 se of choline for PC production via both the CDP-choline and PEMT pathways shows the substantial dema

77 synthesis of phosphatidylcholine (PC) by the CDP-choline (Kennedy) pathway.

78 nolamine (PE) are synthesized de novo by the CDP-choline and CDP-ethanolamine (Kennedy) pathway, in w

79 Phospho-choline is converted to PC by the CDP-choline pathway, explaining the phenotype conferred

80 cant fate for this DAG is consumption by the CDP-choline pathway.

81 the synthesis of phosphatidylcholine by the CDP-choline pathway.

82 d membranes and is synthesised mainly by the CDP-choline pathway.

83 tion of phosphatidylcholine synthesis by the CDP-choline pathway.

84 otein kinase A regulates PC synthesis by the CDP-choline pathway.

85 PC molecules produced from the CDP-choline pathway were mainly comprised of medium chai

86 te and were more diverse than those from the CDP-choline pathway.

87 As the rate-limiting enzyme in the CDP-choline pathway for PC synthesis, CTP:phosphocholine

88 In yeast, mutations in the CDP-choline pathway for phosphatidylcholine biosynthesis

89 line by ATP, the first committed step in the CDP-choline pathway for phosphatidylcholine biosynthesis

90 Mutations (cki1, cct1, and cpt1) in the CDP-choline pathway for phosphatidylcholine synthesis su

91 CHKA, which encodes the first enzyme in the CDP-choline pathway for the synthesis of phosphatidylcho

92 rase (CT) is the rate-limiting enzyme in the CDP-choline pathway of PC biosynthesis, which is utilize

93 esis of CCT, the rate-limiting enzyme in the CDP-choline pathway, is elevated in fibroblasts overexpr

94 eport that strains carrying mutations in the CDP-choline pathway, such as cki1, exhibit a choline exc

95 se (CCT), the second of three enzymes in the CDP-choline pathway, which is used to synthesize phospha

96 Pcyt2, but not of Pcyt1a (which mediates the CDP-choline pathway), in activated T cells impairs the d

97 le detectable impact on the operation of the CDP-choline metabolic pathway in adult tissues.

98 uirement is abrogated by inactivation of the CDP-choline pathway for phosphatidylcholine biosynthesis

99 e to phosphocholine as the first step of the CDP-choline pathway for the biosynthesis of phosphatidyl

100 ng that XBP-1(S) increases the output of the CDP-choline pathway primarily via its effects on CCT.

101 to distinguish the products from that of the CDP-choline pathway.

102 this phospholipid occurs via two routes, the CDP-choline pathway, which uses host choline as a precur

103 synthesis of phosphatidylcholine through the CDP-choline pathway.

104 is in the brain is predominantly through the CDP-choline pathway.

105 In addition to the CDP-choline pathway for phosphatidylcholine (PC) synthes

106 While the contribution to the CDP-choline pathway remained intact in hepatocarcinoma c

107 the synthesis of phosphatidylcholine via the CDP-choline branch of the Kennedy pathway.

108 sis both as an intact choline moiety via the CDP-choline pathway and as a methyl donor via PE methyla

109 recovery of de novo PC biosynthesis via the CDP-choline pathway restores autophagosome formation and

110 dylethanolamine or from free choline via the CDP-choline pathway.

111 le for phosphatidylcholine synthesis via the CDP-choline pathway.

112 of phosphatidylcholine biosynthesis via the CDP-choline pathway.

113 ynthesis of phosphatidylcholine (PC) via the CDP-choline-dependent Kennedy pathway.

114 (CCT), the rate-regulatory enzyme within the CDP-choline pathway, by 40% compared with control, but i

115 f choline to form choline phosphate and then CDP-choline.

116 First, membrane-free nuclei retain all three CDP-choline pathway enzymes in proportions comparable wi

117 holine and cytidine 5'-triphosphate (CTP) to CDP-choline for the eventual synthesis of phosphatidylch

118 holine and cytidine 5'-triphosphate (CTP) to CDP-choline for the subsequent synthesis of phosphatidyl

119 ked the pressor and bradycardic responses to CDP-choline while neomycine or furegrelate partially att

120 se inhibitors on cardiovascular responses to CDP-choline.

121 his phosphocholine transferase activity used CDP-choline as a substrate and required a conserved hist

122 Our data support a model where CDP-choline hydrolysis is catalyzed by the enclosed Nudi

123 Supplementation with CDP-choline increased phosphatidylcholine synthesis, rev

124 Treatment with CDP-choline ameliorated SAND, suggesting that it may be