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1 CPMV also exhibited clear treatment efficacy and systemi
2 CPMV and eCPMV could each be developed as novel adjuvant
3 CPMV nanoparticles are stable, nontoxic, modifiable with
4 CPMV or QB VLPs could be stockpiled, and epitopes exchan
5 CPMV-eVLP mimic the morphology of wild-type (WT) CPMV bu
6 ne the immunotherapeutic differences between CPMV and eCPMV, which is essential for the further devel
7 onstrated, the specific interactions between CPMV and mammalian cells need to be characterized furthe
8 cancer cells (cervical, breast, and colon): CPMV nanoparticles enter cells via the surface marker vi
9 nes and immune cells, but the RNA-containing CPMV particles were uniquely able to boost populations o
12 ediated tumor angiogenesis using fluorescent CPMV provides a means to identify arterial and venous ve
15 on of CPMV-BP is important to understand how CPMV is trafficked through the mammalian system and may
16 the Cowpea Mosaic Virus hypertranslational "CPMV-HT" expression system, which provides high yields o
22 ovalbumin (OVA) as a model antigen, OVA-Lip-CPMV vaccination protects mice from lung metastasis post
23 -Luc tumor model in female mice, the TCL-Lip-CPMV conjugate vaccine protects mice from tumor challeng
24 cy against a poorly immunogenic tumour, make CPMV an attractive and novel immunotherapy against metas
26 the ability to produce assembled capsids of CPMV in the absence of replication to examine the putati
28 The CD46 peptide presented in the context of CPMV is also up to 100-fold more effective than the solu
29 r results will facilitate the development of CPMV and eCPMV as immunotherapeutic vaccine platforms wi
31 revious reports described the engineering of CPMV through genetic or chemical modification, we report
32 bly detecting the virus in crude extracts of CPMV-infected leaves and can therefore form the basis fo
33 oreover, we demonstrate that this feature of CPMV can be used to specifically encapsidate custom RNA
34 vide a useful means for functionalization of CPMV toward its application as drug and/or contrast agen
36 t although the host range for replication of CPMV is confined to plants, mammalian cells nevertheless
37 ory CD46 peptide expressed on the surface of CPMV retains virus-binding activity and is capable of in
38 rinsic interest in CPMV as a plant pathogen, CPMV is of major interest in biotechnology applications
39 ion of 130-155 fluorescent dye molecules per CPMV using DAPI (4',6-diamidino-2-phenylindole dihydroch
50 reagent selected for its ability to bind to CPMV-eVLP and have shown that the selected Affimer also
51 ctron microscopy (cryo-EM) maps of wild type CPMV containing RNA-2, and of naturally-formed empty CPM
53 properties of wild-type cowpea mosaic virus (CPMV) (RNA containing) and eCPMV (RNA-free VLPs) produce
60 the peptide epitopes to cowpea mosaic virus (CPMV) nanoparticles and virus-like particles (VLPs) deri
61 like nanoparticles from cowpea mosaic virus (CPMV) reduces established B16F10 lung melanoma and simul
65 0), vaccinia (MVA), and cowpea mosaic virus (CPMV), were compared by AC capacitance scanning probe mi
68 have produced a 3.4 angstrom structure of WT CPMV bound to the Affimer using cryo-electron microscopy
70 -eVLP mimic the morphology of wild-type (WT) CPMV but lack any infectious genomic material and so do