ライフサイエンスコーパス: CSF-1 receptor

1 Imatinib mesylate (IM) blocks the CSF-1 receptor.

2 ly EGF receptor and macrophages express only CSF-1 receptor.

3 KB) domain binds in vitro and in vivo to the CSF-1 receptor.

4 ls expressing this mutated form of the human CSF-1 receptor.

5 s of CSF-1 reduce the gene expression of the CSF-1 receptor.

6 tent with tissue-specific down-modulation of CSF-1 receptors.

7 ing through the colony-stimulating factor-1 (CSF-1) receptor.

8 where it is targeted to trophoblast bearing CSF-1-receptors.

9 ly, bone marrow M phi preincubated with anti-CSF-1 receptor Ab or anti-CSF-1 neutralizing Ab were res

10 r studies showed that the mRNA levels of the CSF-1 receptor also parallel this time course.

11 he autocrine effect is inhibited through the CSF-1 receptor, analysis of the CSF-1 receptor mRNA leve

12 Colony stimulating factor-1 (Csf-1) receptor and its ligand Csf-1 control macrophage

13 ranulocyte/macrophage CSF (GM-CSF) or CD115 (CSF-1 receptor) and nearly completely (up to 90%) by bot

14 ssion of CD86, and lost expression of CD115 (CSF-1 receptor) and proliferative responsiveness to CSF-

15 eptor, CCR1, and regulatory receptors c-Fms (CSF-1 receptor) and RANK (receptor activator of nuclear

16 However, these cells uniformly express the CSF-1 receptor, and their morphology, phagocytosis and r

17 ia depletion, via treatment of mice with the CSF-1 receptor antagonist PLX5622, and abrogated neurona

18 pletion of MR(hi) dermal macrophages by anti-CSF-1 receptor antibody reversed the nonhealing phenotyp

19 CSF-1 receptors are continuously subject to down-modulat

20 Analyses of CSF-1 receptor autophosphorylation mutants show that, al

21 In addition, there is evidence that the CSF-1 receptor carboxy-terminus is involved in down regu

22 the protein tyrosine phosphorylation of the CSF-1 receptor (CSF-1R) and many other, primarily cytoso

23 we demonstrate the immunolocalisation of the CSF-1 receptor (CSF-1R) as well as its ligand (CSF-1) in

24 imulating factor-1 (CSF-1) activation of the CSF-1 receptor (CSF-1R) causes Cbl protooncoprotein tyro

25 The CSF-1 receptor (CSF-1R) is a tyrosine kinase that is tar

26 The CSF-1 receptor (CSF-1R) is expressed in >50% of human br

27 In the absence of SHPTP1, the CSF-1 receptor (CSF-1R) is hyperphosphorylated upon CSF-

28 The CSF-1 receptor (CSF-1R) regulates CNS microglial develop

29 We used an inhibitor of the CSF-1 receptor (CSF-1R) to target TAMs in a mouse proneu

30 Colony-stimulating factor-1 (CSF-1)-induced CSF-1 receptor (CSF-1R) tyrosine phosphorylation and ubi

31 lony-stimulating factor-1 (CSF-1)-stimulated CSF-1 receptor (CSF-1R) tyrosine phosphorylation initiat

32 myeloid progenitor 32D cell line expressing CSF-1 receptor (CSF-1R), CSF-1 activation of the extrace

33 roduction, are thought to be mediated by the CSF-1 receptor (CSF-1R), encoded by the c-fms proto-onco

34 ogenic factor, MIP-1alpha, were elevated and CSF-1 receptor (CSF-1R)-dependent production of MIP-1alp

35 One example is the CSF-1 receptor (CSF-1R, CD115, c-fms), which is used as

36 the JMD of the colony stimulating factor-1 (CSF-1) receptor (CSF-1R) binds to Src family kinases (SF

37 F) of the human colony-stimulating factor 1 (CSF-1) receptor (CSF-1R) impairs ligand-stimulated tyros

38 Colony-stimulating factor 1 (CSF-1) receptor (CSF-1R, or macrophage CSF receptor [M-C

39 H-3T3 cells expressing a partially defective CSF-1 receptor, CSF-1R (Y809F), exhibited impaired ERK1

40 CSF-1 receptor (CSF1R) signaling is important for the re

41 rrow chimeric mice, we have established that CSF-1 receptor-deficient hematopoietic precursors failed

42 imulating factor-1 (CSF-1) but are absent in CSF-1 receptor-deficient mice.

43 biquitin-protein ligase c-Cbl is involved in CSF-1 receptor degradation.

44 ain with lpr (C3H-lpr); and 3) modulation of CSF-1 receptor expression by CSF-1 is more rapid in MRL

45 wnregulating CSF-1 production and abrogating CSF-1 receptor expression.

46 F-1 signaling, PLCgamma1 is recruited to the CSF-1 receptor following exposure to the cytokine.

47 Instead, inflammatory DCs required Csf-1 receptor for their development.

48 the macrophage colony-stimulating factor-1 (CSF-1) receptor, has been observed in a variety of carci

49 in vivo and establish the importance of the CSF-1 receptor in this process.

50 on of the human colony-stimulating factor 1 (CSF-1) receptor in NIH 3T3 cells leads to activation of

51 Furthermore, blocking CSF-1 or the CSF-1 receptor induced less TEC apoptosis than the isoty

52 n the expression of the c-fms gene and CSF-1/CSF-1 receptor-induced invasion and anchorage-independen

53 eatment of Pten null mice with the selective CSF-1 receptor inhibitor GW2580 decreases MDSC infiltrat

54 Use of chimeric receptors indicates that the CSF-1 receptor is cleaved at least two times, once in th

55 o phorbol 12-myristate 13-acetate (PMA), the CSF-1 receptor is subject to proteolytic processing.

56 The colony-stimulating factor 1 (CSF-1) receptor is a protein-tyrosine kinase that regula

57 The colony-stimulating factor-1 (CSF-1) receptor is a protein-tyrosine kinase that regula

58 leukin-34 (IL-34), an alternative ligand for Csf-1 receptor, is produced by keratinocytes in the epid

59 by in vivo macrophage suppression using the CSF-1 receptor kinase inhibitor GW2580.

60 While alterations in the CSF-1 receptor-mediated clearance of CSF-1 appeared not

61 through the CSF-1 receptor, analysis of the CSF-1 receptor mRNA levels in cultured dental follicle c

62 nces CSF-1 gene expression, has no effect on CSF-1 receptor mRNA levels.

63 nd 2) WT bone marrow M phi blocked with anti-CSF-1 receptor or anti-CSF-1 Ab compared with the isotyp

64 beta1 is inhibited by blocking EGF receptor, CSF-1 receptor, or macrophage function, indicating that

65 Diabetes occurred in the anti-CSF-1 receptor protected mice after treatment with a blo

66 Immunostaining for the CSF-1 receptor protein shows that it is present in the d

67 eatment of NOD mice with an antibody against CSF-1 receptor reduced diabetes incidence and led to the

68 r NOD mice with a monoclonal antibody to the CSF-1 receptor resulted in depletion of the resident mac

69 We further provide evidence that the CSF-1 receptor's carboxy-terminus is a substrate for aut

70 s (LCs) and microglia is highly dependent on Csf-1 receptor signaling but independent of Csf-1.

71 s loop by blockade of either EGF receptor or CSF-1 receptor signaling is sufficient to inhibit both m

72 Moreover, administration of a CSF-1 receptor-specific (CSF-1R-specific) antibody after

73 ence of diabetes, NOD mice treated with anti-CSF-1 receptor starting at 3 or 10 wk of age still conta

74 g a form of the colony-stimulating factor-1 (CSF-1) receptor that is partially defective in transduci

75 codes a soluble colony-stimulating factor 1 (CSF-1) receptor that neutralizes the effects of CSF-1 in

76 ansduction pathways that connect the surface CSF-1 receptor to these genes in the nucleus.

77 in of the human colony stimulating factor-1 (CSF-1) receptor to sequences encoding the transmembrane

78 g domain of the colony-stimulating factor-1 (CSF-1) receptor to the transmembrane and cytoplasmic dom

79 ononuclear cells and BARF1 encodes a soluble CSF-1 receptor, we examined whether recombinant BARF1 or

80 depends on the colony-stimulating factor 1 (CSF-1) receptor, which has two ligands: CSF-1 and interl

81 opolysaccharide, and PMA and may provide the CSF-1 receptor with an additional mechanism for signal t

82 S cells diminished the surface expression of CSF-1 receptors, with 50 J/m2 causing a significant redu

83 d Myc and cyclin D1 to complement the mutant CSF-1 receptor Y809F (containing a Y-to-F mutation at po