ライフサイエンスコーパス: CDP

1 CDP (3.0 mg/kg) administered alone did not disrupt escap

2 CDP ameliorated deleterious effects of DZP in both setti

3 CDP coadministered with 0.3 mg/kg SCP impaired escape on

4 CDP combines the use of ion-exchange membranes and porou

5 CDP is also related to disruption of vitamin K-dependent

6 CDP protects alpha from its inhibition.

7 CDP-6-deoxy-L-threo-D-glycero-4-hexulose 3-dehydrase (E1

8 CDP-6-deoxy-l-threo-d-glycero-4-hexulose-3-dehydrase (E1

9 CDP-Chase is the first identified member of a novel Nudi

10 CDP-choline also elevated hypothalamic extracellular tot

11 CDP-choline caused a dose- and time-dependent increase i

12 CDP-choline treatment significantly attenuated the infar

13 CDP-treated mice exhibited reductions in stress-induced

14 CDP/Cut is a transcriptional repressor that decreases FI

15 CDPs are versatile molecular auxiliaries that form robus

16 CDPs from Batf3(-/-) mice that were specified toward dev

17 lent labeling of alpha with the sugar of F(2)CDP (one label/alpha2beta2).

18 beta' with [1'-(3)H]-F(2)CDP or [5-(3)H]-F(2)CDP and reisolation of the protein by Sephadex G-50 chro

19 complex, when incubated with 1 equiv of F(2)CDP catalyzes the release of two fluorides and cytosine

20 chanisms share many common features with F(2)CDP inactivation of the class I RNRs.

21 20 nmol min(-1) mg(-1)) establishes that F(2)CDP is a substoichiometric inactivator of RNR.

22 ation of this alpha/beta' with [1'-(3)H]-F(2)CDP or [5-(3)H]-F(2)CDP and reisolation of the protein b

23 entify the new radical formed, [1'-(2)H]-F(2)CDP was studied with wt- and C225S-RNR by 9 and 140 GHz

24 Incubation of [1'-(3)H]-F(2)CDP with active site mutants C444S/A, C218S/A, and E431Q

25 Gemcitabine 5'-diphosphate (F(2)CDP) is a potent inhibitor of ribonucleotide reductases

26 psed to a doublet) relative to [1'-(1)H]-F(2)CDP.

27 Risk reductions in 3M-CDP and 6M-CDP were 77.2% (p=0.007) and 80.2% (p=0.040),

28 ylation but not reverse sialylation; (ii) 5'-CDP, a potent forward sialyltransferase inhibitor, did n

29 Risk reductions in 3M-CDP and 6M-CDP were 77.2% (p=0.007) and 80.2% (p=0.040), respective

30 A CDP molecule anchors the Hda domains in a conformation t

31 o process a C-2 deoxygenated substrate and a CDP-linked substrate was also demonstrated.

32 o transfers a ribitol phosphate group from a CDP -ribitol present in muscles to alpha-DG, while in vi

33 and catalyse the displacement of CMP from a CDP-alcohol by a second alcohol.

34 sfer of a substituted phosphate group from a CDP-linked donor to an alcohol acceptor.

35 ional cloning strategy, we here identified a CDP-ethanolamine:ceramide ethanolamine phosphotransferas

36 ISPD is a CDP-ribitol (ribose) pyrophosphorylase that generates th

37 The introduction of a CDP auxiliary was anticipated to promote the molecular a

38 tion, characterization, and utilization of a CDP that binds to the transferrin receptor (TfR), a nati

39 We found that a CDP with a negative surface charge rapidly removes all z

40 review [the acyl-CoA dehydrogenases (ACDs), CDP-6-deoxy-l-threo-d-glycero-4-hexulose-3-dehydrase red

41 g (ANX), and cell death protease activation (CDP).

42 that this transition was driven by an active CDP-choline pathway that synthesized PC enriched in spec

43 the presence of a mixture of 20 microM ADP, CDP, GDP, and UDP, the Km for the phosphorolysis of the

44 the appropriate second subunit beta(alpha), CDP and effector ATP to trap an amino tyrosyl radical (N

45 Y122*-beta2, Y731F-alpha2 (or Y730F-alpha2), CDP, and ATP at different temperatures (2-37 degrees C)

46 quench analysis of the F3Y(*)-beta2, alpha2, CDP, and ATP (effector) reaction show generation of 0.5

47 y, the reaction of F(3)Y(356)-beta2, alpha2, CDP, and ATP has been examined by stopped-flow (SF) abso

48 yrosine at Y122 (F3Y122*-beta2) with alpha2, CDP (substrate), and ATP (effector) has now afforded the

49 analysis of its reaction with Y731F-alpha2, CDP, and ATP at pH 8.2 and 25 degrees C shows F2Y356* ge

50 strategy used by A. phagocytophilum to alter CDP activity and thereby globally influence neutrophil f

51 f R293A ScRR1 complexed with dGTP and AMPPNP-CDP [AMPPNP, adenosine 5-(beta,gamma-imido)triphosphate

52 structures of the apo-, AMPPNP only-, AMPPNP-CDP-, AMPPNP-UDP-, dGTP-ADP- and TTP-GDP-bound complexes

53 of ScRR1 are crucial in facilitating ADP and CDP substrate selection.

54 In the presence of rNrdE, ATP, and CDP, Mn(III)(2)-Y(*) and Fe(III)(2)-Y(*) rNrdF generate

55 oning of dietary choline between betaine and CDP-PC among NP (MTHFR rs1801133 and MTR rs1805087 WT) a

56 uctures in the apo, CMP-bound, CDP-bound and CDP-glycerol-bound states define functional roles for ea

57 hes of the Kennedy pathways (CDP-choline and CDP-ethanolamine) are the predominant pathways responsib

58 line, uridine (a precursor for UTP, CTP, and CDP-choline), and a PUFA (e.g., docosahexaenoic acid); m

59 nomolar concentrations of ADP, UDP, GDP, and CDP are shown.

60 We find that interaction models of HNF1 and CDP motifs provide excellent prediction of both HNF1 loc

61 ne by several homeodomain proteins: MSX2 and CDP/cut repress whereas DLX3 and DLX5 activate endogenou

62 Unlike eukaryotic Cls (that use PG and CDP-diacylglycerol as substrates) or ClsA, the combined

63 hosphatidylglycerol, phosphatidylserine, and CDP-diacylglycerol) and inhibited by zwitterionic (phosp

64 athway intermediates phosphoethanolamine and CDP-ethanolamine, and an increase in the methylated deri

65 r in P. falciparum, thus making the SDPM and CDP-choline pathways the only routes for phosphatidylcho

66 ADP is not bound at the catalytic site, and CDP binds farther from the catalytic site compared to wi

67 Both mutants exhibited hyper-PRM, -ANX, and -CDP responses to RP-1 at both pHs and hypo-ENR at pH 5.5

68 CUTL1, also known as CDP (CCAAT Displacement Protein), Cut, or Cux-1, is a ho

69 e identify other possible substrates such as CDP-choline, ATP, and ADP.

70 ria for the quantification of AMP, ADP, ATP, CDP, CTP, FAD, GDP, GTP, UDP, and UTP.

71 This NS3a-based CDP system represents a new modality for engineering che

72 N(4)-Benzyloxy-CDP (15, MRS2964) and N(4)-methoxy-Cp(3)U (23, MRS2957)

73 The reaction of F(3)Y(356)-beta2, CDP, and ATP has also been examined with NH(2)Y(731)-alp

74 Studies with NH(2)Y(731(730))-alpha2, beta2, CDP, and ATP resulted in detection of NH(2)Y radical (NH

75 EPR spectroscopies in the presence of beta2, CDP, and ATP.

76 he first time a potential connection between CDP and FIH that could lead to the development of future

77 R293A ScRR1 is unable to bind ADP and binds CDP with 2-fold lower affinity compared to wild-type ScR

78 Both CDP and HIF levels are increased in several cancers and

79 cterium salmoninarum, with and without bound CDP-diacylglycerol to 3.6 and 2.5 A resolution, respecti

80 substrate/specificity effector-pairs bound (CDP/dATP, UDP/dATP, ADP/dGTP, GDP/TTP) that reveal the c

81 Structures in the apo, CMP-bound, CDP-bound and CDP-glycerol-bound states define functiona

82 hatidylinositol biosynthesis is catalysed by CDP-alcohol phosphotransferases, transmembrane enzymes t

83 nal step of PtdCho synthesis is catalyzed by CDP-choline:1,2-diacylglycerol cholinephosphotransferase

84 membrane phospholipids and was inhibited by CDP-diacylglycerol and sphingoid bases.

85 rokaryotes and eukaryotes, being produced by CDP-DAG synthase (CDS).

86 PtdCho, which was significantly restored by CDP-choline treatment.

87 gdoms of life, and it is catalysed solely by CDP-APs.

88 ling, rdgB (retinal degeneration B) and cds (CDP-diacylglycerol synthase).

89 tions of a benzodiazepine, chlordiazepoxide (CDP), with a noncompetitive N-methyl-d-aspartate recepto

90 the anxiolytic efficacy of chlordiazepoxide (CDP; 15 mg/kg) on 24 hr retest.

91 effects of the anxiolytic chlorodiazepoxide (CDP; 10 mg/kg) on subjects' performance in a battery of

92 oline into the cytidine diphosphate-choline (CDP-choline) PC biosynthetic pathway relative to betaine

93 nthesis of phosphatidylcholine from choline (CDP-choline pathway), the parasite synthesizes this majo

94 that included methotrexate (MTX), cisplatin (CDP), and doxorubicin (ADM) with or without ifosfamide (

95 robe on cathepsin L, a protease that cleaves CDP into a form with increased DNA binding ability.

96 th the residues from an absolutely conserved CDP-AP signature motif (D(1)xxD(2)G(1)xxAR...G(2)xxxD(3)

97 In contrast, CDP-diacylglycerol synthases that provide PIS with its s

98 vel posttranslational process controls Cutl1/CDP activity and gene expression in the mammary gland.

99 n of the transcription factor Cut, a Cut/Cux/CDP family member, at 10B.

100 TP:glucose-1-phosphate cytidylyltransferase, CDP-Glc 4,6-dehydratase, NADH-dependent SAM:C-methyltran

101 irst human disorder arising due to defective CDP-ethanolamine biosynthesis and provide new insight in

102 ted a 4-epimer CDP-3-C-methyl-6-deoxyallose (CDP-cillose).

103 nantly yielded CDP-3-C-methyl-6-deoxygulose (CDP-cereose) and likely generated a 4-epimer CDP-3-C-met

104 hosphatidylcholine through a licCA-dependent CDP-choline pathway identified only in the genus Trepone

105 SAM:C-methyltransferase, and NADPH-dependent CDP-3-C-methyl-6-deoxyhexose 4-reductase.

106 Cytidine diphosphate diacylglycerol (CDP-DAG) is a central lipid intermediate for several pat

107 by the cytidine diphosphate diacylglycerol (CDP-DAG) pathway, is avirulent in the mouse model of sys

108 ) biosynthesis via the cytidine diphosphate (CDP)-choline pathway at the expense of betaine synthesis

109 naturally occurring nucleoside diphosphates, CDP, GDP, and ADP exhibited agonist potencies over 100-f

110 m radiolabeled cytidine 5'-diphosphocholine (CDP-choline) in HCCs.

111 rdic effect of cytidine 5'-diphosphocholine (CDP-choline).

112 Cytidine-5'-diphosphocholine (CDP-choline, Citicoline, Somazina) is in clinical use (i

113 Activities of the cytidine diphosphocholine (CDP-choline) and phosphatidylethanolamine-N-methyltransf

114 se enzymes in the cytidine diphosphocholine (CDP-choline) pathway of PtdCho biosynthesis.

115 ment and the inclusion of convective drying (CDP) and ohmic heating (OHP) were assayed.

116 ycero-4-hexulose-3-dehydrase reductase (E3), CDP-4-aceto-3,6-dideoxygalactose synthase (YerE), UDP-ga

117 C59-encoded dolichol kinase and CDS1-encoded CDP-diacylglycerol synthase enzymes.

118 aled reduced expression of the gene encoding CDP-diacylglycerol synthase 1 (Cds1), an enzyme that cat

119 CDP-cereose) and likely generated a 4-epimer CDP-3-C-methyl-6-deoxyallose (CDP-cillose).

120 DP binding and a 2-fold loss of affinity for CDP compared to the wild type.

121 reas they are 20% and 23%, respectively, for CDP reduction.

122 tial, base-catalysed mechanism universal for CDP-APs, in which the fourth aspartate (D4) acts as the

123 62%) compared to the equivalent dose of free CDP-choline (by 26%) after 1 h focal cerebral ischemia a

124 in vitro phosphatidylcholine formation from CDP-choline and diacylglycerol, and full activity requir

125 fferent hydrolysates were produced: (i) from CDP (IC(50)=287 mug/mL) and (ii) from beta-lactoglobulin

126 athway forming phosphatidylethanolamine from CDP-ethanolamine.

127 s the formation of phosphatidylinositol from CDP-diacylglycerol and inositol.

128 l-phosphate synthase is not synthesized from CDP-DAG, as was previously thought.

129 phosphatidylserine (PS) is synthesized from CDP-diacylglycerol and serine, a route that is different

130 hi) and Id2(lo) CDPs to Zeb2(lo) and Id2(hi) CDPs, which represent the earliest committed cDC1 progen

131 sex-differentially enriched motifs for HNF6/CDP factors.

132 However, CDP-treated mice did not exhibit facilitated acquisition

133 in turn develops into monocytes, and a human CDP (hCDP) that is restricted to produce the three major

134 electrodes and its suitability for improving CDP.

135 ial cells in vitro, we show ECs deficient in CDP-diacylglycerol synthase 2 are uniquely sensitive to

136 Levels of furosine were higher in CDP (46.6-110.1mg/100g protein) than in OHP (13.7-42.0mg

137 ternal resistance and overall performance in CDP.

138 defined a potential phosphorylation site in CDP (serine 987) that modulates FIH expression.

139 Irf8 expression in CDPs required prior autoactivation of Irf8 that was depe

140 enhancer prevented the induction of Irf8 in CDPs and abolished cDC1 specification.

141 hanism by which A. phagocytophilum increases CDP activity, we assessed the effects of this microbe on

142 ransferase (lyso-PAF-AT) and DTT-insensitive CDP-choline 1-alkyl-2-acetyl-sn-glycerol cholinephosphot

143 st integral membrane proteins from the large CDP-alcohol phosphatidyltransferase family are involved

144 mmary glands have high levels of full-length CDP (200 kDa) that binds to negative regulatory elements

145 omeodomain into cells containing full-length CDP also abrogated NRE binding.

146 During late pregnancy, full-length CDP levels decline, and a 150-kDa form of CDP (CDP150) a

147 and below a lesion at the lumbar 3/4 level, CDPs recorded from transplanted animals were significant

148 for the transition from Zeb2(hi) and Id2(lo) CDPs to Zeb2(lo) and Id2(hi) CDPs, which represent the e

149 y, and protein interaction capabilities make CDPs an attractive mid-size biologic scaffold to complem

150 line cytidylyltransferase (CCT), which makes CDP-choline.

151 nsferase domain (IPCT) fused with a membrane CDP-alcohol phosphotransferase domain (DIPPS) at 2.65 A

152 IFO added to MTX, CDP, and ADM from the preoperative phase does not improv

153 who have a poor histologic response to MTX, CDP, and ADM.

154 toperatively when pathologic response to MTX-CDP-ADM was poor (arm A) or given in the primary phase o

155 n the primary phase of chemotherapy with MTX-CDP-ADM (arm B).

156 g mammary extracts or transfection of mutant CDP cDNAs missing the homeodomain into cells containing

157 photophysical studies of CDP-naphthalimide (CDP-NI) conjugates led to the identification of two AIEg

158 of cyclic dipeptide tethered naphthalimides (CDP-NIs) to evaluate their AIEgenic properties and appli

159 istration of DCS (7.5 and 15 mg/kg), but not CDP (15 mg/kg) or DCS (30 mg/kg), significantly and sele

160 Thus, CCR9(-) pDC-like cells are novel CDP-derived circulating DC precursors with pDC and cDC p

161 y also caused increases in the activities of CDP-diacylglycerol synthase, phosphatidylserine decarbox

162 AP kinase, and modulation of the activity of CDP/cut and C/EBPalpha, two transcription regulators of

163 erebroventricular (i.c.v.) administration of CDP-choline was made and blood pressure and heart rate w

164 hilum infection also enhances the binding of CDP to the promoters of human neutrophil peptide 1 and C

165 However, the mechanism of conversion of CDP-choline to phosphatidylcholine remained unclear.

166 ase (E3), catalyzes the C-3 deoxygenation of CDP-4-keto-6-deoxy-D-glucose to form the dehydrated prod

167 e (E1), which catalyzes C-3 deoxygenation of CDP-4-keto-6-deoxyglucose in the biosynthesis of 3,6-did

168 es of this design for further development of CDP into a mature technology.

169 id not compromise the anxiolytic efficacy of CDP in control mice, the results showed that posttrainin

170 th CDP levels decline, and a 150-kDa form of CDP (CDP150) appears concomitantly with a decline in DNA

171 rase (CPCT) which catalyzes the formation of CDP-choline, a key intermediate in the choline branch of

172 nd in the endoplasmic reticulum by fusion of CDP-ethanolamine and diacylglycerol.

173 Bacillus cereus catalyzes the hydrolysis of CDP-choline to produce CMP and phosphocholine.

174 s inhibitor] 5 min prior to the injection of CDP-choline to determine the effects of these inhibitors

175 is associated with an increase in levels of CDP-ribitol, the substrate for the ribitol-5-phosphate t

176 in these neurons led to a mislocalization of CDP(+) neurons in deeper layers of the cortex.

177 CCT1 exhibited a V max of 23904 nmol of CDP-choline min (-1) mg (-1) and apparent K m values for

178 cathepsin L activity and the proteolysis of CDP.

179 Developmental regulation of CDP was recapitulated in the normal mammary epithelial l

180 idylcholine is balanced by the repression of CDP-diacylglycerol pathway enzymes and the induction of

181 s report, we demonstrate the central role of CDP-diacylglycerol synthetase (CDS) in the regulation of

182 The systematic photophysical studies of CDP-naphthalimide (CDP-NI) conjugates led to the identif

183 rogenitors (CDPs), but not for transition of CDP to mature DCs.

184 Direct use of CDP-ribitol is also effective for matriglycan expression

185 d cell-intrinsic defects in the formation of CDPs and all splenic DC subsets.

186 Interestingly, the accumulation rate of CDPs is inversely correlated with longevity, suggesting

187 Our work highlights the utility of CDPs as a diverse, easy-to-screen scaffold family worthy

188 , contrary to the membrane topology of other CDP-alcohol phosphotransferases.

189 peptide interaction, we demonstrate that our CDP system can be used to confer temporal control over d

190 P-CDP performed particularly well for positively charged M

191 CCAC and 30 and 40000 g mg(-1) min(-1) for P-CDP.

192 These data highlight advantages of P-CDP adsorbents relevant to MP removal during water and w

193 AC and faster but more selective uptake on P-CDP.

194 ance of porous beta-cyclodextrin polymers (P-CDP) as adsorbents of MPs in aquatic matrixes.

195 d almost no effect on adsorption of MPs to P-CDP.

196 The two branches of the Kennedy pathways (CDP-choline and CDP-ethanolamine) are the predominant pa

197 a-lactoglobulin and casein-derived peptides (CDP) from whey.

198 spired bioengineered cystine-dense peptides (CDPs) for various biological targets.

199 Cystine-dense peptides (CDPs) have drawn recent interest as drugs or drug-delive

200 chrinate (CS), choline dihydrogen phosphate (CDP), choline lactate (CL), and choline tartarate (CT))

201 categorized as a cellodextrin phosphorylase (CDP).

202 The CDP-alcohol phosphotransferase (CDP-AP) family of integral membrane enzymes catalyses th

203 le cationic cyclodextrin-containing polymer (CDP)-based siRNA nanoparticles and, thereby, facilitate

204 ormance of three beta-cyclodextrin polymers (CDPs), an anion-exchange (AE) resin, and a cation-exchan

205 action based on capacitive Donnan potential (CDP) is a recently suggested technique for sustainable p

206 When cord dorsum potentials (CDPs), evoked by electrical stimulation of the L4/L5 dor

207 rs of the B. cereus sensu lato group produce CDP-3-C-methyl-6-deoxy sugars for the formation of cereo

208 ella typhi enzyme complexed with the product CDP-glucose is a fully integrated hexamer displaying 32

209 haracteristic carbamylation-derived product (CDP), over time in skin of mammalian species with differ

210 xy-D-glucose to form the dehydrated product, CDP-4-keto-3,6-dideoxy- d-glucose, in the ascarylose bio

211 ing of the common dendritic cell progenitor (CDP) and identified a cluster of cells that expressed tr

212 rf8 in the common dendritic cell progenitor (CDP) is required for classical type 1 dendritic cell (cD

213 nitor (MDP) cells; and common DC progenitor (CDP) and DC precursor (pre-DC) cells.

214 rose directly from the common DC progenitor (CDP).

215 n the common dendritic cell (DC) progenitor (CDP), the committed conventional DC precursor (pre-cDC),

216 In contrast, common DC progenitors (CDP) and pre-DCs, which give rise to lymphoid organ DCs

217 rs differentiate into common DC progenitors (CDPs), and as lymphoid-primed multipotent progenitors (L

218 m/progenitor cells to common DC progenitors (CDPs), but not for transition of CDP to mature DCs.

219 ors (MDPs) and common dendritic progenitors (CDPs), demonstrate increasing commitment to the DC linea

220 month (6M) confirmed disability progression (CDP) were evaluated post hoc.

221 layed time to confirmed disease progression (CDP) in pre-planned sub-group analyses.

222 t was time to confirmed disease progression (CDP), a prespecified increase in Expanded Disability Sta

223 oup-I/Y (HMGI/Y), CAAT displacement protein (CDP) and poly(ADP-ribose) polymerase-1 (PARP-1).

224 Cutl1/CCAAT displacement protein (CDP) is a transcriptional repressor of mouse mammary tum

225 rotein (CBP) and CCAAT displacement protein (CDP) to rs3289C as the factors responsible for transcrip

226 of a repressor, CCAAT displacement protein (CDP), to the gp91(phox) promoter, thereby diminishing th

227 ammalian homologs CAAT Displacement Protein (CDP; now CUX1) and CAAT Enhancer Binding Protein (C/EBP)

228 at in RCC, the Cut-like homeodomain protein (CDP/Cut) is involved in FIH transcriptional regulation a

229 alized the ER and Golgi, probably to provide CDP-DAG for the phosphatidylinositol synthases.

230 Our chemically disrupted proximity (CDP) system is based on the interaction between the hepa

231 Chondrodysplasia punctata (CDP) is a rare, heterogeneous congenital skeletal dyspla

232 lution crystal structure of a representative CDP-AP from Archaeoglobus fulgidus.

233 deficient in the function of the ER-resident CDP-DG synthase Cds1 exhibit markedly increased triacylg

234 ed by GM-CSF, independent of cDC-restricted (CDP) and monocyte-restricted (cMoP) progenitors.

235 e including DKs, phytol kinases, and several CDP-diacylglycerol synthetases has been identified, and

236 proinflammatory transcription factors Stat4, CDP, GRE, CBF, Ets-1/PEA3, and TFIID, a pattern easily d

237 in the presence of alpha(2) and a substrate (CDP), leading to speculation that HU might intercept a t

238 ability to process the predicted substrate, CDP-4-amino-4,6-dideoxyglucose, using PLP as the coenzym

239 alpha binds NDP substrates (CDP, UDP, ADP, and GDP, C site) as well as ATP and dNTPs

240 he CHO1-encoded phosphatidylserine synthase (CDP-diacylglycerol pathway enzyme) and loss of the zinc-

241 he CHO1-encoded phosphatidylserine synthase (CDP-diacylglycerol:l-serine O-phosphatidyltransferase, E

242 TFN-CDP exhibits adsorption distribution coefficients (log K

243 But TFN-CDP does not bind many anionic MPs strongly, including a

244 coming, we reduced the nitrile groups in TFN-CDP to primary amines, which reverses its affinity towar

245 1.5 for anionic MPs, whereas the reduced TFN-CDP exhibits log K(D) values of -0.5-1.5 for cationic MP

246 nked with tetrafluoroterephthalonitrile (TFN-CDP) has high affinity for cationic and many neutral MPs

247 ysteine protease inhibitor demonstrated that CDP is proteolytically processed within the homeodomain

248 tin immunoprecipitation assays, we show that CDP binds to the FIH-1 promoter in vivo and that this bi

249 Our data show that CDP-choline liposomes significantly (P < 0.01) decreased

250 Immunohistochemical studies showed that CDP-choline increased COX-1 and -2 immunoreactivities in

251 The results suggest that CDP-choline may stimulate prostaglandin synthesis throug

252 Taken together, these results suggest that CDP-choline significantly restores Ptd-Cho levels by dif

253 The CDP-alcohol phosphotransferase (CDP-AP) family of integr

254 se of choline for PC production via both the CDP-choline and PEMT pathways shows the substantial dema

255 synthesis of phosphatidylcholine (PC) by the CDP-choline (Kennedy) pathway.

256 ination of diacylglycerol utilization by the CDP-ethanolamine pathway led to a 10-fold increase in tr

257 synthesis of phosphatidylethanolamine by the CDP-ethanolamine pathway.

258 inct from pre-cDCs can be generated from the CDP.

259 ssibility of the clamp binding motifs in the CDP-bound structure of Hda suggests that conformational

260 As the rate-limiting enzyme in the CDP-choline pathway for PC synthesis, CTP:phosphocholine

261 esis of CCT, the rate-limiting enzyme in the CDP-choline pathway, is elevated in fibroblasts overexpr

262 ept-1), which encodes the last enzyme in the CDP-ETA Kennedy pathway.

263 amine kinase catalyzes the first step in the CDP-ethanolamine pathway for the formation of the major

264 regulation correlated with increases in the CDP-ethanolamine pathway intermediates phosphoethanolami

265 le detectable impact on the operation of the CDP-choline metabolic pathway in adult tissues.

266 e to phosphocholine as the first step of the CDP-choline pathway for the biosynthesis of phosphatidyl

267 ng that XBP-1(S) increases the output of the CDP-choline pathway primarily via its effects on CCT.

268 this phospholipid occurs via two routes, the CDP-choline pathway, which uses host choline as a precur

269 synthesis of phosphatidylcholine through the CDP-choline pathway.

270 Thus, the CDP-bound Hda dimer likely represents an inactive form o

271 the synthesis of phosphatidylcholine via the CDP-choline branch of the Kennedy pathway.

272 the synthesis of major phospholipids via the CDP-diacylglycerol pathway.

273 e and the synthesis of phospholipids via the CDP-ethanolamine branch of the Kennedy pathway were cont

274 ynthesis of phosphatidylethanolamine via the CDP-ethanolamine branch of the Kennedy pathway.

275 r phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway.

276 ur results suggest that interfering with the CDP-DG route of phosphatidic acid utilization rewires ce

277 synthase constitutes a new branch within the CDP-alcohol phosphotransferase superfamily with homologu

278 The CDPs with a positive surface charge rapidly remove all a

279 The speculative function of this CDP in the carbohydrate metabolism of T. africanus TCF52

280 e for the conversion of phosphatidic acid to CDP-diacylglycerol in phospholipid biosynthesis.

281 We have used data reported by companies to CDP for public disclosure to build a database of 866 pro

282 holine and cytidine 5'-triphosphate (CTP) to CDP-choline for the eventual synthesis of phosphatidylch

283 of DCS abolished the anxiolytic response to CDP challenge.

284 ng DCS (15 mg/kg) on behavioral responses to CDP (15 mg/kg) challenge on 24 hr retest.

285 ked the pressor and bradycardic responses to CDP-choline while neomycine or furegrelate partially att

286 se inhibitors on cardiovascular responses to CDP-choline.

287 y, can transaminate the natural substrate to CDP-4,6-dideoxy-4-amino-D-galactose without E3.

288 Although time to CDP between groups was not significant, overall subgroup

289 Differences in time to CDP between rituximab and placebo did not reach signific

290 Subgroup analysis showed time to CDP was delayed in rituximab-treated patients aged <51 y

291 ruginosa dTDP-Glc PPase and Salmonella typhi CDP-Glc PPase.

292 Furthermore, we have defined a unique CDP/Cut binding site on the FIH promoter.

293 transferases, transmembrane enzymes that use CDP-diacylglycerol as donor substrate for this reaction,

294 his phosphocholine transferase activity used CDP-choline as a substrate and required a conserved hist

295 Our data support a model where CDP-choline hydrolysis is catalyzed by the enclosed Nudi

296 nborn metabolic diseases are associated with CDP, including peroxisomal and cholesterol biosynthesis

297 linical symptoms of diseases coexisting with CDP.

298 ed for the nucleotide radical generated with CDP and E441Q-RNR.

299 Treatment with CDP-choline ameliorated SAND, suggesting that it may be

300 The last enzyme predominantly yielded CDP-3-C-methyl-6-deoxygulose (CDP-cereose) and likely ge