ライフサイエンスコーパス: CRH

1 CRH (corticotropin-releasing hormone), a peptide release

2 CRH actions in NAc may vary by the individual's stress h

3 CRH functions in the contexts of acute and chronic stres

4 CRH(+) fibers are found in nucleus accumbens (NAc), wher

5 CRH(+) NAc afferents were selectively enriched in NAc-pr

6 CRH, at nanomolar, presumed-stress levels, rapidly aboli

7 CRH-mediated spine loss required network activity and th

8 et, and interacts with the CREB homologue-1 (CRH-1) transcription factor in vivo.

9 e role of a specific isoform of CREB1/CRH-1, CRH-1e, in Caenorhabditis elegans memory formation and c

10 show that a specific isoform of CREB1/CRH-1, CRH-1e, is primarily responsible for memory related func

11 include endocrine neurons producing DH44, a CRH-like peptide, and insulin-like peptides.

12 current and activity-induced expression of a CRH-1/CREB transcriptional target (gem-4 Copine), which

13 Chemogenetic stimulation of AmPir activated CRH neurons and induced an increase in blood stress horm

14 h in turn increased the production of active CRH and GC.

15 Levels of active CRH peptide are dependent on the processing of its precu

16 alin inflammatory pain test, we administered CRH or the CRH receptor antagonist alpha-helical CRH(9-4

17 sing hormone/hypothalamic-pituitary-adrenal (CRH/HPA) axis and the sympathomedullary system.

18 The CRHR1 preferred agonist CRH stimulated tube formation, proliferation, and migrat

19 CVS did not alter CRH median eminence immunoreactivity, indicating that CV

20 more, we report striking synchronicity among CRH neurons even across hemispheres, which suggests tigh

21 activity appeared highly synchronized among CRH neurons, and also across hemispheres.

22 ned anxiety and activations of the amygdala, CRH/HPA axis, the sympathomedullary system and their seq

23 e findings show that activation of amygdalar CRH+ neurons induces resilience, and suppresses the gain

24 deactivating calcineurin decrease CRTC-1 and CRH-1 activity and induce transcriptional responses simi

25 he synergistic actions of corticosterone and CRH at hippocampal synapses underlie memory impairments

26 el synergistic actions of corticosterone and CRH on hippocampal synaptic plasticity and spine structu

27 on of the stress hormones corticosterone and CRH recapitulated the physiological and structural defec

28 Mechanistically, corticosterone and CRH synergized at the spine-actin regulator RhoA, promot

29 e, synergistic actions of corticosterone and CRH underlie enduring memory impairments after concurren

30 Mechanistically, corticosterone and CRH, via their cognate receptors, acted synergistically

31 al genetic approaches to map both global and CRH(+) projection sources to NAc in mice.

32 ces include a substantial increase of MT and CRH immunoreactivity in the dorsal lateral septum (LS) a

33 -week body weight gain and altered NR3C1 and CRH gene expression in the hypothalamus.

34 circuits to coordinate responses to OXT and CRH.

35 32% and 74% of nonneuroendocrine TH, TRH and CRH neurons were responsive to GH in the PVH of Fluoro-G

36 %, 49% and 75% of neuroendocrine TH, TRH and CRH neurons, and 67%, 32% and 74% of nonneuroendocrine T

37 h we name CRH2, to CRH1 (previously known as CRH) and urocortin1/urotensin1 (UCN1/UTS1) in primitive

38 Bar(CRH) neurons have unexpectedly long dendrites, which may

39 Axons from Bar(CRH) neurons project to the lumbosacral spinal cord and

40 er for corticotrophin-releasing hormone (Bar(CRH) ).

41 ng data and future experiments targeting Bar(CRH) neurons and their synaptic afferents to study mictu

42 signaling uncovered a specific link between CRH-activated CRHR1, sAC, and endosome-based signaling.

43 ponses, recorded for 60min, were affected by CRH but not by ahCRH treatment.

44 aptic structure and function, are engaged by CRH and contribute to spine destabilization.

45 el granular exo-endocytic pathway induced by CRH on peritoneal MC.

46 ative membrane trafficking route mediated by CRH.

47 regulated kinase 1/2 activation triggered by CRH-stimulated CRHR1, but only sAC activity is essential

48 uropeptides found in the mammalian PVN (CCK, CRH, ENK, NTS, SS, VIP, OXT, AVP), we provide the first

49 pathway an ideal candidate for coordinating CRH synthesis and release.

50 sible for the LTM related functions of CREB1/CRH-1 while being dispensable for its innate chemotaxis

51 ates the role of a specific isoform of CREB1/CRH-1, CRH-1e, in Caenorhabditis elegans memory formatio

52 We show that a specific isoform of CREB1/CRH-1, CRH-1e, is primarily responsible for memory relat

53 mation in the animal and expression of CREB1/CRH-1e in a single pair of neurons is sufficient to resc

54 dies of the impact of the OXT/OXTR and CRHBP/CRH pathways in males and females will be important in d

55 ion of BDNF, or its receptor TrkB, decreased CRH expression and normal HPA functions.

56 potential roles for the molecularly-defined, CRH-dependent circuit in modulation of reward and motiva

57 dentifies secretagogin neurons as a distinct CRH-releasing neuron population reliant on secretagogin'

58 resents a novel mechanism of endocannabinoid-CRH interactions in regulating amygdala output.

59 tivity, indicating that CVS does not enhance CRH storage within the median eminence.

60 in corticotroph excitability and exaggerated CRH/AVP-stimulated ACTH secretion in vitro.

61 CRH expression from over-use and exhaustion, CRH is also enhanced by glucocorticoids at both the leve

62 cortisol secretion in response to exogenous CRH stimulation, inferring rapid feedback inhibition at

63 ted higher stress (P < .001) and craving for CRH compared with controls.

64 idual's stress history, suggesting roles for CRH in neuroplasticity and adaptation of the reward circ

65 These findings indicate that forebrain CRH hyper-signaling in early-life is sufficient to incre

66 By using immunohistochemistry we found CRH-ir neurons surrounded by PTH2R-ir fibers and TIP39-i

67 Further, CRH-1e expression in RIM neurons is sufficient to rescue

68 or the CRH receptor antagonist alpha-helical CRH(9-41) (ahCRH) intracerebroventricularly to male and

69 pal CRH expression, and blocking hippocampal CRH receptor type-1 (CRHR1) immediately following early-

70 ggest that persistently elevated hippocampal CRH-CRF(1) interaction contributes importantly to the st

71 Early-life adversity increases hippocampal CRH expression, and blocking hippocampal CRH receptor ty

72 establishing the contribution of hippocampal CRH-CRFR(1) signaling to these processes highlights the

73 We present cath-resolve-hits (CRH), a new tool that uses a dynamic-programming algorit

74 In conclusion, the stress hormone CRH co-opts mechanisms that contribute to the plasticity

75 (CRHBP), an antagonist of the stress hormone CRH, is specifically expressed in OxtrINs.

76 ss hormones corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone.

77 rations of corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) cause a depolarizati

78 etagogues, corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) to control the relea

79 etagogues, corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) to control the relea

80 ocin (OX), corticotrophin releasing hormone (CRH) and calcitonin gene-related peptide (CGRP).

81 The corticotropin-releasing hormone (CRH) and its type 1 receptor (CRHR1) play a central role

82 s including corticotropin-releasing hormone (CRH) and neurotensin (NT), secreted in response to the m

83 pothalamic corticotrophin-releasing hormone (CRH) and then stimulation of the adrenal by ACTH.

84 europeptide Corticotropin Releasing Hormone (CRH) based on the immobilization of half-antibody fragme

85 t level of corticotrophin-releasing hormone (CRH) can activate a dynamic pituitary-adrenal peripheral

86 pression of corticotropin-releasing hormone (CRH) can at least partially account for the various effe

87 lly labeled corticotropin-releasing hormone (CRH) cells, which represent a major regulator of the str

88 ction with corticotrophin releasing hormone (CRH) drive.

89 The corticotrophin-releasing hormone (CRH) family of peptides modulates intestinal inflammatio

90 europeptide corticotropin-releasing hormone (CRH) from hippocampal interneurons, activating receptors

91 release of corticotropin-releasing hormone (CRH) from the paraventricular nucleus (PVN) of the hypot

92 ypothalamic corticotropin-releasing hormone (CRH) gene expression and potently enhances GR-dependent

93 eurohormone corticotropin-releasing hormone (CRH) in hypothalamic neurons has been implicated as a ke

94 or intra-LC corticotropin releasing hormone (CRH) infusion supported aversion learning with intra-LC

95 Corticotropin-releasing hormone (CRH) is a central integrator in the brain of endocrine a

96 Corticotropin-releasing hormone (CRH) is a major regulator of the hypothalamic-pituitary-

97 Corticotropin-releasing hormone (CRH) is an essential, evolutionarily-conserved stress ne

98 Corticotropin releasing hormone (CRH) is disrupted in individuals with PTSD and early-lif

99 Corticotropin-releasing hormone (CRH) is secreted under stress and regulates the hypothal

100 Corticotropin-releasing hormone (CRH) is suggested to be involved in the regulation of pa

101 strate that corticotropin-releasing hormone (CRH) neurons are modulated by the stress-derived neurost

102 e (TRH) and corticotropin-releasing hormone (CRH) neurons expressed GH-induced pSTAT5, respectively.

103 -responsive corticotropin-releasing hormone (CRH) neurons in female mice.

104 y inputs to corticotropin-releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus

105 napses onto corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus of the hypot

106 Corticotropin-releasing hormone (CRH) neurons in the parvocellular paraventricular nucleu

107 ypothalamic corticotropin-releasing hormone (CRH) neurons, which control stress hormone levels.

108 ngth in PVN corticotropin-releasing hormone (CRH) neurons, with GLP-1R activation promoting a protein

109 sterone and corticotropin-releasing hormone (CRH) on synaptic physiology and dendritic spine structur

110 ived either corticotropin releasing hormone (CRH) or saline intravenously.

111 asopressin, corticotropin-releasing hormone (CRH) or thyrotropin-releasing hormone.

112 hippocampal corticotropin-releasing hormone (CRH) permeate memory-forming hippocampal synapses, yet i

113 ypothalamic corticotropin-releasing hormone (CRH) regulates neuroendocrine functions such as adrenal

114 Corticotropin-releasing hormone (CRH) released from the paraventricular nucleus of the hy

115 The corticotropin-releasing hormone (CRH) system coordinates neuroendocrine and behavioral re

116 The corticotrophin-releasing hormone (CRH) system integrates the stress response and is associ

117 tion of the corticotropin-releasing hormone (CRH) system within the extended amygdala appears to medi

118 nges to the corticotropin-releasing hormone (CRH) system; and structural, functional, and epigenetic

119 ticoids and corticotropin releasing hormone (CRH) underlie the physiology of change and adaptation.

120 pression of corticotropin-releasing hormone (CRH) were not affected by oxazepam.

121 europeptide corticotropin-releasing hormone (CRH) within the hippocampus during stress influences neu

122 f amygdalar corticotropin-releasing hormone (CRH)+ neurons abolished the increase in DRv TPH2+ neuron

123 the role of corticotropin-releasing hormone (CRH), a hypothalamic hormone also released during stress

124 a implicate corticotropin-releasing hormone (CRH), acting through its CRH1 receptor, in stress- and d

125 Although corticotropin-releasing hormone (CRH), produced by parvocellular neurons of the hypothala

126 Corticotropin-releasing hormone (CRH), through the hypothalamic pituitary adrenal axis an

127 to measure corticotropin-releasing hormone (CRH), urocortin (Ucn), beta-endorphin (beta-END), ACTH,

128 pression of corticotropin-releasing hormone (CRH), urocortin, proopiomelanocortin (POMC), and POMC-de

129 tocin (MT), corticotropin-releasing hormone (CRH), vasoactive intestinal polypeptide, tyrosine hydrox

130 e mammalian corticotropin-releasing hormone (CRH), were specifically activated by nutritive sugars.

131 europeptide corticotropin-releasing hormone (CRH), which influence the integrity of dendritic spines

132 PA axis is corticotrophin-releasing hormone (CRH), which is made in the parventricular nucleus and is

133 effects of corticotropin-releasing hormone (CRH), which is released from inflamed tissues by cellula

134 raced local corticotropin-releasing hormone (CRH)-expressing inhibitory interneurons with extensive p

135 to both the corticotropin-releasing hormone (CRH)-immunoreactive cell bodies and dendrites within the

136 resembling corticotropin-releasing hormone (CRH).

137 express the corticotropin-releasing hormone (CRH).

138 ting genes, corticotropin releasing hormone (CRH; P=0.05) and glucocorticoid receptor (NR3C1; P=0.002

139 dogenous corticotropin-releasing hormone(+) (CRH(+)) LC inputs from the amygdala increase tonic LC ac

140 However, how CRH-producing neurons in an intact animal respond to dif

141 Thus, our work reveals how CRH neurons respond to different levels of acute stress

142 However, CRH is also secreted outside the brain where it exerts p

143 third intracellular loop (IC3) of the human CRH-R1alpha important for cAMP and ERK1/2 pathways activ

144 orticoid release, whereas extra-hypothalamic CRH has a key role in stressor-triggered behaviors.

145 oids at both the level of extra-hypothalamic CRH sites and at the level of the placenta and fetal pro

146 ith intracellular mechanisms in hypothalamic CRH neuroendocrine neurons that initiate the adrenocorti

147 sted whether the innervation of hypothalamic CRH neurons of rat pups that received augmented maternal

148 pathway in rat paraventricular hypothalamic CRH (corticotropin-releasing hormone) neuroendocrine neu

149 In addition to hypothalamus, CRH is expressed in brain regions including amygdala and

150 release but were associated with changes in CRH receptor type 1 expression.

151 To investigate the role of the GR in CRH neurons, we have targeted the deletion of the GR, sp

152 hese mice, resulting in a modest increase in CRH expression in the paraventricular nucleus, hypoplast

153 arly life or adulthood causes an increase in CRH release in a variety of neural sites.

154 In vitro, the T allele resulted in CRH promoter activity that was higher following both sti

155 fects of social buffering and reduced STP in CRH(PVN) neurons from females but not males.

156 aused the recruitment of previously inactive CRH neurons in an intensity-dependent manner, thus incre

157 ectopic expression of BDNF in vivo increased CRH, whereas reduced expression of BDNF, or its receptor

158 atter function of glucocorticoids increasing CRH gene expression underlies the physiology of change t

159 amplitude of Ca(2+) transients in individual CRH neurons in response to such stressors.

160 The response magnitude of individual CRH cells covaried with stressor intensity.

161 ndent increase in the activity of individual CRH cells, and by an increase in the pool of responsive

162 Cre-dependent viruses injected into CRH-Cre mice enabled selective mapping of CRH(+) afferen

163 Intravenous CRH elevated heart rates in all groups; however, cocaine

164 on supported aversion learning with intra-LC CRH infusion associated with increased olfactory bulb NE

165 tial specificity of the effect of early-life CRH exposure on adult behavior, the tetracycline-off sys

166 undamental physiological feature of limiting CRH expression from over-use and exhaustion, CRH is also

167 Local CRH signaling onto adult-born neurons promotes and/or st

168 e AAV1-directed axonal tracing to verify NAc CRH(+) fiber projections and established the identity of

169 cells via validated antisera against native CRH.

170 In cultured rat hippocampal neurons, CRH application reduced dendritic spine density in a tim

171 ctions of the stress-activated neuropeptide, CRH, contribute to the deleterious effects of early-life

172 usion, these data demonstrate the ability of CRH to affect the behavioral responses to an inflammator

173 urther show that two specific amino acids of CRH-1 are required for the process of memory formation i

174 es are to uncover how the dynamic actions of CRH integrate with the well-established roles of adrenal

175 arval zebrafish, we recorded the activity of CRH cells, while the larvae were exposed to stressors of

176 Addition of CRH (1 muM) to LAD2 cells, which are "primed" with SP fo

177 though previous, nonselective attenuation of CRH production or action, genetically in mice and pharma

178 We quantified the relative contribution of CRH(+) neurons to total NAc-directed projections.

179 l microdomains of IC3 in the coordination of CRH-R1 signaling activity.

180 cesses of the half-antibody and detection of CRH, using cyclic voltammetry and electrochemical impeda

181 r was obtained for the specific detection of CRH, within a range of 10.0-80.0 mug mL(-1), with a limi

182 s fixed for immunohistochemical detection of CRH.

183 1 and CRH2 likely evolved via duplication of CRH during a whole-genome duplication early in the verte

184 as evidenced by the fact that the effect of CRH is mimicked by forskolin and 8-bromo-cAMP.

185 After transient elevation of CRH during development only, behavioral testing in adult

186 icular nucleus resulted in an enhancement of CRH expression and an up-regulation of hypothalamic leve

187 latency (FSL) and decreased excitability of CRH neurons.

188 results in a decrease in the excitability of CRH neurons.

189 lacks agonistic effects on the expression of CRH in the central amygdala and antagonizes GR-mediated

190 glucocorticoids to direct the expression of CRH.

191 forebrain-restricted inducible expression of CRH.

192 However, the origin and extent of CRH(+) inputs to NAc are incompletely understood.

193 hereas the reduced excitatory innervation of CRH-expressing neurons dissipated by adulthood, increase

194 Subjects received 1 microg/kg of CRH intravenously.

195 ndicated the capacity of differing levels of CRH activity in different brain areas to produce behavio

196 UVB stimulated plasma levels of CRH, Ucn, beta-END, ACTH, and CORT and increased skin ex

197 t and becomes disrupted for higher levels of CRH.

198 to CRH-Cre mice enabled selective mapping of CRH(+) afferents.

199 PC2, which is essential in the maturation of CRH from its prohormone, pro-CRH.

200 Here we demonstrate a novel mechanism of CRH-induced anxiety that relies on modulation of endocan

201 cord blood leukocyte promoter methylation of CRH (P=0.05) and NR3C1 (P=0.04); and 33% lower (P=0.07)

202 s, the stressor strength-dependent output of CRH neurons emerges by a dual mechanism that involves bo

203 which the level, rather than the pattern, of CRH determines the dynamics of glucocorticoid hormone se

204 irtuin 1 (Sirt1) regulates the production of CRH post-translationally by affecting PC2.

205 sal GC levels by enhancing the production of CRH through an increase in the biosynthesis of PC2, whic

206 dendrites and decrease at the soma region of CRH neurons.

207 We find the differential regulation of CRH relies upon the cAMP response-element binding protei

208 ood, increased NRSF levels and repression of CRH expression persisted, suggesting that augmented earl

209 hat stressor strength-dependent responses of CRH neurons emerge via an intensity-dependent increase i

210 While restraint of CRH by glucocorticoids is a fundamental physiological fe

211 nscription factor in C. elegans Silencing of CRH-1e-expressing neurons during training for LTM format

212 al prefrontal cortex as principal sources of CRH(+) projections to NAc.

213 els, and had no effect on UVB stimulation of CRH and Ucn levels in the plasma, demonstrating the requ

214 as a cellular entry point into the study of CRH-mediated, anxiety-like behaviors and their therapeut

215 manner that might promote the suppression of CRH expression and studied the cellular mechanisms under

216 The synchronicity of CRH neurons within and across hemispheres ensures that t

217 ranscriptional responses similar to those of CRH-1 null worms.

218 does not affect the overall transcription of CRH, the mineralocorticoid receptor (MR), the serotonin

219 area (AmPir), contained neurons upstream of CRH neurons that were activated by volatile predator odo

220 th restraining and enhancing capabilities on CRH gene expression.

221 remodeling of synaptic contacts was found on CRH neurons in response to chronic stress.

222 otentiates the inhibitory effects of GABA on CRH neurons, decreasing the activity of the HPA axis.

223 hibitory synaptic contacts were increased on CRH neurons; however, the excitatory/inhibitory input ra

224 The effects of THDOC on CRH neurons are mediated by actions on GABA(A)R delta su

225 miniature excitatory synaptic currents onto CRH neurons were reduced in "care-augmented" rats compar

226 that positive feedback of neurosteroids onto CRH neurons is required to mount the physiological respo

227 lls in PVN only occasionally expressed OX or CRH but not CART.

228 In particular, CRH and NT have synergistic effects on mast cell secreti

229 e, the molecular mechanism regulating phasic CRH release remains poorly understood.

230 Placental CRH concentrations were quantified in maternal blood col

231 d receptor (NR3C1; P=0.002); lower placental CRH transcript abundance (P=0.04); lower cord blood leuk

232 d HPA axis responses (rapidly increased pPVN CRH mRNA expression, ACTH, and corticosterone secretion)

233 ndent on the processing of its precursor pro-CRH by the action of two members of the family of prohor

234 e maturation of CRH from its prohormone, pro-CRH.

235 We examined neuroendocrine, PVN CRH neurons and report that social isolation alters the

236 sical stress has sex-specific effects on PVN CRH neurons.

237 nd the selective urocortin 3 (UCN3) receptor CRH-R2, but not UCN3 itself.

238 1 corticotropin-releasing hormone receptor (CRH-R1) influences biological responses important for ad

239 ever, the molecular mechanisms that regulate CRH are not fully understood.

240 addition to CRH, another gene that resembles CRH in sequence and syntenic environment.

241 and by an increase in the pool of responsive CRH cells at the population level.

242 nner, thus increasing the pool of responsive CRH cells.

243 ization of nonhypothalamic stress-responsive CRH systems.

244 se studies suggest that forebrain-restricted CRH signaling during development can permanently alter s

245 k against an existing algorithm, which shows CRH delivers very similar or slightly improved results a

246 s, we induced transient, forebrain-specific, CRH overexpression during early-life (pre-puberty, CRHOE

247 UVB stimulated CRH gene and protein expression in the brain that was lo

248 ntegrator of stress responses, and, as such, CRH gene variation may contribute to individual differen

249 d CRHR2 in patients with IC/BPS, and suggest CRH signaling may be associated with IC/BPS symptoms.

250 Here we found that CRH expression is augmented in hippocampus of middle-age

251 Functionally, we found that CRH signaling in the amygdala promotes an anxious phenot

252 We found that CRH triggers substantial exocytosis, which is even stron

253 Specifically, we found that CRH, through activation of the CRH receptor type 1 (CRHR

254 We hypothesized that CRH hyper-signaling in the forebrain during early develo

255 amination of the cAMP response revealed that CRH-activated CRHR1 generates cAMP after endocytosis.

256 Our data suggest that CRH promoter variation that confers increased stress rea

257 d anxiety responses, these data suggest that CRH signaling coordinates a disruption of tonic AEA acti

258 es modulates intestinal inflammation and the CRH receptor 2 (CRHR2) suppresses postnatal angiogenesis

259 e amygdala, the noradrenergic system and the CRH/HPA axis participate in multiple reinforcing positiv

260 he morning when arousal systems, such as the CRH/HPA axis and the noradrenergic systems, are at their

261 onally, the association constant between the CRH and the immobilized half-antibody was calculated at

262 lving multidirectional crosstalk between the CRH/ACTH pathways, autonomic nervous system, vasopressin

263 Production of CRHBP blocks the CRH-induced potentiation of postsynaptic layer 2/3 pyram

264 ropin-releasing factor (CRF), encoded by the CRH gene, is a key integrator of stress responses, and,

265 To better evaluate the CRH-mediated behavioral alterations in the formalin infl

266 Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS experience

267 le nucleotide polymorphism (rs110402) in the CRH receptor 1 (CRHR1) gene show behavioral and neuroend

268 ildhood trauma and sequence variation in the CRH receptor 1 gene (CRHR1) that increase risk for affec

269 during the formalin interphase period in the CRH-treated group compared to saline control groups; how

270 r understanding the diverse functions of the CRH family of peptides across vertebrates.

271 Moreover, administration of the CRH receptor type 1 (CRFR(1)) blocker NBI 30775 directly

272 we found that CRH, through activation of the CRH receptor type 1 (CRHR1), evokes a rapid induction of

273 The interaction of the CRH with the recognition layer of the immobilized half-a

274 o functionally dissect the complexity of the CRH/CRHR1 system is to unravel the identity of CRHR1-exp

275 dent manner, and this action depended on the CRH receptor type 1.

276 GABA)-containing, inhibitory synapses on the CRH synthesizing neurons.

277 matory pain test, we administered CRH or the CRH receptor antagonist alpha-helical CRH(9-41) (ahCRH)

278 otide polymorphism (SNP) is found within the CRH promoter (-248C--> T).

279 This CRH-stimulated mechanism is mediated through activation

280 t vertebrate genomes possess, in addition to CRH, another gene that resembles CRH in sequence and syn

281 alpain recruitment contributed critically to CRH-induced spine loss.

282 response of cocaine-dependent individuals to CRH administration.

283 d stresscopin-related peptide, paralogous to CRH, were also identified based on the conserved signali

284 ontaining dendritic spines were resistant to CRH.

285 reased subjective and heart rate response to CRH and a relationship between stress and craving in coc

286 and increase in excitability in response to CRH and AVP the patterns of electrical excitability and

287 d the subjective and physiologic response to CRH in cocaine-dependent individuals and controls.

288 This oscillatory response to CRH is dose dependent and becomes disrupted for higher l

289 The corticotropin response to CRH was independent of sex and cocaine dependence.

290 or the transition to bursting in response to CRH.

291 enatal cocaine enhanced the CORT response to CRH/saline injections up to 60 min in males but not in f

292 d the relationship of this second vertebrate CRH gene, which we name CRH2, to CRH1 (previously known

293 are found in nucleus accumbens (NAc), where CRH modulates reward/motivation behaviors.

294 ase expression of functional CRHR-1, whereas CRH induces NK-1 gene expression.

295 athematical modelling to investigate whether CRH and AVP promote distinct patterns of electrical exci

296 mathematical modeling to investigate whether CRH and AVP promote distinct patterns of electrical exci

297 Treatment of LAD2 cells with CRH (1 muM) for 6 hours induces gene expression of NK-1

298 ver, repeated stimulation of mast cells with CRH (1 muM) leads to downregulation of CRHR-1 and upregu

299 Co-stimulation with CRH and AVP results in complex patterns of excitability

300 The structural motifs within CRH-R1 that mediate G protein activation and signaling s