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1 CT-1 action on motoneurons was inhibited by phosphatidyl
2 CT-1 also induced the degradation of the NF-kappa B cyto
3 CT-1 and gp130/LIF receptor were widely present in the c
4 CT-1 and IGF-I may be considered promising candidate tro
5 CT-1 induces a distinct pattern of immediate early genes
6 CT-1 induces a hypertrophic response in cardiomyocytes t
7 CT-1 is a new member of the interleukin 6 (IL-6)/leukemi
8 CT-1 is highly expressed in embryonic skeletal muscle, s
9 CT-1 is released from the heart in response to hypoxic s
10 CT-1 is the first bona fide muscle-derived neurotrophic
11 CT-1 may be important in normal motoneuron development a
12 CT-1 was injected through the penile vein 30 min before
13 CT-1, however, follows a strict degradation pathway afte
15 otrophic factor (BDNF), and cardiotrophin-1 (CT-1) are the most potent neurotrophic factors for moton
17 systemic administration of cardiotrophin-1 (CT-1) is able to improve renal function and to decrease
20 the metabolic properties of cardiotrophin-1 (CT-1), a member of the interleukin-6 family of cytokines
23 isolated a novel cytokine, cardiotrophin-1 (CT-1), from an in vitro embryonic stem cell system of ca
34 RAP-alpha1 variant, which contains NT-1 and CT-1 domains, and T-cell responses were characterized.
35 mice demonstrated increased alpha-actin and CT-1 mRNA expression, and airway myocytes isolated from
38 eral of these cytokines (LIF, OSM, CNTF, and CT-1) also utilize the LIF receptor (LIFR) as a componen
39 directed against endogenous IGF-I, GDNF, and CT-1, significantly decreased mean single-twitch force.
42 ial study was carried out with wild-type and CT-1 null mice in fed (ad libitum) and food-restricted c
48 ion, we investigated the interaction between CT-1/gp130/LIF receptor and ET-1/endothelin type A (ET(A
50 Together, the inhibitors completely blocked CT-1-dependent NF-kappa B activation and cytoprotection.
52 by nuclear run-on transcription assays, both CT-1 and alpha-adrenergic stimulation lead to an increas
54 e essential for cardiac fibroblast growth by CT-1 and that there is synergism with ET-1/ET(A) recepto
55 kinases, whereas the hypertrophy induced by CT-1 may be mediated by alternative pathways, e.g. Janus
61 ice and characterization of 24-h circulating CT-1 profiles in normal-weight and overweight/obese subj
66 binding of CT-1 to CNTFR alpha was detected, CT-1 may use a novel cytokine receptor alpha subunit.
68 d by an Ab directed at a C-terminal epitope (CT-1) but not with an Ab recognizing a protected intralu
70 cells stimulated by endogenous and exogenous CT-1 requires gp130/LIF receptor as well as ET(A) recept
71 but not bovine insulin-primed CTL expressed CT-1, a carbohydrate epitope of CD45, and bovine insulin
72 either to increase levels of trophic factors CT-1, IGF-I, glial cell line-derived neurotrophic factor
73 t study documents that gp130 is required for CT-1 signaling in cardiomyocytes, by demonstrating that
74 -kappa B and that NF-kappa B is required for CT-1 to mediate its full cytoprotective effects in cardi
75 se observations suggest a potential role for CT-1 in the regulation of metabolic circadian rhythms.
82 rhythms of Vo2 were conserved in young lean CT-1(-/-) mice (2 mo), CT-1 deficiency caused a phase sh
84 nserved in young lean CT-1(-/-) mice (2 mo), CT-1 deficiency caused a phase shift of the acrophase.
89 nal cell survival, we studied the ability of CT-1 to promote cardiac myocyte survival and proliferati
90 igned to identify the presence and action of CT-1 and its receptor complex, glycoprotein130 (gp130) a
100 l cells blocked the antiapoptotic effects of CT-1, indicating a requirement of the MAP kinase pathway
102 e the developmental pattern of expression of CT-1 during murine embryogenesis, we have developed anti
106 reviously unrecognized physiological role of CT-1 in metabolic adaptations, through the regulation of
110 t a subset of gp130 cytokines, in particular CT-1, LIF, and OSM, has the ability to impair subsequent
111 ined with positron emission tomography (PET)/CT 1 and 15 hours after an oral Copper-64 ( 64 Cu) dose.
112 18 MBq of (61)Cu-PSMA and then underwent PET/CT 1, 2, and 4 hours after administration and blood samp
115 o have uptake in cervical lymph nodes on PET/CT-1, and 2 of 3 IRSS stage IIIB patients with pathologi
118 Moreover, the circadian pattern of plasma CT-1 levels was evaluated in normal-weight and overweigh
120 ERK, or Akt pathways each partially reduced CT-1-mediated NF-kappa B activation, as well as the cyto
125 ell epitopes may vary antigenically and that CT-1 may be differentially expressed with respect to the
126 Northern blot analysis demonstrated that CT-1 gene expression was present in normal atrium and ve
128 ponsible for this effect, we documented that CT-1 activated both signal transducer and activator of t
129 A cell proliferation assay documents that CT-1 provokes an approximate 2-fold increase in embryoni
130 sphorylated, providing further evidence that CT-1 signals through the gp130/LIFRbeta heterodimer in c
136 Sequence similarity data suggested that CT-1 is a novel member of a family of structurally relat
139 (LIFRbeta) antagonist effectively blocks the CT-1 induction of c-fos, indicating a requirement for LI
142 ontrast to alpha-adrenergic stimulation, the CT-1 responsive cis-regulatory elements are located outs
147 hymic masses, 25 were evaluated at follow-up CT 1 year later: Five had increased in diameter, two had
149 tential activation of atrial and ventricular CT-1 expression in pacing-induced experimental congestiv
153 In the present study, we analyzed whether CT-1 also acts to peripherally regulate metabolic rhythm